DD223710A5 - Verfahren zur herstellung von substituierten phenylalkyl (piperazinyl oder homopiperazinyl)-propyl-(harnstoffen oder thioharnstoffen). - Google Patents

Verfahren zur herstellung von substituierten phenylalkyl (piperazinyl oder homopiperazinyl)-propyl-(harnstoffen oder thioharnstoffen). Download PDF

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Publication number
DD223710A5
DD223710A5 DD84264150A DD26415084A DD223710A5 DD 223710 A5 DD223710 A5 DD 223710A5 DD 84264150 A DD84264150 A DD 84264150A DD 26415084 A DD26415084 A DD 26415084A DD 223710 A5 DD223710 A5 DD 223710A5
Authority
DD
German Democratic Republic
Prior art keywords
compound
alkyl
formula
mmol
carbon atoms
Prior art date
Application number
DD84264150A
Other languages
German (de)
English (en)
Inventor
John P Devlin
Karl D Hargrave
Edward Barsumian
Genus I Possanza
Original Assignee
Boehringer Ingelheim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Ltd filed Critical Boehringer Ingelheim Ltd
Publication of DD223710A5 publication Critical patent/DD223710A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DD84264150A 1983-06-16 1984-06-14 Verfahren zur herstellung von substituierten phenylalkyl (piperazinyl oder homopiperazinyl)-propyl-(harnstoffen oder thioharnstoffen). DD223710A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50483783A 1983-06-16 1983-06-16

Publications (1)

Publication Number Publication Date
DD223710A5 true DD223710A5 (de) 1985-06-19

Family

ID=24007953

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84264150A DD223710A5 (de) 1983-06-16 1984-06-14 Verfahren zur herstellung von substituierten phenylalkyl (piperazinyl oder homopiperazinyl)-propyl-(harnstoffen oder thioharnstoffen).

Country Status (25)

Country Link
EP (1) EP0129207B1 (ko)
JP (1) JPS6075469A (ko)
KR (1) KR890000175B1 (ko)
AR (1) AR242377A1 (ko)
AT (1) ATE33023T1 (ko)
AU (1) AU565041B2 (ko)
CA (1) CA1219260A (ko)
CS (1) CS244821B2 (ko)
DD (1) DD223710A5 (ko)
DE (1) DE3469896D1 (ko)
DK (1) DK160554C (ko)
ES (3) ES533448A0 (ko)
FI (1) FI76327C (ko)
GR (1) GR82367B (ko)
HU (1) HU192409B (ko)
IE (1) IE59034B1 (ko)
IL (1) IL72123A (ko)
NO (1) NO161618C (ko)
NZ (1) NZ208535A (ko)
PH (1) PH24059A (ko)
PL (2) PL146314B1 (ko)
PT (1) PT78729B (ko)
SU (2) SU1542415A3 (ko)
YU (2) YU104584A (ko)
ZA (1) ZA844527B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661481A (en) * 1983-06-16 1987-04-28 Boehringer Ingelheim Pharmaceuticals, Inc Substituted phenylalkylhomopiperazinylpropyl(ureas or thioureas) useful for treatment of immulogical, inflammatory and allergic disorders
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
JP2722250B2 (ja) * 1989-05-30 1998-03-04 興和株式会社 新規なジアミン化合物及びこれを含有する脳機能障害改善剤
JPH0525145A (ja) * 1991-07-15 1993-02-02 Mochida Pharmaceut Co Ltd アレルギー性疾患治療剤
JP3719612B2 (ja) * 1993-06-14 2005-11-24 塩野義製薬株式会社 ヘテロ環を含有する尿素誘導体
ITRM20060090A1 (it) * 2006-02-22 2007-08-23 Sigma Tau Ind Farmaceuti Nuovi composti inibitori cpt a livello del snc come farmaci antidiabetici e o antiobesita
TW201446748A (zh) 2007-08-22 2014-12-16 Astrazeneca Ab 環丙基醯胺衍生物
TW201039825A (en) * 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
EP2536702A4 (en) 2010-02-18 2013-07-10 Astrazeneca Ab NEW CRYSTALLINE FORM OF A CYCLOPROPYLBENZAMIDE DERIVATIVE
EP3484880B1 (en) 2016-07-13 2020-09-02 Leo Pharma A/S Heteroaromatic modulators of the retinoid-related orphan receptor gamma

Also Published As

Publication number Publication date
PH24059A (en) 1990-03-05
FI76327C (fi) 1988-10-10
ES537661A0 (es) 1985-11-01
PL252851A1 (en) 1986-07-01
NO161618C (no) 1989-09-06
PT78729B (en) 1986-10-21
ZA844527B (en) 1986-02-26
ES8506651A1 (es) 1985-08-01
FI842408A0 (fi) 1984-06-14
IL72123A0 (en) 1984-10-31
DK294084D0 (da) 1984-06-15
GR82367B (ko) 1984-12-13
CA1219260A (en) 1987-03-17
JPS6075469A (ja) 1985-04-27
YU150186A (en) 1987-06-30
AU2940484A (en) 1984-12-20
EP0129207A3 (en) 1985-07-31
DK160554B (da) 1991-03-25
EP0129207B1 (en) 1988-03-16
NO842417L (no) 1984-12-17
PL248207A1 (en) 1985-08-13
SU1542415A3 (ru) 1990-02-07
PL146314B1 (en) 1989-01-31
NZ208535A (en) 1987-02-20
AU565041B2 (en) 1987-09-03
IE59034B1 (en) 1993-12-15
FI842408A (fi) 1984-12-17
IE841499L (en) 1984-12-16
ES537662A0 (es) 1985-09-16
ES8601928A1 (es) 1985-11-01
IL72123A (en) 1987-09-16
KR890000175B1 (ko) 1989-03-09
DK294084A (da) 1984-12-17
JPH0469147B2 (ko) 1992-11-05
ES533448A0 (es) 1985-08-01
DK160554C (da) 1991-09-09
KR850000422A (ko) 1985-02-27
SU1387877A3 (ru) 1988-04-07
ES8600255A1 (es) 1985-09-16
YU104584A (en) 1986-12-31
DE3469896D1 (en) 1988-04-21
FI76327B (fi) 1988-06-30
EP0129207A2 (en) 1984-12-27
CS244821B2 (en) 1986-08-14
HUT34464A (en) 1985-03-28
NO161618B (no) 1989-05-29
PT78729A (en) 1984-07-01
PL147413B1 (en) 1989-05-31
HU192409B (en) 1987-06-29
ATE33023T1 (de) 1988-04-15
AR242377A1 (es) 1993-03-31

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