ES8506651A1 - Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas y tioureas) sustituidas - Google Patents

Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas y tioureas) sustituidas

Info

Publication number
ES8506651A1
ES8506651A1 ES533448A ES533448A ES8506651A1 ES 8506651 A1 ES8506651 A1 ES 8506651A1 ES 533448 A ES533448 A ES 533448A ES 533448 A ES533448 A ES 533448A ES 8506651 A1 ES8506651 A1 ES 8506651A1
Authority
ES
Spain
Prior art keywords
homopiperazinyl
thioureas
ureas
piperazinyl
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533448A
Other languages
English (en)
Other versions
ES533448A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOEHRINGER INGELHEIM Ltd
Boehringer Ingelheim Corp
Original Assignee
BOEHRINGER INGELHEIM Ltd
Boehringer Ingelheim Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM Ltd, Boehringer Ingelheim Corp filed Critical BOEHRINGER INGELHEIM Ltd
Publication of ES8506651A1 publication Critical patent/ES8506651A1/es
Publication of ES533448A0 publication Critical patent/ES533448A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN METODO DE PREPARAR FENILALQUIL-(PIPERAZINIL U HOMOPIPERAZINIL)-PROPIL-(UREAS Y TIOUREAS) SUSTITUIDAS DE FORMULA GENERAL (I).CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) DONDE X ES OXIGENO O AZUFRE Y CONVERTIR OPCIONALMENTE EL PRODUCTO DE LA REACCION EN UNA SAL DE ADICION DE ACIDO NO TOXICA DE FORMULA (I) FARMACOLOGICAMENTE ACEPTABLE.TIENE ACTIVIDAD COMO ANTIHISTAMINICOS O INHIBIDORES DE LA LIBERACION DE MEDIADORES A PARTIR DE LOS BASOFILOS O MASTOCITOS.
ES533448A 1983-06-16 1984-06-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas y tioureas) sustituidas Granted ES533448A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50483783A 1983-06-16 1983-06-16

Publications (2)

Publication Number Publication Date
ES8506651A1 true ES8506651A1 (es) 1985-08-01
ES533448A0 ES533448A0 (es) 1985-08-01

Family

ID=24007953

Family Applications (3)

Application Number Title Priority Date Filing Date
ES533448A Granted ES533448A0 (es) 1983-06-16 1984-06-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas y tioureas) sustituidas
ES537662A Expired ES8600255A1 (es) 1983-06-16 1984-11-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas o tioureas)sustituidas
ES537661A Expired ES8601928A1 (es) 1983-06-16 1984-11-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas o tioureas)sustituidas)

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES537662A Expired ES8600255A1 (es) 1983-06-16 1984-11-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas o tioureas)sustituidas
ES537661A Expired ES8601928A1 (es) 1983-06-16 1984-11-15 Un metodo de preparar fenilalquil(piperazinil u homopiperazinil)propil-(ureas o tioureas)sustituidas)

Country Status (25)

Country Link
EP (1) EP0129207B1 (es)
JP (1) JPS6075469A (es)
KR (1) KR890000175B1 (es)
AR (1) AR242377A1 (es)
AT (1) ATE33023T1 (es)
AU (1) AU565041B2 (es)
CA (1) CA1219260A (es)
CS (1) CS244821B2 (es)
DD (1) DD223710A5 (es)
DE (1) DE3469896D1 (es)
DK (1) DK160554C (es)
ES (3) ES533448A0 (es)
FI (1) FI76327C (es)
GR (1) GR82367B (es)
HU (1) HU192409B (es)
IE (1) IE59034B1 (es)
IL (1) IL72123A (es)
NO (1) NO161618C (es)
NZ (1) NZ208535A (es)
PH (1) PH24059A (es)
PL (2) PL146314B1 (es)
PT (1) PT78729B (es)
SU (2) SU1542415A3 (es)
YU (2) YU104584A (es)
ZA (1) ZA844527B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661481A (en) * 1983-06-16 1987-04-28 Boehringer Ingelheim Pharmaceuticals, Inc Substituted phenylalkylhomopiperazinylpropyl(ureas or thioureas) useful for treatment of immulogical, inflammatory and allergic disorders
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
JP2722250B2 (ja) * 1989-05-30 1998-03-04 興和株式会社 新規なジアミン化合物及びこれを含有する脳機能障害改善剤
JPH0525145A (ja) * 1991-07-15 1993-02-02 Mochida Pharmaceut Co Ltd アレルギー性疾患治療剤
JP3719612B2 (ja) * 1993-06-14 2005-11-24 塩野義製薬株式会社 ヘテロ環を含有する尿素誘導体
ITRM20060090A1 (it) * 2006-02-22 2007-08-23 Sigma Tau Ind Farmaceuti Nuovi composti inibitori cpt a livello del snc come farmaci antidiabetici e o antiobesita
TW201446748A (zh) 2007-08-22 2014-12-16 Astrazeneca Ab 環丙基醯胺衍生物
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
BR112012020629A2 (pt) 2010-02-18 2018-06-19 Astrazeneca Ab forma cristalina, e, método para a terapia de um distúrbio
US10662181B2 (en) 2016-07-13 2020-05-26 Leo Pharma A/S Heteroaromatic modulators of the retinoid-related orphan receptor gamma

Also Published As

Publication number Publication date
DK160554C (da) 1991-09-09
NZ208535A (en) 1987-02-20
PL248207A1 (en) 1985-08-13
PL252851A1 (en) 1986-07-01
CS244821B2 (en) 1986-08-14
ZA844527B (en) 1986-02-26
AR242377A1 (es) 1993-03-31
NO161618B (no) 1989-05-29
EP0129207A3 (en) 1985-07-31
AU2940484A (en) 1984-12-20
DD223710A5 (de) 1985-06-19
ES537662A0 (es) 1985-09-16
PT78729A (en) 1984-07-01
IE59034B1 (en) 1993-12-15
AU565041B2 (en) 1987-09-03
JPS6075469A (ja) 1985-04-27
ES533448A0 (es) 1985-08-01
EP0129207B1 (en) 1988-03-16
FI842408A0 (fi) 1984-06-14
EP0129207A2 (en) 1984-12-27
FI76327B (fi) 1988-06-30
ATE33023T1 (de) 1988-04-15
HUT34464A (en) 1985-03-28
DE3469896D1 (en) 1988-04-21
YU150186A (en) 1987-06-30
PL147413B1 (en) 1989-05-31
ES8600255A1 (es) 1985-09-16
JPH0469147B2 (es) 1992-11-05
YU104584A (en) 1986-12-31
PT78729B (en) 1986-10-21
CA1219260A (en) 1987-03-17
HU192409B (en) 1987-06-29
FI842408A (fi) 1984-12-17
SU1387877A3 (ru) 1988-04-07
KR890000175B1 (ko) 1989-03-09
PL146314B1 (en) 1989-01-31
ES537661A0 (es) 1985-11-01
IL72123A (en) 1987-09-16
IE841499L (en) 1984-12-16
IL72123A0 (en) 1984-10-31
NO842417L (no) 1984-12-17
SU1542415A3 (ru) 1990-02-07
DK294084A (da) 1984-12-17
ES8601928A1 (es) 1985-11-01
FI76327C (fi) 1988-10-10
NO161618C (no) 1989-09-06
DK294084D0 (da) 1984-06-15
GR82367B (es) 1984-12-13
KR850000422A (ko) 1985-02-27
DK160554B (da) 1991-03-25
PH24059A (en) 1990-03-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20011110