DD256133A5 - Neue 8- bzw. 1,8-substituierte ergolenderivate und verfahren zu ihrer herstellung - Google Patents

Neue 8- bzw. 1,8-substituierte ergolenderivate und verfahren zu ihrer herstellung Download PDF

Info

Publication number
DD256133A5
DD256133A5 DD87302104A DD30210487A DD256133A5 DD 256133 A5 DD256133 A5 DD 256133A5 DD 87302104 A DD87302104 A DD 87302104A DD 30210487 A DD30210487 A DD 30210487A DD 256133 A5 DD256133 A5 DD 256133A5
Authority
DD
German Democratic Republic
Prior art keywords
group
acid
acyl group
general formula
variant
Prior art date
Application number
DD87302104A
Other languages
German (de)
English (en)
Inventor
Tibor Keve
Gabor Megyeri
Bela Stefko
Lajos Jun Kovacs
Anna Kassai
Bela Kiss
Istvan Laszlovszky
Erzsebet Lapis
Eva Palosi
Dora Groo
Laszlo Szporny
Original Assignee
�������@������@����������@����@��Kk��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �������@������@����������@����@��Kk�� filed Critical �������@������@����������@����@��Kk��
Publication of DD256133A5 publication Critical patent/DD256133A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DD87302104A 1986-04-25 1987-04-24 Neue 8- bzw. 1,8-substituierte ergolenderivate und verfahren zu ihrer herstellung DD256133A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU861719A HU196598B (en) 1986-04-25 1986-04-25 Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

Publications (1)

Publication Number Publication Date
DD256133A5 true DD256133A5 (de) 1988-04-27

Family

ID=10955843

Family Applications (1)

Application Number Title Priority Date Filing Date
DD87302104A DD256133A5 (de) 1986-04-25 1987-04-24 Neue 8- bzw. 1,8-substituierte ergolenderivate und verfahren zu ihrer herstellung

Country Status (30)

Country Link
US (1) US4859682A (hu)
JP (1) JPS62258379A (hu)
KR (1) KR920008167B1 (hu)
CN (1) CN87102944A (hu)
AT (1) AT391472B (hu)
AU (1) AU592637B2 (hu)
BE (1) BE1001159A4 (hu)
CH (1) CH669791A5 (hu)
CS (1) CS268534B2 (hu)
DD (1) DD256133A5 (hu)
DE (1) DE3713768A1 (hu)
DK (1) DK208887A (hu)
EG (1) EG18272A (hu)
ES (1) ES2007339A6 (hu)
FI (1) FI871128A (hu)
FR (1) FR2597869B1 (hu)
GB (1) GB2189487B (hu)
GR (1) GR870645B (hu)
HU (1) HU196598B (hu)
IL (1) IL82324A0 (hu)
IN (1) IN165245B (hu)
IT (1) IT1203976B (hu)
LU (1) LU86853A1 (hu)
NL (1) NL8700966A (hu)
NO (1) NO165800C (hu)
PL (1) PL152619B1 (hu)
PT (1) PT84739B (hu)
SE (1) SE466401B (hu)
SU (1) SU1500161A3 (hu)
ZA (1) ZA872931B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives
DE20320528U1 (de) * 2002-04-30 2004-09-16 Teva Pharmaceuticals Usa, Inc. Neue Kristallformen von Ondansetron und Arzneimittel, welche die neuen Formen enthalten
WO2023018480A1 (en) * 2021-08-09 2023-02-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Selective psychedelic compounds

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE237837C (hu) *
DE1936410A1 (de) * 1969-07-17 1971-02-11 Hoechst Ag O-Acyl-lysergole und Verfahren zu ihrer Herstellung
AR206772A1 (es) * 1972-07-21 1976-08-23 Lilly Co Eli Procedimiento para preparar una nueva d-2-halo-6-metil-8-ciano(carboxamido)metil ergolina
US3992385A (en) * 1975-01-20 1976-11-16 Eli Lilly And Company 2,3-Dihydroergolines
CH619709A5 (en) * 1975-03-14 1980-10-15 Siphar Sa Process for the preparation of carbamates of 2-halogenoergolines and 2-halogenoergolenes
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
US4035094A (en) * 1976-03-11 1977-07-12 Trw Inc. Ball and socket joint
DK75177A (da) * 1976-04-27 1977-10-28 Sandoz Ag Fremgangsmade til fremstilling af prostaglandiner
US4098790A (en) * 1976-09-15 1978-07-04 Eli Lilly And Company Ergoline chlorination process
DE3001752A1 (de) * 1980-01-16 1981-07-30 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DD237837A1 (de) * 1983-11-29 1986-07-30 1086 Berlin,Otto-Nuscke-Str. 2/23,Dd Verfahren zur herstellung von 2-bromergolinen
DE3403067A1 (de) * 1984-01-30 1985-08-14 Eckart Prof. Dr. 6500 Mainz Eich Ergolin-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
DE3413657A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergoline
HU193781B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives

Also Published As

Publication number Publication date
ZA872931B (hu) 1987-10-19
KR870010051A (ko) 1987-11-30
IL82324A0 (en) 1987-10-30
IT1203976B (it) 1989-02-23
EG18272A (en) 1993-04-30
KR920008167B1 (ko) 1992-09-24
GB2189487A (en) 1987-10-28
CS292087A2 (en) 1989-06-13
SU1500161A3 (ru) 1989-08-07
FI871128A0 (fi) 1987-03-13
SE8701700D0 (sv) 1987-04-24
JPH0462316B2 (hu) 1992-10-05
CN87102944A (zh) 1987-11-25
HU196598B (en) 1988-12-28
PT84739B (pt) 1989-12-29
PL265357A1 (en) 1988-07-21
DK208887D0 (da) 1987-04-24
BE1001159A4 (fr) 1989-08-01
CH669791A5 (hu) 1989-04-14
JPS62258379A (ja) 1987-11-10
CS268534B2 (en) 1990-03-14
LU86853A1 (de) 1987-08-12
FI871128A (fi) 1987-10-26
FR2597869B1 (fr) 1991-04-26
GR870645B (en) 1987-08-28
IT8720271A0 (it) 1987-04-24
ES2007339A6 (es) 1989-06-16
GB8709893D0 (en) 1987-06-03
ATA102287A (de) 1990-04-15
NO871721L (no) 1987-10-26
AU7194587A (en) 1987-10-29
DK208887A (da) 1987-10-26
AU592637B2 (en) 1990-01-18
US4859682A (en) 1989-08-22
GB2189487B (en) 1990-05-23
AT391472B (de) 1990-10-10
PL152619B1 (en) 1991-01-31
SE466401B (sv) 1992-02-10
NO165800C (no) 1991-04-10
SE8701700L (sv) 1987-10-26
FR2597869A1 (fr) 1987-10-30
NO165800B (no) 1991-01-02
IN165245B (hu) 1989-09-09
NO871721D0 (no) 1987-04-24
NL8700966A (nl) 1987-11-16
PT84739A (en) 1987-05-01
DE3713768A1 (de) 1987-10-29

Similar Documents

Publication Publication Date Title
DE3785613T2 (de) Verfahren zur herstellung von 2-halogenierten ergolinderivaten.
CH617196A5 (hu)
DE2025624C2 (de) 5'-0-Ester von ara-Cytidin und Verfahren zu ihrer Herstellung
CH649295A5 (de) Optisch aktive oder razemische brom-e-homo-eburanderivate.
DD256133A5 (de) Neue 8- bzw. 1,8-substituierte ergolenderivate und verfahren zu ihrer herstellung
DE2335750C3 (de) D-6-Methylergolin-derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE2634336C3 (de) Diaminoandrostan-Derivate, deren Säureadditionssalze und quaternären Salze sowie ein Verfahren zur Herstellung dieser Verbindungen
DE3026602C2 (hu)
DE69623656T2 (de) Trans apovincaminsäure-esterderivate als arzneimittel
DE1914981A1 (de) Verfahren zur Herstellung heterocyclischer Verbindungen
DE2804894A1 (de) Halogen-benzofuranon-carbonsaeuren
DE2903917C2 (hu)
DE3619617A1 (de) Verfahren zur herstellung von 2-brom-(alpha)-ergokryptin
DE2938313C2 (hu)
DD236095A5 (de) Verfahren zur herstellung von neuen nitronpovincamsaeure-derivaten
DE3231449A1 (de) Imidazolderivate und verfahren zu ihrer herstellung
CH658656A5 (de) Neue eburnamenin-14-carbonsaeure-derivate, verfahren zu ihrer herstellung und die neuen verbindungen enthaltende arzneimittelpraeparate.
DE1695682A1 (de) Neue heterocyclischer Verbindungen und Verfahren zu deren Herstellung
AT337195B (de) Verfahren zur herstellung von neuen 1-phthalazonderivaten
AT309447B (de) Verfahren zur Herstellung von neuen Benzodiazepinderivaten und ihren Säureadditionssalzen
AT309449B (de) Verfahren zur Herstellung von neuen Benzodiazepinderivats und dessen Säureadditionssalzen
CH652126A5 (en) Process for preparing halovincaminic acid and haloapovincaminic acid ester derivatives
DE2128466A1 (de) Phenazindenvate
AT350548B (de) Verfahren zur herstellung von einem neuen benzofuranderivat und den saeureadditionssalzen hievon
AT311352B (de) Verfahren zur Herstellung von neuen Benzodiazepinderivaten und ihren Säureadditionssalzen

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee