DE68926302T2 - Nucleinsäuresonden, welche verbesserte molekularschalter enthalten, und analysemethoden und kits, bei welchen die sonden verwendet werden - Google Patents

Nucleinsäuresonden, welche verbesserte molekularschalter enthalten, und analysemethoden und kits, bei welchen die sonden verwendet werden

Info

Publication number
DE68926302T2
DE68926302T2 DE68926302T DE68926302T DE68926302T2 DE 68926302 T2 DE68926302 T2 DE 68926302T2 DE 68926302 T DE68926302 T DE 68926302T DE 68926302 T DE68926302 T DE 68926302T DE 68926302 T2 DE68926302 T2 DE 68926302T2
Authority
DE
Germany
Prior art keywords
probe
nucleic acid
kits
acid probes
analysis methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68926302T
Other languages
English (en)
Other versions
DE68926302D1 (de
Inventor
Paul Lizardi
Fred Kramer
Sanjay Tyagi
Cesar Guerra
Hilda Buyoli
Barbara C Chu
Gerald F Joyce
Leslie E Orgel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicine And Dentistry Of Ne Us, University of
Salk Institute for Biological Studies
Original Assignee
Public Health Research Institute Of City Of New York Inc New York Ny Us
NEW YORK HEALTH RES INST
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Public Health Research Institute Of City Of New York Inc New York Ny Us, NEW YORK HEALTH RES INST, Salk Institute for Biological Studies filed Critical Public Health Research Institute Of City Of New York Inc New York Ny Us
Publication of DE68926302D1 publication Critical patent/DE68926302D1/de
Application granted granted Critical
Publication of DE68926302T2 publication Critical patent/DE68926302T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6867—Replicase-based amplification, e.g. using Q-beta replicase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE68926302T 1988-09-30 1989-09-29 Nucleinsäuresonden, welche verbesserte molekularschalter enthalten, und analysemethoden und kits, bei welchen die sonden verwendet werden Expired - Lifetime DE68926302T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/251,696 US5118801A (en) 1988-09-30 1988-09-30 Nucleic acid process containing improved molecular switch
PCT/US1989/004275 WO1990003446A1 (en) 1988-09-30 1989-09-29 Nucleic acid probes containing improved molecular switch, and assays and kits incorporating same

Publications (2)

Publication Number Publication Date
DE68926302D1 DE68926302D1 (de) 1996-05-23
DE68926302T2 true DE68926302T2 (de) 1996-11-28

Family

ID=22953028

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926302T Expired - Lifetime DE68926302T2 (de) 1988-09-30 1989-09-29 Nucleinsäuresonden, welche verbesserte molekularschalter enthalten, und analysemethoden und kits, bei welchen die sonden verwendet werden

Country Status (10)

Country Link
US (2) US5118801A (de)
EP (1) EP0436644B1 (de)
JP (1) JP2806455B2 (de)
AT (1) ATE136941T1 (de)
AU (1) AU647376B2 (de)
DE (1) DE68926302T2 (de)
DK (1) DK56091A (de)
ES (1) ES2023290A6 (de)
FI (1) FI911536A0 (de)
WO (1) WO1990003446A1 (de)

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US5118801A (en) 1992-06-02
WO1990003446A1 (en) 1990-04-05
JP2806455B2 (ja) 1998-09-30
ATE136941T1 (de) 1996-05-15
DK56091A (da) 1991-05-30
JPH07508398A (ja) 1995-09-21
EP0436644B1 (de) 1996-04-17
AU647376B2 (en) 1994-03-24
ES2023290A6 (es) 1992-01-01
AU4346689A (en) 1990-04-18
DE68926302D1 (de) 1996-05-23
EP0436644A1 (de) 1991-07-17
DK56091D0 (da) 1991-03-27
US5312728A (en) 1994-05-17

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