DE60330890D1 - Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung - Google Patents

Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung

Info

Publication number
DE60330890D1
DE60330890D1 DE60330890T DE60330890T DE60330890D1 DE 60330890 D1 DE60330890 D1 DE 60330890D1 DE 60330890 T DE60330890 T DE 60330890T DE 60330890 T DE60330890 T DE 60330890T DE 60330890 D1 DE60330890 D1 DE 60330890D1
Authority
DE
Germany
Prior art keywords
hemmers
application
pharmaceutical composition
hiv integrase
integrase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60330890T
Other languages
English (en)
Inventor
Qiyue Hu
Atsuo Kuki
Dawn Marie Nowlin
Michael Bruno Plewe
Hai Wang
Junhu Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE60330890D1 publication Critical patent/DE60330890D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60330890T 2002-10-31 2003-10-27 Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung Expired - Lifetime DE60330890D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42251302P 2002-10-31 2002-10-31
PCT/IB2003/004735 WO2004039803A2 (en) 2002-10-31 2003-10-27 Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use

Publications (1)

Publication Number Publication Date
DE60330890D1 true DE60330890D1 (de) 2010-02-25

Family

ID=32230367

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60330890T Expired - Lifetime DE60330890D1 (de) 2002-10-31 2003-10-27 Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung

Country Status (16)

Country Link
US (3) US7135482B2 (de)
EP (1) EP1558611B1 (de)
JP (1) JP2006506398A (de)
AR (1) AR041864A1 (de)
AT (1) ATE454385T1 (de)
AU (1) AU2003269421A1 (de)
BR (1) BR0315820A (de)
CA (1) CA2500487A1 (de)
DE (1) DE60330890D1 (de)
GT (1) GT200300231A (de)
MX (1) MXPA05004343A (de)
NL (1) NL1024676C2 (de)
PA (1) PA8586801A1 (de)
TW (1) TW200424199A (de)
UY (1) UY28048A1 (de)
WO (1) WO2004039803A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt) 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
WO2005103003A2 (en) * 2004-04-26 2005-11-03 Pfizer Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
JP2007534738A (ja) * 2004-04-26 2007-11-29 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
EP1873155A1 (de) * 2004-04-26 2008-01-02 Pfizer Inc. Hemmer des HIV-Integrase-Enzyms
BRPI0514724A (pt) * 2004-09-07 2008-06-24 Pfizer inibidores da enzima hiv integrase
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
US7741315B2 (en) * 2005-05-10 2010-06-22 Merck Sharp & Dohme Corp. HIV integrase inhibitors
US20090170846A1 (en) * 2005-10-03 2009-07-02 Pfizer Inc Inhibitors of the hiv integrase enzyme
EP1934220A1 (de) * 2005-10-07 2008-06-25 Pfizer Products Incorporated Inhibitoren des hiv-integrase-enzyms
US20080079207A1 (en) * 2006-09-28 2008-04-03 Williams Controils Industries, Inc. Methods and apparatus for a lever control
WO2009146555A1 (en) 2008-06-04 2009-12-10 Ambrilia Biopharma Inc. Hiv integrase inhibitors from pyridoxine
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
SG10201408512RA (en) * 2009-12-23 2015-02-27 Univ Leuven Kath Novel antiviral compounds
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
EP2785184B1 (de) 2011-11-30 2020-06-10 Emory University ZUSAMMENSETZUNGEN ENTHAlTEND JAK-HEMMER UND HAART-MEDIKAMENTE ZUR VORBEUGUNG ODER BEHANDLUNG VON HIV
GB201321735D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
GB8720125D0 (en) 1987-08-26 1987-09-30 Roussel Lab Ltd Chemical compounds
US5616609A (en) 1991-08-08 1997-04-01 Ikekawa; Tetsuro Carcinostatic compound and production thereof
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
US5262537A (en) * 1993-03-19 1993-11-16 Anaquest, Inc. Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid
US5726203A (en) 1993-07-19 1998-03-10 Li; Zelin Qinghaosu derivatives against AIDS
GB2306476A (en) * 1995-10-27 1997-05-07 Merck & Co Inc Hiv integrase inhibitors
US6057297A (en) * 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
WO1998018473A1 (en) * 1996-10-31 1998-05-07 Merck & Co., Inc. Benzodiazepine hydrazide derivatives as inhibitors of hiv integrase
GB2327674A (en) * 1997-07-29 1999-02-03 Merck & Co Inc HIV integrase inhibitors
US6403347B1 (en) * 1998-02-03 2002-06-11 Merck & Co., Inc. HIV integrase inhibitors
ATE229954T1 (de) 1998-06-12 2003-01-15 Sod Conseils Rech Applic Betacarbolinverbindungen
ATE367393T1 (de) * 1999-05-12 2007-08-15 Us Health Thiazepin-hemmer von hiv-1 integrase
US6245806B1 (en) * 1999-08-03 2001-06-12 Merck & Co., Inc. HIV integrase inhibitors
AU8009900A (en) * 1999-10-13 2001-04-23 Merck & Co., Inc. Hiv integrase inhibitors
EP1209158A1 (de) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substitutierte beta-Carboline
CN1239472C (zh) * 2000-06-16 2006-02-01 布里斯托尔-迈尔斯斯奎布公司 Hiv整合酶抑制剂
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
WO2002070491A1 (fr) * 2001-03-01 2002-09-12 Shionogi & Co., Ltd. Derive a noyau heteroaromatique azote presentant une activite d'inhibiteur d'integrase du vih
US7148237B2 (en) 2001-03-01 2006-12-12 Shionogi & Co., Ltd. Nitrogen-containing heteroaryl compounds having HIV integrase inhibitory activity
JP2003171381A (ja) 2001-09-25 2003-06-20 Takeda Chem Ind Ltd エントリー阻害剤
JP2003119137A (ja) 2001-10-10 2003-04-23 Japan Tobacco Inc Ｈｉｖ阻害剤
ATE348828T1 (de) 2001-10-19 2007-01-15 Transtech Pharma Inc Beta-carbolin-derivate als ptp-inhibitoren
SI1441734T1 (sl) 2001-10-26 2007-08-31 Angeletti P Ist Richerche Bio Dihidropirimidin karboksamidni inhibitorji HIV-integraze
AU2002349675A1 (en) 2001-12-05 2003-06-17 Shionogi And Co., Ltd. Derivative having hiv integrase inhibitory activity
NZ533413A (en) 2001-12-12 2006-09-29 Bristol Myers Squibb Co HIV integrase inhibitors
AU2003216049B2 (en) 2002-01-17 2008-07-17 Merck Sharp & Dohme Corp. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
US7323460B2 (en) 2002-03-15 2008-01-29 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors
AU2003215469A1 (en) * 2002-03-28 2003-10-13 Procyon Biopharma Inc. Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
US20050165000A1 (en) * 2002-04-10 2005-07-28 Robertson Sandra K. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
WO2004035076A1 (en) 2002-10-15 2004-04-29 Chiron Corporation Treatment of tnf-alpha-mediated disorders with casein kinase i epsilon inhibitors
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt) * 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
WO2005103003A2 (en) 2004-04-26 2005-11-03 Pfizer Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
JP2007534738A (ja) 2004-04-26 2007-11-29 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
BRPI0514724A (pt) 2004-09-07 2008-06-24 Pfizer inibidores da enzima hiv integrase

Also Published As

Publication number Publication date
NL1024676A1 (nl) 2004-05-06
EP1558611A2 (de) 2005-08-03
US7368571B2 (en) 2008-05-06
UY28048A1 (es) 2004-05-31
US7135482B2 (en) 2006-11-14
US20080221154A1 (en) 2008-09-11
TW200424199A (en) 2004-11-16
US20070004768A1 (en) 2007-01-04
PA8586801A1 (es) 2005-02-04
WO2004039803A3 (en) 2004-09-16
GT200300231A (es) 2004-06-23
WO2004039803A2 (en) 2004-05-13
AR041864A1 (es) 2005-06-01
US20040147547A1 (en) 2004-07-29
JP2006506398A (ja) 2006-02-23
BR0315820A (pt) 2005-09-13
CA2500487A1 (en) 2004-05-13
EP1558611B1 (de) 2010-01-06
MXPA05004343A (es) 2005-08-03
AU2003269421A1 (en) 2004-05-25
NL1024676C2 (nl) 2005-12-14
ATE454385T1 (de) 2010-01-15
AU2003269421A8 (en) 2004-05-25

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Legal Events

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8364 No opposition during term of opposition