UY28048A1 - Inhibidores de hiv-integrasa,composiciones farmacéuticas y métodos para su uso - Google Patents

Inhibidores de hiv-integrasa,composiciones farmacéuticas y métodos para su uso

Info

Publication number
UY28048A1
UY28048A1 UY28048A UY28048A UY28048A1 UY 28048 A1 UY28048 A1 UY 28048A1 UY 28048 A UY28048 A UY 28048A UY 28048 A UY28048 A UY 28048A UY 28048 A1 UY28048 A1 UY 28048A1
Authority
UY
Uruguay
Prior art keywords
hiv
integress
inhibitors
methods
pharmaceutical compositions
Prior art date
Application number
UY28048A
Other languages
English (en)
Inventor
Qiyue Hu
Atsuo Kuki
Dawn Marie Nowlin
Michael Bruno Plewe
Hai Wang
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY28048A1 publication Critical patent/UY28048A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen compuestos de hidroxamatos bicíclicos representados por la fórmula I: Los compuestos de hidroxamato bicíclicos y las composiciones que contienen estos compuestos pueden ser usados para inhibir o modular una actividad enzimática de HIV- integrasa y para tratar enfermedades y estados mediados por HIV.
UY28048A 2002-10-31 2003-10-28 Inhibidores de hiv-integrasa,composiciones farmacéuticas y métodos para su uso UY28048A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42251302P 2002-10-31 2002-10-31

Publications (1)

Publication Number Publication Date
UY28048A1 true UY28048A1 (es) 2004-05-31

Family

ID=32230367

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28048A UY28048A1 (es) 2002-10-31 2003-10-28 Inhibidores de hiv-integrasa,composiciones farmacéuticas y métodos para su uso

Country Status (16)

Country Link
US (3) US7135482B2 (es)
EP (1) EP1558611B1 (es)
JP (1) JP2006506398A (es)
AR (1) AR041864A1 (es)
AT (1) ATE454385T1 (es)
AU (1) AU2003269421A1 (es)
BR (1) BR0315820A (es)
CA (1) CA2500487A1 (es)
DE (1) DE60330890D1 (es)
GT (1) GT200300231A (es)
MX (1) MXPA05004343A (es)
NL (1) NL1024676C2 (es)
PA (1) PA8586801A1 (es)
TW (1) TW200424199A (es)
UY (1) UY28048A1 (es)
WO (1) WO2004039803A2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
MXPA06012449A (es) 2004-04-26 2007-01-17 Pfizer Inhibidores de la enzima integrasa de vih.
EP1873155A1 (en) * 2004-04-26 2008-01-02 Pfizer Inc. Inhibitors of the HIV integrase enzyme
JP2007534738A (ja) * 2004-04-26 2007-11-29 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
JP2008512442A (ja) * 2004-09-07 2008-04-24 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
WO2006121831A2 (en) * 2005-05-10 2006-11-16 Merck & Co., Inc. Hiv integrase inhibitors
JP2009510157A (ja) * 2005-10-03 2009-03-12 ファイザー・プロダクツ・インク Ｈｉｖインテグラーゼ酵素の阻害剤
KR20080042171A (ko) * 2005-10-07 2008-05-14 화이자 프로덕츠 인코포레이티드 Ｈｉｖ 인테그라제 효소의 억제제
US20080079207A1 (en) * 2006-09-28 2008-04-03 Williams Controils Industries, Inc. Methods and apparatus for a lever control
US8742123B2 (en) 2008-06-04 2014-06-03 Taimed Biologics, Inc. HIV integrase inhibitors from pyridoxine
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
MX2012007410A (es) 2009-12-23 2012-07-17 Univ Leuven Kath Compuestos antivirales novedosos.
US9132129B2 (en) 2010-11-15 2015-09-15 Katholieke Universiteit Leuven Antiviral compounds
WO2013082476A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
GB201321735D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
GB8720125D0 (en) 1987-08-26 1987-09-30 Roussel Lab Ltd Chemical compounds
AU2409992A (en) * 1991-08-08 1993-03-02 Tsumura & Co. Carcinostatic compound and production thereof
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
US5262537A (en) * 1993-03-19 1993-11-16 Anaquest, Inc. Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid
AU7225494A (en) * 1993-07-19 1995-02-20 Zelin Li Qinghaosu derivatives against aids
GB2306476A (en) * 1995-10-27 1997-05-07 Merck & Co Inc Hiv integrase inhibitors
US6057297A (en) 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
WO1998018473A1 (en) * 1996-10-31 1998-05-07 Merck & Co., Inc. Benzodiazepine hydrazide derivatives as inhibitors of hiv integrase
GB2327674A (en) * 1997-07-29 1999-02-03 Merck & Co Inc HIV integrase inhibitors
US6403347B1 (en) * 1998-02-03 2002-06-11 Merck & Co., Inc. HIV integrase inhibitors
IL140197A0 (en) 1998-06-12 2002-02-10 Sod Conseils Rech Applic β-CARBOLINE COMPOUNDS
WO2000068235A1 (en) * 1999-05-12 2000-11-16 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health Thiazepine inhibitors of hiv-1 integrase
US6245806B1 (en) * 1999-08-03 2001-06-12 Merck & Co., Inc. HIV integrase inhibitors
WO2001027309A1 (en) * 1999-10-13 2001-04-19 Merck & Co., Inc. Hiv integrase inhibitors
EP1209158A1 (en) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
JP2004503523A (ja) * 2000-06-16 2004-02-05 ブリストルーマイヤーズ　スクイブ　カンパニー Ｈｉｖインテグラーゼ阻害剤
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
BR0207809A (pt) 2001-03-01 2004-03-09 Shionogi & Co Compostos heteroarila contendo nitrogênio possuindo atividade inibidora contra integrase de hiv
WO2002070491A1 (fr) * 2001-03-01 2002-09-12 Shionogi & Co., Ltd. Derive a noyau heteroaromatique azote presentant une activite d'inhibiteur d'integrase du vih
JP2003171381A (ja) 2001-09-25 2003-06-20 Takeda Chem Ind Ltd エントリー阻害剤
JP2003119137A (ja) 2001-10-10 2003-04-23 Japan Tobacco Inc Ｈｉｖ阻害剤
JP2005508968A (ja) 2001-10-19 2005-04-07 トランス　テック　ファーマ，インコーポレイテッド ＰＴＰ阻害剤としてのβ−カルボリン誘導体
ATE355064T1 (de) 2001-10-26 2006-03-15 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
JP4497347B2 (ja) 2001-12-05 2010-07-07 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する誘導体
RU2284315C2 (ru) 2001-12-12 2006-09-27 Бристол-Маерс Сквибб Компани Ингибиторы вич-интегразы и содержащие их фармацевтические композиции
ES2291642T3 (es) 2002-01-17 2008-03-01 MERCK & CO., INC. Hidroxinaftiridinoncarboxamidas utiles como inhibidores de la integrasa de vih.
WO2003077850A2 (en) 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2003082881A2 (en) * 2002-03-28 2003-10-09 Procyon Biopharma Inc. Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
US20050165000A1 (en) * 2002-04-10 2005-07-28 Robertson Sandra K. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
WO2004035076A1 (en) 2002-10-15 2004-04-29 Chiron Corporation Treatment of tnf-alpha-mediated disorders with casein kinase i epsilon inhibitors
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
JP2007534738A (ja) 2004-04-26 2007-11-29 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
MXPA06012449A (es) 2004-04-26 2007-01-17 Pfizer Inhibidores de la enzima integrasa de vih.
JP2008512442A (ja) 2004-09-07 2008-04-24 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤

Also Published As

Publication number Publication date
WO2004039803A3 (en) 2004-09-16
US20080221154A1 (en) 2008-09-11
US7135482B2 (en) 2006-11-14
JP2006506398A (ja) 2006-02-23
MXPA05004343A (es) 2005-08-03
BR0315820A (pt) 2005-09-13
DE60330890D1 (de) 2010-02-25
TW200424199A (en) 2004-11-16
AU2003269421A8 (en) 2004-05-25
AU2003269421A1 (en) 2004-05-25
NL1024676C2 (nl) 2005-12-14
US20040147547A1 (en) 2004-07-29
ATE454385T1 (de) 2010-01-15
CA2500487A1 (en) 2004-05-13
GT200300231A (es) 2004-06-23
US7368571B2 (en) 2008-05-06
WO2004039803A2 (en) 2004-05-13
EP1558611A2 (en) 2005-08-03
PA8586801A1 (es) 2005-02-04
NL1024676A1 (nl) 2004-05-06
US20070004768A1 (en) 2007-01-04
EP1558611B1 (en) 2010-01-06
AR041864A1 (es) 2005-06-01

Similar Documents

Publication Publication Date Title
UY28048A1 (es) Inhibidores de hiv-integrasa,composiciones farmacéuticas y métodos para su uso
EA200700138A1 (ru) Замещённые индолильные алкиламинопроизводные в качестве новых ингибиторов гистондеацетилазы
HN2003000064A (es) Derivados de nicotinamida utiles como inhibidores de pde4
NO20060168L (no) Pyridinylkarbamater som hormonsensitive lipaseinhibitorer
BRPI0409227C1 (pt) composto, composição farmacêutica, uso de um composto e processo para a preparação de um composto de fórmula (i)
CR7807A (es) Piperacinil y diacepanil benzamidas y benztioamidas
CR7716A (es) Uso de inhibidores de la ikb-quinasa para el tratamiento del dolor
CR7882A (es) Compuestos 2-(1H-Indazol-6-ilamino-benzamidas como inhibidores proteinquinasas utiles para el tratamiento de enfermedades oftalmicas
NO20061253L (no) Acetylenderivater som inhibitorer av histon deacetylase
ES2181614T3 (es) Sulfonilfenilheterociclos sustituidos como inhibidores de ciclooxigenasa-2 y 5-lipoxigenasa.
PA8550101A1 (es) Derivados de benzamida tiazol y composiciones farmacéuticas para inhibir la proliferación de células, y métodos para su utilización
CU23218A3 (es) Derivados espirociclicos nuevos y su uso como inhibidores de fosfodiesterasa - 7
ATE489360T1 (de) Inhibitoren der histon-deacetylase
MY142589A (en) Benzimidazole derivatives : preparation and pharmaceutical applications
EA200700143A1 (ru) Производные замещенного пропенилпиперазина в качестве новых ингибиторов гистондеацетилазы
CR6073A (es) Compuestos heterociclicos como inhibidores de enzimas de rotamasa
AR009358A1 (es) Compuesto espirociclico inhibidor de la metaloproteasa
UY29239A1 (es) Nuevos derivados de piridotienopirimidina
DK0763017T3 (da) N-(3-amino-2-hydroxybutyl)sulfonamidderivater som HIV-proteaseinhibitorer
PA8525801A1 (es) Compuestos de pirazol, composiciones farmacéuticas, y métodos para modular y/o inhibir la actividad de erab/hadh2
GT200400143A (es) Compuestos
ATE253359T1 (de) Antithrombotische mittel
ATE443044T1 (de) Tace inhibitoren
DE69702182T2 (de) Alkylierte styrole als prodrugs zu cox-2-inhibitoren
DE69828522D1 (de) Antithrombotische mittel

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20150126