ATE454385T1 - Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung - Google Patents

Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung

Info

Publication number
ATE454385T1
ATE454385T1 AT03751203T AT03751203T ATE454385T1 AT E454385 T1 ATE454385 T1 AT E454385T1 AT 03751203 T AT03751203 T AT 03751203T AT 03751203 T AT03751203 T AT 03751203T AT E454385 T1 ATE454385 T1 AT E454385T1
Authority
AT
Austria
Prior art keywords
application
pharmaceutical composition
hiv integrase
integrase inhibitor
inhibitor
Prior art date
Application number
AT03751203T
Other languages
English (en)
Inventor
Qiyue Hu
Atsuo Kuki
Dawn Marie Nowlin
Michael Bruno Plewe
Hai Wang
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE454385T1 publication Critical patent/ATE454385T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
AT03751203T 2002-10-31 2003-10-27 Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung ATE454385T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42251302P 2002-10-31 2002-10-31
PCT/IB2003/004735 WO2004039803A2 (en) 2002-10-31 2003-10-27 Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use

Publications (1)

Publication Number Publication Date
ATE454385T1 true ATE454385T1 (de) 2010-01-15

Family

ID=32230367

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03751203T ATE454385T1 (de) 2002-10-31 2003-10-27 Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung

Country Status (16)

Country Link
US (3) US7135482B2 (de)
EP (1) EP1558611B1 (de)
JP (1) JP2006506398A (de)
AR (1) AR041864A1 (de)
AT (1) ATE454385T1 (de)
AU (1) AU2003269421A1 (de)
BR (1) BR0315820A (de)
CA (1) CA2500487A1 (de)
DE (1) DE60330890D1 (de)
GT (1) GT200300231A (de)
MX (1) MXPA05004343A (de)
NL (1) NL1024676C2 (de)
PA (1) PA8586801A1 (de)
TW (1) TW200424199A (de)
UY (1) UY28048A1 (de)
WO (1) WO2004039803A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
WO2004067531A1 (en) 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
EP1873155A1 (de) * 2004-04-26 2008-01-02 Pfizer Inc. Hemmer des HIV-Integrase-Enzyms
WO2005103051A1 (en) 2004-04-26 2005-11-03 Pfizer Inc. Inhibitors of the hiv integrase enzyme
EP1756103A2 (de) 2004-04-26 2007-02-28 Pfizer, Inc. Pyrrolopyridinderivate und deren verwendung als inhibitoren der hiv-integrase
BRPI0514724A (pt) * 2004-09-07 2008-06-24 Pfizer inibidores da enzima hiv integrase
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
JP4982482B2 (ja) * 2005-05-10 2012-07-25 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラ−ゼ阻害剤
WO2007039802A1 (en) * 2005-10-03 2007-04-12 Pfizer Products Inc. Inhibitors of the hiv integrase enzyme
BRPI0616657A2 (pt) * 2005-10-07 2011-06-28 Pfizer Prod Inc inibidores da enzima hiv integrase
US20080079207A1 (en) * 2006-09-28 2008-04-03 Williams Controils Industries, Inc. Methods and apparatus for a lever control
RU2010153656A (ru) 2008-06-04 2012-07-20 Амбрилиа Байофарма Инк. (Ca) Ингибиторы интегразы вич из пиридоксина
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
MX2012007410A (es) * 2009-12-23 2012-07-17 Univ Leuven Kath Compuestos antivirales novedosos.
CA2817165A1 (en) 2010-11-15 2012-05-24 Patrick Chaltin Novel antiviral compounds
CN104185420B (zh) 2011-11-30 2017-06-09 埃默里大学 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂
GB201321735D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
GB8720125D0 (en) 1987-08-26 1987-09-30 Roussel Lab Ltd Chemical compounds
JP3128823B2 (ja) * 1991-08-08 2001-01-29 哲郎 池川 制癌化合物およびその製造法
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
US5262537A (en) * 1993-03-19 1993-11-16 Anaquest, Inc. Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid
US5726203A (en) * 1993-07-19 1998-03-10 Li; Zelin Qinghaosu derivatives against AIDS
GB2306476A (en) * 1995-10-27 1997-05-07 Merck & Co Inc Hiv integrase inhibitors
US6057297A (en) 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
EP0949926A4 (de) * 1996-10-31 2001-01-17 Merck & Co Inc Benzodiazepin hydrozidderivate als hiv-interase inhibitoren
GB2327674A (en) * 1997-07-29 1999-02-03 Merck & Co Inc HIV integrase inhibitors
US6403347B1 (en) * 1998-02-03 2002-06-11 Merck & Co., Inc. HIV integrase inhibitors
ES2188184T3 (es) 1998-06-12 2003-06-16 Sod Conseils Rech Applic Compuestos de beta-carbolinas.
EP1187837B1 (de) * 1999-05-12 2007-07-18 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Thiazepin-hemmer von hiv-1 integrase
US6245806B1 (en) * 1999-08-03 2001-06-12 Merck & Co., Inc. HIV integrase inhibitors
AU8009900A (en) * 1999-10-13 2001-04-23 Merck & Co., Inc. Hiv integrase inhibitors
EP1209158A1 (de) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substitutierte beta-Carboline
JP2004517802A (ja) * 2000-06-16 2004-06-17 ブリストルーマイヤーズ スクイブ カンパニー Ｈｉｖインテグラーゼ阻害剤
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
US7148237B2 (en) 2001-03-01 2006-12-12 Shionogi & Co., Ltd. Nitrogen-containing heteroaryl compounds having HIV integrase inhibitory activity
JP4176477B2 (ja) * 2001-03-01 2008-11-05 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環誘導体
JP2003171381A (ja) 2001-09-25 2003-06-20 Takeda Chem Ind Ltd エントリー阻害剤
JP2003119137A (ja) 2001-10-10 2003-04-23 Japan Tobacco Inc Ｈｉｖ阻害剤
EP1438310B1 (de) 2001-10-19 2006-12-20 TransTech Pharma Inc. Beta-carbolin-derivate als ptp-inhibitoren
PT1441734E (pt) 2001-10-26 2007-05-31 Isti Di Ric Di Bio Moleco P An Di-hidroxipirimidinocarboxamidas inibidoras da integrase do vih
JP4497347B2 (ja) 2001-12-05 2010-07-07 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する誘導体
CA2469592C (en) 2001-12-12 2005-08-23 Bristol-Myers Squibb Company Hiv integrase inhibitors
AU2003216049B2 (en) 2002-01-17 2008-07-17 Merck Sharp & Dohme Corp. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
JP4494020B2 (ja) 2002-03-15 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド
AU2003215469A1 (en) * 2002-03-28 2003-10-13 Procyon Biopharma Inc. Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
US20050165000A1 (en) * 2002-04-10 2005-07-28 Robertson Sandra K. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
AU2002335027A1 (en) 2002-10-15 2004-05-04 Chiron Corporation Treatment of tnf-alpha-mediated disorders with casein kinase i epsilon inhibitors
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
WO2004067531A1 (en) 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
WO2005103051A1 (en) 2004-04-26 2005-11-03 Pfizer Inc. Inhibitors of the hiv integrase enzyme
EP1756103A2 (de) 2004-04-26 2007-02-28 Pfizer, Inc. Pyrrolopyridinderivate und deren verwendung als inhibitoren der hiv-integrase
BRPI0514724A (pt) 2004-09-07 2008-06-24 Pfizer inibidores da enzima hiv integrase

