DE68924273D1 - Therapeutisch aktive verbindung und verfahren zu deren herstellung. - Google Patents

Therapeutisch aktive verbindung und verfahren zu deren herstellung.

Info

Publication number
DE68924273D1
DE68924273D1 DE68924273T DE68924273T DE68924273D1 DE 68924273 D1 DE68924273 D1 DE 68924273D1 DE 68924273 T DE68924273 T DE 68924273T DE 68924273 T DE68924273 T DE 68924273T DE 68924273 D1 DE68924273 D1 DE 68924273D1
Authority
DE
Germany
Prior art keywords
production
therapeutically active
active connection
connection
therapeutically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68924273T
Other languages
English (en)
Other versions
DE68924273T2 (de
Inventor
Arne Braendstroem
Per Lindberg
Gunnel Sunden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hassle AB filed Critical Hassle AB
Application granted granted Critical
Publication of DE68924273D1 publication Critical patent/DE68924273D1/de
Publication of DE68924273T2 publication Critical patent/DE68924273T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE68924273T 1988-12-22 1989-12-20 Therapeutisch aktive verbindung und verfahren zu deren herstellung. Expired - Fee Related DE68924273T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE19888804629A SE8804629D0 (sv) 1988-12-22 1988-12-22 New therapeutically active compounds
PCT/SE1989/000740 WO1990006925A1 (en) 1988-12-22 1989-12-20 New therapeutically active compound and a process for its preparation

Publications (2)

Publication Number Publication Date
DE68924273D1 true DE68924273D1 (de) 1995-10-19
DE68924273T2 DE68924273T2 (de) 1996-02-15

Family

ID=20374310

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68924273T Expired - Fee Related DE68924273T2 (de) 1988-12-22 1989-12-20 Therapeutisch aktive verbindung und verfahren zu deren herstellung.

Country Status (32)

Country Link
US (2) US5008278A (de)
EP (1) EP0449940B1 (de)
JP (1) JP2793906B2 (de)
KR (1) KR910700249A (de)
CN (1) CN1028231C (de)
AR (1) AR248136A1 (de)
AT (1) ATE127799T1 (de)
AU (1) AU634741B2 (de)
BG (1) BG60102B2 (de)
CA (1) CA2005986C (de)
DD (2) DD296079A5 (de)
DE (1) DE68924273T2 (de)
DK (1) DK170800B1 (de)
EG (1) EG19303A (de)
FI (2) FI913035A0 (de)
GR (1) GR1002252B (de)
HR (1) HRP920831A2 (de)
HU (2) HU205927B (de)
IE (1) IE894048L (de)
IL (1) IL92798A0 (de)
LT (2) LT3914B (de)
LV (1) LV10187B (de)
NZ (1) NZ231872A (de)
PH (1) PH27400A (de)
PL (1) PL161150B1 (de)
PT (1) PT92648B (de)
RO (1) RO110494B1 (de)
RU (2) RU2073676C1 (de)
SE (1) SE8804629D0 (de)
WO (1) WO1990006925A1 (de)
YU (1) YU46806B (de)
ZA (2) ZA899795B (de)

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WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
TNSN95063A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux benzimidazoles substitues
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
ATE414509T1 (de) * 1994-07-08 2008-12-15 Astrazeneca Ab Aus vielen einzeleinheiten zusammengesetzte tablettierte dosisform
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
DE19758573C2 (de) * 1997-11-26 2001-03-01 Implex Hear Tech Ag Fixationselement für ein implantierbares Mikrofon
WO1999053918A1 (fr) * 1998-04-20 1999-10-28 Eisai Co., Ltd. Compositions stabilisees contenant des composes du type benzimidazole
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
DE60036014T2 (de) 1999-10-20 2008-04-30 Eisai R&D Management Co., Ltd. Methode zur stabilisierung von benzimidazol-verbindungen
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
US20040006111A1 (en) * 2002-01-25 2004-01-08 Kenneth Widder Transmucosal delivery of proton pump inhibitors
US20050234103A1 (en) * 2002-03-26 2005-10-20 Reddy Manne S Crystalline forms of rabeprazole sodium
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
EP1603537A4 (de) * 2003-02-20 2009-11-04 Santarus Inc Neuartige formulierung, antazidkomplex-immediatfreisetzung für eine schnelle und anhaltende unterdrückung von magensäure
EP1648416A4 (de) * 2003-07-18 2012-03-28 Santarus Inc Pharmazeutische formulierungen zur hemmung der säuresekretion und herstellungs- und anwendungsverfahren
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
TWI337877B (en) * 2003-07-18 2011-03-01 Santarus Inc Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
NZ546148A (en) 2003-09-26 2009-05-31 Alza Corp Drug coating providing high drug loading and methods for providing the same
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
RU2467747C2 (ru) 2006-07-25 2012-11-27 Векта Лтд. Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
KR20110079641A (ko) 2008-09-09 2011-07-07 아스트라제네카 아베 제약 조성물을 이를 필요로 하는 환자에게 전달하는 방법
CA2764963C (en) 2009-06-25 2016-11-01 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (de) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Kombinationspräparat mit fester Dosierung zur Behandlung von Erkrankungen einhergehend mit Helicobacter pylori
EA028049B1 (ru) 2011-12-28 2017-10-31 Поузен Инк. Улучшенные композиции и способы доставки омепразола и ацетилсалициловой кислоты

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US428098A (en) 1890-05-20 Electric railway
US727150A (en) 1902-06-18 1903-05-05 Peter Paul Keller Adjustable hanger for incandescent lamps.
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (de) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
DE3215503A1 (de) 1982-04-26 1983-11-03 Zängl GmbH, 8000 München Elektrisch beheiztes schneidgeraet
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL71664A (en) * 1983-05-03 1987-11-30 Byk Gulden Lomberg Chem Fab Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
JPS6261978A (ja) * 1985-09-12 1987-03-18 Otsuka Pharmaceut Co Ltd ５−フルオロ−１ｈ−ベンズイミダゾ−ル誘導体
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
JPH0676323B2 (ja) * 1987-08-28 1994-09-28 東京田辺製薬株式会社 抗潰瘍剤

Also Published As

Publication number Publication date
LT3980B (en) 1996-06-25
FI954768A (fi) 1995-10-06
SE8804629D0 (sv) 1988-12-22
DK122291A (da) 1991-06-24
EG19303A (en) 1994-11-30
US5039808A (en) 1991-08-13
DD296078A5 (de) 1991-11-21
DK170800B1 (da) 1996-01-22
IE894048L (en) 1990-06-22
HU901084D0 (en) 1991-09-30
BG60102B2 (en) 1993-10-29
LV10187B (en) 1995-04-20
ZA899795B (en) 1990-08-29
RO110494B1 (ro) 1996-01-30
CN1043713A (zh) 1990-07-11
ATE127799T1 (de) 1995-09-15
CN1028231C (zh) 1995-04-19
RU2073676C1 (ru) 1997-02-20
EP0449940A1 (de) 1991-10-09
RU2042673C1 (ru) 1995-08-27
DE68924273T2 (de) 1996-02-15
PT92648B (pt) 1995-09-12
HU205926B (en) 1992-07-28
LTIP1726A (en) 1995-07-25
HUT57202A (en) 1991-11-28
KR910700249A (ko) 1991-03-14
YU46806B (sh) 1994-06-10
JP2793906B2 (ja) 1998-09-03
DK122291D0 (da) 1991-06-21
EP0449940B1 (de) 1995-09-13
AR248136A1 (es) 1995-06-30
IL92798A0 (en) 1990-09-17
AU4817590A (en) 1990-07-10
PH27400A (en) 1993-06-21
PL161150B1 (en) 1993-05-31
NZ231872A (en) 1992-03-26
LV10187A (lv) 1994-10-20
YU242689A (en) 1991-04-30
HRP920831A2 (en) 1995-12-31
FI954768A0 (fi) 1995-10-06
DD296079A5 (de) 1991-11-21
ZA899794B (en) 1990-08-29
AU634741B2 (en) 1993-03-04
GR890100838A (el) 1991-03-15
CA2005986C (en) 1999-08-03
US5008278A (en) 1991-04-16
LT3914B (en) 1996-04-25
LTIP1721A (en) 1995-07-25
PT92648A (pt) 1990-06-29
CA2005986A1 (en) 1990-06-22
HU205927B (en) 1992-07-28
WO1990006925A1 (en) 1990-06-28
FI913035A0 (fi) 1991-06-20
GR1002252B (en) 1996-04-23
JPH04502461A (ja) 1992-05-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee