ES2051675T3 - Inhibidores de protorfirinogeno y su uso en composiciones para detectar y tratar tumores. - Google Patents
Inhibidores de protorfirinogeno y su uso en composiciones para detectar y tratar tumores.Info
- Publication number
- ES2051675T3 ES2051675T3 ES90901350T ES90901350T ES2051675T3 ES 2051675 T3 ES2051675 T3 ES 2051675T3 ES 90901350 T ES90901350 T ES 90901350T ES 90901350 T ES90901350 T ES 90901350T ES 2051675 T3 ES2051675 T3 ES 2051675T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- protorphyrinogen
- inhibitors
- compositions
- detect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SE EXPONE UN METODO Y UN COMPUESTO FARMACEUTICO PARA ACABAR CON LAS CELULAS TUMOROSAS EN LOS MAMIFEROS AL SOMETER A LAS MISMAS A LA LUZ EN PRESENCIA DE UN TETRAPIROLE ACTIVADO POR LA LUZ, EN EL QUE EL MEJORAMIENTO COMPRENDE EL TRATAMIENTO DE DICHAS CELULAS CON UN COMPUESTO QUE INHIBE LA CONVERSION ENZIMATICA DEL PROTOPORFIRINOGENO EN PROTOPORFIRINA IX AL OXIDAR DICHO PROTOPORFIRINOGENO EN DICHAS CELULAS QUE CAUSAN UNA CONSTRUCCION DE PROTORPORFIRINA IX EN DICHAS CELULAS. TAMBIEN SE EXPONE UN METODO PARA LA PRODUCCION DE PROTOPORFIRINA IX QUE COMPRENDE EL CRECIMIENTO DE LA MICROALGA EUKARIOTICA EN LA PRESENCIA DE UN INHIBIDOR OXIDADO DE PROTOPORFIRINOGENO.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28515188A | 1988-12-12 | 1988-12-12 | |
US33500789A | 1989-04-07 | 1989-04-07 | |
US35133189A | 1989-05-03 | 1989-05-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2051675T1 ES2051675T1 (es) | 1994-07-01 |
ES2051675T3 true ES2051675T3 (es) | 1994-11-01 |
Family
ID=27403508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90901350T Expired - Lifetime ES2051675T3 (es) | 1988-12-12 | 1989-12-08 | Inhibidores de protorfirinogeno y su uso en composiciones para detectar y tratar tumores. |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP0447491B1 (es) |
JP (1) | JP2545000B2 (es) |
KR (1) | KR930003116B1 (es) |
AR (1) | AR243605A1 (es) |
AT (1) | AT400520B (es) |
AU (1) | AU633537B2 (es) |
BR (1) | BR8907817A (es) |
CA (1) | CA2004979A1 (es) |
CH (1) | CH681779A5 (es) |
DE (2) | DE3991484T (es) |
DK (1) | DK110791A (es) |
EG (1) | EG18822A (es) |
ES (1) | ES2051675T3 (es) |
FI (1) | FI912784A0 (es) |
GB (1) | GB2247404B (es) |
GR (1) | GR1000609B (es) |
HU (1) | HUT58202A (es) |
IE (1) | IE62621B1 (es) |
IL (1) | IL92622A (es) |
LU (1) | LU87949A1 (es) |
LV (1) | LV10303B (es) |
MC (1) | MC2171A1 (es) |
NO (1) | NO912228D0 (es) |
NZ (1) | NZ231658A (es) |
OA (1) | OA09362A (es) |
PT (1) | PT92546B (es) |
SE (1) | SE505938C2 (es) |
WO (1) | WO1990006748A2 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5298502A (en) * | 1988-12-12 | 1994-03-29 | Fmc Corporation | Method and composition for photodynamic treatment and detection of tumors |
US5132101A (en) * | 1990-05-04 | 1992-07-21 | Cytopharm, Inc. | Acetylene-cumulene porphycene compounds for photodynamic therapy |
US5244671A (en) * | 1991-01-29 | 1993-09-14 | Cytopharm, Inc. | Derivatives of porphycene for photodynamic therapy of cancer |
US5179120A (en) * | 1991-06-28 | 1993-01-12 | Cytopharm, Inc. | Porphycene compounds for photodynamic therapy |
TW492975B (en) * | 1993-07-26 | 2002-07-01 | Novartis Ag | Tryptase inhibitor |
GB9318841D0 (en) * | 1993-09-10 | 1993-10-27 | Res Foundation Of The Norwegia | Composition |
US6023012A (en) * | 1996-02-28 | 2000-02-08 | Novartis Finance Corporation | DNA molecules encoding plant protoporphyrinogen oxidase |
US5767373A (en) * | 1994-06-16 | 1998-06-16 | Novartis Finance Corporation | Manipulation of protoporphyrinogen oxidase enzyme activity in eukaryotic organisms |
US5939602A (en) * | 1995-06-06 | 1999-08-17 | Novartis Finance Corporation | DNA molecules encoding plant protoporphyrinogen oxidase and inhibitor-resistant mutants thereof |
US6084155A (en) * | 1995-06-06 | 2000-07-04 | Novartis Ag | Herbicide-tolerant protoporphyrinogen oxidase ("protox") genes |
EP0883682A1 (en) * | 1996-02-28 | 1998-12-16 | Novartis AG | Dna molecules encoding plant protoporphyrinogen oxidase and inhibitor-resistant mutants thereof |
JPH10330359A (ja) * | 1997-03-31 | 1998-12-15 | Nippon Bayeragrochem Kk | フエニルアセチレン誘導体及び除草剤 |
DE102005017152B4 (de) * | 2005-04-13 | 2007-02-08 | Lindauer Dornier Gmbh | Verfahren zum Trocknen von vorzugsweise plattenförmigen Produkten und Durchlauftrockner in Mehretagenbauweise |
EA023754B1 (ru) | 2009-06-19 | 2016-07-29 | Басф Се | Гербицидные бензоксазиноны |
CN102686583A (zh) * | 2009-11-02 | 2012-09-19 | 巴斯夫欧洲公司 | 除草的四氢邻苯二甲酰亚胺类 |
BR112013007610B1 (pt) | 2010-10-01 | 2018-03-20 | Basf Se | Benzoxazinonas, composições herbicidas, processo para preparar composições herbicidas ativas e método para controlar vegetação indesejada |
CA2818034C (en) | 2010-12-15 | 2019-06-18 | Basf Se | Herbicidal compositions comprising a benzoxazinone compound and an n-acylsulfamoylphenylurea safener |
CN102875569A (zh) * | 2012-09-27 | 2013-01-16 | 南开大学 | 具有除草活性和抗肝癌活性的异噁唑并嘧啶酮(或三嗪酮)类化合物 |
US11185075B2 (en) * | 2016-12-16 | 2021-11-30 | Basf Se | Herbicidal phenyltriazolinones |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4393071A (en) * | 1975-03-17 | 1983-07-12 | Naoharu Fujii | Method of treating gastric, mammary, lung and uterus tumors |
US4404019A (en) * | 1980-12-24 | 1983-09-13 | Sumitomo Chemical Company, Limited | 3-Chloro-1-phenyl-1,2,4-triazolin-5-ones and their use as herbicides |
CH651029A5 (de) * | 1980-12-25 | 1985-08-30 | Nihon Nohyaku Co Ltd | Triazolin-derivate, verfahren zu ihrer herstellung und sie enthaltende herbizide mittel. |
JPS60190711A (ja) * | 1984-03-09 | 1985-09-28 | Tokyo Tanabe Co Ltd | プロトポルフイリン類注射用製剤 |
US4755217A (en) * | 1987-01-15 | 1988-07-05 | Fmc Corporation | Triazinedione herbicides |
US4761174A (en) * | 1987-04-14 | 1988-08-02 | Fmc Corporation | Triazolin-5-one herbicides |
-
1989
- 1989-12-06 NZ NZ231658A patent/NZ231658A/en unknown
- 1989-12-07 IE IE392589A patent/IE62621B1/en not_active IP Right Cessation
- 1989-12-08 AT AT0903489A patent/AT400520B/de not_active IP Right Cessation
- 1989-12-08 BR BR898907817A patent/BR8907817A/pt not_active Application Discontinuation
- 1989-12-08 KR KR1019900701747A patent/KR930003116B1/ko not_active IP Right Cessation
- 1989-12-08 AU AU48222/90A patent/AU633537B2/en not_active Ceased
- 1989-12-08 CA CA002004979A patent/CA2004979A1/en not_active Abandoned
- 1989-12-08 EP EP90901350A patent/EP0447491B1/en not_active Expired - Lifetime
- 1989-12-08 HU HU901144A patent/HUT58202A/hu unknown
- 1989-12-08 CH CH2658/90A patent/CH681779A5/de unknown
- 1989-12-08 ES ES90901350T patent/ES2051675T3/es not_active Expired - Lifetime
- 1989-12-08 DE DE19893991484 patent/DE3991484T/de active Pending
- 1989-12-08 WO PCT/US1989/005599 patent/WO1990006748A2/en active Application Filing
- 1989-12-08 DE DE3991484A patent/DE3991484C2/de not_active Expired - Fee Related
- 1989-12-08 MC MC89@@D patent/MC2171A1/xx unknown
- 1989-12-08 JP JP2501659A patent/JP2545000B2/ja not_active Expired - Lifetime
- 1989-12-10 IL IL9262289A patent/IL92622A/en not_active IP Right Cessation
- 1989-12-11 AR AR89315638A patent/AR243605A1/es active
- 1989-12-12 PT PT92546A patent/PT92546B/pt not_active IP Right Cessation
- 1989-12-12 GR GR890100817A patent/GR1000609B/el unknown
- 1989-12-21 EG EG60989A patent/EG18822A/xx active
-
1991
- 1991-05-15 GB GB9110472A patent/GB2247404B/en not_active Expired - Fee Related
- 1991-06-10 FI FI912784A patent/FI912784A0/fi not_active Application Discontinuation
- 1991-06-11 NO NO912228A patent/NO912228D0/no unknown
- 1991-06-11 DK DK110791A patent/DK110791A/da unknown
- 1991-06-12 OA OA60016A patent/OA09362A/xx unknown
- 1991-06-12 LU LU87949A patent/LU87949A1/fr unknown
- 1991-06-12 SE SE9101807A patent/SE505938C2/sv not_active IP Right Cessation
-
1993
- 1993-09-09 LV LVP-93-1060A patent/LV10303B/lv unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2051675T3 (es) | Inhibidores de protorfirinogeno y su uso en composiciones para detectar y tratar tumores. | |
ES2159851T3 (es) | Amidas de acidos aminotiofenocarboxilicos y su empleo como inhibidores de la fosfodiestearasa. | |
ATE116857T1 (de) | Oligodesoxynukleotide als inhibitoren der replikation von retroviren und der expression von onkogenen. | |
ES2037013T3 (es) | Procedimiento para preparar tieno-1,4-diazepinas. | |
ES2059880T3 (es) | Utilizacion del acido estearidonico para el tratamiento de las enfermedades inflamatorias. | |
ES2152444T3 (es) | Derivados de acido benzazepin-, benzoxazepin- y benzotiazepin-n-acetico, asi como procedimiento para su preparacion y medicamentos que contienen a estos compuestos. | |
ES2058185T3 (es) | Derivados de camptotecina y procedimiento para su preparacion. | |
BG45701A3 (en) | Method for preparing of alpha- heterocyclic substituted tolunitriles | |
ES2161291T3 (es) | N-(indol-2-carbonil)amidas y derivados como inhibidores de la glucogeno fosforilasa. | |
MX9405383A (es) | Imidazo(4,5-c) piridin-4-aminas. | |
CO4940451A1 (es) | Derivados de acido barbiturico con actividad antimetastica y antitumoral | |
ES2164920T3 (es) | Nuevos derivados heterociclicos y uso medicinal de los mismos. | |
MX9700237A (es) | Combinaciones inhibidoras de proteasa retroviral. | |
ES2039278T3 (es) | Procedimiento para preparar inhibidores de 5-alfa-reductasa de esteroides. | |
ES2059575T3 (es) | Aductos modificados de poliepoxido y polioxialquilen-poliamidas. | |
ES2089687T3 (es) | 4-fenil-piridonas y 4-fenil-2-alcoxipiridinas sustituidas como inhibidores de la hmg-coa-reductasa. | |
ES2134924T3 (es) | Acidos sulfonilalcanoilamino-hidroxietilamino-sulfamicos utiles como inhibidores de proteasas retrovirales. | |
AR035640A1 (es) | Uso de inhibidores de il-18 en la fabricacion de medicamentos para el tratamiento y/o prevencion de arteriosclerosis; metodo de tratamiento o prevencion de arteriosclerosis utilizando dichos inhibidores; uso del il-18 como marcador de mala prognosis clinica en fallas cardiacas. | |
ES2138603T3 (es) | Procedimiento para el aislamiento de los factores ix, x y ii altamente purificados a partir del complejo protrombinico o del plasma humano. | |
ES2180933T3 (es) | Inhibidor de la serina-proteasa. | |
ES2047033T3 (es) | Un metodo para preparar compuestos de hidroxivitamina d. | |
AR003176A1 (es) | Una composicion farmaceutica para inhibir el crecimiento de cancer | |
UY28048A1 (es) | Inhibidores de hiv-integrasa,composiciones farmacéuticas y métodos para su uso | |
ES2187738T3 (es) | Derivados de flavonas, su procedimiento de preparacion y los compuestos farmaceuticos que las contienen. | |
ES2059534T3 (es) | Nuevos derivados benzopiranos antihipertensivos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 447491 Country of ref document: ES |