DE69220084T2 - Diagnostische Anwendungen der Bildung von doppelten D-Loops. - Google Patents

Diagnostische Anwendungen der Bildung von doppelten D-Loops.

Info

Publication number
DE69220084T2
DE69220084T2 DE69220084T DE69220084T DE69220084T2 DE 69220084 T2 DE69220084 T2 DE 69220084T2 DE 69220084 T DE69220084 T DE 69220084T DE 69220084 T DE69220084 T DE 69220084T DE 69220084 T2 DE69220084 T2 DE 69220084T2
Authority
DE
Germany
Prior art keywords
pct
date
probe
dna
formation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69220084T
Other languages
English (en)
Other versions
DE69220084D1 (de
Inventor
Elissa Sena
Cornelia Calhoun
David Zarling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tapestry Pharmaceuticals Inc
Original Assignee
Daikin Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/520,321 external-priority patent/US5223414A/en
Priority claimed from US07/755,462 external-priority patent/US5273881A/en
Application filed by Daikin Industries Ltd filed Critical Daikin Industries Ltd
Publication of DE69220084D1 publication Critical patent/DE69220084D1/de
Application granted granted Critical
Publication of DE69220084T2 publication Critical patent/DE69220084T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Stabilization Of Oscillater, Synchronisation, Frequency Synthesizers (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
DE69220084T 1990-05-07 1992-09-04 Diagnostische Anwendungen der Bildung von doppelten D-Loops. Expired - Fee Related DE69220084T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/520,321 US5223414A (en) 1990-05-07 1990-05-07 Process for nucleic acid hybridization and amplification
US07/755,462 US5273881A (en) 1990-05-07 1991-09-04 Diagnostic applications of double D-loop formation
US91079192A 1992-07-09 1992-07-09
PCT/JP1992/001135 WO1993005178A1 (en) 1990-05-07 1992-09-04 Diagnostic applications of double d-loop formation

Publications (2)

Publication Number Publication Date
DE69220084D1 DE69220084D1 (de) 1997-07-03
DE69220084T2 true DE69220084T2 (de) 1997-09-11

Family

ID=27414753

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69220084T Expired - Fee Related DE69220084T2 (de) 1990-05-07 1992-09-04 Diagnostische Anwendungen der Bildung von doppelten D-Loops.

Country Status (13)

Country Link
US (1) US5670316A (de)
EP (1) EP0612352B1 (de)
JP (1) JP2745816B2 (de)
KR (1) KR100245284B1 (de)
AT (1) ATE153707T1 (de)
AU (1) AU661505B2 (de)
CA (1) CA2116215C (de)
DE (1) DE69220084T2 (de)
DK (1) DK0612352T3 (de)
ES (1) ES2101867T3 (de)
FI (1) FI941016A (de)
NO (1) NO313557B1 (de)
WO (1) WO1993005178A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method
EP0672159B1 (de) * 1992-04-24 2005-12-28 Sri International Targeting homologer sequenzen in eukaryotenzellen
US5929043A (en) * 1995-01-31 1999-07-27 Pangene Corporation Recombinase mediated DNA therapies
FR2737502B1 (fr) * 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
US6335164B1 (en) 1996-08-29 2002-01-01 Daikin Industries, Ltd. Methods for targeting, enriching, detecting and/or isolating target nucleic acid sequence using RecA-like recombinase
JP3891620B2 (ja) * 1996-11-14 2007-03-14 株式会社アイシン・コスモス研究所 ヘアピン型構造の核酸プローブ分子、及び該核酸プローブ分子を利用した核酸検出方法
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
US6524856B1 (en) 1997-12-11 2003-02-25 Pangene Corporation Use of consensus sequences for targeted homologous gene isolation and recombination in gene families
WO1999050446A1 (de) * 1998-04-01 1999-10-07 Wolfrum Juergen Verfahren und vorrichtung zur quantifizierung von dna und rna
US6287772B1 (en) 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
US6541227B1 (en) * 1998-10-12 2003-04-01 Aisin Seiki Kabushiki Kaisha Preparation of labeled DNA
JP4265028B2 (ja) * 1999-04-14 2009-05-20 アイシン精機株式会社 二本鎖ｄｎａの特異的切断方法およびそのためのキット
AU4657500A (en) * 1999-04-21 2000-11-02 Pangene Corporation Locked nucleic acid hybrids and methods of use
ATE433499T1 (de) * 1999-12-21 2009-06-15 Ortho Clinical Diagnostics Inc Detektion von nukleinsäuren
CA2397357A1 (en) * 1999-12-28 2001-07-05 David A. Zarling Recombinase mediated gene chip detection
US20020132259A1 (en) * 2001-02-21 2002-09-19 Wagner Robert E. Mutation detection using MutS and RecA
AU2002303176A1 (en) * 2001-03-27 2002-10-15 University Of Delaware Genomics applications for modified oligonucleotides
US6929915B2 (en) 2001-04-20 2005-08-16 The Penn State Research Foundation Methods for nucleic acid manipulation
US7468244B2 (en) * 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
EP1446502A4 (de) * 2001-09-28 2005-02-09 Univ Delaware Nachweis und trennung von polymorphismen
US7244562B2 (en) * 2001-11-01 2007-07-17 Gene Check, Inc. RecA assisted detection of mutations, single nucleotide polymorphisms and specific sequences
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
EP2428588B1 (de) * 2002-02-21 2016-08-10 Alere San Diego, Inc. Rekombinase-Polymerase-Verstärkung
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
CN1330775C (zh) * 2002-05-08 2007-08-08 爱科来株式会社 靶核酸的检测方法
EP1543155A4 (de) * 2002-07-17 2006-08-16 Us Genomics Inc Verfahren und zusammensetzungen zur analyse von polymeren unter verwendung chimärer tags
AU2004219662A1 (en) * 2003-03-11 2004-09-23 Gene Check, Inc. RecA-assisted allele specific oligonucleotide extension method
JP2007501003A (ja) * 2003-08-01 2007-01-25 ユー．エス． ジェノミクス， インコーポレイテッド 非切断条件下で核酸を分析するための配列特異的エンドヌクレアーゼの使用に関連した方法および組成物
WO2005017205A2 (en) * 2003-08-04 2005-02-24 U. S. Genomics, Inc. Nucleic acid mapping using linear analysis
ES2718482T3 (es) * 2004-06-01 2019-07-02 Alere San Diego Inc Kit para amplificación de recombinasa polimerasa
JP2006055065A (ja) * 2004-08-19 2006-03-02 Toyo Kohan Co Ltd 非対称ｐｃｒを用いた核酸の検出方法、ポリヌクレオチドプローブ、それを固定するプローブ固定化担体およびキット
WO2006051988A1 (ja) * 2004-11-15 2006-05-18 Riken 核酸の増幅方法
ES2420831T3 (es) 2005-07-25 2013-08-27 Alere San Diego, Inc. Procedimientos para multiplexar la ampliación de la recombinasa polimerasa
