DE68924273D1 - Therapeutisch aktive verbindung und verfahren zu deren herstellung. - Google Patents
Therapeutisch aktive verbindung und verfahren zu deren herstellung.Info
- Publication number
- DE68924273D1 DE68924273D1 DE68924273T DE68924273T DE68924273D1 DE 68924273 D1 DE68924273 D1 DE 68924273D1 DE 68924273 T DE68924273 T DE 68924273T DE 68924273 T DE68924273 T DE 68924273T DE 68924273 D1 DE68924273 D1 DE 68924273D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- therapeutically active
- active connection
- connection
- therapeutically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE19888804629A SE8804629D0 (sv) | 1988-12-22 | 1988-12-22 | New therapeutically active compounds |
PCT/SE1989/000740 WO1990006925A1 (en) | 1988-12-22 | 1989-12-20 | New therapeutically active compound and a process for its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68924273D1 true DE68924273D1 (de) | 1995-10-19 |
DE68924273T2 DE68924273T2 (de) | 1996-02-15 |
Family
ID=20374310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68924273T Expired - Fee Related DE68924273T2 (de) | 1988-12-22 | 1989-12-20 | Therapeutisch aktive verbindung und verfahren zu deren herstellung. |
Country Status (32)
Country | Link |
---|---|
US (2) | US5008278A (de) |
EP (1) | EP0449940B1 (de) |
JP (1) | JP2793906B2 (de) |
KR (1) | KR910700249A (de) |
CN (1) | CN1028231C (de) |
AR (1) | AR248136A1 (de) |
AT (1) | ATE127799T1 (de) |
AU (1) | AU634741B2 (de) |
BG (1) | BG60102B2 (de) |
CA (1) | CA2005986C (de) |
DD (2) | DD296079A5 (de) |
DE (1) | DE68924273T2 (de) |
DK (1) | DK170800B1 (de) |
EG (1) | EG19303A (de) |
FI (2) | FI913035A0 (de) |
GR (1) | GR1002252B (de) |
HR (1) | HRP920831A2 (de) |
HU (2) | HU205927B (de) |
IE (1) | IE894048L (de) |
IL (1) | IL92798A0 (de) |
LT (2) | LT3914B (de) |
LV (1) | LV10187B (de) |
NZ (1) | NZ231872A (de) |
PH (1) | PH27400A (de) |
PL (1) | PL161150B1 (de) |
PT (1) | PT92648B (de) |
RO (1) | RO110494B1 (de) |
RU (2) | RU2073676C1 (de) |
SE (1) | SE8804629D0 (de) |
WO (1) | WO1990006925A1 (de) |
YU (1) | YU46806B (de) |
ZA (2) | ZA899795B (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993006097A1 (en) * | 1991-09-20 | 1993-04-01 | Merck & Co., Inc. | Novel process for the preparation of anti-ulcer agents |
TNSN95063A1 (fr) * | 1994-05-27 | 1996-02-06 | Astra Ab | Nouveaux benzimidazoles substitues |
SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
ATE414509T1 (de) * | 1994-07-08 | 2008-12-15 | Astrazeneca Ab | Aus vielen einzeleinheiten zusammengesetzte tablettierte dosisform |
SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
DE19758573C2 (de) * | 1997-11-26 | 2001-03-01 | Implex Hear Tech Ag | Fixationselement für ein implantierbares Mikrofon |
WO1999053918A1 (fr) * | 1998-04-20 | 1999-10-28 | Eisai Co., Ltd. | Compositions stabilisees contenant des composes du type benzimidazole |
TWI243672B (en) | 1999-06-01 | 2005-11-21 | Astrazeneca Ab | New use of compounds as antibacterial agents |
DE60036014T2 (de) | 1999-10-20 | 2008-04-30 | Eisai R&D Management Co., Ltd. | Methode zur stabilisierung von benzimidazol-verbindungen |
SE0000774D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
SE0101379D0 (sv) | 2001-04-18 | 2001-04-18 | Diabact Ab | Komposition som hämmar utsöndring av magsyra |
US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
SE0102993D0 (sv) | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
US20040006111A1 (en) * | 2002-01-25 | 2004-01-08 | Kenneth Widder | Transmucosal delivery of proton pump inhibitors |
US20050234103A1 (en) * | 2002-03-26 | 2005-10-20 | Reddy Manne S | Crystalline forms of rabeprazole sodium |
SE0203065D0 (sv) | 2002-10-16 | 2002-10-16 | Diabact Ab | Gastric acid secretion inhibiting composition |
EP1603537A4 (de) * | 2003-02-20 | 2009-11-04 | Santarus Inc | Neuartige formulierung, antazidkomplex-immediatfreisetzung für eine schnelle und anhaltende unterdrückung von magensäure |
EP1648416A4 (de) * | 2003-07-18 | 2012-03-28 | Santarus Inc | Pharmazeutische formulierungen zur hemmung der säuresekretion und herstellungs- und anwendungsverfahren |
US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
TWI337877B (en) * | 2003-07-18 | 2011-03-01 | Santarus Inc | Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders |
NZ546148A (en) | 2003-09-26 | 2009-05-31 | Alza Corp | Drug coating providing high drug loading and methods for providing the same |
US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
RU2467747C2 (ru) | 2006-07-25 | 2012-11-27 | Векта Лтд. | Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi |
US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
KR20110079641A (ko) | 2008-09-09 | 2011-07-07 | 아스트라제네카 아베 | 제약 조성물을 이를 필요로 하는 환자에게 전달하는 방법 |
CA2764963C (en) | 2009-06-25 | 2016-11-01 | Astrazeneca Ab | Method for treating a patient at risk for developing an nsaid-associated ulcer |
WO2011080502A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
US20120294937A1 (en) | 2009-12-29 | 2012-11-22 | Novartis Ag | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
WO2011080500A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
EP2601947A1 (de) | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Kombinationspräparat mit fester Dosierung zur Behandlung von Erkrankungen einhergehend mit Helicobacter pylori |
EA028049B1 (ru) | 2011-12-28 | 2017-10-31 | Поузен Инк. | Улучшенные композиции и способы доставки омепразола и ацетилсалициловой кислоты |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US428098A (en) | 1890-05-20 | Electric railway | ||
US727150A (en) | 1902-06-18 | 1903-05-05 | Peter Paul Keller | Adjustable hanger for incandescent lamps. |
SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
IN148930B (de) * | 1977-09-19 | 1981-07-25 | Hoffmann La Roche | |
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
CH644116A5 (de) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
DE3215503A1 (de) | 1982-04-26 | 1983-11-03 | Zängl GmbH, 8000 München | Elektrisch beheiztes schneidgeraet |
SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
IL71664A (en) * | 1983-05-03 | 1987-11-30 | Byk Gulden Lomberg Chem Fab | Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same |
JPS6150979A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
JPS6150978A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
US4738975A (en) * | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
JPS6261978A (ja) * | 1985-09-12 | 1987-03-18 | Otsuka Pharmaceut Co Ltd | 5−フルオロ−1h−ベンズイミダゾ−ル誘導体 |
SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
JPS62201884A (ja) * | 1986-02-28 | 1987-09-05 | Tokyo Tanabe Co Ltd | ベンズイミダゾール誘導体及びその製造法 |
FI90544C (fi) * | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
NZ234564A (en) * | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
FI96860C (fi) * | 1987-06-17 | 1996-09-10 | Eisai Co Ltd | Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi |
DE3722810A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung |
DK171989B1 (da) * | 1987-08-04 | 1997-09-08 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler |
JPH0676323B2 (ja) * | 1987-08-28 | 1994-09-28 | 東京田辺製薬株式会社 | 抗潰瘍剤 |
-
1988
- 1988-12-22 SE SE19888804629A patent/SE8804629D0/xx unknown
-
1989
- 1989-12-18 EG EG62189A patent/EG19303A/xx active
- 1989-12-18 IE IE894048A patent/IE894048L/xx unknown
- 1989-12-18 AR AR89315705A patent/AR248136A1/es active
- 1989-12-19 CA CA002005986A patent/CA2005986C/en not_active Expired - Lifetime
- 1989-12-19 IL IL92798A patent/IL92798A0/xx not_active IP Right Cessation
- 1989-12-19 GR GR890100838A patent/GR1002252B/el unknown
- 1989-12-19 PH PH39732A patent/PH27400A/en unknown
- 1989-12-19 NZ NZ231872A patent/NZ231872A/en unknown
- 1989-12-20 JP JP2501537A patent/JP2793906B2/ja not_active Expired - Fee Related
- 1989-12-20 WO PCT/SE1989/000740 patent/WO1990006925A1/en active Application Filing
- 1989-12-20 DE DE68924273T patent/DE68924273T2/de not_active Expired - Fee Related
- 1989-12-20 AU AU48175/90A patent/AU634741B2/en not_active Ceased
- 1989-12-20 HU HU901095A patent/HU205927B/hu not_active IP Right Cessation
- 1989-12-20 EP EP90901079A patent/EP0449940B1/de not_active Expired - Lifetime
- 1989-12-20 ZA ZA899795A patent/ZA899795B/xx unknown
- 1989-12-20 HU HU901084A patent/HU205926B/hu not_active IP Right Cessation
- 1989-12-20 DD DD89335981A patent/DD296079A5/de not_active IP Right Cessation
- 1989-12-20 ZA ZA899794A patent/ZA899794B/xx unknown
- 1989-12-20 AT AT90901079T patent/ATE127799T1/de not_active IP Right Cessation
- 1989-12-20 RO RO147866A patent/RO110494B1/ro unknown
- 1989-12-20 RU SU894895789A patent/RU2073676C1/ru active
- 1989-12-20 DD DD89335980A patent/DD296078A5/de not_active IP Right Cessation
- 1989-12-20 US US07/454,047 patent/US5008278A/en not_active Expired - Lifetime
- 1989-12-21 PT PT92648A patent/PT92648B/pt not_active IP Right Cessation
- 1989-12-21 CN CN89109587A patent/CN1028231C/zh not_active Expired - Fee Related
- 1989-12-21 YU YU242689A patent/YU46806B/sh unknown
- 1989-12-22 PL PL1989282923A patent/PL161150B1/pl unknown
-
1990
- 1990-08-21 KR KR1019900701828A patent/KR910700249A/ko not_active Application Discontinuation
- 1990-12-20 US US07/633,007 patent/US5039808A/en not_active Expired - Lifetime
-
1991
- 1991-06-19 BG BG94659A patent/BG60102B2/bg unknown
- 1991-06-20 FI FI913035A patent/FI913035A0/fi not_active Application Discontinuation
- 1991-06-21 RU SU914895805A patent/RU2042673C1/ru active
- 1991-06-21 DK DK122291A patent/DK170800B1/da not_active IP Right Cessation
-
1992
- 1992-10-02 HR HR920831A patent/HRP920831A2/hr not_active Application Discontinuation
-
1993
- 1993-06-30 LV LVP-93-860A patent/LV10187B/en unknown
- 1993-12-30 LT LTIP1726A patent/LT3914B/lt not_active IP Right Cessation
- 1993-12-30 LT LTIP1721A patent/LT3980B/lt not_active IP Right Cessation
-
1995
- 1995-10-06 FI FI954768A patent/FI954768A0/fi not_active Application Discontinuation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |