DD296078A5 - Verfahren zur herstellung von benzimidazolen - Google Patents

Verfahren zur herstellung von benzimidazolen Download PDF

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Publication number
DD296078A5
DD296078A5 DD89335980A DD33598089A DD296078A5 DD 296078 A5 DD296078 A5 DD 296078A5 DD 89335980 A DD89335980 A DD 89335980A DD 33598089 A DD33598089 A DD 33598089A DD 296078 A5 DD296078 A5 DD 296078A5
Authority
DD
German Democratic Republic
Prior art keywords
compound
compounds
administration
bioavailability
prepared
Prior art date
Application number
DD89335980A
Other languages
German (de)
English (en)
Inventor
Arne E Braendstroem
Per L Lindbergh
Gunnel E Sunden
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �����@������������������k�� filed Critical �����@������������������k��
Publication of DD296078A5 publication Critical patent/DD296078A5/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28Sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD89335980A 1988-12-22 1989-12-20 Verfahren zur herstellung von benzimidazolen DD296078A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE19888804629A SE8804629D0 (sv) 1988-12-22 1988-12-22 New therapeutically active compounds

Publications (1)

Publication Number Publication Date
DD296078A5 true DD296078A5 (de) 1991-11-21

Family

ID=20374310

Family Applications (2)

Application Number Title Priority Date Filing Date
DD89335980A DD296078A5 (de) 1988-12-22 1989-12-20 Verfahren zur herstellung von benzimidazolen
DD89335981A DD296079A5 (de) 1988-12-22 1989-12-20 Verfahren zur herstellung von benzimidazolen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DD89335981A DD296079A5 (de) 1988-12-22 1989-12-20 Verfahren zur herstellung von benzimidazolen

Country Status (32)

Country Link
US (2) US5008278A (fr)
EP (1) EP0449940B1 (fr)
JP (1) JP2793906B2 (fr)
KR (1) KR910700249A (fr)
CN (1) CN1028231C (fr)
AR (1) AR248136A1 (fr)
AT (1) ATE127799T1 (fr)
AU (1) AU634741B2 (fr)
BG (1) BG60102B2 (fr)
CA (1) CA2005986C (fr)
DD (2) DD296078A5 (fr)
DE (1) DE68924273T2 (fr)
DK (1) DK170800B1 (fr)
EG (1) EG19303A (fr)
FI (2) FI913035A0 (fr)
GR (1) GR1002252B (fr)
HR (1) HRP920831A2 (fr)
HU (2) HU205927B (fr)
IE (1) IE894048L (fr)
IL (1) IL92798A0 (fr)
LT (2) LT3980B (fr)
LV (1) LV10187B (fr)
NZ (1) NZ231872A (fr)
PH (1) PH27400A (fr)
PL (1) PL161150B1 (fr)
PT (1) PT92648B (fr)
RO (1) RO110494B1 (fr)
RU (2) RU2073676C1 (fr)
SE (1) SE8804629D0 (fr)
WO (1) WO1990006925A1 (fr)
YU (1) YU46806B (fr)
ZA (2) ZA899794B (fr)

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TNSN95063A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux benzimidazoles substitues
EP0723436B1 (fr) * 1994-07-08 2001-09-26 AstraZeneca AB Forme posologique sous forme de comprime composite (i)
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
DE19758573C2 (de) * 1997-11-26 2001-03-01 Implex Hear Tech Ag Fixationselement für ein implantierbares Mikrofon
WO1999053918A1 (fr) * 1998-04-20 1999-10-28 Eisai Co., Ltd. Compositions stabilisees contenant des composes du type benzimidazole
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
WO2001028559A1 (fr) 1999-10-20 2001-04-26 Eisai Co., Ltd. Procede de stabilisation de composes benzimidazoles
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
MXPA04007169A (es) * 2002-01-25 2004-10-29 Santarus Inc Suministro transmucosal de inhibidores de bomba de protones.
US20050234103A1 (en) * 2002-03-26 2005-10-20 Reddy Manne S Crystalline forms of rabeprazole sodium
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
CA2517005A1 (fr) * 2003-02-20 2004-09-02 Santarus, Inc. Liberation immediate d'un complexe antacide d'omeprazole presentant une nouvelle formulation pour une elimination rapide et prolongee d'acide gastrique
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
WO2005007115A2 (fr) * 2003-07-18 2005-01-27 Santarus, Inc. Formulations pharmaceutiques utilisees pour inhiber une secretion acide et procede de fabrication associe
AR045061A1 (es) * 2003-07-18 2005-10-12 Santarus Inc Formulacion farmaceutica y metodo para tratar trastornos gastrointestinales causados por acido
ATE544447T1 (de) 2003-09-26 2012-02-15 Alza Corp Arzneistoffcoating mit hohem wirkstoffanteil sowie methoden zu dessen herstellung
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
RU2467747C2 (ru) 2006-07-25 2012-11-27 Векта Лтд. Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
CA2736547C (fr) 2008-09-09 2016-11-01 Pozen Inc. Procede d'administration d'une composition pharmaceutique a un patient en ayant besoin
AU2010263304A1 (en) 2009-06-25 2012-02-02 Astrazeneca Ab Method for treating a patient at risk for developing an NSAID-associated ulcer
WO2011080501A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080500A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080502A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
EP2601947A1 (fr) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Combinaison à dose fixe pour le traitement de maladies associées à Hélicobacter pylori
MX2014007935A (es) 2011-12-28 2014-11-14 Pozen Inc Composiciones y metodos mejorados para el suministro de omeprazol y de acido acetilsalicilico.

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US428098A (en) 1890-05-20 Electric railway
US727150A (en) 1902-06-18 1903-05-05 Peter Paul Keller Adjustable hanger for incandescent lamps.
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (fr) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
DE3215503A1 (de) 1982-04-26 1983-11-03 Zängl GmbH, 8000 München Elektrisch beheiztes schneidgeraet
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL71664A (en) * 1983-05-03 1987-11-30 Byk Gulden Lomberg Chem Fab Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
JPS6261978A (ja) * 1985-09-12 1987-03-18 Otsuka Pharmaceut Co Ltd 5−フルオロ−1h−ベンズイミダゾ−ル誘導体
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
JPH0676323B2 (ja) * 1987-08-28 1994-09-28 東京田辺製薬株式会社 抗潰瘍剤

Also Published As

Publication number Publication date
US5008278A (en) 1991-04-16
HU901084D0 (en) 1991-09-30
YU242689A (en) 1991-04-30
GR1002252B (en) 1996-04-23
PH27400A (en) 1993-06-21
RO110494B1 (ro) 1996-01-30
HRP920831A2 (en) 1995-12-31
KR910700249A (ko) 1991-03-14
HU205927B (en) 1992-07-28
JP2793906B2 (ja) 1998-09-03
DE68924273T2 (de) 1996-02-15
BG60102B2 (bg) 1993-10-29
EP0449940A1 (fr) 1991-10-09
DK122291D0 (da) 1991-06-21
PT92648A (pt) 1990-06-29
GR890100838A (el) 1991-03-15
CA2005986A1 (fr) 1990-06-22
DD296079A5 (de) 1991-11-21
HUT57202A (en) 1991-11-28
AR248136A1 (es) 1995-06-30
LTIP1726A (en) 1995-07-25
CN1028231C (zh) 1995-04-19
AU4817590A (en) 1990-07-10
NZ231872A (en) 1992-03-26
LV10187B (en) 1995-04-20
PT92648B (pt) 1995-09-12
RU2042673C1 (ru) 1995-08-27
WO1990006925A1 (fr) 1990-06-28
JPH04502461A (ja) 1992-05-07
SE8804629D0 (sv) 1988-12-22
IL92798A0 (en) 1990-09-17
LT3980B (en) 1996-06-25
YU46806B (sh) 1994-06-10
FI954768A (fi) 1995-10-06
LT3914B (en) 1996-04-25
HU205926B (en) 1992-07-28
FI913035A0 (fi) 1991-06-20
IE894048L (en) 1990-06-22
PL161150B1 (en) 1993-05-31
RU2073676C1 (ru) 1997-02-20
US5039808A (en) 1991-08-13
ZA899794B (en) 1990-08-29
DK170800B1 (da) 1996-01-22
FI954768A0 (fi) 1995-10-06
LTIP1721A (en) 1995-07-25
ZA899795B (en) 1990-08-29
EG19303A (en) 1994-11-30
ATE127799T1 (de) 1995-09-15
DE68924273D1 (de) 1995-10-19
AU634741B2 (en) 1993-03-04
DK122291A (da) 1991-06-24
LV10187A (lv) 1994-10-20
CN1043713A (zh) 1990-07-11
EP0449940B1 (fr) 1995-09-13
CA2005986C (fr) 1999-08-03

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Legal Events

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ENJ Ceased due to non-payment of renewal fee