US20090064377A1 (en) * 2005-09-29 2009-03-05 Daphne Yvette Rainey-Wittich Method and means for targeted nucleotide exchange
US20090061413A1 (en) * 2006-02-27 2009-03-05 Salinas Frank G Isothermal screening of hiv-1 related nucleic acids
US20080003600A1 (en) * 2006-02-27 2008-01-03 Salinas Frank G Isothermal screening of breast cancer related nucleic acid
US20070202522A1 (en) * 2006-02-27 2007-08-30 Salinas Frank G Isothermal screening of tumor cell related nucleic acids
US20080220421A1 (en) * 2006-02-27 2008-09-11 Salinas Frank G Isothermal screening for nucleic acids associated with diseases and conditions of the gi tract
EP2426221B1 (de) 2006-05-04 2016-06-22 Alere San Diego, Inc. Rekombinase-Polymerase-Amplifikation
US9469867B2 (en) 2009-05-20 2016-10-18 Alere San Diego, Inc. DNA glycosylase/lyase and AP endonuclease substrates
EP3360974A1 (de) 2009-06-05 2018-08-15 Alere San Diego, Inc. Reagentien zur rekombinase polymerase amplifikation
CA2792433C (en) 2010-03-08 2016-10-11 Gerassimos Makrigiorgos Full cold-pcr enrichment with reference blocking sequence
CA2830361C (en) 2011-03-31 2021-03-16 Dana-Farber Cancer Institute, Inc. Methods and compositions to enable multiplex cold-pcr
US8809021B2 (en) 2011-04-07 2014-08-19 Alere San Diego Inc. Monitoring recombinase polymerase amplification mixtures
CN114854832A (zh) 2012-04-19 2022-08-05 生命技术公司 核酸扩增
EP3095879B1 (de) 2012-04-19 2018-09-19 Life Technologies Corporation Nukleinsäureamplifikation
WO2014020137A1 (en) * 2012-08-02 2014-02-06 Qiagen Gmbh Recombinase mediated targeted dna enrichment for next generation sequencing
EP2895620B1 (de) 2012-09-11 2017-08-02 Life Technologies Corporation Nukleinsäureamplifikation
WO2014043143A1 (en) 2012-09-11 2014-03-20 Life Technologies Corporation Nucleic acid amplification
EP3102691B1 (de) 2014-02-03 2019-09-11 Thermo Fisher Scientific Baltics UAB Verfahren zur kontrollierten dna-fragmentierung
WO2015191815A1 (en) 2014-06-13 2015-12-17 Life Technologies Corporation Multiplex nucleic acid amplification
JP6698708B2 (ja) 2015-06-09 2020-05-27 ライフ テクノロジーズ コーポレーション 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体
US11725230B2 (en) 2015-06-24 2023-08-15 Dana-Farber Cancer Institute, Inc. Selective degradation of wild-type DNA and enrichment of mutant alleles using nuclease
WO2017100283A1 (en) 2015-12-09 2017-06-15 Life Technologies Corporation Detection and quantification of nucleic acid molecules associated with a surface
LT3402880T (lt) 2016-01-15 2024-03-12 Thermo Fisher Scientific Baltics Uab Termofiliniai dnr polimerazės mutantai
WO2017214561A1 (en) 2016-06-10 2017-12-14 Life Technologies Corporation Methods and compositions for nucleic acid amplification
WO2018071522A1 (en) 2016-10-11 2018-04-19 Life Technologies Corporation Rapid amplification of nucleic acids
CA3046953A1 (en) 2016-12-12 2018-06-21 Dana Farber Cancer Institute, Inc. Compositions and methods for molecular barcoding of dna molecules prior to mutation enrichment and/or mutation detection
WO2018231818A1 (en) 2017-06-16 2018-12-20 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
EP3645710A1 (de) 2017-06-26 2020-05-06 Thermo Fisher Scientific Baltics Uab Thermophile dna-polymerase-mutanten
EP3707274B1 (de) 2017-11-07 2023-09-13 Life Technologies Corporation Verfahren und zusammensetzungen zur manipulation von nukleinsäuren
CN113906148A (zh) 2019-05-03 2022-01-07 生命技术公司 用于操纵核酸的方法和组合物
US11905558B2 (en) 2019-08-21 2024-02-20 Life Technologies Corporation System and method for sequencing
US20220170093A1 (en) 2020-11-16 2022-06-02 Life Technologies Corporation System and method for sequencing
NL2033124B1 (en) 2022-09-23 2024-03-29 Rapidemic B V Methods and device for multiple-label nucleic acid amplification and detection

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
CA1254114A (en) * 1984-05-07 1989-05-16 Allied Corporation Displacement polynucleotide assay employing recombination protein and diagnostic kit
EP0183822A4 (de) * 1984-06-01 1988-08-29 Nat Biomedical Res Foundation Katalysierte nukleinsäurehybridisierung mittels enzymreagenz.
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4888274A (en) * 1985-09-18 1989-12-19 Yale University RecA nucleoprotein filament and methods
WO1987001730A1 (en) * 1985-09-18 1987-03-26 Yale University RecA NUCLEOPROTEIN FILAMENT AND METHODS
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
EP0322311B1 (de) * 1987-12-21 1994-03-23 Applied Biosystems, Inc. Verfahren und Testsatz zum Nachweis einer Nukleinsäure-Sequenz
US5273881A (en) * 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor

Also Published As

Publication number Publication date
FI941016A0 (fi) 1994-03-03
KR100245284B1 (ko) 2000-03-02
US5670316A (en) 1997-09-23
NO940744L (de) 1994-05-02
ATE153707T1 (de) 1997-06-15
JPH06510201A (ja) 1994-11-17
FI941016A (fi) 1994-05-03
JP2745816B2 (ja) 1998-04-28
DE69220084D1 (de) 1997-07-03
WO1993005178A1 (en) 1993-03-18
EP0612352A1 (de) 1994-08-31
CA2116215C (en) 1998-12-22
ES2101867T3 (es) 1997-07-16
AU2540192A (en) 1993-04-05
NO940744D0 (no) 1994-03-03
CA2116215A1 (en) 1993-03-05
DK0612352T3 (da) 1997-06-30
AU661505B2 (en) 1995-07-27
NO313557B1 (no) 2002-10-21
EP0612352B1 (de) 1997-05-28

Similar Documents

Publication Publication Date Title
DE69220084D1 (de) Diagnostische Anwendungen der Bildung von doppelten D-Loops.
ATE167680T1 (de) Pteridin-nukleotidderivate als fluoreszierende sonden
ATE466960T1 (de) Verwendung von nukleinsäureliganden in der durchflusszytometrie
ATE147794T1 (de) Chemisches verfahren zur analyse von dns- sequenzen
ES2186293T3 (es) Metodo para la amplificacion exponencial directa y secuenciacion de moleculas de dna y su aplicacion.
DE69636127D1 (de) Multiparameter fluoreszenz in situ hybridisierung
DE69333073D1 (de) Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
EA200100402A1 (ru) Способы амплификации и секвенирования нуклеиновых кислот
ATE216728T1 (de) Verfahren zur präparierung und hybridisierung von spezifischen proben
ATE133713T1 (de) Nukleinsäuremultimere und amplifizierte nukleinsäurehybridisierungstests damit
KR970028548A (ko) 핵산의 형광 편광도 검출방법
DE60235005D1 (de) Nachweis der instabilität von mikrosatelliten und
ATE160822T1 (de) Identifizierung von salmonella durch die polymerase-ketten-reaktion
DE69934418D1 (de) MUTIERTE MITGLIEDER DER TGF-BETA-SUPERFAMILIE, EINSCHLIEßLICH MORPHOGENETISCHER PROTEINE
DE69328951D1 (de) Nukleinsäuresonden für Mykobacterium Tuberkulosis
CA2112096A1 (fr) Sequences d'adn du papillomavirus hpv42 - application au diagnostic
ATE166395T1 (de) Für c.difficile spezifische oligonukleotide
DE59814032D1 (de) Nucleinsäuremolekül, kit und verwendung
ES2019162A6 (es) Un metodo para detectar al menos una secuencia diana especifica de acido nucleico en una muestra que la contiene.
ATE291435T1 (de) Chlorzoxazon zur behandlung von psoriasis
ES2170620A1 (es) Procedimiento de cuantificacion de acidos nucleicos mediante amplificacion por reaccion en cadena de polimerasa hemi-competitiva.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NAPRO BIO THERAPEUTICS.INC., NEWARK, DEL., US

8328 Change in the person/name/address of the agent

Representative=s name: VOSSIUS & PARTNER, 81675 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: TAPESTRY PHARMACEUTICALS, INC. (N.D.GES.D. STAATES

8339 Ceased/non-payment of the annual fee