DD148050A5 - Verfahren zur herstellung neuer n-aryl-bzw.benzimidazolione - Google Patents

Verfahren zur herstellung neuer n-aryl-bzw.benzimidazolione Download PDF

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Publication number
DD148050A5
DD148050A5 DD77217954A DD21795477A DD148050A5 DD 148050 A5 DD148050 A5 DD 148050A5 DD 77217954 A DD77217954 A DD 77217954A DD 21795477 A DD21795477 A DD 21795477A DD 148050 A5 DD148050 A5 DD 148050A5
Authority
DD
German Democratic Republic
Prior art keywords
alkylene
group
preparation
general formula
application
Prior art date
Application number
DD77217954A
Other languages
German (de)
English (en)
Inventor
Herbert Koeppe
Anton Mentrup
Ernst-Otto Renth
Kurt Schromm
Wolfgang Hoefke
Gojko Muacevic
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of DD148050A5 publication Critical patent/DD148050A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
DD77217954A 1976-10-05 1977-10-03 Verfahren zur herstellung neuer n-aryl-bzw.benzimidazolione DD148050A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762644833 DE2644833A1 (de) 1976-10-05 1976-10-05 Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DD148050A5 true DD148050A5 (de) 1981-05-06

Family

ID=5989679

Family Applications (5)

Application Number Title Priority Date Filing Date
DD77217954A DD148050A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer n-aryl-bzw.benzimidazolione
DD77217961A DD148052A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer zwischenprodukte von arzneimitteln
DD77212491A DD143074A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer n-aryl bzw.benzimidazolinone
DD77201314A DD134642A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer 1-aryloxy-2-hydroxy-3-alkylenaminopropane
DD77217956A DD148051A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer zwischenprodukte zur herstellung pharmazeutisch verwendbarer verbindungen

Family Applications After (4)

Application Number Title Priority Date Filing Date
DD77217961A DD148052A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer zwischenprodukte von arzneimitteln
DD77212491A DD143074A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer n-aryl bzw.benzimidazolinone
DD77201314A DD134642A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer 1-aryloxy-2-hydroxy-3-alkylenaminopropane
DD77217956A DD148051A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer zwischenprodukte zur herstellung pharmazeutisch verwendbarer verbindungen

Country Status (33)

Country Link
US (7) US4256756A (OSRAM)
JP (1) JPS5368775A (OSRAM)
AT (15) AT361908B (OSRAM)
AU (1) AU514600B2 (OSRAM)
BE (1) BE859415A (OSRAM)
BG (1) BG33153A3 (OSRAM)
CA (4) CA1101859A (OSRAM)
CS (1) CS197304B2 (OSRAM)
DD (5) DD148050A5 (OSRAM)
DE (1) DE2644833A1 (OSRAM)
DK (1) DK439077A (OSRAM)
ES (16) ES462868A1 (OSRAM)
FI (1) FI69066C (OSRAM)
FR (1) FR2394534A1 (OSRAM)
GB (3) GB1592976A (OSRAM)
GR (1) GR64229B (OSRAM)
HK (1) HK19385A (OSRAM)
HU (1) HU177173B (OSRAM)
IE (3) IE46159B1 (OSRAM)
IL (1) IL53043A (OSRAM)
LU (1) LU78240A1 (OSRAM)
MY (1) MY8500909A (OSRAM)
NL (1) NL7710840A (OSRAM)
NO (1) NO151411C (OSRAM)
NZ (1) NZ185356A (OSRAM)
PH (4) PH15763A (OSRAM)
PL (1) PL113879B1 (OSRAM)
PT (1) PT67107B (OSRAM)
SE (1) SE442400B (OSRAM)
SG (1) SG70884G (OSRAM)
SU (1) SU665801A3 (OSRAM)
YU (1) YU40484B (OSRAM)
ZA (1) ZA775905B (OSRAM)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404380A (en) * 1977-02-14 1983-09-13 Mead Johnson & Company Triazolopyrimidines
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
BE883069A (fr) * 1979-05-04 1980-08-18 Continental Pharma Derives de phenylethylamine, leur preparation et utilisation ainsi que composition contenant ces derives.
US4434174A (en) 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
IE810250L (en) 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
US4349673A (en) * 1980-12-23 1982-09-14 Merck & Co., Inc. Benzoxazines
US4656168A (en) * 1980-12-23 1987-04-07 Merck & Co., Inc. (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation
US4473501A (en) * 1981-05-04 1984-09-25 G. D. Searle & Co. Dihydro azino isoquinolines
US4379508A (en) * 1981-10-14 1983-04-12 Nestier Corporation Nesting tray with stacking keyed interlock
IT1193608B (it) * 1983-01-21 1988-07-21 Pierrel Spa Derivati di arilossipropanolamina,procedimento per la loro preparazione composizioni farmaceutiche che li contengono e loro impiego terapeutico
DE3324903A1 (de) * 1983-07-09 1985-01-17 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung substituierter ethylenharnstoffe sowie neue n-vinylethylenharnstoffe
GB8419797D0 (en) * 1984-08-03 1984-09-05 Beecham Group Plc Compounds
DE3807922A1 (de) * 1988-03-10 1989-09-21 Boehringer Mannheim Gmbh Substituierte heterocyclen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
TW203049B (OSRAM) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
US6557907B2 (en) 1993-05-14 2003-05-06 William W. Rowley Polyethylene connectors
US6860524B1 (en) 1993-05-14 2005-03-01 William W. Rowley Polyolefin connectors
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US6848719B2 (en) 2001-09-06 2005-02-01 William W. Rowley Bendable polymer-lined water heater connector
MY143244A (en) * 2002-11-26 2011-04-15 Smithkline Beecham Corp Calcilytic compounds
CA2511496A1 (en) * 2002-12-23 2004-07-15 Artesian Therapeutics, Inc. Cardiotonic compounds with inhibitory activity against .beta.-adrenergic receptors and phosphodiesterase
DE102004045648A1 (de) * 2004-09-21 2006-03-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika zur Behandlung von Atemwegserkrankungen
US20080255134A1 (en) * 2004-11-30 2008-10-16 Artesian Therapeutics, Inc. Cardiotonic Compounds With Inhibitory Activity Against Beta-Adrenergic Receptors And Phosphodiesterase
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
EP3075401B1 (en) * 2007-11-29 2024-04-03 Inolex Investment Corporation Preservation for cosmetic, toiletry and pharmaceutical compositions
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL284529A (OSRAM) * 1961-10-24
GB1066613A (en) * 1965-03-03 1967-04-26 Ici Ltd Naphthalene derivatives
SE378102B (OSRAM) * 1969-11-28 1975-08-18 Teikoku Hormone Mfg Co Ltd
ZA71932B (en) * 1970-02-27 1971-10-27 Ici Ltd Organic compounds
BE787103A (fr) * 1971-08-04 1973-02-02 Pfizer Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant
US3894030A (en) * 1973-01-04 1975-07-08 Janssen Pharmaceutica Nv 1-{8 1-(2-Hydroxy-3-aryloxypropyl)-4-piperidyl{9 -2-benzimidazolinones and related compounds
US3818017A (en) * 1973-01-04 1974-06-18 Janssen Pharmaceutica Nv 1-{8 1-(2-hydroxy-3-aryloxypropyl)-4-piperidyl{9 -2-benzimidazolinones and related compounds
GB1456525A (en) * 1973-07-18 1976-11-24 Ici Ltd Process for the manufacture of alkanolamine derivatives
DE2503222A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
CH624395A5 (OSRAM) * 1976-01-08 1981-07-31 Ciba Geigy Ag
DE2609645A1 (de) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen

Also Published As

Publication number Publication date
AT362364B (de) 1981-05-11
NO773384L (no) 1978-04-06
HU177173B (en) 1981-08-28
ES471807A1 (es) 1979-02-01
PH18363A (en) 1985-06-13
JPS6210988B2 (OSRAM) 1987-03-10
ES471795A1 (es) 1979-02-01
DD148051A5 (de) 1981-05-06
PH15763A (en) 1983-03-22
PL113879B1 (en) 1981-01-31
ES471803A1 (es) 1979-02-01
US4296117A (en) 1981-10-20
FR2394534A1 (fr) 1979-01-12
US4343800A (en) 1982-08-10
FR2394534B1 (OSRAM) 1982-04-30
ATA56880A (de) 1980-09-15
US4212877A (en) 1980-07-15
AT361911B (de) 1981-04-10
IE46159B1 (en) 1983-03-09
ES471800A1 (es) 1979-02-01
PH19028A (en) 1985-12-06
ATA57680A (de) 1980-12-15
AT361914B (de) 1981-04-10
ES471804A1 (es) 1979-02-01
US4256756A (en) 1981-03-17
ES471799A1 (es) 1979-02-01
GB1592977A (en) 1981-07-15
AT361908B (de) 1981-04-10
ATA56980A (de) 1980-09-15
ATA57980A (de) 1980-12-15
ES471797A1 (es) 1979-02-01
GB1592975A (en) 1981-07-15
ES462868A1 (es) 1978-12-16
ATA57280A (de) 1980-10-15
ES471801A1 (es) 1979-02-01
FI69066B (fi) 1985-08-30
ATA57780A (de) 1980-12-15
US4604468A (en) 1986-08-05
NZ185356A (en) 1981-05-01
FI69066C (fi) 1985-12-10
AT361913B (de) 1981-04-10
BG33153A3 (bg) 1982-12-15
AT362362B (de) 1981-05-11
ATA57180A (de) 1980-09-15
DK439077A (da) 1978-04-06
NO151411B (no) 1984-12-27
AT361912B (de) 1981-04-10
GR64229B (en) 1980-02-14
IE46160B1 (en) 1983-03-09
ZA775905B (en) 1979-06-27
AT362365B (de) 1981-05-11
PT67107B (de) 1980-04-07
ATA58080A (de) 1981-04-15
YU40484B (en) 1986-02-28
SE7711168L (sv) 1978-05-18
BE859415A (fr) 1978-04-05
ATA57880A (de) 1980-10-15
US4381309A (en) 1983-04-26
AT362363B (de) 1981-05-11
JPS5368775A (en) 1978-06-19
AT363081B (de) 1981-07-10
ES471808A1 (es) 1979-02-01
YU236977A (en) 1983-01-21
PT67107A (de) 1977-11-01
AT363082B (de) 1981-07-10
ATA57380A (de) 1980-10-15
ATA57580A (de) 1980-12-15
AT361915B (de) 1981-04-10
ES471802A1 (es) 1979-02-01
IL53043A (en) 1982-01-31
MY8500909A (en) 1985-12-31
AU514600B2 (en) 1981-02-19
AU2933377A (en) 1979-04-12
IE822410L (en) 1978-04-05
PH16053A (en) 1983-06-09
FI772823A7 (fi) 1978-04-06
DD134642A5 (de) 1979-03-14
AT363080B (de) 1981-07-10
AT364828B (de) 1981-11-25
CA1101859A (en) 1981-05-26
NL7710840A (nl) 1978-04-07
ES471794A1 (es) 1979-02-01
AT363079B (de) 1981-07-10
CA1126271A (en) 1982-06-22
NO151411C (no) 1985-04-10
ES471805A1 (es) 1979-02-01
US4255430A (en) 1981-03-10
ATA679377A (de) 1980-09-15
DE2644833A1 (de) 1978-04-20
CA1127643A (en) 1982-07-13
ES471798A1 (es) 1979-02-01
ES471796A1 (es) 1979-02-01
ES471806A1 (es) 1979-02-01
IE46158L (en) 1978-04-05
CS197304B2 (en) 1980-04-30
DD143074A5 (de) 1980-07-30
LU78240A1 (OSRAM) 1979-02-02
IE822409L (en) 1978-04-05
PL201286A1 (pl) 1978-12-04
SU665801A3 (ru) 1979-05-30
IL53043A0 (en) 1977-12-30
ATA57480A (de) 1980-10-15
HK19385A (en) 1985-03-22
CA1125751A (en) 1982-06-15
DD148052A5 (de) 1981-05-06
SE442400B (sv) 1985-12-23
ATA57080A (de) 1980-09-15
GB1592976A (en) 1981-07-15
SG70884G (en) 1985-04-04
IE46158B1 (en) 1983-03-09
ATA56780A (de) 1980-09-15

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