ES2151600T3 - Derivados de n-(3-amino-2-hidroxibutil)sulfonamida utilizados como inhibidores de proteasa de vih. - Google Patents
Derivados de n-(3-amino-2-hidroxibutil)sulfonamida utilizados como inhibidores de proteasa de vih.Info
- Publication number
- ES2151600T3 ES2151600T3 ES95921534T ES95921534T ES2151600T3 ES 2151600 T3 ES2151600 T3 ES 2151600T3 ES 95921534 T ES95921534 T ES 95921534T ES 95921534 T ES95921534 T ES 95921534T ES 2151600 T3 ES2151600 T3 ES 2151600T3
- Authority
- ES
- Spain
- Prior art keywords
- hiv protease
- protease inhibitors
- hydroxibute
- derivatives
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
INHIBIDORES DE PROTEASA DE VIH DE FORMULA (1), EN LOS QUE Q{SUB,1} A Q{SUB,8}, E E Y SON COMO SE DEFINE EN LA REIVINDICACION 1, OBTENIBLES MEDIANTE SINTESIS QUIMICA, INHIBEN O BLOQUEAN LA ACTIVIDAD BIOLOGICA DE LA ENZIMA DE PROTEASA DE VIH, HACIENDO QUE TERMINE LA REPLICACION DEL VIRUS DE VIH. ESTOS COMPUESTOS, ASI COMO COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS Y OPCIONALMENTE OTROS AGENTES ANTI-VIRALES COMO INGREDIENTES ACTIVOS, SON ADECUADOS PARA EL TRATAMIENTO DE PACIENTES O HUESPEDES INFECTADOS CON EL VIRUS VIH, EL CUAL SE SABE CAUSA SIDA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/247,983 US5527829A (en) | 1994-05-23 | 1994-05-23 | HIV protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2151600T3 true ES2151600T3 (es) | 2001-01-01 |
Family
ID=22937168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95921534T Expired - Lifetime ES2151600T3 (es) | 1994-05-23 | 1995-05-23 | Derivados de n-(3-amino-2-hidroxibutil)sulfonamida utilizados como inhibidores de proteasa de vih. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5527829A (es) |
EP (1) | EP0763017B1 (es) |
JP (2) | JP3732858B2 (es) |
AT (1) | ATE196288T1 (es) |
AU (1) | AU2658695A (es) |
CA (1) | CA2190472A1 (es) |
DE (1) | DE69518840T2 (es) |
DK (1) | DK0763017T3 (es) |
ES (1) | ES2151600T3 (es) |
GR (1) | GR3035014T3 (es) |
PT (1) | PT763017E (es) |
WO (1) | WO1995032185A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US6878728B1 (en) | 1999-06-11 | 2005-04-12 | Vertex Pharmaceutical Incorporated | Inhibitors of aspartyl protease |
US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
MY126358A (en) * | 1996-03-22 | 2006-09-29 | Glaxo Group Ltd | Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs |
US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
US5925759A (en) * | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
US6001851A (en) * | 1997-03-13 | 1999-12-14 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
DE19730602A1 (de) * | 1997-07-17 | 1999-01-21 | Clariant Gmbh | 3-Acetoxy-2-methylbenzoesäurechlorid und ein Verfahren zu seiner Herstellung |
US6084107A (en) * | 1997-09-05 | 2000-07-04 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
AU767728B2 (en) | 1998-06-19 | 2003-11-20 | Vertex Pharmaceuticals Incorporated | Sulfonamide inhibitors of aspartyl protease |
TWI260322B (en) | 1999-02-12 | 2006-08-21 | Vertex Pharma | Inhibitors of aspartyl protease |
US6403799B1 (en) | 1999-10-21 | 2002-06-11 | Agouron Pharmaceuticals, Inc. | Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors |
US6506786B2 (en) | 2001-02-13 | 2003-01-14 | Pharmacor Inc. | HIV protease inhibitors based on amino acid derivatives |
DE10226219A1 (de) * | 2002-06-13 | 2004-01-08 | Bayer Ag | Verfahren zur Herstellung von 3-Acyloxy-2-methylbenzoesäuren |
US7388008B2 (en) * | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
WO2006114001A1 (en) * | 2005-04-27 | 2006-11-02 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics of protease inhibitors and protease inhibitor precursors |
EP1971615B1 (en) * | 2005-11-30 | 2014-01-01 | TaiMed Biologics, Inc. | Lysme-based prodrugs of aspartyl protease inhibitors and processes for their preparation |
JP5401652B2 (ja) * | 2006-09-21 | 2014-01-29 | タイメッド バイオロジクス インコーポレイテッド | プロテアーゼ阻害剤 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
