SMT202100594T1 - Recettori chimerici dell'antigene bcma - Google Patents

Recettori chimerici dell'antigene bcma

Info

Publication number
SMT202100594T1
SMT202100594T1 SM20210594T SMT202100594T SMT202100594T1 SM T202100594 T1 SMT202100594 T1 SM T202100594T1 SM 20210594 T SM20210594 T SM 20210594T SM T202100594 T SMT202100594 T SM T202100594T SM T202100594 T1 SMT202100594 T1 SM T202100594T1
Authority
SM
San Marino
Prior art keywords
chimeric antigen
antigen receptors
bcma chimeric
bcma
receptors
Prior art date
Application number
SM20210594T
Other languages
English (en)
Italian (it)
Inventor
Richard Morgan
Kevin Friedman
Original Assignee
2Seventy Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 2Seventy Bio Inc filed Critical 2Seventy Bio Inc
Publication of SMT202100594T1 publication Critical patent/SMT202100594T1/it

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
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  • Diabetes (AREA)
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SM20210594T 2014-12-12 2015-12-07 Recettori chimerici dell'antigene bcma SMT202100594T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462091419P 2014-12-12 2014-12-12
US201562200505P 2015-08-03 2015-08-03
EP19193858.8A EP3628687B1 (en) 2014-12-12 2015-12-07 Bcma chimeric antigen receptors

Publications (1)

Publication Number Publication Date
SMT202100594T1 true SMT202100594T1 (it) 2021-11-12

Family

ID=56108356

Family Applications (2)

Application Number Title Priority Date Filing Date
SM20190596T SMT201900596T1 (it) 2014-12-12 2015-12-07 Recettori chimerici di antigene per bcma
SM20210594T SMT202100594T1 (it) 2014-12-12 2015-12-07 Recettori chimerici dell'antigene bcma

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Application Number Title Priority Date Filing Date
SM20190596T SMT201900596T1 (it) 2014-12-12 2015-12-07 Recettori chimerici di antigene per bcma

Country Status (30)

Country Link
US (11) US10383929B2 (enExample)
EP (4) EP3230321B1 (enExample)
JP (4) JP6671370B2 (enExample)
KR (3) KR102731379B1 (enExample)
CN (2) CN107207598B (enExample)
AU (2) AU2015360845B2 (enExample)
BR (1) BR112017012502B1 (enExample)
CA (1) CA2970466A1 (enExample)
CL (2) CL2017001515A1 (enExample)
CO (1) CO2017006808A2 (enExample)
CY (2) CY1122528T1 (enExample)
DK (2) DK3230321T3 (enExample)
EA (1) EA036379B1 (enExample)
EC (1) ECSP17044494A (enExample)
ES (2) ES2750725T3 (enExample)
HK (1) HK1245801B (enExample)
HR (2) HRP20211648T1 (enExample)
HU (2) HUE056074T2 (enExample)
IL (2) IL252783B (enExample)
LT (2) LT3628687T (enExample)
MX (2) MX383542B (enExample)
NZ (1) NZ733025A (enExample)
PL (2) PL3230321T3 (enExample)
PT (2) PT3628687T (enExample)
RS (2) RS59537B1 (enExample)
SG (2) SG10202013144UA (enExample)
SI (2) SI3230321T1 (enExample)
SM (2) SMT201900596T1 (enExample)
WO (1) WO2016094304A2 (enExample)
ZA (1) ZA201704059B (enExample)

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DK2925864T3 (en) 2012-11-27 2019-02-11 Childrens Medical Ct Corp DIRECTIONAL TARGETING OF DISTANT BCL11A CONTROLS FOR FETAL HEMOGLOBIN REINUCTION
KR101605421B1 (ko) 2014-03-05 2016-03-23 국립암센터 B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도
CA2946312A1 (en) 2014-04-23 2015-10-29 Juno Therapeutics, Inc. Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy
MX382565B (es) 2014-04-25 2025-03-13 2Seventy Bio Inc Receptores de antigenos quimericos del promotor mnd.
AU2015249381B2 (en) 2014-04-25 2020-04-30 Children's Medical Center Corporation Compositions and methods to treating hemoglobinopathies
KR102161927B1 (ko) 2014-04-25 2020-10-06 블루버드 바이오, 인코포레이티드. 양자 세포 치료제를 제조하는 개선된 방법
ES2846811T3 (es) 2014-06-06 2021-07-29 Bluebird Bio Inc Composiciones de células T mejoradas
JP7054622B2 (ja) 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置
SG10201900455YA (en) 2014-07-24 2019-02-27 Bluebird Bio Inc Bcma chimeric antigen receptors
KR20240130831A (ko) 2014-12-05 2024-08-29 메모리얼 슬로안 케터링 캔서 센터 B-세포 성숙화 항원을 표적화하는 키메라 항원 수용체 및 그의 용도
PL3226897T3 (pl) 2014-12-05 2021-08-30 Memorial Sloan Kettering Cancer Center Przeciwciała do celowania w antygen dojrzewania limfocytów b i sposoby ich zastosowania
WO2016094304A2 (en) 2014-12-12 2016-06-16 Bluebird Bio, Inc. Bcma chimeric antigen receptors
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