ES2051675T1 - Uso de ciertos herbicidas en el tratamiento del cancer y produccion de protoporfirina ix. - Google Patents

Uso de ciertos herbicidas en el tratamiento del cancer y produccion de protoporfirina ix.

Info

Publication number
ES2051675T1
ES2051675T1 ES90901350T ES90901350T ES2051675T1 ES 2051675 T1 ES2051675 T1 ES 2051675T1 ES 90901350 T ES90901350 T ES 90901350T ES 90901350 T ES90901350 T ES 90901350T ES 2051675 T1 ES2051675 T1 ES 2051675T1
Authority
ES
Spain
Prior art keywords
protoporphyrine
cells
treatment
production
protoporphyrinogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES90901350T
Other languages
English (en)
Other versions
ES2051675T3 (es
Inventor
Blaik Phillip Halling
Debra Ann Witkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FMC Corp
Original Assignee
FMC Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FMC Corp filed Critical FMC Corp
Publication of ES2051675T1 publication Critical patent/ES2051675T1/es
Application granted granted Critical
Publication of ES2051675T3 publication Critical patent/ES2051675T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

SE EXPONE UN METODO Y UN COMPUESTO FARMACEUTICO PARA ACABAR CON LAS CELULAS TUMOROSAS EN LOS MAMIFEROS AL SOMETER A LAS MISMAS A LA LUZ EN PRESENCIA DE UN TETRAPIROLE ACTIVADO POR LA LUZ, EN EL QUE EL MEJORAMIENTO COMPRENDE EL TRATAMIENTO DE DICHAS CELULAS CON UN COMPUESTO QUE INHIBE LA CONVERSION ENZIMATICA DEL PROTOPORFIRINOGENO EN PROTOPORFIRINA IX AL OXIDAR DICHO PROTOPORFIRINOGENO EN DICHAS CELULAS QUE CAUSAN UNA CONSTRUCCION DE PROTORPORFIRINA IX EN DICHAS CELULAS. TAMBIEN SE EXPONE UN METODO PARA LA PRODUCCION DE PROTOPORFIRINA IX QUE COMPRENDE EL CRECIMIENTO DE LA MICROALGA EUKARIOTICA EN LA PRESENCIA DE UN INHIBIDOR OXIDADO DE PROTOPORFIRINOGENO.
ES90901350T 1988-12-12 1989-12-08 Inhibidores de protorfirinogeno y su uso en composiciones para detectar y tratar tumores. Expired - Lifetime ES2051675T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28515188A 1988-12-12 1988-12-12
US33500789A 1989-04-07 1989-04-07
US35133189A 1989-05-03 1989-05-03

Publications (2)

Publication Number Publication Date
ES2051675T1 true ES2051675T1 (es) 1994-07-01
ES2051675T3 ES2051675T3 (es) 1994-11-01

Family

ID=27403508

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90901350T Expired - Lifetime ES2051675T3 (es) 1988-12-12 1989-12-08 Inhibidores de protorfirinogeno y su uso en composiciones para detectar y tratar tumores.

Country Status (28)

Country Link
EP (1) EP0447491B1 (es)
JP (1) JP2545000B2 (es)
KR (1) KR930003116B1 (es)
AR (1) AR243605A1 (es)
AT (1) AT400520B (es)
AU (1) AU633537B2 (es)
BR (1) BR8907817A (es)
CA (1) CA2004979A1 (es)
CH (1) CH681779A5 (es)
DE (2) DE3991484T (es)
DK (1) DK110791A (es)
EG (1) EG18822A (es)
ES (1) ES2051675T3 (es)
FI (1) FI912784A0 (es)
GB (1) GB2247404B (es)
GR (1) GR1000609B (es)
HU (1) HUT58202A (es)
IE (1) IE62621B1 (es)
IL (1) IL92622A (es)
LU (1) LU87949A1 (es)
LV (1) LV10303B (es)
MC (1) MC2171A1 (es)
NO (1) NO912228L (es)
NZ (1) NZ231658A (es)
OA (1) OA09362A (es)
PT (1) PT92546B (es)
SE (1) SE505938C2 (es)
WO (1) WO1990006748A2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298502A (en) * 1988-12-12 1994-03-29 Fmc Corporation Method and composition for photodynamic treatment and detection of tumors
US5132101A (en) * 1990-05-04 1992-07-21 Cytopharm, Inc. Acetylene-cumulene porphycene compounds for photodynamic therapy
US5244671A (en) * 1991-01-29 1993-09-14 Cytopharm, Inc. Derivatives of porphycene for photodynamic therapy of cancer
US5179120A (en) * 1991-06-28 1993-01-12 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
TW492975B (en) * 1993-07-26 2002-07-01 Novartis Ag Tryptase inhibitor
GB9318841D0 (en) * 1993-09-10 1993-10-27 Res Foundation Of The Norwegia Composition
US5939602A (en) * 1995-06-06 1999-08-17 Novartis Finance Corporation DNA molecules encoding plant protoporphyrinogen oxidase and inhibitor-resistant mutants thereof
US5767373A (en) * 1994-06-16 1998-06-16 Novartis Finance Corporation Manipulation of protoporphyrinogen oxidase enzyme activity in eukaryotic organisms
US6023012A (en) * 1996-02-28 2000-02-08 Novartis Finance Corporation DNA molecules encoding plant protoporphyrinogen oxidase
US6084155A (en) * 1995-06-06 2000-07-04 Novartis Ag Herbicide-tolerant protoporphyrinogen oxidase ("protox") genes
UA70912C2 (uk) * 1996-02-28 2004-11-15 Cінгента Партісіпейшнс Аг Молекула днк, яка кодує стійку до дії інгібітора рослинну протопорфіриногеноксидазу, спосіб одержання стійких до гербіциду рослин, спосіб боротьби з ростом небажаних рослин
JPH10330359A (ja) * 1997-03-31 1998-12-15 Nippon Bayeragrochem Kk フエニルアセチレン誘導体及び除草剤
DE102005017152B4 (de) * 2005-04-13 2007-02-08 Lindauer Dornier Gmbh Verfahren zum Trocknen von vorzugsweise plattenförmigen Produkten und Durchlauftrockner in Mehretagenbauweise
SI2443102T1 (sl) 2009-06-19 2013-08-30 Basf Se Herbicidni benzoksazinoni
WO2011051393A1 (en) * 2009-11-02 2011-05-05 Basf Se Herbicidal tetrahydrophthalimides
JP2013540113A (ja) * 2010-10-01 2013-10-31 ビーエーエスエフ ソシエタス・ヨーロピア 除草性ベンゾオキサジノン
AU2011344311B2 (en) 2010-12-15 2015-05-14 Basf Se Herbicidal compositions
CN102875569A (zh) * 2012-09-27 2013-01-16 南开大学 具有除草活性和抗肝癌活性的异噁唑并嘧啶酮(或三嗪酮)类化合物
WO2018108695A1 (en) * 2016-12-16 2018-06-21 Basf Se Herbicidal phenyltriazolinones

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393071A (en) * 1975-03-17 1983-07-12 Naoharu Fujii Method of treating gastric, mammary, lung and uterus tumors
US4404019A (en) * 1980-12-24 1983-09-13 Sumitomo Chemical Company, Limited 3-Chloro-1-phenyl-1,2,4-triazolin-5-ones and their use as herbicides
CH651029A5 (de) * 1980-12-25 1985-08-30 Nihon Nohyaku Co Ltd Triazolin-derivate, verfahren zu ihrer herstellung und sie enthaltende herbizide mittel.
JPS60190711A (ja) * 1984-03-09 1985-09-28 Tokyo Tanabe Co Ltd プロトポルフイリン類注射用製剤
US4761174A (en) * 1987-04-14 1988-08-02 Fmc Corporation Triazolin-5-one herbicides
US4755217A (en) * 1987-01-15 1988-07-05 Fmc Corporation Triazinedione herbicides

