DD240889A5 - Verfahren zur herstellung substituierter 3,4-diamino-1,2,5-thiadiazol-verbindungen - Google Patents

Verfahren zur herstellung substituierter 3,4-diamino-1,2,5-thiadiazol-verbindungen Download PDF

Info

Publication number
DD240889A5
DD240889A5 DD85277533A DD27753385A DD240889A5 DD 240889 A5 DD240889 A5 DD 240889A5 DD 85277533 A DD85277533 A DD 85277533A DD 27753385 A DD27753385 A DD 27753385A DD 240889 A5 DD240889 A5 DD 240889A5
Authority
DD
German Democratic Republic
Prior art keywords
general formula
compound
lower alkyl
group
hydrogen atom
Prior art date
Application number
DD85277533A
Other languages
German (de)
English (en)
Inventor
Aldo A Algieri
Ronnie R Crenshaw
Original Assignee
�������`�����@�������k��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �������`�����@�������k�� filed Critical �������`�����@�������k��
Publication of DD240889A5 publication Critical patent/DD240889A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DD85277533A 1984-06-22 1985-06-19 Verfahren zur herstellung substituierter 3,4-diamino-1,2,5-thiadiazol-verbindungen DD240889A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/623,588 US4644006A (en) 1984-06-22 1984-06-22 Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity

Publications (1)

Publication Number Publication Date
DD240889A5 true DD240889A5 (de) 1986-11-19

Family

ID=24498651

Family Applications (1)

Application Number Title Priority Date Filing Date
DD85277533A DD240889A5 (de) 1984-06-22 1985-06-19 Verfahren zur herstellung substituierter 3,4-diamino-1,2,5-thiadiazol-verbindungen

Country Status (33)

Country Link
US (1) US4644006A (xx)
JP (2) JPS6118775A (xx)
KR (1) KR900004321B1 (xx)
AR (1) AR240935A1 (xx)
AT (1) AT390790B (xx)
AU (2) AU580605B2 (xx)
BE (1) BE902724A (xx)
CA (2) CA1267412A (xx)
CH (1) CH665210A5 (xx)
CS (1) CS257276B2 (xx)
DD (1) DD240889A5 (xx)
DE (1) DE3522101A1 (xx)
DK (1) DK282885A (xx)
ES (2) ES8702902A1 (xx)
FI (1) FI852405L (xx)
FR (1) FR2566406B1 (xx)
GB (2) GB2161157B (xx)
GR (1) GR851514B (xx)
HU (1) HU193992B (xx)
IE (2) IE58261B1 (xx)
IL (1) IL75567A0 (xx)
IT (1) IT1190372B (xx)
LU (1) LU85969A1 (xx)
NL (1) NL8501766A (xx)
NO (1) NO161856C (xx)
NZ (1) NZ212403A (xx)
OA (1) OA08039A (xx)
PT (1) PT80684B (xx)
SE (1) SE464305B (xx)
SU (1) SU1537136A3 (xx)
YU (2) YU45725B (xx)
ZA (1) ZA854710B (xx)
ZW (1) ZW10385A1 (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535227A4 (en) * 1990-05-29 1993-08-18 Nippon Soda Co., Ltd. N-substituted heterocyclic amidine derivative
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3657237A (en) * 1968-05-22 1972-04-18 Frosst & Co Charles E Process for making 1 2 5-thiadiazoles in the sinister configuration
DK160611C (da) * 1979-09-04 1991-09-16 Bristol Myers Squibb Co Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 1,2,5-thiadiazol-1-oxider og -1,1-dioxider
EP0040696B1 (en) * 1980-04-30 1986-08-27 Merck & Co. Inc. Aminothiadiazoles as gastric secretion inhibitors
US4394508A (en) * 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
DE3168031D1 (en) * 1980-07-30 1985-02-14 Ici Plc Guanidine derivatives
EP0060730A3 (en) * 1981-03-18 1982-12-08 Imperial Chemical Industries Plc Bicyclic derivatives
EP0065823A1 (en) * 1981-05-13 1982-12-01 Imperial Chemical Industries Plc Heterocyclic guanidines as histamine H-2 antagonists
US4528375A (en) * 1982-03-29 1985-07-09 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
ZW7683A1 (en) * 1982-03-29 1984-01-04 Bristol Myers Co Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine h2 receptor antagonist activity
US4528377A (en) * 1982-03-29 1985-07-09 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4517366A (en) * 1982-03-29 1985-05-14 Bristol-Myers Company Intermediates for preparing 3,4-diamino-1,2,5-thiadiazoles
US4528378A (en) * 1982-03-29 1985-07-09 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4588826A (en) * 1982-03-29 1986-05-13 Bristol-Myers Company Ethanediimidamide intermediates
FI832519L (fi) * 1982-07-12 1984-01-13 Bristol Myers Co Farmaceutiska foerfaranden och sammansaettningar
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
JPS5978171A (ja) * 1982-10-26 1984-05-04 Ikeda Mohandou:Kk 複素環式化合物
US4440933A (en) * 1983-03-16 1984-04-03 Bristol-Myers Company Process for preparing 1,2,5-thiadiazoles

Also Published As

Publication number Publication date
AU2977589A (en) 1989-06-01
CA1267412A (en) 1990-04-03
OA08039A (fr) 1987-01-31
IT8521217A0 (it) 1985-06-20
SE8503110D0 (sv) 1985-06-20
GB8716149D0 (en) 1987-08-12
CS424785A2 (en) 1987-09-17
GR851514B (xx) 1985-11-25
IL75567A0 (en) 1985-10-31
DK282885D0 (da) 1985-06-21
SU1537136A3 (ru) 1990-01-15
YU105185A (en) 1987-12-31
HUT42087A (en) 1987-06-29
AT390790B (de) 1990-06-25
YU102587A (en) 1988-02-29
SE464305B (sv) 1991-04-08
IE58261B1 (en) 1993-08-25
LU85969A1 (fr) 1986-01-24
GB2192884A (en) 1988-01-27
CH665210A5 (de) 1988-04-29
FR2566406B1 (fr) 1988-01-29
NL8501766A (nl) 1986-01-16
NO161856C (no) 1989-10-04
AU4392085A (en) 1986-01-02
NO852519L (no) 1985-12-23
YU45822B (sh) 1992-07-20
IE851557L (en) 1985-12-22
JPS6118775A (ja) 1986-01-27
FI852405A0 (fi) 1985-06-17
ES544409A0 (es) 1987-01-16
FI852405L (fi) 1985-12-23
ES8702902A1 (es) 1987-01-16
KR860000275A (ko) 1986-01-27
CS257276B2 (en) 1988-04-15
GB2161157A (en) 1986-01-08
BE902724A (fr) 1985-12-23
GB2192884B (en) 1988-08-10
US4644006A (en) 1987-02-17
JPS61186369A (ja) 1986-08-20
ZW10385A1 (en) 1986-02-05
AR240935A2 (es) 1991-03-27
KR900004321B1 (ko) 1990-06-22
NZ212403A (en) 1989-04-26
AU614331B2 (en) 1991-08-29
CA1297875C (en) 1992-03-24
IT1190372B (it) 1988-02-16
ATA185885A (de) 1989-12-15
ZA854710B (en) 1986-02-26
AU580605B2 (en) 1989-01-19
DE3522101A1 (de) 1986-01-02
SE8503110L (sv) 1985-12-23
AR240935A1 (es) 1991-03-27
GB8515749D0 (en) 1985-07-24
YU45725B (sh) 1992-07-20
FR2566406A1 (fr) 1985-12-27
IE57937B1 (en) 1993-05-19
NO161856B (no) 1989-06-26
PT80684A (en) 1985-07-01
HU193992B (en) 1987-12-28
ES551506A0 (es) 1987-01-16
DK282885A (da) 1985-12-23
GB2161157B (en) 1988-08-10
PT80684B (en) 1987-05-08
ES8702881A1 (es) 1987-01-16

Similar Documents

Publication Publication Date Title
DE2951675C2 (de) Guanidinothiazolverbindungen, Verfahren zu deren Herstellung und Arzneimittelzubereitungen
DE3218584C2 (xx)
DE2807392A1 (de) Neue chinazolinverbindungen, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3005786A1 (de) Cyanoguanidinderivate und verfahren zu deren herstellung
DE1770571C3 (de) 2-Oxo-3-benzothiazolinacetamid-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2322880A1 (de) Neue organische verbindungen und verfahren zu deren herstellung
DD207913A5 (de) Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen
DD218364A5 (de) Verfahren zur herstellung von 3-(amino- oder subst.-amino)-4-(subst.-amino)-1,2,5-thiadiazol verbindungen
US4692531A (en) Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
EP0526395A1 (de) Arylalkylaminderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2819874A1 (de) Bisamidine, verfahren zu ihrer herstellung und ihre verwendung als histamin- h tief 2 - receptor-antagonisten
DD240889A5 (de) Verfahren zur herstellung substituierter 3,4-diamino-1,2,5-thiadiazol-verbindungen
US4503051A (en) Substituted 3-cyclobutene-1,2-diones, pharmaceutical compositions thereof and methods of use
DE2824066A1 (de) Neue, zur ulcusbehandlung brauchbare verbindungen, verfahren zu deren herstellung, arzneimittel und zwischenprodukte
US4539316A (en) Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
DD210909A5 (de) Verfahren zur herstellung von substituierten 3,4-diamino-1,2,5-thiadiazolverbindungen
EP0302164B1 (de) Guanidincarbonsäureester, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
CH652401A5 (de) Amino-2,1,3-benzothiadiazol- und -benzoxadiazol-derivate, ihre herstellung und sie enthaltende arzneimittel.
DE2140865A1 (de) 1-imidazolyl-methanphosphonsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4546188A (en) Substituted 1,2-diaminocyclobutene-3,4-diones
EP0592453B1 (de) Aminoalkylsubstituierte 2-amino-1,3,4-thiadiazole, ihre herstellung und verwendung
DE3107599C2 (de) N-Cyan-N'-methyl-N"-{2-[(5-methylthio-imidazol-4-yl)-methylthio]-äthyl}-guanidin, Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel
DE2441929A1 (de) Arzneimittelpraeparate, in diesen praeparaten enthaltene neue wirkstoffe und verfahren zu deren herstellung
US4607105A (en) 3-cyclobutene-1,2-dione intermediates
US4788184A (en) Substituted 3-cyclobutene-1,2-diones as anti-ulcer agents

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee