DE2915082C2 - - Google Patents

Info

Publication number
DE2915082C2
DE2915082C2 DE2915082A DE2915082A DE2915082C2 DE 2915082 C2 DE2915082 C2 DE 2915082C2 DE 2915082 A DE2915082 A DE 2915082A DE 2915082 A DE2915082 A DE 2915082A DE 2915082 C2 DE2915082 C2 DE 2915082C2
Authority
DE
Germany
Prior art keywords
indicator
enzyme
nucleic acid
dna
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2915082A
Other languages
German (de)
English (en)
Other versions
DE2915082C3 (de
DE2915082A1 (de
Inventor
Philippe Kourilsky
Stratis Avrameas
Geb. Contamine Brigitte Cami
Jean-Luc Paris Fr Guesdon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur
Original Assignee
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9207099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE2915082(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Institut Pasteur filed Critical Institut Pasteur
Publication of DE2915082A1 publication Critical patent/DE2915082A1/de
Application granted granted Critical
Publication of DE2915082C2 publication Critical patent/DE2915082C2/de
Publication of DE2915082C3 publication Critical patent/DE2915082C3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE2915082A 1978-04-13 1979-04-12 Verfahren und Verwendung eines Reagenzsatzes zum Nachweis und zur Charakterisierung von Nukleinsäuren und ihren Sequenzen Expired - Lifetime DE2915082C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7810975A FR2422956A1 (fr) 1978-04-13 1978-04-13 Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede

Publications (3)

Publication Number Publication Date
DE2915082A1 DE2915082A1 (de) 1979-10-31
DE2915082C2 true DE2915082C2 (OSRAM) 1989-07-13
DE2915082C3 DE2915082C3 (de) 1995-04-20

Family

ID=9207099

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2915082A Expired - Lifetime DE2915082C3 (de) 1978-04-13 1979-04-12 Verfahren und Verwendung eines Reagenzsatzes zum Nachweis und zur Charakterisierung von Nukleinsäuren und ihren Sequenzen

Country Status (9)

Country Link
US (3) US4581333A (OSRAM)
JP (1) JPS54143297A (OSRAM)
BE (1) BE875598A (OSRAM)
CH (1) CH647870A5 (OSRAM)
DE (1) DE2915082C3 (OSRAM)
FR (1) FR2422956A1 (OSRAM)
GB (1) GB2019408B (OSRAM)
IT (1) IT1119725B (OSRAM)
NL (1) NL191541C (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220854B1 (en) 1982-06-23 2007-05-22 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides

Families Citing this family (286)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US5605800A (en) * 1978-04-13 1997-02-25 Institut Pasteur Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method
US6270955B1 (en) 1978-12-22 2001-08-07 Biogen, Inc. Pharmaceutical compositions and methods for producing antibodies to hepatitis b virus and kits and methods for detecting antibodies to hepatitis b virus
US6835557B1 (en) 1980-01-08 2004-12-28 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
IE57069B1 (en) 1980-04-03 1992-04-22 Biogen Inc Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
EP0329198B1 (en) * 1981-04-17 1998-06-10 Yale University Base modified oligo- and polynucleotides and methods of preparing and using same
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
JPS5840099A (ja) * 1981-07-17 1983-03-08 アモコ・コ−ポレ−ション 光−放射ポリヌクレオチドの交雑診断方法
ATE39267T1 (de) * 1981-09-25 1988-12-15 John A Webster Jr Verfahren zur identifizierung und charakterisierung von organismen.
US4717653A (en) * 1981-09-25 1988-01-05 Webster John A Jr Method for identifying and characterizing organisms
EP0155359B1 (en) * 1981-09-25 1988-01-07 John A. Webster, Jr. Method for identifying and characterizing organisms
US5614361A (en) * 1981-09-25 1997-03-25 Webster, Jr.; John A. Method for identifying and characterizing organisms
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
FR2518755B1 (fr) * 1981-12-23 1986-04-11 Pasteur Institut Sonde contenant un acide nucleique modifie et reconnaissable par des anticorps specifiques et utilisation de cette sonde pour detecter et caracteriser une sequence d'adn homologue
JPS58502165A (ja) * 1981-12-23 1983-12-15 アンステイテユ・パストウ−ル 特異抗体により認識し得る修飾核酸プローブを使用して核酸配列の存在を検出する方法
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US5260433A (en) * 1982-06-23 1993-11-09 Enzo Diagnostics, Inc. Saccharide specific binding system labeled nucleotides
US5241060A (en) * 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US4556643A (en) * 1982-07-26 1985-12-03 Agracetus Assay method and probe for polynucleotide sequences
US6818393B1 (en) 1982-07-30 2004-11-16 Biomirieux Sa DNA sequences coding for the DR beta-chain locus of the human lymphocyte antigen complex and polypeptides, diagnostic typing processes and products related thereto
CA1295562C (en) * 1982-07-30 1992-02-11 Bernard Francois Mach DNA SEQUENCES CODING FOR THE DR.beta.-CHAIN LOCUS OF THE HUMAN LYMPHOCYTE ANTIGEN COMPLEX AND POLYPEPTIDES, DIAGNOSTIC TYPING PROCESSES AND PRODUCTS RELATED THERETO
US4689295A (en) * 1983-01-20 1987-08-25 Integrated Genetics, Inc. Test for Salmonella
US4994373A (en) * 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
GB8306426D0 (en) * 1983-03-09 1983-04-13 Malcolm A D B Detecting polynucleotide sequence
DE3310337A1 (de) * 1983-03-22 1984-09-27 Europäisches Laboratorium für Molekularbiologie (EMBL), 6900 Heidelberg Verfahren zur durchfuehrung von hybridisierungsreaktionen
GB8311905D0 (en) * 1983-04-29 1983-06-02 Cox R A Isolation and detection of nucleotide sequence
CA1228811A (en) 1983-05-05 1987-11-03 Robert G. Pergolizzi Assay method utilizing polynucleotide sequences
CA1220818A (en) * 1983-05-05 1987-04-21 Hugh A.O. Hill Assay techniques utilising specific binding agents
US5221609A (en) * 1983-05-31 1993-06-22 Orgenics Ltd. Molecular genetic probe, and method of forming same, assay technique and kit using said molecular genetic probe
JPH0743376B2 (ja) * 1983-05-31 1995-05-15 オルジェニックス リミテッド 核酸配列の検定方法及び分子遺伝子プローブ
US4987065A (en) * 1983-07-05 1991-01-22 Enzo Biochem, Inc. In vivo labelling of polynucleotide sequences
CA1222705A (en) * 1983-07-14 1987-06-09 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4959309A (en) * 1983-07-14 1990-09-25 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US4626501A (en) * 1983-09-02 1986-12-02 Integrated Genetics, Inc. Labeled DNA
CA1256005A (en) * 1983-09-26 1989-06-20 W. Peter Hansen Sandwich hybridization method for nucleic acid detection
FR2552879B1 (fr) * 1983-10-03 1987-08-14 Pasteur Institut Procede et reactifs pour la detection d'une anomalie genetique dans une matiere biologique, notamment dans une preparation de leucocytes
US4743535A (en) * 1984-11-07 1988-05-10 Miles Inc. Hybridization assay employing labeled probe and anti-hybrid
WO1985002627A1 (en) * 1983-12-16 1985-06-20 Genetics International, Inc. Assay for nucleic acids
US4843122A (en) * 1984-01-30 1989-06-27 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4849208A (en) * 1984-01-30 1989-07-18 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US5002885A (en) * 1984-01-30 1991-03-26 Enzo Biochem, Inc. Detectable molecules, method preparation and use
US4707440A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US4849505A (en) * 1984-01-30 1989-07-18 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4943523A (en) * 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
AU3844485A (en) * 1984-02-09 1985-08-15 Enzo Biochem Inc. Heterologous detection of cabeled dna
US4748111A (en) * 1984-03-12 1988-05-31 Molecular Diagnostics, Inc. Nucleic acid-protein conjugate used in immunoassay
US4582789A (en) * 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
US4617261A (en) * 1984-03-21 1986-10-14 Cetus Corporation Process for labeling nucleic acids and hybridization probes
US4840892A (en) * 1984-05-15 1989-06-20 Smithkline Beckman Corporation Polynucleotide hybridization probes
US4670380A (en) * 1984-05-23 1987-06-02 Molecular Diagnostics, Inc. Assays utilizing labeled nucleic acid probes
DE3431536A1 (de) * 1984-08-28 1986-03-13 Boehringer Mannheim Gmbh, 6800 Mannheim Derivatisierte nucleinsaeure-sequenz, verfahren zu deren herstellung sowie deren verwendung zum nachweis von nucleinsaeuren
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US4692509A (en) * 1984-11-27 1987-09-08 Molecular Diagnostics, Inc. Radioactive labeling of proteins with nucleosides or nucleotides
DE3587845T2 (de) * 1984-12-03 1994-10-20 Hoechst Celanese Corp Verfahren zur Bestimmung eines Liganden.
US4670379A (en) * 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
FR2578847A1 (fr) * 1985-03-13 1986-09-19 Centre Nat Rech Scient Sonde adn destinee au diagnostic antenatal de certaines anomalies chromosomiques
US6197563B1 (en) 1985-03-28 2001-03-06 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences
US6040166A (en) * 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
GB8509880D0 (en) * 1985-04-17 1985-05-22 Ici Plc Testing device
US5273882A (en) * 1985-06-13 1993-12-28 Amgen Method and kit for performing nucleic acid hybridization assays
IL79112A (en) * 1985-06-13 1992-01-15 Abbott Lab Method for the isolation of a nucleic acid sequence and kit for performing a hybridization assay
US4806631A (en) * 1985-09-30 1989-02-21 Miles Inc. Immobilization of nucleic acids on solvolyzed nylon supports
US4806546A (en) * 1985-09-30 1989-02-21 Miles Inc. Immobilization of nucleic acids on derivatized nylon supports
US4789630A (en) * 1985-10-04 1988-12-06 Cetus Corporation Ionic compounds containing the cationic meriquinone of a benzidine
NZ218050A (en) * 1985-11-13 1989-05-29 Wistar Inst Test for the presence of htlv-1v
JPS63502477A (ja) * 1985-12-03 1988-09-22 エル・ギユ−リイ・エム・ラフアツト 病気診断のための方法、装置および製品
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US5756696A (en) * 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
US6280929B1 (en) 1986-01-16 2001-08-28 The Regents Of The University Of California Method of detecting genetic translocations identified with chromosomal abnormalities
US6872817B1 (en) 1986-01-16 2005-03-29 The Regents Of The Univ. Of California Method of staining target interphase chromosomal DNA
US5447841A (en) * 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US7115709B1 (en) * 1986-01-16 2006-10-03 The Regents Of The University Of California Methods of staining target chromosomal DNA employing high complexity nucleic acid probes
US6475720B1 (en) 1986-01-16 2002-11-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US4935357A (en) * 1986-02-05 1990-06-19 New England Biolabs, Inc. Universal restriction endonuclease
US5418133A (en) * 1986-08-12 1995-05-23 The Australian National University Sex determination in cattle, sheep and goats using y-chromosome polynucleotides
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US5660983A (en) * 1986-12-04 1997-08-26 Mycogen Plant Science, Inc. Maize cytoplasmic male sterility type T (cms-T) mitochondria DNA
AU619170B2 (en) * 1987-01-09 1992-01-23 Abbott Laboratories Diagnostic assays using nucleic acid probes
AU622104B2 (en) * 1987-03-11 1992-04-02 Sangtec Molecular Diagnostics Ab Method of assaying of nucleic acids, a reagent combination and kit therefore
EP0304934A3 (de) * 1987-08-26 1989-07-26 Hunger, Hans-Dieter Markierte molekulare Sonden, Verfahren zu ihrer Herstellung und ihre Verwendung
US5384241A (en) * 1987-09-11 1995-01-24 Enzo Diagnostics, Inc. Specific binding assay compound with inhibitive self-quenching characteristics
US6004745A (en) * 1987-09-21 1999-12-21 Gen-Probe Incorporated Hybridization protection assay
CA1339872C (en) * 1987-09-21 1998-05-19 Lyle John Arnold Jr. Homogeneous protection assay
US5639604A (en) * 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
DE3732145A1 (de) * 1987-09-24 1989-04-06 Merck Patent Gmbh Verfahren und reagenz zur durchfuehrung von hybridisierungsreaktionen
DE3742706A1 (de) * 1987-12-16 1989-06-29 Erich Prof Dr Med Liebhardt Verfahren zum identifizieren unbekannten biologischen materials
US5354657A (en) * 1988-01-12 1994-10-11 Boehringer Mannheim Gmbh Process for the highly specific detection of nucleic acids in solid
FR2680374B2 (fr) * 1988-03-25 1993-11-12 Bioprobe Systems Sa Procede de coloration d'acides nucleiques detectes par marquage non radioactif et ensemble de reactifs pour la mise en óoeuvre de ce procede.
US6326136B1 (en) * 1988-04-01 2001-12-04 Digene Corporation Macromolecular conjugate made using unsaturated aldehydes
US5109124A (en) * 1988-06-01 1992-04-28 Biogen, Inc. Nucleic acid probe linked to a label having a terminal cysteine
US5858652A (en) * 1988-08-30 1999-01-12 Abbott Laboratories Detection and amplification of target nucleic acid sequences
US6203977B1 (en) * 1988-11-15 2001-03-20 Yale University Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization
US5489507A (en) * 1988-11-30 1996-02-06 Perkin-Elmer Corporation DNA detection by color complementation
US5237016A (en) * 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
EP0385410B1 (en) * 1989-02-28 1996-10-02 Canon Kabushiki Kaisha Partially double-stranded oligonucleotide and method for forming oligonucleotide
EP0462224B1 (en) * 1989-03-10 1994-08-31 Millipore Corporation Sequencing nucleic acids using chemiluminescent detection
DE4001154A1 (de) * 1990-01-17 1991-07-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von modifizierten nukleinsaeuren
CA2031659A1 (en) * 1990-01-26 1991-07-27 John B. Findlay Water-insoluble reagent, nucleic acid probe, test kit and diagnostic and purification methods
NL9001639A (nl) * 1990-07-19 1992-02-17 Amc Amsterdam Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen.
US5714327A (en) * 1990-07-19 1998-02-03 Kreatech Diagnostics Platinum-containing compounds, methods for their preparation and applications thereof
JPH0499500A (ja) * 1990-08-17 1992-03-31 Kikkoman Corp アビジンまたはアビジン標識体の定量法およびビオチンまたはビオチン標識体の定量法
WO1992008808A1 (en) * 1990-11-14 1992-05-29 Siska Diagnostics, Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
ATE185573T1 (de) * 1991-01-14 1999-10-15 Univ New York Cytokin-induziertes protein, tsg-6, seine dna und verwendung
WO1992012176A1 (en) * 1991-01-14 1992-07-23 New York University Cytokine-induced protein, tsg-14, dna coding therefor and uses thereof
US5552279A (en) * 1991-03-22 1996-09-03 Amoco Corporation Nucleic acid probes for the detection of mycoplasma pneumoniae and mycoplasma genitalium
US5843667A (en) * 1991-03-22 1998-12-01 Amoco Corporation Nucleic acid probes for the detection for genital mycoplasmas
EP0648281A4 (en) * 1991-09-10 1997-06-04 Jack D Love TARGETED AMPLIFICATION OF DNA AND RNA AND SIGNAL AMPLIFICATION.
WO1993013114A1 (en) 1991-12-24 1993-07-08 Isis Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR MODULATING β-AMYLOID
US5965362A (en) 1992-03-04 1999-10-12 The Regents Of The University Of California Comparative genomic hybridization (CGH)
ES2161715T3 (es) 1992-03-04 2001-12-16 Univ California Hibridacion genomica comparativa (hgc).
US7534567B2 (en) 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
WO1993020234A1 (en) * 1992-03-31 1993-10-14 E.I. Du Pont De Nemours And Company A rapid, high capacity nucleic acid based assay
WO1994014067A1 (en) * 1992-12-14 1994-06-23 T Cell Sciences, Inc. Diagnosis and therapy of sarcoidosis
KR0169057B1 (ko) * 1993-08-10 1999-01-15 도다 미키오 핵산의 검출법
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5922544A (en) * 1994-12-29 1999-07-13 Eiken Kagaku Kabushiki Kaish Method of cell detection
US5753787A (en) * 1995-04-10 1998-05-19 Yale University Nucleic acids encoding ancylostoma secreted protein
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US6297027B1 (en) 1996-07-31 2001-10-02 Purina Mills, Inc. Bovine leptin protein, nucleic acid sequences coding therefor and uses thereof
US6277592B1 (en) 1996-07-31 2001-08-21 Purina Mills, Inc. Porcine leptin protein, nucleic acid sequences coding therefor and uses thereof
US20020137904A1 (en) * 1998-03-27 2002-09-26 Patricia A. Billing-Medel Reagents and methods useful for detecting diseases of the gastrointestinal tract
EP2060630B1 (en) 1997-04-10 2012-10-24 Stichting Katholieke Universiteit University Medical Centre Nijmegen PCA3, PCA3 genes, and methods of use
US20050208567A1 (en) * 1997-04-25 2005-09-22 Billing-Medel Patricia A Reagents and methods useful for detecting diseases of the prostate
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
IL124275A (en) * 1997-05-02 2002-03-10 Bio Merieux Vitek Inc A method to produce sequences of nucleic acids
WO1998050583A1 (en) 1997-05-02 1998-11-12 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6558901B1 (en) 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
FR2767337B1 (fr) 1997-08-14 2002-07-05 Pasteur Institut Sequences nucleiques de polypeptides exportes de mycobacteri es, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
CN1280619A (zh) 1997-11-28 2001-01-17 根瑟特公司 沙眼衣原体的基因组序列和多肽,其片段以及其用途,特别是用于诊断、预防和治疗感染
US20040062775A1 (en) 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
CA2315037A1 (en) 1997-12-19 1999-07-01 Beth Israel Deaconess Medical Center Methods and compositions for inhibiting tumor cell growth
US6183957B1 (en) 1998-04-16 2001-02-06 Institut Pasteur Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library application to the detection of mycobacteria
US6322976B1 (en) 1998-05-28 2001-11-27 Medical Research Council Compositions and methods of disease diagnosis and therapy
EP1190097A2 (en) 1999-06-22 2002-03-27 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
EP1187939B9 (en) 1999-07-09 2009-08-12 Gen-Probe Incorporated Detection of hiv-1 by nucleic acid amplification
ATE321857T1 (de) 1999-09-29 2006-04-15 Diagnocure Inc Pca3 mrna in gutartigen und bösartigen prostatageweben
GB9928787D0 (en) 1999-12-03 2000-02-02 Medical Res Council Direct screening method
FR2803913B1 (fr) 2000-01-13 2002-08-16 Pasteur Sanofi Diagnostics Procede d'immobilisation de reactif(s) affin(s) sur phase solide hydrophobe
US6543535B2 (en) 2000-03-15 2003-04-08 Exxonmobil Upstream Research Company Process for stimulating microbial activity in a hydrocarbon-bearing, subterranean formation
EP1925672A1 (en) 2001-06-22 2008-05-28 Syngeta Participations AG Abiotic stress responsive polynucleotides and polypeptides
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
US6942972B2 (en) * 2001-10-24 2005-09-13 Beckman Coulter, Inc. Efficient synthesis of protein-oligonucleotide conjugates
US6956484B2 (en) * 2001-12-21 2005-10-18 Reconnaissance International Substance testing devices with photo identification
US20030175828A1 (en) * 2002-03-15 2003-09-18 Lazar James G. Signal amplification by Hybrid Capture
US7199107B2 (en) * 2002-05-23 2007-04-03 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
ES2370169T3 (es) 2002-06-14 2011-12-13 Gen-Probe Incorporated Composiciones y métodos para detectar el virus de la hepatitis b.
US7115374B2 (en) 2002-10-16 2006-10-03 Gen-Probe Incorporated Compositions and methods for detecting West Nile virus
JP4824540B2 (ja) 2003-02-07 2011-11-30 ダイアノキュアー インク． サンプル中の前立腺癌を検出する方法
EP2251442B9 (en) 2003-12-19 2012-04-25 Gen-Probe Incorporated Compositions, methods and kits for detecting the nucleic acids of HIV-1 and HIV-2
WO2005079474A2 (en) 2004-02-17 2005-09-01 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
CA2562517A1 (en) * 2004-04-16 2005-10-27 Spartan Bioscience Inc. System for rapid nucleic acid amplification and detection
CA2565980A1 (en) 2004-05-12 2005-12-01 Luca Technologies, Llc Generation of hydrogen from hydrocarbon-bearing materials
EP2412830B1 (en) 2004-07-13 2014-11-19 Gen-Probe Incorporated Compositions and methods for detection of Hepatitis A virus nucleic acid
DK2975139T3 (da) 2004-09-30 2019-12-09 Gen Probe Inc Assay til at detektere og kvantificere hiv-1
AU2005333163B2 (en) * 2004-11-09 2011-06-16 Gen-Probe Incorporated Compositions and methods for detecting Group A streptococci
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US7472576B1 (en) 2004-11-17 2009-01-06 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Portland State University Nanometrology device standards for scanning probe microscopes and processes for their fabrication and use
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
US20060177859A1 (en) * 2005-02-07 2006-08-10 Gen-Probe Incorporated Compositions and methods for detecting group B streptococci
US20060223153A1 (en) * 2005-04-05 2006-10-05 Luca Technologies, Llc Generation of materials with enhanced hydrogen content from anaerobic microbial consortia
US20060223159A1 (en) * 2005-04-05 2006-10-05 Luca Technologies, Llc Generation of materials with enhanced hydrogen content from microbial consortia including thermotoga
US20060223160A1 (en) * 2005-04-05 2006-10-05 Luca Technologies, Llc Systems and methods for the isolation and identification of microorganisms from hydrocarbon deposits
US7426960B2 (en) 2005-05-03 2008-09-23 Luca Technologies, Inc. Biogenic fuel gas generation in geologic hydrocarbon deposits
EP1877418B1 (en) 2005-05-06 2013-11-20 Gen-Probe Incorporated Compositions and assays to detect influenza virus a nucleic acids
ATE551433T1 (de) 2005-05-06 2012-04-15 Gen Probe Inc Verfahren und produkte zum erfassen von nukleinsäurezielen
CA2625414A1 (en) 2005-10-17 2007-04-26 Gen-Probe Incorporated Compositions and methods to detect legionella pneumophila nucleic acid
US8969033B2 (en) * 2005-11-02 2015-03-03 Battelle Energy Alliance, Llc Alteration and modulation of protein activity by varying post-translational modification
US7416879B2 (en) 2006-01-11 2008-08-26 Luca Technologies, Inc. Thermacetogenium phaeum consortium for the production of materials with enhanced hydrogen content
US7977282B2 (en) * 2006-04-05 2011-07-12 Luca Technologies, Inc. Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material
US7696132B2 (en) * 2006-04-05 2010-04-13 Luca Technologies, Inc. Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material
US20100248322A1 (en) * 2006-04-05 2010-09-30 Luca Technologies, Inc. Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material
US7588897B2 (en) * 2006-05-12 2009-09-15 Gen-Probe Incorporated Compositions and methods to detect Enterococci nucleic acid
CA2658105C (en) 2006-08-01 2016-07-05 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
EP3121286B1 (en) 2006-12-21 2019-11-20 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
EP1978111B1 (en) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
CN103157400B (zh) 2007-06-21 2014-12-24 简·探针公司 用于将容器暴露于多个热区的仪器和方法
WO2009085704A2 (en) * 2007-12-26 2009-07-09 Gen-Probe Incorporated Compositions and methods to detect candida albicans nucleic acid
US9732330B2 (en) 2008-01-25 2017-08-15 Battelle Energy Alliance, Llc Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes
US7960534B2 (en) 2008-02-26 2011-06-14 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
US8492114B2 (en) * 2008-01-25 2013-07-23 Battelle Energy Alliance, Llc Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes
AU2009206670A1 (en) 2008-01-25 2009-07-30 Battelle Energy Alliance, Llc Thermal and acid tolerant beta-xylosidases, genes encoding, related organisms, and methods
US8426185B2 (en) 2008-01-31 2013-04-23 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
US8557557B2 (en) * 2008-01-31 2013-10-15 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
AU2009210489A1 (en) 2008-01-31 2009-08-13 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic biopolymer- degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
US8497110B2 (en) * 2008-01-31 2013-07-30 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
BRPI0907407A2 (pt) 2008-02-22 2019-09-24 Battelle Energy Alliance Llc controle transcricional em alicyclobacillus acidocaldarius e genes, proteínas e métodos associados
JP2011517931A (ja) 2008-02-27 2011-06-23 バテル エナジー アライアンス，エルエルシー アリサイクロバチルス・アシドカルダリウスおよび関連生物体からの好熱性および好熱好酸性グリコシル化遺伝子および酵素、方法
BRPI0908553A2 (pt) * 2008-02-28 2019-09-24 Battelle Energy Alliance Llc genes e enzimas termofílicos e termoacidofílicos do metabolismo do alicyclobacillus acidocaldarius, organismos relacionados e métodos
WO2009131683A2 (en) 2008-04-21 2009-10-29 Gen-Probe Incorporated Method for detecting chikungunya virus
EP2479287B1 (en) 2008-05-13 2014-07-23 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
CA2723917A1 (en) 2008-05-30 2009-12-30 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of salmonella
US8097412B2 (en) * 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
CA2638458A1 (en) * 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
US20100035309A1 (en) * 2008-08-06 2010-02-11 Luca Technologies, Inc. Analysis and enhancement of metabolic pathways for methanogenesis
EP2389449B1 (en) 2008-12-30 2015-02-18 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of listeria
CA2750900C (en) 2009-01-30 2017-03-28 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
EP3705486B1 (en) 2009-02-26 2022-11-16 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
US20100248321A1 (en) * 2009-03-27 2010-09-30 Luca Technologies, Inc. Surfactant amendments for the stimulation of biogenic gas generation in deposits of carbonaceous materials
EP2449132B1 (en) 2009-07-01 2015-05-13 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US8479813B2 (en) * 2009-12-16 2013-07-09 Luca Technologies, Inc. Biogenic fuel gas generation in geologic hydrocarbon deposits
EP2536849B1 (en) 2010-02-17 2016-05-11 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
EP2561094B1 (en) 2010-04-21 2017-03-29 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acid
US20110275135A1 (en) 2010-05-05 2011-11-10 Battelle Energy Alliance, Llc Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles
CA2802741C (en) 2010-06-30 2020-07-07 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
EP3301195B1 (en) 2010-07-12 2022-11-02 Gen-Probe Incorporated Compositions and assays to detect 2009 swine h1n1 influenza a virus nucleic acid
EP4050109A1 (en) 2010-08-18 2022-08-31 Fred Hutchinson Cancer Center Agents for use in treating facioscapulohumeral dystrophy (fshd)
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
WO2012037531A1 (en) 2010-09-16 2012-03-22 Gen-Probe Incorporated Capture probes immobilizable via l-nucleotide tail
GB2497495B (en) 2010-10-04 2018-06-06 Gen Probe Prodesse Inc Compositions, methods and kits to detect adenovirus nucleic acids
USRE49975E1 (en) 2011-03-10 2024-05-21 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
EP3604559A1 (en) 2011-04-25 2020-02-05 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
EP3536810B1 (en) 2011-07-15 2023-05-10 Gen-Probe Incorporated Compositions and method for detecting human parvovirus nucleic acid and hepatitis a virus nucleic acid
WO2013036928A1 (en) 2011-09-08 2013-03-14 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
AU2012312169B2 (en) 2011-09-21 2016-01-14 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
EP2817416B1 (en) 2012-02-24 2018-10-31 Gen-Probe Prodesse Inc. Detection of shiga toxin genes in bacteria
US9004162B2 (en) 2012-03-23 2015-04-14 Transworld Technologies Inc. Methods of stimulating acetoclastic methanogenesis in subterranean deposits of carbonaceous material
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
US9139870B2 (en) 2012-08-30 2015-09-22 Gen-Probe Incorporated Multiphase nucleic acid amplification
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
WO2014160432A1 (en) * 2013-03-13 2014-10-02 Tufts University Fragment complementation based assays
CN105452488B (zh) 2013-08-14 2020-07-14 简·探针公司 用于检测hev核酸的组合物和方法
MX373669B (es) 2013-09-25 2020-04-02 Zoetis Services Llc Composicion de vacuna de circovirus porcino tipo 2b divergente y procedimientos de uso.
US10093989B2 (en) 2014-10-20 2018-10-09 Gen-Probe Incorporated Red blood cell lysis solution
EP3736346B1 (en) 2015-01-09 2023-12-20 Gen-Probe Incorporated Methods and compositions for diagnosing bacterial vaginosis
CN107429297A (zh) 2015-03-16 2017-12-01 简·探针公司 用于检测细菌核酸和诊断细菌性阴道病的方法和组合物
CN108350407B (zh) 2015-12-11 2022-07-08 杰诺玛迪克斯公司 用于核酸扩增的管密封系统和方法
JP6894439B2 (ja) 2016-01-04 2021-06-30 ジェン−プローブ・インコーポレーテッド Ｃａｎｄｉｄａ種を検出するための方法及び組成物
WO2017136782A1 (en) 2016-02-05 2017-08-10 Mark Filipowsky Dried amplification compositions
EP3736332B1 (en) 2016-04-27 2025-02-12 Gen-Probe Incorporated Blood cell lysis reagent
CA3026723C (en) 2016-06-10 2023-03-21 Gen-Probe Incorporated Compositions and methods for detecting zika virus nucleic acid
JP7167013B2 (ja) 2016-10-19 2022-11-08 ジェン－プローブ・インコーポレーテッド Ｃ型肝炎ウイルスを検出または定量するための組成物および方法
EP3541959A1 (en) 2016-11-21 2019-09-25 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis b virus
EP4219770A3 (en) 2017-03-24 2023-08-16 Gen-Probe Incorporated Compositions and methods for detection of rsv b in samples
EP4056716A1 (en) 2017-03-24 2022-09-14 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
CA3225845A1 (en) 2017-03-25 2018-10-04 Gen-Probe Incorporated Methods and compositions to detect combinations of viral nucleic acids
EP3624834A1 (en) 2017-05-17 2020-03-25 Thunder Biotech Inc. Transgenic macrophages, chimeric antigen receptors, and associated methods
JP7292217B2 (ja) 2017-06-07 2023-06-16 ジーイーエヌ－プローブ・インコーポレーテッド 試料中のバベシア種の核酸の検出
US20210155978A1 (en) 2017-07-10 2021-05-27 Gen-Probe Incorporated Analytical systems and methods for nucleic acid amplification using sample assigning parameters
EP4219766A3 (en) 2017-08-11 2023-10-11 Gen-Probe Incorporated Compositions and methods for detecting staphylococcus aureus
JP2020534836A (ja) * 2017-09-29 2020-12-03 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ サンプルを試験するためのセンサ装置及び方法
AU2018369872B2 (en) 2017-11-17 2022-11-24 Gen-Probe Incorporated Compositions and methods for detecting C1orf43 nucleic acid
EP3724354A1 (en) 2017-12-15 2020-10-21 Gen-Probe Incorporated Compositions and methods for detecting toxigenic clostridium difficile
US20210052643A1 (en) 2018-01-05 2021-02-25 Thunder Biotech, Inc. Modified macrophages and macrophage precursors and associated methods
AU2019212931A1 (en) 2018-01-29 2020-08-27 Gen-Probe Incorporated Analytical systems and methods
US12416024B2 (en) 2018-03-29 2025-09-16 Transworld Technologies Inc. Biologically enhanced oil recovery methods
GB2597566B (en) 2018-06-13 2023-02-01 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
WO2020014400A1 (en) 2018-07-10 2020-01-16 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
EP3830302B1 (en) 2018-08-01 2022-10-05 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
CA3108105A1 (en) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
EP3841224A1 (en) 2018-08-21 2021-06-30 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
KR20250151588A (ko) 2018-08-24 2025-10-21 젠-프로브 인코포레이티드 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
CA3112651A1 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
CA3112342A1 (en) 2018-10-01 2020-04-09 Gen-Probe Incorporated Compositions and methods for amplifying or detecting varicella-zoster virus
JP7542546B2 (ja) 2018-10-22 2024-08-30 ジェン－プローブ・インコーポレーテッド ヒトポリオーマウイルスｂｋウイルスを増幅、検出または定量化するための組成物および方法
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
EP4389916A3 (en) 2019-03-22 2024-10-16 Gen-Probe Incorporated Compositions and methods for detecting group a streptococcus
CA3137749C (en) 2019-05-03 2023-12-05 Gen-Probe Incorporated Receptacle transport system for an analytical system
WO2021031109A1 (zh) 2019-08-20 2021-02-25 深圳华大智造极创科技有限公司 一种基于发光标记物光信号动力学及二次发光信号对多核苷酸进行测序的方法
US20220298548A1 (en) 2019-08-23 2022-09-22 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
WO2021046270A1 (en) 2019-09-05 2021-03-11 Gen-Probe Incorporated Detection of chlamydia trachomatis nucleic acid variants
WO2021178644A1 (en) 2020-03-04 2021-09-10 Gen-Probe Incorporated Compositions and methods for detecting sars-cov-2 nucleic acid
EP4146821A1 (en) 2020-05-07 2023-03-15 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
AU2021365165A1 (en) 2020-10-21 2023-06-15 Gen-Probe Incorporated Fluid container management system
JP2024526908A (ja) 2021-07-27 2024-07-19 ジェン－プローブ・インコーポレーテッド 胃腸病原体を検出するための組成物及び方法
WO2023175434A1 (en) 2022-03-15 2023-09-21 Diagenode S.A. Detection of methylation status of a dna sample
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
AU2023408044A1 (en) 2022-12-19 2025-07-31 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2024161179A1 (en) 2023-01-31 2024-08-08 Mobidiag Oy Compositions and methods for detecting stx nucleic acids
WO2024192338A1 (en) 2023-03-16 2024-09-19 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal parasites
EP4455303A1 (en) 2023-04-28 2024-10-30 Mobidiag Oy Nucleic acid amplification process controls
EP4454758A1 (en) 2023-04-28 2024-10-30 Mobidiag Oy Nucleic acid amplification process controls
EP4455304A1 (en) 2023-04-28 2024-10-30 Mobidiag Oy Nucleic acid amplification process controls

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654090A (en) * 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) * 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US4067774A (en) * 1971-05-14 1978-01-10 Syva Company Compounds for enzyme amplification assay
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3880934A (en) * 1972-02-10 1975-04-29 Syntex Inc Nitrophenyloxy-butanediols
NL171930C (nl) * 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US4002532A (en) * 1974-10-21 1977-01-11 Weltman Joel K Enzyme conjugates
IN142734B (OSRAM) * 1975-04-28 1977-08-20 Miles Lab
US4016043A (en) * 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US4134792A (en) * 1976-12-06 1979-01-16 Miles Laboratories, Inc. Specific binding assay with an enzyme modulator as a labeling substance
US4139346A (en) * 1977-11-28 1979-02-13 Enzo Bio Chem Incorporated Nucleic acid and protein binding paper
US4318980A (en) * 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US5605800A (en) * 1978-04-13 1997-02-25 Institut Pasteur Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method
US4228237A (en) * 1978-09-21 1980-10-14 Calbiochem-Behring Corp. Methods for the detection and determination of ligands
EP0041426B1 (fr) * 1980-05-22 1985-11-13 Institut Pasteur Produit de couplage entre une lectine et un ligand spécifique, obtention et application dans le domaine biologique
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4442204A (en) * 1981-04-10 1984-04-10 Miles Laboratories, Inc. Homogeneous specific binding assay device and preformed complex method
JPH0743376B2 (ja) * 1983-05-31 1995-05-15 オルジェニックス リミテッド 核酸配列の検定方法及び分子遺伝子プローブ
EP0155854B1 (en) * 1984-03-22 1990-09-26 Bresatec Limited Non-radioactive biological probes
DE3568063D1 (en) * 1985-01-10 1989-03-09 Molecular Diagnostics Inc Photochemical method of labelling nucleic acids for detection in hybridization assays
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220854B1 (en) 1982-06-23 2007-05-22 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides

Also Published As

Publication number Publication date
DE2915082C3 (de) 1995-04-20
US5876928A (en) 1999-03-02
GB2019408B (en) 1982-08-18
FR2422956A1 (fr) 1979-11-09
NL191541C (nl) 1995-09-04
NL7902911A (nl) 1979-10-16
DE2915082A1 (de) 1979-10-31
US5955262A (en) 1999-09-21
NL191541B (nl) 1995-05-01
IT7921838A0 (it) 1979-04-13
CH647870A5 (fr) 1985-02-15
BE875598A (fr) 1979-10-15
JPH0364119B2 (OSRAM) 1991-10-03
FR2422956B1 (OSRAM) 1980-11-28
US4581333A (en) 1986-04-08
GB2019408A (en) 1979-10-31
IT1119725B (it) 1986-03-10
JPS54143297A (en) 1979-11-08

Similar Documents

Publication Publication Date Title
DE2915082C2 (OSRAM)
DE69116993T2 (de) Verfahren zum nukleotidsequenzennachweis mittels technik der sandwich-hybridisierung
DE3854056T2 (de) Verfahren zum Nachweis einer Nukleinsäure-Sequenz in einer Probe.
DE69730974T2 (de) Verfahren zur isolierung von nukleinsäuren unter anwendung von alkaliner phosphatase
DE3750198T3 (de) Hybridisierungssonden.
DE69902996T2 (de) Techniken zu detektion von fehlpaarungen
DE69305662T2 (de) Brett-stabiles Produkt und Verfahren zur Isolierung der RNA, DNA und Proteine
DE68926302T2 (de) Nucleinsäuresonden, welche verbesserte molekularschalter enthalten, und analysemethoden und kits, bei welchen die sonden verwendet werden
DE3486467T3 (de) Verfahren zum Nachweis, Identifizieren und Quantifizieren von Organismen und Viren
DE19530132C2 (de) Verfahren zur Reinigung, Stabilisierung oder Isolierung von Nukleinsäuren aus biologischen Materialien
EP0120376B1 (de) Verfahren zur Durchführung von Hybridisierungsreaktionen
DE69433816T2 (de) Die bestimmung von nukleinsäuremutationen durch analyse des sputum
DE3650416T2 (de) Zelluläres verfahren zur bestimmung des originalen gewebes.
DE69328118T2 (de) Verbesserter strangverdrängungstest und dafür verwendbarer komplex
DE3687645T2 (de) Verfahren der beschleunigten wiederassoziation der nukleinsaeure.
DE69004632T2 (de) Verfahren zum Nachweis von Nucleinsäuren.
DE3505287A1 (de) Verbesserte nucleinsaeure-reagenzien, verfahren zu ihrer herstellung und ihre verwendung
DE4216949A1 (de) Verfahren zur Präparierung und Hybridisierung von spezifischen Proben
DE69332016T2 (de) Methode zum Nachweis von Bioindividuen mittels einer Nukleinsäureprobe nicht-natürlichen Typs und Probe zur Verwendung hierin
DE69332666T2 (de) Verfahren zur einfachen nukleotid-primer-verlängerung zum nachweis spezifischer allele und dafür geeigneter kit
DE68928080T2 (de) Einstufiges in situ-hybridierungstestverfahren
DE3407196A1 (de) Verfahren zur identifizierung einzelner mitglieder einer spezies von organismen
DE69330463T2 (de) Isolierte nukleotid-sequenzen zum nachweis von neisseria gonorrhoeae
DE4333805C2 (de) Verfahren zur Extraktion von Nucleinsäuren und Verfahren zum Nachweis spezifizierter Nucleinsäuresequenzen
DE3485834T2 (de) Verfahren zum bestimmen von nukleinsaeuresequenzen.

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8128 New person/name/address of the agent

Representative=s name: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. VOSSIUS, D.,

8128 New person/name/address of the agent

Representative=s name: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. TAUCHNER, P.,

D2 Grant after examination
8363 Opposition against the patent
8328 Change in the person/name/address of the agent

Free format text: TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT. HEUNEMANN, D., DIPL.-PHYS. DR.RER.NAT., PAT.-ANWAELTE, 8000 MUENCHEN

8366 Restricted maintained after opposition proceedings
8305 Restricted maintenance of patent after opposition
D4 Patent maintained restricted