DE3023855A1 (de) * | 1980-06-25 | 1982-01-14 | Bayer Ag, 5090 Leverkusen | Reaktivfarbstoffe, verfahren zu ihrer herstellung und ihre verwendung zum faerben und bedrucken hydroxylgruppenhaltiger oder stickstoffhaltiger fasermaterialien |
IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
IL91307A0 (en) * | 1988-08-24 | 1990-03-19 | Merck & Co Inc | Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them |
EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
US5063208A (en) * | 1989-07-26 | 1991-11-05 | Abbott Laboratories | Peptidyl aminodiol renin inhibitors |
WO1991008221A1 (en) * | 1989-12-04 | 1991-06-13 | Wisconsin Alumni Research Foundation | Peptide inhibitors of hiv protease |
GB8927915D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Novel alcohols |
GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
CA2056911C (en) * | 1990-12-11 | 1998-09-22 | Yuuichi Nagano | Hiv protease inhibitors |
RU2120447C1 (ru) * | 1991-02-08 | 1998-10-20 | Санкио Компани Лимитед | ПРОИЗВОДНЫЕ β АМИНО α ГИДРОКСИКАРБОНОВЫХ КИСЛОТ ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ ИЛИ ЭФИРОВ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ |
US5235039A (en) * | 1991-06-10 | 1993-08-10 | Eli Lilly And Company | Substrates for hiv protease |
CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
DE4126482A1 (de) * | 1991-08-10 | 1993-02-11 | Bayer Ag | (alpha)-trifluormethyl-substituierte, gesaettigt-bicyclische amine und verfahren zu deren herstellung |
US5516784A (en) * | 1991-08-13 | 1996-05-14 | Schering Corporation | Anti-HIV (AIDS) agents |
EP0534511A1 (en) * | 1991-08-16 | 1993-03-31 | Merck & Co. Inc. | HIV protease inhibitors useful for the treatment of aids |
US5256783A (en) * | 1991-09-18 | 1993-10-26 | Hoffmann-La Roche Inc. | Method for producing 2-isoquinoline compounds |
WO1993008184A1 (en) * | 1991-10-23 | 1993-04-29 | Merck & Co., Inc. | Hiv protease inhibitors |
WO1993013066A1 (en) * | 1991-12-20 | 1993-07-08 | Syntex (U.S.A.) Inc. | Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors |
DK0560268T3 (da) * | 1992-03-13 | 1995-06-12 | Bio Mega Boehringer Ingelheim | Substituerede pipecolinsyrederivater som HIV-proteasehæmmere |
WO1993023379A1 (en) * | 1992-05-21 | 1993-11-25 | Monsanto Company | Retroviral protease inhibitors |
KR100336699B1 (ko) * | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
US5463104A (en) * | 1992-08-25 | 1995-10-31 | G. D. Searle & Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
-
1994
- 1994-05-23 US US08/247,983 patent/US5527829A/en not_active Expired - Fee Related
-
1995
- 1995-05-23 CA CA002190472A patent/CA2190472A1/en not_active Abandoned
- 1995-05-23 PT PT95921534T patent/PT763017E/pt unknown
- 1995-05-23 AT AT95921534T patent/ATE196288T1/de not_active IP Right Cessation
- 1995-05-23 ES ES95921534T patent/ES2151600T3/es not_active Expired - Lifetime
- 1995-05-23 EP EP95921534A patent/EP0763017B1/en not_active Expired - Lifetime
- 1995-05-23 WO PCT/US1995/006866 patent/WO1995032185A1/en active IP Right Grant
- 1995-05-23 AU AU26586/95A patent/AU2658695A/en not_active Abandoned
- 1995-05-23 DE DE69518840T patent/DE69518840T2/de not_active Expired - Fee Related
- 1995-05-23 DK DK95921534T patent/DK0763017T3/da active
- 1995-05-23 JP JP53056295A patent/JP3732858B2/ja not_active Expired - Fee Related
-
2000
- 2000-12-06 GR GR20000402705T patent/GR3035014T3/el not_active IP Right Cessation
-
2005
- 2005-07-26 JP JP2005216300A patent/JP2006022106A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
PT763017E (pt) | 2001-01-31 |
JPH10501796A (ja) | 1998-02-17 |
JP2006022106A (ja) | 2006-01-26 |
US5527829A (en) | 1996-06-18 |
ATE196288T1 (de) | 2000-09-15 |
GR3035014T3 (en) | 2001-03-30 |
WO1995032185A1 (en) | 1995-11-30 |
DE69518840T2 (de) | 2001-01-11 |
AU2658695A (en) | 1995-12-18 |
DE69518840D1 (en) | 2000-10-19 |
CA2190472A1 (en) | 1995-11-30 |
JP3732858B2 (ja) | 2006-01-11 |
EP0763017B1 (en) | 2000-09-13 |
EP0763017A1 (en) | 1997-03-19 |
DK0763017T3 (da) | 2001-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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