Also Published As

Publication number Publication date
NL1024676A1 (nl) 2004-05-06
AR041864A1 (es) 2005-06-01
PA8586801A1 (es) 2005-02-04
BR0315820A (pt) 2005-09-13
AU2003269421A1 (en) 2004-05-25
EP1558611A2 (de) 2005-08-03
DE60330890D1 (de) 2010-02-25
US7368571B2 (en) 2008-05-06
MXPA05004343A (es) 2005-08-03
TW200424199A (en) 2004-11-16
JP2006506398A (ja) 2006-02-23
US20040147547A1 (en) 2004-07-29
WO2004039803A3 (en) 2004-09-16
NL1024676C2 (nl) 2005-12-14
WO2004039803A2 (en) 2004-05-13
US20070004768A1 (en) 2007-01-04
UY28048A1 (es) 2004-05-31
CA2500487A1 (en) 2004-05-13
GT200300231A (es) 2004-06-23
EP1558611B1 (de) 2010-01-06
US20080221154A1 (en) 2008-09-11
AU2003269421A8 (en) 2004-05-25
US7135482B2 (en) 2006-11-14

Similar Documents

Publication Publication Date Title
ATE454385T1 (de) Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung
DK1564210T3 (da) 4-Oxoquinolinforbindelser og anvendelse deraf som HIV-integraseinhibitorer
EE05475B1 (et) Superantigeeni sisaldav konjugaat, konjugaadi kasutamine ja konjugaati sisaldav farmatseutiline kompositsioon
FI20011478A0 (fi) Farmaseuttinen koostumus
CL2004001174A1 (es) Composicion farmaceutica que comprende: 1-(4-fluorofenil)-3(r)-[3-(4-fluorofenil)-3(s)-hidroxipropil]-4(s)-(4-hidroxifenil)-2-acetidinona (ezetimiba) y excipientes; y su uso en el tratamiento y/o prevencion de aterosclerosis, hipercolesterolemia, dia
DE60201988D1 (de) Pharmazeutische dosierungsform von amorphem nilfenavir mesylat
NO20033384D0 (no) Farmasöytisk formulering
NO20024528L (no) Proteaseinhibitor, farmasoytisk sammensetning og anvendelse av forbindelsen
DE60336664D1 (de) Nichtnukleosidische reverse-transkriptase-hemmer
EE200300311A (et) Ftalasinoon-piperidinoderivaadid, nende kasutamine ja ravim
NO20033785D0 (no) Farmasöytisk formulering
DE60225014D1 (de) Pharmazeutische zusammensetzungen von amlodipin und atorvastatin
DE60209929D1 (de) Succinate des 5,8,14-triazatetracycloä10.3.1.0 2,11 .0 4,9 ü-hexadeca-2(11),3,5,7,9,-pentaens und pharmazeutische zusammensetzungen
DK1557415T3 (da) Heterocykliske forbindelser og antitumorlægemidler indeholdende samme som den aktive ingrediens
IS7051A (is) Lyfjasamsetningar
NO20035627D0 (no) Farmasöytisk formulering
NO20042916L (no) HIV integrase inhibitorer
FI20022128A0 (fi) Farmaseuttinen koostumus
DE60217390D1 (de) Bicalutamid enthaltende pharmazeutische zusammensetzung
DE10291905D2 (de) Pharmazeutische Zusammensetzung
EE200300465A (et) Püridoindolooni derivaatidel põhinevad farmatseutilised kompositsioonid
DE10107261B4 (de) Pharmazeutische Zusammensetzung
EE200300563A (et) Bensüülaminopürimidiiniühendid, nende kasutamine ja ravim
IT1318654B1 (it) Composizioni farmaceutiche comprendenti agenti antiinfiammatori e lorousi.
PT1467737E (pt) Composicao farmaceutica orodispersivel de piribedil

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties