DE14172396T1 - Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester - Google Patents

Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester Download PDF

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DE14172396T1
DE14172396T1 DE14172396.5T DE14172396T DE14172396T1 DE 14172396 T1 DE14172396 T1 DE 14172396T1 DE 14172396 T DE14172396 T DE 14172396T DE 14172396 T1 DE14172396 T1 DE 14172396T1
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composition
active ingredient
autoimmune disease
controlled release
daily dosage
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Florian SCHÖNHARTING
Bernd W. MÜLLER
Henrik Nilsson
Joseph R. Robinson
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Forward Pharma AS
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Abstract

Pharmazeutische Zusammensetzung mit kontrollierter Freisetzung zur oralen Verwendung bestehend aus Dimethylfumarat als Wirkstoff, wobei die tägliche Dosierung zwischen 480 und 720 mg Wirkstoff verabreicht in einer bis drei Dosierungen liegt, wobei die Zusammensetzung zur Verwendung bei der Behandlung einer Autoimmunkrankheit ist, wobei die Autoimmunkrankheit ausgewählt ist aus: i. Polyarthritis ii. multipler Sklerose (MS), iii. juveniler Diabetes Mellitus, iv. Hashimoto-Thyreoiditis, v. Grave’s disease, vi. SLE (systemischem Lupus Erythematodes), vii. Sjögren Syndrom, viii. perniziöser Anämie, ix. chronisch aktiver (lupoider) Hepatitis, x. rheumatoider Arthritis (RA), xi. optischer Neuritis.

Claims (11)

  1. Pharmazeutische Zusammensetzung mit kontrollierter Freisetzung zur oralen Verwendung bestehend aus Dimethylfumarat als Wirkstoff, wobei die tägliche Dosierung zwischen 480 und 720 mg Wirkstoff verabreicht in einer bis drei Dosierungen liegt, wobei die Zusammensetzung zur Verwendung bei der Behandlung einer Autoimmunkrankheit ist, wobei die Autoimmunkrankheit ausgewählt ist aus: i. Polyarthritis ii. multipler Sklerose (MS), iii. juveniler Diabetes Mellitus, iv. Hashimoto-Thyreoiditis, v. Grave’s disease, vi. SLE (systemischem Lupus Erythematodes), vii. Sjögren Syndrom, viii. perniziöser Anämie, ix. chronisch aktiver (lupoider) Hepatitis, x. rheumatoider Arthritis (RA), xi. optischer Neuritis.
  2. Zusammensetzung nach Anspruch 1, welche eine Dosierungsform mit pH-kontrollierter Freisetzung ist.
  3. Zusammensetzung nach Anspruch 2, welche mit einer magensaftresistenten Beschichtung versehen ist.
  4. Zusammensetzung nach Anspruch 3, welche eine multipartikuläre Zusammensetzung ist und deren einzelne Einheiten mit einer magensaftresistenten Beschichtung versehen sind.
  5. Zusammensetzung nach Anspruch 1, wobei die tägliche Dosierung zwischen 480 und 600 mg Wirkstoff liegt.
  6. Zusammensetzung nach Anspruch 1, wobei die tägliche Dosierung zwischen 600 und 720 mg Wirkstoff liegt.
  7. Zusammensetzung nach Anspruch 1, wobei die tägliche Dosierung 480 mg Wirkstoff ist.
  8. Zusammensetzung nach Anspruch 1, wobei die Dosierungsform 120, 180 oder 240 mg Wirkstoff umfasst.
  9. Zusammensetzung nach Anspruch 1, wobei die Autoimmunkrankheit multiple Sklerose ist.
  10. Pharmazeutische Zusammensetzung mit kontrollierter Freisetzung zur oralen Verwendung bestehend aus Dimethylfumarat als Wirkstoff, wobei die tägliche Dosierung 480 mg Wirkstoff verabreicht in einer bis drei Dosierungen ist, wobei die Zusammensetzung zur Verwendung bei der Behandlung einer Autoimmunkrankheit ist, wobei die Autoimmunkrankheit ausgewählt ist aus: i. Polyarthritis ii. multipler Sklerose (MS), iii. juveliner Diabetes Mellitus Typ I, iv. Hashimoto-Thyreoiditis, v. Grave’s disease, vi. SLE (systemischem Lupus Erythematodes), vii. Sjögren Syndrom, viii. perniziöser Anämie, ix. chronisch aktiver (lupoider) Hepatitis, x. rheumatoider Arthritis (RA), xi. optischer Neuritis.
  11. Zusammensetzung nach Anspruch 10 zur Verwendung bei der Behandlung von multipler Sklerose.
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