Also Published As

Publication number Publication date
DK110791D0 (da) 1991-06-11
GB9110472D0 (en) 1991-11-27
CA2004979A1 (en) 1990-06-12
IL92622A0 (en) 1990-08-31
IL92622A (en) 1996-05-14
EG18822A (en) 1994-09-29
ATA903489A (de) 1995-06-15
EP0447491A1 (en) 1991-09-25
MC2171A1 (fr) 1992-05-22
GB2247404A (en) 1992-03-04
DK110791A (da) 1991-08-12
JP2545000B2 (ja) 1996-10-16
NO912228D0 (no) 1991-06-11
SE505938C2 (sv) 1997-10-27
AR243605A1 (es) 1993-08-31
ES2051675T3 (es) 1994-11-01
BR8907817A (pt) 1991-10-22
CH681779A5 (es) 1993-05-28
KR910700046A (ko) 1991-03-13
GR890100817A (en) 1991-03-15
AU4822290A (en) 1990-07-10
OA09362A (en) 1992-09-15
IE62621B1 (en) 1995-02-22
PT92546A (pt) 1990-06-29
NO912228L (no) 1991-06-11
LV10303A (lv) 1994-10-20
NZ231658A (en) 1992-05-26
LV10303B (en) 1995-08-20
LU87949A1 (fr) 1991-12-16
DE3991484T (es) 1991-11-21
FI912784A0 (fi) 1991-06-10
WO1990006748A2 (en) 1990-06-28
KR930003116B1 (ko) 1993-04-19
AT400520B (de) 1996-01-25
WO1990006748A3 (en) 1990-10-04
IE893925L (en) 1990-06-12
SE9101807D0 (sv) 1991-06-12
JPH04501420A (ja) 1992-03-12
AU633537B2 (en) 1993-02-04
SE9101807L (sv) 1991-06-12
HUT58202A (en) 1992-02-28
EP0447491B1 (en) 1993-08-11
PT92546B (pt) 1995-09-12
GB2247404B (en) 1993-03-03
GR1000609B (el) 1992-08-31
DE3991484C2 (de) 1995-02-23

Similar Documents

Publication Publication Date Title
ES2051675T1 (es) Uso de ciertos herbicidas en el tratamiento del cancer y produccion de protoporfirina ix.
AR248136A1 (es) Procedimiento e intermediarios para la preparacion de 5 5 5 5 5
ES2037013T3 (es) Procedimiento para preparar tieno-1,4-diazepinas.
ATE116857T1 (de) Oligodesoxynukleotide als inhibitoren der replikation von retroviren und der expression von onkogenen.
ES2131116T3 (es) Analogos de nucleotidos enantiomericos antirretrovirales.
ES2060611T3 (es) Fotoiniciadores correactivos.
NO944997D0 (no) Trombin-blodfraksjon for anvendelse ved en medisinsk fremgangsmåte
ES2059575T3 (es) Aductos modificados de poliepoxido y polioxialquilen-poliamidas.
ES2063013T3 (es) Procedimiento para eliminar pirogenos.
ES2159851T3 (es) Amidas de acidos aminotiofenocarboxilicos y su empleo como inhibidores de la fosfodiestearasa.
ATE71298T1 (de) Immunoregulation.
ES2129423T3 (es) Vacunas.
AR009560A1 (es) Prolongacion de la sobrevida de injertos con porfirinas
CO4940451A1 (es) Derivados de acido barbiturico con actividad antimetastica y antitumoral
ES2138603T3 (es) Procedimiento para el aislamiento de los factores ix, x y ii altamente purificados a partir del complejo protrombinico o del plasma humano.
ES2089687T3 (es) 4-fenil-piridonas y 4-fenil-2-alcoxipiridinas sustituidas como inhibidores de la hmg-coa-reductasa.
ES2001003A4 (es) Metodo para preparar polimeros de sulfometil-poliacrilamidas.
ES2045484T3 (es) Nuevos derivados de la vitamina d: aplicaciones terapeuticas y a las dosificaciones de los metabolitos de la vitamina d.
IT1111875B (it) Collegamento ad innesto disimpegnabile,come pure spina e pezzo intermedio per il collegamento di una fibra per la conduzione di luce o con una sorgente di luce rispettivamente con un detettore di luce
ES2166900T3 (es) Derivados de ara-c.
ATE82654T1 (de) Frequenz-gekoppelte laser-lichtquelle.
ES2187534T3 (es) Procedimiento para la preparacion de n-metil-3-(metil-4-piperi dinil)-14-indol-5-etanosulfonamida.
ES2098316T3 (es) Procedimiento de purificacion de carrageninas comerciales.
MX9301863A (es) Morfolin y tiomorfolin 4-ilamidas
ES2026485T3 (es) Esteres de salsalato con guayacol para tratar bronconeumopatias flogisticas.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 447491

Country of ref document: ES