AR248136A1 - Procedimiento e intermediarios para la preparacion de 5 5 5 5 5 - Google Patents

Procedimiento e intermediarios para la preparacion de 5 5 5 5 5

Info

Publication number
AR248136A1
AR248136A1 AR89315705A AR31570589A AR248136A1 AR 248136 A1 AR248136 A1 AR 248136A1 AR 89315705 A AR89315705 A AR 89315705A AR 31570589 A AR31570589 A AR 31570589A AR 248136 A1 AR248136 A1 AR 248136A1
Authority
AR
Argentina
Prior art keywords
procedure
preparation
intermediaries
ciclopropilmetoxi
bencimidazole
Prior art date
Application number
AR89315705A
Other languages
English (en)
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Application granted granted Critical
Publication of AR248136A1 publication Critical patent/AR248136A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE 5-FLUOR-2-¡¡(4-CICLOPROPILMETOXI-2- PIRIDINIL)METIL¿SULFINIL¿-1H-BENCIMIDAZOL (COMPUESTO I) Y SALES FISIOLOGICAMENTE ACEPTABLES DEL MISMO, ASI COMO SUS ENANTIOMEROS OPTICOS, QUE COMPRENDE LA ETAPA DE OXIDACION DE 5-FLUOR-2-¡¡(4-CICLOPROPILMETOXI-2- PIRIDINIL)METIL¿TIO¿-1H-BENCIMIDAZOL, DESPUES DE LO CUAL EL COMPUESTO I ASI OBTENIDO, SI SE DESEA, SE CONVIERTE EN UNA SAL O EN UN ISOMERO OPTICO PURO.
AR89315705A 1988-12-22 1989-12-18 Procedimiento e intermediarios para la preparacion de 5 5 5 5 5 AR248136A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE19888804629A SE8804629D0 (sv) 1988-12-22 1988-12-22 New therapeutically active compounds

Publications (1)

Publication Number Publication Date
AR248136A1 true AR248136A1 (es) 1995-06-30

Family

ID=20374310

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89315705A AR248136A1 (es) 1988-12-22 1989-12-18 Procedimiento e intermediarios para la preparacion de 5 5 5 5 5

Country Status (32)

Country Link
US (2) US5008278A (es)
EP (1) EP0449940B1 (es)
JP (1) JP2793906B2 (es)
KR (1) KR910700249A (es)
CN (1) CN1028231C (es)
AR (1) AR248136A1 (es)
AT (1) ATE127799T1 (es)
AU (1) AU634741B2 (es)
BG (1) BG60102B2 (es)
CA (1) CA2005986C (es)
DD (2) DD296078A5 (es)
DE (1) DE68924273T2 (es)
DK (1) DK170800B1 (es)
EG (1) EG19303A (es)
FI (2) FI913035A0 (es)
GR (1) GR1002252B (es)
HR (1) HRP920831A2 (es)
HU (2) HU205927B (es)
IE (1) IE894048L (es)
IL (1) IL92798A0 (es)
LT (2) LT3914B (es)
LV (1) LV10187B (es)
NZ (1) NZ231872A (es)
PH (1) PH27400A (es)
PL (1) PL161150B1 (es)
PT (1) PT92648B (es)
RO (1) RO110494B1 (es)
RU (2) RU2073676C1 (es)
SE (1) SE8804629D0 (es)
WO (1) WO1990006925A1 (es)
YU (1) YU46806B (es)
ZA (2) ZA899795B (es)

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NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
TNSN95063A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux benzimidazoles substitues
PT1078628E (pt) * 1994-07-08 2009-01-27 Astrazeneca Ab Forma de dosagem em comprimidos com unidades múltiplas
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
DE19758573C2 (de) * 1997-11-26 2001-03-01 Implex Hear Tech Ag Fixationselement für ein implantierbares Mikrofon
EP1004305B1 (en) * 1998-04-20 2011-09-28 Eisai R&D Management Co., Ltd. Stabilized compositions containing benzimidazole-type compounds
SE9900274D0 (sv) * 1999-01-28 1999-01-28 Astra Ab New compound
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
RU2232159C2 (ru) * 1999-07-29 2004-07-10 Регентский Совет Университета Калифорнии Производные бензимидазола и фармацевтические композиции, содержащие пролекарство ингибитора протонного насоса
DE60036014T2 (de) 1999-10-20 2008-04-30 Eisai R&D Management Co., Ltd. Methode zur stabilisierung von benzimidazol-verbindungen
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
MXPA04007169A (es) * 2002-01-25 2004-10-29 Santarus Inc Suministro transmucosal de inhibidores de bomba de protones.
US20050234103A1 (en) * 2002-03-26 2005-10-20 Reddy Manne S Crystalline forms of rabeprazole sodium
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
JP2006518751A (ja) * 2003-02-20 2006-08-17 サンタラス インコーポレイティッド 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物
TWI398273B (zh) * 2003-07-18 2013-06-11 Santarus Inc 用於抑制酸分泌之醫藥調配物及其製備及使用之方法
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
MXPA06000524A (es) * 2003-07-18 2006-08-11 Santarus Inc Formulacion farmaceutica y metodo para tratar desordenes gastrointestinales provocados por acido.
KR20060092255A (ko) 2003-09-26 2006-08-22 알자 코포레이션 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
RU2325960C2 (ru) * 2005-09-22 2008-06-10 Белорусский Национальный Технический Университет Способ получения товарной продукции на литейно-прокатном комплексе металлургического мини-завода
AU2007278986B2 (en) 2006-07-25 2010-09-16 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
AU2009290712A1 (en) 2008-09-09 2010-03-18 Astrazeneca Ab Method for delivering a pharmaceutical composition to patient in need thereof
CA2764963C (en) 2009-06-25 2016-11-01 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
BR112014016085A8 (pt) 2011-12-28 2017-07-04 Pozen Inc composições aprimoradas e métodos para distribuição de omeprazol mais ácido acetilsalicílico

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US428098A (en) 1890-05-20 Electric railway
US727150A (en) 1902-06-18 1903-05-05 Peter Paul Keller Adjustable hanger for incandescent lamps.
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (es) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
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DE3215503A1 (de) 1982-04-26 1983-11-03 Zängl GmbH, 8000 München Elektrisch beheiztes schneidgeraet
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL71664A (en) * 1983-05-03 1987-11-30 Byk Gulden Lomberg Chem Fab Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
JPS6261978A (ja) * 1985-09-12 1987-03-18 Otsuka Pharmaceut Co Ltd ５−フルオロ−１ｈ−ベンズイミダゾ−ル誘導体
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
JPH0676323B2 (ja) * 1987-08-28 1994-09-28 東京田辺製薬株式会社 抗潰瘍剤

Also Published As

Publication number Publication date
RO110494B1 (ro) 1996-01-30
KR910700249A (ko) 1991-03-14
US5039808A (en) 1991-08-13
DE68924273T2 (de) 1996-02-15
SE8804629D0 (sv) 1988-12-22
BG60102B2 (bg) 1993-10-29
CA2005986A1 (en) 1990-06-22
DE68924273D1 (de) 1995-10-19
DK122291D0 (da) 1991-06-21
WO1990006925A1 (en) 1990-06-28
IE894048L (en) 1990-06-22
EG19303A (en) 1994-11-30
EP0449940B1 (en) 1995-09-13
FI913035A7 (fi) 1991-06-20
LV10187A (lv) 1994-10-20
DK170800B1 (da) 1996-01-22
NZ231872A (en) 1992-03-26
HU205927B (en) 1992-07-28
CA2005986C (en) 1999-08-03
AU634741B2 (en) 1993-03-04
FI913035A0 (fi) 1991-06-20
LT3914B (en) 1996-04-25
CN1028231C (zh) 1995-04-19
PL161150B1 (en) 1993-05-31
HU205926B (en) 1992-07-28
PH27400A (en) 1993-06-21
YU46806B (sh) 1994-06-10
YU242689A (en) 1991-04-30
RU2073676C1 (ru) 1997-02-20
JPH04502461A (ja) 1992-05-07
RU2042673C1 (ru) 1995-08-27
ATE127799T1 (de) 1995-09-15
ZA899794B (en) 1990-08-29
HUT57202A (en) 1991-11-28
FI954768L (fi) 1995-10-06
PT92648B (pt) 1995-09-12
EP0449940A1 (en) 1991-10-09
DD296078A5 (de) 1991-11-21
GR890100838A (el) 1991-03-15
LV10187B (en) 1995-04-20
ZA899795B (en) 1990-08-29
PT92648A (pt) 1990-06-29
LT3980B (en) 1996-06-25
LTIP1721A (en) 1995-07-25
LTIP1726A (en) 1995-07-25
AU4817590A (en) 1990-07-10
HRP920831A2 (en) 1995-12-31
FI954768A7 (fi) 1995-10-06
HU901084D0 (en) 1991-09-30
DK122291A (da) 1991-06-24
FI954768A0 (fi) 1995-10-06
GR1002252B (en) 1996-04-23
IL92798A0 (en) 1990-09-17
DD296079A5 (de) 1991-11-21
JP2793906B2 (ja) 1998-09-03
US5008278A (en) 1991-04-16
CN1043713A (zh) 1990-07-11

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