DE29923839U1 - Mit Druck beaufschlagte Dosierinhalatoren (MDI) - Google Patents
Mit Druck beaufschlagte Dosierinhalatoren (MDI)Info
- Publication number
- DE29923839U1 DE29923839U1 DE29923839U DE29923839U DE29923839U1 DE 29923839 U1 DE29923839 U1 DE 29923839U1 DE 29923839 U DE29923839 U DE 29923839U DE 29923839 U DE29923839 U DE 29923839U DE 29923839 U1 DE29923839 U1 DE 29923839U1
- Authority
- DE
- Germany
- Prior art keywords
- pressurized metering
- pressurized
- metering inhalers
- inhalers according
- inner surfaces
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measurement Of Radiation (AREA)
- Steroid Compounds (AREA)
Description
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Claims (11)
1. Mit Druck beaufschlagte Dosierinhalatoren, die eine Lösung eines Wirkstoffs in
einem Fluorkohlenwasserstoff-Treibmittel, ein Cosolvens und gegebenenfalls eine
schwerflüchtige Komponente enthalten, dadurch gekennzeichnet, dass ein Teil der
Innenflächen oder die gesamten Innenflächen der Inhalatoren aus Edelstahl oder
anodisiertem Aluminium besteht/bestehen oder mit einer inerten organischen Beschichtung
ausgekleidet ist/sind.
2. Mit Druck beaufschlagte Dosierinhalatoren nach Anspruch 1, wobei die Wirkstoffe
aus β2-Agonisten, Steroiden oder anticholinergen Mitteln und Kombinationen davon
ausgewählt sind.
3. Mit Druck beaufschlagte Dosierinhalatoren nach Anspruch 2, wobei der Wirkstoff
Ipratropiumbromid, Oxitropiumbromid, Tiotropiumbromid, Flunisolid, Triamcinolonacetonid,
Fluticasonpropionat, Mometasonfuroat, Budesonid, Ciclesonid, Rofleponid und deren
Epimere ist.
4. Mit Druck beaufschlagte Dosierinhalatoren nach einem der Ansprüche 1 bis 3, die
eine schwerflüchtige Komponente ausgewählt aus Glycerin, Polyethylenglycol und
Isopropylmyristat enthalten.
5. Mit Druck beaufschlagte Dosierinhalatoren nach einem der Ansprüche 1 bis 4, wobei
das Cosolvens Ethanol ist.
6. Mit Druck beaufschlagte Dosierinhalatoren nach einem der Ansprüche 1 bis 5, wobei
das Treibmittel aus HFA 227, HFA 134a und deren Gemischen ausgewählt ist.
7. Mit Druck beaufschlagte Dosierinhalatoren nach einem der Ansprüche 1 bis 6, wobei
die inerte organische Beschichtung ein Perfluoralkoxyalkan, ein Epoxyphenolharz oder ein
fluoriertes Ethylen-Propylen-Polyethersulfon ist.
8. Mit Druck beaufschlagte Dosierinhalatoren nach einem der Ansprüche 1 bis 7, wobei
ein Teil der Innenflächen oder die gesamten Innenflächen mit einem Epoxyphenolharz
beschichtet ist/sind.
9. Mit Druck beaufschlagte Dosierinhalatoren nach einem der Ansprüche 1 bis 6, wobei
ein Teil der Innenflächen oder die gesamten Innenflächen aus anodisiertem Aluminium
besteht/bestehen.
10. Stabilisierte Aerosollösungsformulierung, die aus einem Wirkstoff in einem
Fluorkohlenwasserstoff-Treibmittel, einem Cosolvens und gegebenenfalls einer schwer
flüchtigen Komponente besteht, zur Verwendung in einem mit Druck beaufschlagten
Dosierinhalator gemäß einem der Ansprüche 1 bis 9.
11. Aerosollösungsformulierung von Dexbudesonid in einem Fluorkohlenwasserstoff-
Treibmittel und Ethanol als Cosolvens, weiter umfassend eine schwerflüchtige Verbindung
ausgewählt aus Glycerin, Isopropylmyristat und Polyethylenglycol.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI982559 IT1303789B1 (it) | 1998-11-25 | 1998-11-25 | "inalatori dosati pressurizzati" |
IT1999MI001712 IT1313582B1 (it) | 1999-07-30 | 1999-07-30 | Inalatori dosati pressurizzati. |
PCT/EP1999/009002 WO2000030608A1 (en) | 1998-11-25 | 1999-11-23 | Pressurised metered dose inhalers (mdi) |
Publications (1)
Publication Number | Publication Date |
---|---|
DE29923839U1 true DE29923839U1 (de) | 2001-03-01 |
Family
ID=26331622
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69942896T Expired - Lifetime DE69942896D1 (de) | 1998-11-25 | 1999-11-23 | Druckdosierinhalatoren |
DE29923839U Ceased DE29923839U1 (de) | 1998-11-25 | 1999-11-23 | Mit Druck beaufschlagte Dosierinhalatoren (MDI) |
DE69929358T Expired - Lifetime DE69929358T2 (de) | 1998-11-25 | 1999-11-23 | Mit Druck beaufschlagte Dosierinhalatoren |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69942896T Expired - Lifetime DE69942896D1 (de) | 1998-11-25 | 1999-11-23 | Druckdosierinhalatoren |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69929358T Expired - Lifetime DE69929358T2 (de) | 1998-11-25 | 1999-11-23 | Mit Druck beaufschlagte Dosierinhalatoren |
Country Status (36)
Country | Link |
---|---|
US (8) | US7347199B1 (de) |
EP (4) | EP1674079A3 (de) |
JP (1) | JP2002530156A (de) |
KR (1) | KR100696746B1 (de) |
CN (1) | CN1200690C (de) |
AR (1) | AR021391A1 (de) |
AT (2) | ATE314838T1 (de) |
AU (1) | AU764696C (de) |
BG (1) | BG65596B1 (de) |
BR (1) | BR9916868B1 (de) |
CA (2) | CA2698376A1 (de) |
CO (1) | CO5170487A1 (de) |
CY (1) | CY1105356T1 (de) |
CZ (1) | CZ301305B6 (de) |
DE (3) | DE69942896D1 (de) |
DK (1) | DK1131051T3 (de) |
DZ (1) | DZ2947A1 (de) |
EA (1) | EA004132B1 (de) |
EE (1) | EE04259B1 (de) |
EG (1) | EG25278A (de) |
ES (1) | ES2255767T3 (de) |
GE (1) | GEP20033129B (de) |
HK (1) | HK1040063B (de) |
HU (1) | HU226735B1 (de) |
IL (3) | IL143294A0 (de) |
MA (1) | MA26764A1 (de) |
NO (1) | NO330194B1 (de) |
NZ (2) | NZ527190A (de) |
PL (2) | PL200658B1 (de) |
SA (1) | SA99200825B1 (de) |
SI (1) | SI1131051T1 (de) |
SK (1) | SK285246B6 (de) |
TN (1) | TNSN99220A1 (de) |
TR (2) | TR200101441T2 (de) |
TW (1) | TWI226247B (de) |
WO (1) | WO2000030608A1 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010031244A1 (en) * | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
SE9703407D0 (sv) | 1997-09-19 | 1997-09-19 | Astra Ab | New use |
SE9802073D0 (sv) | 1998-06-11 | 1998-06-11 | Astra Ab | New use |
DZ2947A1 (fr) * | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
US6739333B1 (en) | 1999-05-26 | 2004-05-25 | Boehringer Ingelheim Pharma Kg | Stainless steel canister for propellant-driven metering aerosols |
US6315985B1 (en) * | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
IT1317720B1 (it) * | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani. |
IT1317846B1 (it) * | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
IT1318514B1 (it) * | 2000-05-12 | 2003-08-27 | Chiesi Farma Spa | Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari. |
ME00220B (me) * | 2000-05-22 | 2010-10-10 | Chiesi Farm Spa | Stabilne farmaceutske formulacije rastvora za inhalatore odmjerene doze pod pritiskom |
US20060257324A1 (en) * | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
DE10062712A1 (de) * | 2000-12-15 | 2002-06-20 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden |
US20020085978A1 (en) * | 2000-11-10 | 2002-07-04 | Mina Buenafe | Degradation-resistant glucocorticosteroid formulations |
EP1241113A1 (de) | 2001-03-12 | 2002-09-18 | CHIESI FARMACEUTICI S.p.A. | Inhalator mit Mitteln um chemische Stabilität der darin enthaltenen medizinischen Aerosollösung zu verbessern |
GB0106046D0 (en) * | 2001-03-12 | 2001-05-02 | Glaxo Group Ltd | Canister |
DE10130371A1 (de) * | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
EP1273292B1 (de) * | 2001-07-02 | 2004-05-26 | CHIESI FARMACEUTICI S.p.A. | Optimierte Tobramycin-Formulierung zur Aerosolbildung |
EP1321159A1 (de) | 2001-12-21 | 2003-06-25 | CHIESI FARMACEUTICI S.p.A. | Betätigungsvorrichtung für Druckdosierinhalator mit lasergebohrten Löchern |
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US20040126325A1 (en) * | 2002-03-12 | 2004-07-01 | David Lewis | Medicinal aerosol solution formulation products with improved chemical stability |
DE10214263A1 (de) * | 2002-03-28 | 2003-10-16 | Boehringer Ingelheim Pharma | HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum |
JP2006516545A (ja) * | 2003-02-04 | 2006-07-06 | クリサリス テクノロジーズ インコーポレイテッド | パーフルオロカーボン及びハイドロフルオロカーボン製剤及びその製法及び使用法 |
EP1915985A1 (de) | 2003-03-20 | 2008-04-30 | Boehringer Ingelheim Pharmaceuticals Inc. | Formulierung für einen Dosierinhalator mit Hydrofluoralkanen als Treibstoffen |
EA009087B1 (ru) | 2003-03-20 | 2007-10-26 | Бёрингер Ингельхайм Фармасьютиклз, Инк. | Состав для ингалятора, выдающего мерную дозу препарата, с использованием гидрофторалканов в качестве пропеллентов |
GB0311701D0 (en) * | 2003-05-21 | 2003-06-25 | Karib Kemi Pharm Liited | Improved metered dose inhaler product |
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US7273603B2 (en) * | 2003-07-11 | 2007-09-25 | Boehringer Ingelheim International Gmbh | HFC solution formulations containing an anticholinergic |
DE10345065A1 (de) * | 2003-09-26 | 2005-04-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum |
US20050136009A1 (en) * | 2003-10-20 | 2005-06-23 | Schering Corporation | Pharmaceutical compositions |
EP1595531A1 (de) * | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stabile Arzneimittellösung für Druckdosierinhalatoren |
UA88894C2 (ru) * | 2004-02-27 | 2009-12-10 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Стабильные фармацевтические композиции в виде растворов для ингаляторов с дозатором, которые находятся под давлением |
IL177103A0 (en) * | 2004-02-27 | 2006-12-10 | Chiesi Farma Spa | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
PL1809243T5 (pl) | 2004-07-02 | 2022-12-27 | Boehringer Ingelheim International Gmbh | Preparaty aerozolowe w postaci zawiesin z tg 227 ea jako propelent aerozolowy |
NZ556376A (en) | 2005-02-25 | 2010-01-29 | Chiesi Farma Spa | Pharmaceutical aerosol formulations for pressurized metered dose inhalers comprising a sequestering agent |
MX2007012084A (es) * | 2005-03-30 | 2007-11-21 | Schering Corp | Medicamentos y metodos que combinan un anticolinergico, un corticosteroide y un agonista beta de accion prolongada. |
DE102006017320A1 (de) | 2006-04-11 | 2007-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel |
US8227027B2 (en) | 2007-12-07 | 2012-07-24 | Presspart Gmbh & Co. Kg | Method for applying a polymer coating to an internal surface of a container |
US20130005822A1 (en) | 2010-03-15 | 2013-01-03 | Rubin Bruce K | Aerosolized dapsone as a therapy for inflammation of the airway and abnormal mucociliary transport |
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GB201108039D0 (en) * | 2011-05-13 | 2011-06-29 | Mexichem Amanco Holding Sa | Compositions |
CN102379846B (zh) * | 2011-10-21 | 2014-07-02 | 江苏长风药业有限公司 | 以氢氟烷烃和聚乙二醇为辅料氟替卡松丙酸酯气雾剂制剂 |
GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
CN103207032A (zh) * | 2012-01-13 | 2013-07-17 | 热敏碟公司 | 低型面温度传感器探针 |
KR101313993B1 (ko) * | 2012-07-24 | 2013-10-01 | 한국화학연구원 | 약물 흡입 장치 |
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