CY1122528T1 - Χιμαιρικοι υποδοχεις αντιγονου bcma - Google Patents

Χιμαιρικοι υποδοχεις αντιγονου bcma

Info

Publication number
CY1122528T1
CY1122528T1 CY20191101066T CY191101066T CY1122528T1 CY 1122528 T1 CY1122528 T1 CY 1122528T1 CY 20191101066 T CY20191101066 T CY 20191101066T CY 191101066 T CY191101066 T CY 191101066T CY 1122528 T1 CY1122528 T1 CY 1122528T1
Authority
CY
Cyprus
Prior art keywords
bcma
antigone
chimeral
receptors
cell
Prior art date
Application number
CY20191101066T
Other languages
Greek (el)
English (en)
Inventor
Richard Morgan
Kevin FRIEDMAN
Original Assignee
Bluebird Bio, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bluebird Bio, Inc. filed Critical Bluebird Bio, Inc.
Publication of CY1122528T1 publication Critical patent/CY1122528T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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CY20191101066T 2014-12-12 2019-10-10 Χιμαιρικοι υποδοχεις αντιγονου bcma CY1122528T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462091419P 2014-12-12 2014-12-12
US201562200505P 2015-08-03 2015-08-03
PCT/US2015/064269 WO2016094304A2 (en) 2014-12-12 2015-12-07 Bcma chimeric antigen receptors

Publications (1)

Publication Number Publication Date
CY1122528T1 true CY1122528T1 (el) 2021-01-27

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Family Applications (2)

Application Number Title Priority Date Filing Date
CY20191101066T CY1122528T1 (el) 2014-12-12 2019-10-10 Χιμαιρικοι υποδοχεις αντιγονου bcma
CY20211100919T CY1124886T1 (el) 2014-12-12 2021-10-20 Χιμαιρικοι υποδοχεις αντιγονου bcma

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CY20211100919T CY1124886T1 (el) 2014-12-12 2021-10-20 Χιμαιρικοι υποδοχεις αντιγονου bcma

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US (11) US10383929B2 (enExample)
EP (4) EP3640262A1 (enExample)
JP (4) JP6671370B2 (enExample)
KR (3) KR102584938B1 (enExample)
CN (2) CN112358551B (enExample)
AU (2) AU2015360845B2 (enExample)
BR (1) BR112017012502B1 (enExample)
CA (1) CA2970466A1 (enExample)
CL (2) CL2017001515A1 (enExample)
CO (1) CO2017006808A2 (enExample)
CY (2) CY1122528T1 (enExample)
DK (2) DK3628687T3 (enExample)
EA (1) EA036379B1 (enExample)
EC (1) ECSP17044494A (enExample)
ES (2) ES2895640T3 (enExample)
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HR (2) HRP20191873T1 (enExample)
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IL (2) IL252783B (enExample)
LT (2) LT3628687T (enExample)
MX (2) MX383542B (enExample)
NZ (1) NZ733025A (enExample)
PL (2) PL3628687T3 (enExample)
PT (2) PT3230321T (enExample)
RS (2) RS62527B1 (enExample)
SG (2) SG10202013144UA (enExample)
SI (2) SI3628687T1 (enExample)
SM (2) SMT202100594T1 (enExample)
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SG10201809290SA (en) 2014-04-25 2019-01-30 Childrens Medical Ct Corp Compositions and Methods to Treating Hemoglobinopathies
SI3689899T1 (sl) * 2014-04-25 2022-01-31 2Seventy Bio, Inc. MND promotor kimeričnih antigenskih receptorjev
EP3738597A1 (en) 2014-04-25 2020-11-18 Bluebird Bio, Inc. Improved methods for manufacturing adoptive cell therapies
NZ726989A (en) 2014-06-06 2020-08-28 Bluebird Bio Inc Improved t cell compositions
WO2016014565A2 (en) 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor
SG10201900455YA (en) 2014-07-24 2019-02-27 Bluebird Bio Inc Bcma chimeric antigen receptors
SG10201900931XA (en) 2014-12-05 2019-02-27 Memorial Sloan Kettering Cancer Center Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof
DK3226897T3 (da) 2014-12-05 2021-04-19 Memorial Sloan Kettering Cancer Center Antistoffer der rammer b-cellemodningsantigen og fremgangsmåder til anvendelse
NZ733025A (en) 2014-12-12 2022-01-28 2Seventy Bio Inc Bcma chimeric antigen receptors
US11253546B2 (en) 2014-12-15 2022-02-22 The Regents Of The University Of California Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20
CA2971186A1 (en) 2014-12-15 2016-06-23 The Regents Of The University Of California Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing
JP6921001B2 (ja) 2015-04-13 2021-08-18 ファイザー・インク Ｂ細胞成熟抗原を標的にするキメラ抗原受容体
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