NL1024676A1 - HIV integrase-remmers, farmaceutische preparaten en methoden voor het gebruik daarvan. - Google Patents

HIV integrase-remmers, farmaceutische preparaten en methoden voor het gebruik daarvan.

Info

Publication number
NL1024676A1
NL1024676A1 NL1024676A NL1024676A NL1024676A1 NL 1024676 A1 NL1024676 A1 NL 1024676A1 NL 1024676 A NL1024676 A NL 1024676A NL 1024676 A NL1024676 A NL 1024676A NL 1024676 A1 NL1024676 A1 NL 1024676A1
Authority
NL
Netherlands
Prior art keywords
methods
pharmaceutical preparations
hiv integrase
integrase inhibitors
inhibitors
Prior art date
Application number
NL1024676A
Other languages
English (en)
Other versions
NL1024676C2 (nl
Inventor
Qiyue Hu
Atsuo Kuki
Dawn Marie Nowlin
Michael Bruno Plewe
Hai Wang
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NL1024676A1 publication Critical patent/NL1024676A1/nl
Application granted granted Critical
Publication of NL1024676C2 publication Critical patent/NL1024676C2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NL1024676A 2002-10-31 2003-10-31 HIV integrase-remmers, farmaceutische preparaten en methoden voor het gebruik daarvan. NL1024676C2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42251302P 2002-10-31 2002-10-31
US42251302 2002-10-31

Publications (2)

Publication Number Publication Date
NL1024676A1 true NL1024676A1 (nl) 2004-05-06
NL1024676C2 NL1024676C2 (nl) 2005-12-14

Family

ID=32230367

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1024676A NL1024676C2 (nl) 2002-10-31 2003-10-31 HIV integrase-remmers, farmaceutische preparaten en methoden voor het gebruik daarvan.

Country Status (16)

Country Link
US (3) US7135482B2 (nl)
EP (1) EP1558611B1 (nl)
JP (1) JP2006506398A (nl)
AR (1) AR041864A1 (nl)
AT (1) ATE454385T1 (nl)
AU (1) AU2003269421A1 (nl)
BR (1) BR0315820A (nl)
CA (1) CA2500487A1 (nl)
DE (1) DE60330890D1 (nl)
GT (1) GT200300231A (nl)
MX (1) MXPA05004343A (nl)
NL (1) NL1024676C2 (nl)
PA (1) PA8586801A1 (nl)
TW (1) TW200424199A (nl)
UY (1) UY28048A1 (nl)
WO (1) WO2004039803A2 (nl)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
EP1756103A2 (en) 2004-04-26 2007-02-28 Pfizer, Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
EP1873155A1 (en) * 2004-04-26 2008-01-02 Pfizer Inc. Inhibitors of the HIV integrase enzyme
BRPI0510306A (pt) * 2004-04-26 2007-09-04 Pfizer inibidores da enzima de hiv integrase,composição farmacêutica contendo os referidos inibidores bem como seu uso
US20070232644A1 (en) * 2004-09-07 2007-10-04 Pfizer Inc. Inhibitors of the Hiv Integrase Enzyme
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
AU2006244424B2 (en) * 2005-05-10 2011-09-22 Merck Sharp & Dohme Corp. HIV integrase inhibitors
CA2623534A1 (en) * 2005-10-03 2007-04-12 Pfizer Products Inc. Inhibitors of the hiv integrase enzyme
EA200800758A1 (ru) * 2005-10-07 2008-08-29 Пфайзер Продактс Инк. Ингибиторы фермента интегразы вич
US20080079207A1 (en) * 2006-09-28 2008-04-03 Williams Controils Industries, Inc. Methods and apparatus for a lever control
JP5514810B2 (ja) * 2008-06-04 2014-06-04 タイメッド バイオロジクス インコーポレイテッド ピリドキシンに由来するｈｉｖインテグラーゼ阻害剤
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
KR101483834B1 (ko) * 2009-12-23 2015-01-16 카트호리이케 유니버시타이트 로이펜 항바이러스 화합물
KR20140003438A (ko) 2010-11-15 2014-01-09 카톨리에케 유니버시테이트 루벤 항바이러스성 축합 헤테로사이클릭 화합물
EP2785184B1 (en) 2011-11-30 2020-06-10 Emory University Compositions comprising jak inhibitors and haart drugs for use in the prevention or treatment of hiv
GB201321735D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

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NZ194747A (en) 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
GB8720125D0 (en) 1987-08-26 1987-09-30 Roussel Lab Ltd Chemical compounds
CA2114728A1 (en) 1991-08-08 1993-02-18 Tetsuro Ikekawa Carcinostatic compound and production thereof
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
US5262537A (en) * 1993-03-19 1993-11-16 Anaquest, Inc. Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid
AU7225494A (en) 1993-07-19 1995-02-20 Zelin Li Qinghaosu derivatives against aids
GB2306476A (en) * 1995-10-27 1997-05-07 Merck & Co Inc Hiv integrase inhibitors
US6057297A (en) 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
EP0949926A4 (en) * 1996-10-31 2001-01-17 Merck & Co Inc BENZODIAZEPINE HYDROCIDE DERIVATIVES AS HIV INTERASE INHIBITORS
GB2327674A (en) * 1997-07-29 1999-02-03 Merck & Co Inc HIV integrase inhibitors
US6403347B1 (en) * 1998-02-03 2002-06-11 Merck & Co., Inc. HIV integrase inhibitors
AU761020B2 (en) 1998-06-12 2003-05-29 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Beta-carboline compounds
DE60035591D1 (de) * 1999-05-12 2007-08-30 Us Health Thiazepin-hemmer von hiv-1 integrase
US6245806B1 (en) * 1999-08-03 2001-06-12 Merck & Co., Inc. HIV integrase inhibitors
WO2001027309A1 (en) * 1999-10-13 2001-04-19 Merck & Co., Inc. Hiv integrase inhibitors
EP1209158A1 (en) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
AU2001266991A1 (en) * 2000-06-16 2002-01-02 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
EP1375486B1 (en) 2001-03-01 2008-10-15 Shionogi & Co., Ltd. Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity
WO2002070491A1 (fr) * 2001-03-01 2002-09-12 Shionogi & Co., Ltd. Derive a noyau heteroaromatique azote presentant une activite d'inhibiteur d'integrase du vih
JP2003171381A (ja) 2001-09-25 2003-06-20 Takeda Chem Ind Ltd エントリー阻害剤
JP2003119137A (ja) 2001-10-10 2003-04-23 Japan Tobacco Inc Ｈｉｖ阻害剤
DE60216952T2 (de) 2001-10-19 2007-07-05 Transtech Pharma Inc. Beta-carbolin-derivate als ptp-inhibitoren
CA2463975A1 (en) 2001-10-26 2003-05-01 Maria Emilia Di Francesco Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
JP4497347B2 (ja) 2001-12-05 2010-07-07 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する誘導体
RU2284315C2 (ru) 2001-12-12 2006-09-27 Бристол-Маерс Сквибб Компани Ингибиторы вич-интегразы и содержащие их фармацевтические композиции
CA2472372C (en) 2002-01-17 2010-08-17 Melissa Egbertson Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors
CA2478310A1 (en) 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as hiv integrase inhibitors
WO2003082881A2 (en) * 2002-03-28 2003-10-09 Procyon Biopharma Inc. Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
EP1499391A2 (en) * 2002-04-10 2005-01-26 Merck & Co., Inc. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
AU2002335027A1 (en) 2002-10-15 2004-05-04 Chiron Corporation Treatment of tnf-alpha-mediated disorders with casein kinase i epsilon inhibitors
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
BRPI0510306A (pt) 2004-04-26 2007-09-04 Pfizer inibidores da enzima de hiv integrase,composição farmacêutica contendo os referidos inibidores bem como seu uso
EP1756103A2 (en) 2004-04-26 2007-02-28 Pfizer, Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
US20070232644A1 (en) 2004-09-07 2007-10-04 Pfizer Inc. Inhibitors of the Hiv Integrase Enzyme

Also Published As

Publication number Publication date
DE60330890D1 (de) 2010-02-25
TW200424199A (en) 2004-11-16
AU2003269421A1 (en) 2004-05-25
US20070004768A1 (en) 2007-01-04
US20080221154A1 (en) 2008-09-11
GT200300231A (es) 2004-06-23
AU2003269421A8 (en) 2004-05-25
US7368571B2 (en) 2008-05-06
WO2004039803A2 (en) 2004-05-13
MXPA05004343A (es) 2005-08-03
US20040147547A1 (en) 2004-07-29
EP1558611B1 (en) 2010-01-06
EP1558611A2 (en) 2005-08-03
BR0315820A (pt) 2005-09-13
NL1024676C2 (nl) 2005-12-14
US7135482B2 (en) 2006-11-14
CA2500487A1 (en) 2004-05-13
UY28048A1 (es) 2004-05-31
WO2004039803A3 (en) 2004-09-16
ATE454385T1 (de) 2010-01-15
AR041864A1 (es) 2005-06-01
PA8586801A1 (es) 2005-02-04
JP2006506398A (ja) 2006-02-23

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Legal Events

Date Code Title Description
AD1A A request for search or an international type search has been filed
RD2N Patents in respect of which a decision has been taken or a report has been made (novelty report)

Effective date: 20051010

PD2B A search report has been drawn up
VD1 Lapsed due to non-payment of the annual fee

Effective date: 20080501