DD276886A5 - Expressin und Sekretion heterologer Proteine durch transformierte Spezies von Yarrowia Lipolytica - Google Patents

Expressin und Sekretion heterologer Proteine durch transformierte Spezies von Yarrowia Lipolytica Download PDF

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Publication number
DD276886A5
DD276886A5 DD29535886A DD29535886A DD276886A5 DD 276886 A5 DD276886 A5 DD 276886A5 DD 29535886 A DD29535886 A DD 29535886A DD 29535886 A DD29535886 A DD 29535886A DD 276886 A5 DD276886 A5 DD 276886A5
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DD
German Democratic Republic
Prior art keywords
lipolytica
gene
dna
transformed
xpr2
Prior art date
Application number
DD29535886A
Other languages
German (de)
English (en)
Inventor
Lance Steven Davidow
John Robert Dezeeuw
Arthur Ernest Franke
Original Assignee
Pfizer
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DD276886A5 publication Critical patent/DD276886A5/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Treatment Of Sludge (AREA)
  • Magnetic Ceramics (AREA)
  • Peptides Or Proteins (AREA)
  • Paper (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
  • Fodder In General (AREA)
  • Noodles (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
DD29535886A 1985-10-18 1986-10-17 Expressin und Sekretion heterologer Proteine durch transformierte Spezies von Yarrowia Lipolytica DD276886A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78920685A 1985-10-18 1985-10-18
US06/841,121 US4937189A (en) 1985-10-18 1986-03-18 Expression and secretion of heterologous proteins by Yarrowia lipolytica transformants

Publications (1)

Publication Number Publication Date
DD276886A5 true DD276886A5 (de) 1990-03-14

Family

ID=27120892

Family Applications (7)

Application Number Title Priority Date Filing Date
DD31347086A DD267995A5 (de) 1985-10-18 1986-10-17 Verfahren zum Herstellen von Plasmid Pxx-11
DD31347486A DD267997A5 (de) 1985-10-18 1986-10-17 Verfahren zur Auffindung von transformierten Yarrowia Lipolytica-Spezies
DD29535886A DD276886A5 (de) 1985-10-18 1986-10-17 Expressin und Sekretion heterologer Proteine durch transformierte Spezies von Yarrowia Lipolytica
DD31347586A DD267998A5 (de) 1985-10-18 1986-10-17 Verfahren zum Herstellen von transformierter Yarrowia Lipolytica, die keinealkalische Protease produziert
DD31347286A DD269397A5 (de) 1985-10-18 1986-10-17 Verfahren zum Herstellen von transformierten Yarrowia Lipolytica
DD31347186A DD269396A5 (de) 1985-10-18 1986-10-17 Verfahren zum Herstellen von Plasmid Pxx-33
DD31347386A DD267996A5 (de) 1985-10-18 1986-10-17 Verfahren zum Herstellen von Plasmid Pxx-22

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DD31347086A DD267995A5 (de) 1985-10-18 1986-10-17 Verfahren zum Herstellen von Plasmid Pxx-11
DD31347486A DD267997A5 (de) 1985-10-18 1986-10-17 Verfahren zur Auffindung von transformierten Yarrowia Lipolytica-Spezies

Family Applications After (4)

Application Number Title Priority Date Filing Date
DD31347586A DD267998A5 (de) 1985-10-18 1986-10-17 Verfahren zum Herstellen von transformierter Yarrowia Lipolytica, die keinealkalische Protease produziert
DD31347286A DD269397A5 (de) 1985-10-18 1986-10-17 Verfahren zum Herstellen von transformierten Yarrowia Lipolytica
DD31347186A DD269396A5 (de) 1985-10-18 1986-10-17 Verfahren zum Herstellen von Plasmid Pxx-33
DD31347386A DD267996A5 (de) 1985-10-18 1986-10-17 Verfahren zum Herstellen von Plasmid Pxx-22

Country Status (24)

Country Link
US (1) US4937189A (no)
EP (1) EP0220864B1 (no)
JP (1) JP3096297B2 (no)
KR (1) KR900008950B1 (no)
CN (3) CN1034428C (no)
AT (1) ATE86302T1 (no)
AU (1) AU586041B2 (no)
CA (1) CA1340837C (no)
DD (7) DD267995A5 (no)
DE (1) DE3687878T2 (no)
DK (1) DK496886A (no)
EG (1) EG18142A (no)
ES (1) ES2038966T3 (no)
FI (1) FI90352C (no)
HU (1) HU209150B (no)
IE (1) IE59774B1 (no)
IL (7) IL99893A (no)
NO (2) NO177318C (no)
NZ (1) NZ217985A (no)
PH (3) PH27026A (no)
PL (2) PL154427B1 (no)
PT (1) PT83562B (no)
RU (2) RU2157845C2 (no)
YU (2) YU46412B (no)

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JPH082304B2 (ja) * 1987-12-17 1996-01-17 オリエンタル酵母工業株式会社 プラスミドとその製造方法
FR2626584B1 (fr) * 1988-01-28 1990-07-13 Agronomique Inst Nat Rech Sequence ars efficace chez yarrowia lipolytica et procede pour sa preparation
EP0382332A3 (en) * 1989-01-06 1990-11-14 Collaborative Research Inc. Improved supersecreting mutants of saccharomyces cerevisiae
JPH0669365B2 (ja) * 1989-05-22 1994-09-07 株式会社ミドリ十字 アルブミン遺伝子を含むプラスミド、形質転換体、形質転換体の製造方法、アルブミンの製造方法
EP0402226A1 (en) * 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
JPH08508892A (ja) * 1993-09-02 1996-09-24 ファイザー・インク． 多重組込みベクター及びヤロウィア・リポリティカ形質転換体
US5837499A (en) * 1993-12-06 1998-11-17 Ciba-Geigy Corporation DNA encoding C5A receptor antagonists having substantially no agonist activity and methods of expressing same
US5807824A (en) * 1993-12-06 1998-09-15 Ciba-Geigy Corporation C5A receptor antagonists having substantially no agonist activity
DE19513152A1 (de) 1995-04-07 1996-10-10 Bundesrep Deutschland Verwendung eines "Immundefizienzvirus-supprimierenden Lymphokins (ISL)" zur Hemmung der Virusvermehrung, insbesondere von Retroviren
AU6125096A (en) * 1995-06-05 1996-12-24 Novartis Ag C5a receptor antagonists having substantially no agonist activity and methods for preparation
EP0747484A1 (en) 1995-06-08 1996-12-11 Institut National De La Recherche Agronomique (Inra) Upstream activator sequences and recombinant promoter sequences functional in yarrowia and vectors containing them
EP0922109A1 (en) 1996-05-21 1999-06-16 Novo Nordisk A/S Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast
FR2782733B1 (fr) 1998-09-01 2002-02-08 Agronomique Inst Nat Rech Procede de transformation non-homologue de yarrowia lipolytica
US20110059496A1 (en) * 2003-06-25 2011-03-10 E. I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
US7459546B2 (en) 2003-06-25 2008-12-02 E.I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase regulatory sequences for gene expression in oleaginous yeast
US7259255B2 (en) * 2003-06-25 2007-08-21 E. I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
US7202356B2 (en) * 2003-11-14 2007-04-10 E. I. Du Pont De Nemours And Company Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast
US7264949B2 (en) * 2004-09-15 2007-09-04 E.I. Du Pont De Nemours And Company Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast
US20060094102A1 (en) * 2004-11-04 2006-05-04 Zhixiong Xue Ammonium transporter promoter for gene expression in oleaginous yeast
EP2371967B1 (en) 2005-03-18 2015-06-03 DSM IP Assets B.V. Production of carotenoids in oleaginous yeast and fungi
WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
FR2927089B1 (fr) * 2008-02-05 2011-03-25 Inst Nat De La Rech Agronomique Inra Procede d'integration ciblee de multicopies d'un gene d'interet dans une souche de yarrowia
US8597931B2 (en) * 2008-07-11 2013-12-03 Institut National De La Recherche Agronomique (Inra) Mutant yeast strains capable of accumulating a large quantity of lipids
FR2962133B1 (fr) 2010-07-01 2014-09-12 Agronomique Inst Nat Rech Optimisation de la synthese et de l'accumulation de lipides
JP2014503216A (ja) * 2010-12-30 2014-02-13 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー スクロース利用のための、ヤロウィア・リポリティカ（Ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）におけるサッカロミセス・セレビシア（Ｓａｃｃｈａｒｏｍｙｃｅｓｃｅｒｅｖｉｓｉａｅ）ＳＵＣ２遺伝子の使用
WO2012135773A1 (en) 2011-03-31 2012-10-04 E. I. Du Pont De Nemours And Company Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast
EP2694657A1 (en) 2011-04-05 2014-02-12 E. I. Du Pont de Nemours and Company Yarrowia n-alkane-hydroxylating cytochrome p450 promoter regions for gene expression in yeast
WO2012138612A1 (en) 2011-04-07 2012-10-11 E. I. Du Pont De Nemours And Company Yarrowia peroxisomal 2,4-dienoyl-coa reductase promoter regions for gene expression in yeast
GB201106188D0 (en) * 2011-04-12 2011-05-25 Csir Production of extracellular polypeptides
FR3002774A1 (fr) 2013-03-04 2014-09-05 Agronomique Inst Nat Rech Levures mutantes ayant une production accrue de lipides et d'acide citrique
FR3005317B1 (fr) 2013-05-02 2016-03-18 Agronomique Inst Nat Rech Levures mutantes capables de produire un acide gras inhabituel
EA035512B1 (ru) 2014-01-31 2020-06-29 ДСМ АйПи АССЕТС Б.В. Промоторы, подходящие для экспрессии гетерологичных генов в дрожжах
US20170145449A1 (en) 2014-06-11 2017-05-25 Institut National De La Recherche Agronomique Improved lipid accumulation in Yarrowia lipolytica strains by overexpression of hexokinase and new strains thereof
WO2016075314A1 (fr) 2014-11-13 2016-05-19 Institut National De La Recherche Agronomique Identification de facteurs de transcription de yarrowia lipolytica affectant la production de proteines
FR3028527A1 (fr) 2014-11-13 2016-05-20 Pivert Identification de facteurs de transcription de yarrowia lipolytica
WO2017100158A1 (en) 2015-12-11 2017-06-15 Danisco Us Inc. Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects
EP3390631B1 (en) 2015-12-18 2020-04-08 Danisco US Inc. Methods and compositions for t-rna based guide rna expression
WO2017194424A1 (en) 2016-05-10 2017-11-16 Institut National De La Recherche Agronomique Mutant yeast strains with enhanced production of erythritol or erythrulose
EP3348647A1 (en) 2017-01-13 2018-07-18 Institut National De La Recherche Agronomique Mutant yeast strain capable of producing medium chain fatty acids

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US4546082A (en) * 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
NZ207926A (en) * 1983-04-25 1988-04-29 Genentech Inc Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
IN163393B (no) * 1983-10-06 1988-09-17 Pfizer
US4628033A (en) * 1983-10-06 1986-12-09 Pfizer Inc. Novel host strain for transformation of Yarrowia lipolytica
EP0166659B1 (fr) * 1984-06-26 1989-08-30 Institut National De La Recherche Agronomique (Inra) Vecteurs de transformation de la levure yarrowia lipolytica, procédé de transformation et levure transformée

Also Published As

Publication number Publication date
PL154427B1 (en) 1991-08-30
FI90352C (fi) 1994-01-25
IL99893A0 (en) 1992-08-18
PH27171A (en) 1993-04-02
YU46412B (sh) 1993-10-20
DD267995A5 (de) 1989-05-17
IL99892A (en) 1993-02-21
AU6416186A (en) 1987-05-14
IE59774B1 (en) 1994-04-06
PH27198A (en) 1993-04-16
DE3687878D1 (de) 1993-04-08
YU177386A (en) 1989-04-30
AU586041B2 (en) 1989-06-29
DD269397A5 (de) 1989-06-28
EG18142A (en) 1992-08-30
RU2157845C2 (ru) 2000-10-20
NO177318C (no) 1995-08-23
IL80297A0 (en) 1987-01-30
US4937189A (en) 1990-06-26
NO178793B (no) 1996-02-26
IE862754L (en) 1987-04-18
DD269396A5 (de) 1989-06-28
EP0220864B1 (en) 1993-03-03
PL261912A1 (en) 1987-10-19
IL99894A (en) 1993-02-21
KR870004138A (ko) 1987-05-07
NO864148L (no) 1987-04-21
IL99892A0 (en) 1992-08-18
KR900008950B1 (ko) 1990-12-15
DD267996A5 (de) 1989-05-17
FI864206A0 (fi) 1986-10-17
DD267997A5 (de) 1989-05-17
IL99893A (en) 1993-02-21
YU124588A (en) 1989-08-31
JP3096297B2 (ja) 2000-10-10
RU2069694C1 (ru) 1996-11-27
NO923616D0 (no) 1992-09-17
PL155850B1 (en) 1992-01-31
HUT43632A (en) 1987-11-30
YU46571B (sh) 1993-11-16
FI864206A (fi) 1987-04-19
CN1138632A (zh) 1996-12-25
NO923616L (no) 1987-04-21
EP0220864A1 (en) 1987-05-06
PH27026A (en) 1993-02-01
HU209150B (en) 1994-03-28
NZ217985A (en) 1991-06-25
DK496886D0 (da) 1986-10-17
ATE86302T1 (de) 1993-03-15
NO177318B (no) 1995-05-15
DE3687878T2 (de) 1993-07-15
IL80297A (en) 1993-02-21
IL99894A0 (en) 1992-08-18
JPS63164889A (ja) 1988-07-08
PT83562B (pt) 1989-05-31
CN1034428C (zh) 1997-04-02
PT83562A (en) 1986-11-01
DD267998A5 (de) 1989-05-17
CN1069346C (zh) 2001-08-08
CN86106522A (zh) 1987-09-16
CA1340837C (en) 1999-12-07
CN1141339A (zh) 1997-01-29
DK496886A (da) 1987-06-11
FI90352B (fi) 1993-10-15
ES2038966T3 (es) 1993-08-16
NO178793C (no) 1996-06-05
NO864148D0 (no) 1986-10-17

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