HRP20211648T1 - Kimerni receptori antigena bcma - Google Patents
Kimerni receptori antigena bcma Download PDFInfo
- Publication number
- HRP20211648T1 HRP20211648T1 HRP20211648TT HRP20211648T HRP20211648T1 HR P20211648 T1 HRP20211648 T1 HR P20211648T1 HR P20211648T T HRP20211648T T HR P20211648TT HR P20211648 T HRP20211648 T HR P20211648T HR P20211648 T1 HRP20211648 T1 HR P20211648T1
- Authority
- HR
- Croatia
- Prior art keywords
- promoter
- vector
- ltr
- vector according
- virus
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title claims 9
- 101100425747 Mus musculus Tnfrsf17 gene Proteins 0.000 title 1
- 239000013598 vector Substances 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 9
- 239000012642 immune effector Substances 0.000 claims 8
- 229940121354 immunomodulator Drugs 0.000 claims 8
- 241000701022 Cytomegalovirus Species 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 claims 4
- 230000008488 polyadenylation Effects 0.000 claims 4
- 230000001177 retroviral effect Effects 0.000 claims 4
- 239000003623 enhancer Substances 0.000 claims 3
- 241000713704 Bovine immunodeficiency virus Species 0.000 claims 2
- 241000713730 Equine infectious anemia virus Species 0.000 claims 2
- 241000713800 Feline immunodeficiency virus Species 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 241000713340 Human immunodeficiency virus 2 Species 0.000 claims 2
- 102100028251 Phosphoglycerate kinase 1 Human genes 0.000 claims 2
- 101710139464 Phosphoglycerate kinase 1 Proteins 0.000 claims 2
- 241000714474 Rous sarcoma virus Species 0.000 claims 2
- 241000713311 Simian immunodeficiency virus Species 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000007469 Actins Human genes 0.000 claims 1
- 108010085238 Actins Proteins 0.000 claims 1
- 101000834253 Gallus gallus Actin, cytoplasmic 1 Proteins 0.000 claims 1
- 102100021519 Hemoglobin subunit beta Human genes 0.000 claims 1
- 108091005904 Hemoglobin subunit beta Proteins 0.000 claims 1
- 208000009889 Herpes Simplex Diseases 0.000 claims 1
- 108700002232 Immediate-Early Genes Proteins 0.000 claims 1
- 241000713883 Myeloproliferative sarcoma virus Species 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 102000010292 Peptide Elongation Factor 1 Human genes 0.000 claims 1
- 108010077524 Peptide Elongation Factor 1 Proteins 0.000 claims 1
- 102100037935 Polyubiquitin-C Human genes 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 102000006601 Thymidine Kinase Human genes 0.000 claims 1
- 108020004440 Thymidine kinase Proteins 0.000 claims 1
- 108010056354 Ubiquitin C Proteins 0.000 claims 1
- 208000010094 Visna Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 108010006025 bovine growth hormone Proteins 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
Claims (20)
1. Kimerni receptor antigena (CAR), naznačen time što sadrži aminokiseline 22-493 u aminokiselinskom slijedu iznijetom u SEQ ID NO: 9.
2. CAR u skladu s patentnim zahtjevom 1, naznačen time što sadrži aminokiselinski slijed iznijet u SEQ ID NO: 9.
3. CAR u skladu s patentnim zahtjevom 2, naznačen time što polinukleotid slijed iznijet u SEQ ID NO: 10 kodira CAR.
4. Vektor, naznačen time što sadrži polinukleotid koji kodira CAR u skladu s patentnim zahtjevom 2.
5. Vektor u skladu s patentnim zahtjevom 4, naznačen time što je vektor ekspresijski vektor, episomski vektor, virusni vektor, retrovirusni vektor ili lentivirusni vektor.
6. Vektor u skladu s patentnim zahtjevom 5, naznačen time što lentivirusni vektor se bira iz skupine koju uglavnom čine: virus ljudske imunodeficijencije 1 (HIV-1); virus ljudske imunodeficijencije 2 (HIV-2), virus visna-maedi (VMV); virus kozjeg artritisa i encefalitisa (CAEV); virus konjske zarazne anemije (EIAV); virus mačje imunodeficijencije (FIV); virus goveđe imunodeficijencije (BIV); i virus majmunske imunodeficijencije (SIV).
7. Vektor u skladu s bilo kojim od patentnih zahtjeva 5 do 6, naznačen time što sadrži lijevi (5’) retrovirusni LTR, signal za pakiranje Psi (Ψ), središnji polipurinski niz/DNA-flap (cPPT/FLAP), retrovirusni eksportirajući element; promotor operabilno vezan na polinukleotid; i desni (3’) retrovirusni LTR.
8. Vektor u skladu s patentnim zahtjevom 7, naznačen time što dodatno sadrži heterologni poliadenilacijski slijed.
9. Vektor u skladu s patentnim zahtjevom 6 ili patentnim zahtjevom 7, naznačen time što je promotor u 5’ LTR zamijenjen heterolognim promotorom.
10. Vektor u skladu s patentnim zahtjevom 8, naznačen time što je heterologni promotor citomegalovirusni (CMV) promotor, promotor iz Rousovog virusa sarkoma (RSV) ili promotor iz majmunskog virusa 40 (SV40).
11. Vektor u skladu s bilo kojim od patentnih zahtjeva 7 do 10, naznačen time što je 5’ LTR ili 3’ LTR lentivirusni LTR.
12. Vektor u skladu s bilo kojim od patentnih zahtjeva 7 do 10, naznačen time što je 3’ LTR samoinaktivirajući (SIN) LTR.
13. Vektor u skladu s bilo kojim od patentnih zahtjeva 7 do 12, naznačen time što je poliadenilacijski slijed poliadenilacija goveđeg hormona rasta ili poliadenilacijski signalni slijed kunićjeg β-globina.
14. Vektor u skladu s bilo kojim od patentnih zahtjeva 7 do 13, naznačen time što se promotor operabilno vezan na polinukleotid u skladu s patentnim zahtjevom 2 bira iz skupine koju čine: promotor citomegalovirusnog neposrednog ranog gena (CMV), promotor elonagacijskog čimbenika 1 alfa (EF1-α), promotor fosfoglicerat-kinaze-1 (PGK), promotor ubikvitina-C (UBQ-C), citomegalovirusni pojačivač/promotor kokošjeg beta-aktina (CAG), poliomni pojačivač/promotor timidin-kinaze iz herpes simpleksa (MC1), beta aktinski promotor (β-ACT), promotor iz majmunskog virusa 40 (SV40), te pojačivač iz virusa mijeloproliferativnog sarkoma, izbačeno negativno kontrolno područje, promotor zamijenjen mjestom vezanja početnice dl587rev (MND).
15. Imunosna efektorska stanica ex vivo ili in vitro, naznačena time što eksprimira polinukleotid koji kodira CAR u skladu s patentnim zahtjevom 2.
16. Imunosna efektorska stanica ex vivo ili in vitro, naznačena time što sadrži vektor u skladu s bilo kojim od patentnih zahtjeva 4 do 14.
17. Imunosna efektorska stanica ex vivo ili in vitro u skladu s bilo kojim od patentnih zahtjeva 15 do 16, naznačena time što se imunosnu efektorsku stanicu bira iz skupine koju čine: T-limfocit i prirodnoubilačka stanica (NK).
18. Pripravak, naznačen time što sadrži imunosnu efektorsku stanicu ex vivo ili in vitro u skladu s bilo kojim od patentnih zahtjeva 15 do 17, kao i fiziološki prihvatljivo pomoćno sredstvo.
19. Postupak dobivanja in vitro ili ex vivo imunosne efektorske stanice koja sadrži CAR u skladu s patentnim zahtjevom 1, naznačen time što se sastoji u unošenju vektora u skladu s bilo kojim od patentnih zahtjeva 4 do 14 u imunosnu efektorsku stanicu.
20. Postupak u skladu s patentnim zahtjevom 19, naznačen time što je imunosna efektorska stanica T-limfocit ili NK stanica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462091419P | 2014-12-12 | 2014-12-12 | |
US201562200505P | 2015-08-03 | 2015-08-03 | |
EP19193858.8A EP3628687B1 (en) | 2014-12-12 | 2015-12-07 | Bcma chimeric antigen receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20211648T1 true HRP20211648T1 (hr) | 2022-02-04 |
Family
ID=56108356
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20211648TT HRP20211648T1 (hr) | 2014-12-12 | 2015-12-07 | Kimerni receptori antigena bcma |
HRP20191873TT HRP20191873T1 (hr) | 2014-12-12 | 2019-10-15 | Kimerni antigenski receptori |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20191873TT HRP20191873T1 (hr) | 2014-12-12 | 2019-10-15 | Kimerni antigenski receptori |
Country Status (29)
Country | Link |
---|---|
US (10) | US10383929B2 (hr) |
EP (4) | EP3971210A1 (hr) |
JP (4) | JP6671370B2 (hr) |
KR (2) | KR102584938B1 (hr) |
CN (2) | CN107207598B (hr) |
AU (2) | AU2015360845B2 (hr) |
BR (1) | BR112017012502B1 (hr) |
CA (1) | CA2970466A1 (hr) |
CL (2) | CL2017001515A1 (hr) |
CO (1) | CO2017006808A2 (hr) |
CY (2) | CY1122528T1 (hr) |
DK (2) | DK3628687T3 (hr) |
EA (1) | EA036379B1 (hr) |
EC (1) | ECSP17044494A (hr) |
ES (2) | ES2895640T3 (hr) |
HK (1) | HK1245801B (hr) |
HR (2) | HRP20211648T1 (hr) |
HU (2) | HUE046815T2 (hr) |
IL (2) | IL252783B (hr) |
LT (2) | LT3628687T (hr) |
MX (2) | MX2017007575A (hr) |
NZ (1) | NZ733025A (hr) |
PL (2) | PL3230321T3 (hr) |
PT (2) | PT3230321T (hr) |
RS (2) | RS62527B1 (hr) |
SG (2) | SG10202013144UA (hr) |
SI (2) | SI3628687T1 (hr) |
WO (1) | WO2016094304A2 (hr) |
ZA (1) | ZA201704059B (hr) |
Families Citing this family (160)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3502240B1 (en) | 2012-11-27 | 2021-05-05 | The Children's Medical Center Corporation | Targeting bcl11a distal regulatory elements for fetal hemoglobin reinduction |
KR101605421B1 (ko) | 2014-03-05 | 2016-03-23 | 국립암센터 | B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도 |
DK3134130T3 (da) | 2014-04-25 | 2019-08-26 | Childrens Medical Center | Sammensætninger og fremgangsmåder til behandling af hæmoglobinopatier |
NZ725169A (en) | 2014-04-25 | 2018-02-23 | Bluebird Bio Inc | Mnd promoter chimeric antigen receptors |
CA2951044C (en) | 2014-06-06 | 2023-10-03 | Bluebird Bio, Inc. | Improved t cell compositions |
US20170226216A1 (en) * | 2014-07-24 | 2017-08-10 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
PL3227432T3 (pl) | 2014-12-05 | 2024-03-11 | Memorial Sloan Kettering Cancer Center | Chimeryczne receptory antygenowe ukierunkowane na antygen dojrzewania komórek b i ich zastosowania |
EP3872094A3 (en) | 2014-12-05 | 2021-12-08 | Memorial Sloan Kettering Cancer Center | Antibodies targeting b-cell maturation antigen and methods of use |
EP3971210A1 (en) | 2014-12-12 | 2022-03-23 | 2seventy bio, Inc. | Composition for use in the treatment of b cell related conditions in a subject in need thereof comprisine an effector cell comrising a bcma chimeric antigen receptors |
US11384350B2 (en) | 2014-12-15 | 2022-07-12 | The Regents Of The University Of California | Cytotoxic molecules responsive to intracellular ligands for selective T cell mediated killing |
TWI700298B (zh) | 2015-04-13 | 2020-08-01 | 美商輝瑞股份有限公司 | 靶向b細胞成熟抗原之嵌合型抗原受體類 |
EP3294873B1 (en) | 2015-05-08 | 2020-08-19 | The Children's Medical Center Corporation | Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction |
EP3331910B1 (en) | 2015-08-03 | 2019-12-11 | EngMab Sàrl | Monoclonal antibodies against human b cell maturation antigen (bcma) |
CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
WO2017099712A1 (en) | 2015-12-07 | 2017-06-15 | Bluebird Bio, Inc. | Improved t cell compositions |
BR112018067679A2 (pt) | 2016-03-04 | 2019-01-15 | Novartis Ag | células que expressam múltiplas moléculas do receptor de antígeno quimérico (car) e seu uso |
TWI795133B (zh) | 2016-04-01 | 2023-03-01 | 美商凱特製藥公司 | Bcma結合分子類及彼等之用途 |
US10597456B2 (en) | 2016-04-01 | 2020-03-24 | Amgen Inc. | Chimeric receptors and methods of use thereof |
IL303785A (en) | 2016-04-01 | 2023-08-01 | Kite Pharma Inc | Chimeric antigen and T cell receptors and methods of use |
CN109415687A (zh) * | 2016-04-07 | 2019-03-01 | 蓝鸟生物公司 | 嵌合抗原受体t细胞组合物 |
EP3471773A4 (en) | 2016-06-21 | 2020-07-08 | Teneobio, Inc. | ANTIBODIES BINDING CD3 |
AU2017319702A1 (en) | 2016-09-02 | 2019-04-11 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
CR20220408A (es) | 2016-09-14 | 2022-10-20 | Teneobio Inc | ANTICUERPOS DE UNIÓN A CD3(Divisional del Expediente 2019-198) |
WO2018085690A1 (en) | 2016-11-04 | 2018-05-11 | Bluebird Bio, Inc. | Anti-bcma car t cell compositions |
AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
US11434299B2 (en) * | 2016-12-21 | 2022-09-06 | Teneobio, Inc. | Anti-BCMA heavy chain-only antibodies |
CN108276493B (zh) * | 2016-12-30 | 2023-11-14 | 南京传奇生物科技有限公司 | 一种嵌合抗原受体及其应用 |
CN110582509A (zh) | 2017-01-31 | 2019-12-17 | 诺华股份有限公司 | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 |
EP4269594A3 (en) | 2017-02-17 | 2023-12-20 | Fred Hutchinson Cancer Center | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
US11261441B2 (en) | 2017-03-29 | 2022-03-01 | Bluebird Bio, Inc. | Vectors and compositions for treating hemoglobinopathies |
SG11201908844YA (en) * | 2017-03-29 | 2019-10-30 | Bluebird Bio Inc | Vectors and compositions for treating hemoglobinopathies |
US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
AU2018263887A1 (en) | 2017-05-01 | 2019-11-21 | Juno Therapeutics, Inc. | Combination of a cell therapy and an immunomodulatory compound |
BR112019023608A2 (pt) | 2017-05-12 | 2020-05-26 | Crispr Therapeutics Ag | Materiais e métodos para células manipuladas e seus usos em imuno-oncologia |
US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
WO2018218135A1 (en) | 2017-05-25 | 2018-11-29 | The Children's Medical Center Corporation | Bcl11a guide delivery |
WO2018232195A1 (en) | 2017-06-14 | 2018-12-20 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
CA3065951A1 (en) | 2017-06-20 | 2018-12-27 | Teneoone, Inc. | Anti-bcma heavy chain-only antibodies |
JP7303126B2 (ja) | 2017-06-20 | 2023-07-04 | テネオバイオ, インコーポレイテッド | 抗bcma重鎖のみ抗体 |
CN107475194B (zh) * | 2017-10-09 | 2018-07-24 | 天津长和生物技术有限公司 | Nkt细胞培养基、培养方法及二者的应用 |
TWI829655B (zh) | 2017-10-18 | 2024-01-21 | 瑞士商諾華公司 | 用於選擇性蛋白質降解的組合物及方法 |
MA50860A (fr) | 2017-11-01 | 2020-09-09 | Juno Therapeutics Inc | Récepterus chimériques d'antigène contre l'antigène de maturation des cellules b et polynucleotides codants |
JP7256197B2 (ja) * | 2017-11-01 | 2023-04-11 | ジュノー セラピューティクス インコーポレイテッド | B細胞成熟抗原に特異的な抗体およびキメラ抗原受容体 |
EP3706754A1 (en) | 2017-11-06 | 2020-09-16 | Juno Therapeutics, Inc. | Combination of a cell therapy and a gamma secretase inhibitor |
EP3710039A4 (en) | 2017-11-13 | 2021-08-04 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR CANCER TREATMENT BY TARGETING THE CLEC2D-KLRB1 PATH |
AU2018369883A1 (en) | 2017-11-15 | 2020-05-28 | Novartis Ag | BCMA-targeting chimeric antigen receptor, CD19-targeting chimeric antigen receptor, and combination therapies |
JP2021503277A (ja) * | 2017-11-20 | 2021-02-12 | ユリウス−マクシミリアン−ウニヴェルシテート・ヴュルツブルク | 非常に低レベルのcd19を発現する骨髄腫細胞を除去するcd19cart細胞 |
KR20200096253A (ko) | 2017-11-30 | 2020-08-11 | 노파르티스 아게 | Bcma-표적화 키메라 항원 수용체, 및 이의 용도 |
CN109971715A (zh) * | 2017-12-28 | 2019-07-05 | 深圳华大生命科学研究院 | 一种扩增特异性car-t细胞的培养方法 |
US20200368268A1 (en) | 2018-01-08 | 2020-11-26 | Novartis Ag | Immune-enhancing rnas for combination with chimeric antigen receptor therapy |
WO2019152660A1 (en) | 2018-01-31 | 2019-08-08 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
US11266690B2 (en) | 2018-02-01 | 2022-03-08 | Nanjing Iaso Biotherapeutics Co., Ltd. | Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof |
US11026975B2 (en) * | 2018-02-01 | 2021-06-08 | Nanjing Iaso Biotherapeutics Co., Ltd. | Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof |
CN110157675B (zh) * | 2018-02-12 | 2022-05-27 | 深圳宾德生物技术有限公司 | 一种靶向性t淋巴细胞及其制备方法和应用 |
WO2019160956A1 (en) | 2018-02-13 | 2019-08-22 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
JP2021514193A (ja) | 2018-02-21 | 2021-06-10 | セルジーン コーポレイション | Bcma結合抗体及びその使用 |
AU2019228128A1 (en) | 2018-03-02 | 2020-09-03 | Cdr-Life Ag | Trispecific antigen binding proteins |
EP3549597A1 (en) * | 2018-04-06 | 2019-10-09 | Heinrich-Heine-Universität Düsseldorf | Synthetic signalling constructs and its use |
CN116514995A (zh) | 2018-04-12 | 2023-08-01 | 上海赛比曼生物科技有限公司 | 靶向bcma的嵌合抗原受体及其制法和应用 |
US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
CA3099364A1 (en) | 2018-05-11 | 2019-11-14 | Crispr Therapeutics Ag | Methods and compositions for treating cancer comprising engineered t cells comprising modified chimeric antigen receptors |
EP3802611A2 (en) | 2018-06-01 | 2021-04-14 | Novartis AG | Binding molecules against bcma and uses thereof |
WO2019232542A2 (en) | 2018-06-01 | 2019-12-05 | Massachusetts Institute Of Technology | Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients |
WO2019241358A2 (en) * | 2018-06-12 | 2019-12-19 | The Regents Of The University Of California | Single-chain bispecific chimeric antigen receptors for the treatment of cancer |
WO2019241426A1 (en) * | 2018-06-13 | 2019-12-19 | Novartis Ag | Bcma chimeric antigen receptors and uses thereof |
US20210261689A1 (en) * | 2018-06-14 | 2021-08-26 | Bluebird Bio, Inc. | Anti-bcma car antibodies, conjugates, and methods of use |
EP3833392A4 (en) * | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | MULTI-SPECIFIC BINDING PROTEINS BINDING TO BCMA, NKG2D AND CD16, AND METHODS OF USE |
SG11202101169PA (en) | 2018-08-10 | 2021-03-30 | Eutilex Co Ltd | Chimeric antigen receptor that binds hla-dr and car-t cell |
EA202190608A1 (ru) * | 2018-08-24 | 2021-06-01 | Шэньчжэнь Преджин Байофарма Ко., Лтд. | Однодоменные анти-bcma антитела и их применение |
CN109134665B (zh) * | 2018-08-24 | 2021-06-11 | 上海先博生物科技有限公司 | 一种基于单域抗体的bcma嵌合抗原受体及应用 |
WO2020047449A2 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
MX2021002393A (es) | 2018-08-31 | 2021-07-15 | Novartis Ag | Metodos de preparacion de celulas que expresan receptores de antigenos quimericos. |
WO2020072700A1 (en) | 2018-10-02 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
WO2020081730A2 (en) | 2018-10-16 | 2020-04-23 | Massachusetts Institute Of Technology | Methods and compositions for modulating microenvironment |
WO2020092455A2 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
EP3873937A2 (en) | 2018-11-01 | 2021-09-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for g protein-coupled receptor class c group 5 member d (gprc5d) |
CA3117978A1 (en) | 2018-11-08 | 2020-05-14 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
AU2019387242A1 (en) * | 2018-11-30 | 2021-06-03 | Windmil Therapeutics, Inc. | Marrow infiltrating lymphocytes (MILs) expressing chimeric antigen receptors (CAR), method of manufacturing same, and method of using in therapy |
KR20210111244A (ko) * | 2018-11-30 | 2021-09-10 | 셀룰래리티 인코포레이티드 | 태반-유래 동종이계 car-t 세포 및 이의 용도 |
WO2020131586A2 (en) | 2018-12-17 | 2020-06-25 | The Broad Institute, Inc. | Methods for identifying neoantigens |
CN109651511B (zh) * | 2018-12-26 | 2020-06-09 | 广州百暨基因科技有限公司 | 一种靶向bcma的嵌合抗原受体及其应用 |
US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
CN113164626A (zh) * | 2019-01-14 | 2021-07-23 | 南京传奇生物科技有限公司 | 嵌合受体多肽及其用途 |
CN111454358A (zh) * | 2019-01-18 | 2020-07-28 | 四川科伦博泰生物医药股份有限公司 | 一种嵌合抗原受体及其应用 |
WO2020176397A1 (en) | 2019-02-25 | 2020-09-03 | Novartis Ag | Mesoporous silica particles compositions for viral delivery |
WO2020186101A1 (en) | 2019-03-12 | 2020-09-17 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
MX2021011196A (es) | 2019-03-15 | 2021-10-22 | Cartesian Therapeutics Inc | Receptores de antigenos quimericos anti-antigeno de maduracion de celulas b (anti-bcma). |
EP3942023A1 (en) | 2019-03-18 | 2022-01-26 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
EP3942025A1 (en) | 2019-03-21 | 2022-01-26 | Novartis AG | Car-t cell therapies with enhanced efficacy |
CA3132587A1 (en) | 2019-03-21 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
EP3946355A4 (en) * | 2019-04-05 | 2023-05-10 | 2seventy bio, Inc. | PREPARATION OF ANTI-BCMA CAR-T CELLS |
WO2020210678A1 (en) | 2019-04-12 | 2020-10-15 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
WO2020219742A1 (en) | 2019-04-24 | 2020-10-29 | Novartis Ag | Compositions and methods for selective protein degradation |
CA3138633A1 (en) | 2019-04-30 | 2020-11-05 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
WO2020236967A1 (en) | 2019-05-20 | 2020-11-26 | The Broad Institute, Inc. | Random crispr-cas deletion mutant |
CR20210622A (es) | 2019-06-14 | 2022-06-27 | Teneobio Inc | Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3 |
CN111850013B (zh) * | 2019-06-25 | 2021-05-18 | 浙江康佰裕生物科技有限公司 | 一种共刺激受体增效的嵌合抗原受体及其应用 |
CN112143700A (zh) * | 2019-06-26 | 2020-12-29 | 上海细胞治疗集团有限公司 | 制备过表达外源基因的免疫效应细胞的方法 |
WO2021030627A1 (en) | 2019-08-13 | 2021-02-18 | The General Hospital Corporation | Methods for predicting outcomes of checkpoint inhibition and treatment thereof |
CA3151344A1 (en) | 2019-08-16 | 2021-02-25 | Janssen Biotech, Inc. | Therapeutic immune cells with improved function and methods for making the same |
US20220298501A1 (en) | 2019-08-30 | 2022-09-22 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
EP4031577A4 (en) * | 2019-09-18 | 2023-12-20 | Board of Regents, The University of Texas System | METHOD FOR CULTURING NATURAL KILLER CELLS AGAINST BCMA-POSITIVE TUMORS |
US20220331363A1 (en) * | 2019-09-20 | 2022-10-20 | Shanghai GenBase Biotechnology Co., Ltd. | Bcma-targeted antibody and chimeric antigen receptor |
WO2021062281A2 (en) * | 2019-09-25 | 2021-04-01 | Fate Therapeutics, Inc. | Multi-targeting effector cells and use thereof |
US11981922B2 (en) | 2019-10-03 | 2024-05-14 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment |
US11793787B2 (en) | 2019-10-07 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis |
US11844800B2 (en) | 2019-10-30 | 2023-12-19 | Massachusetts Institute Of Technology | Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia |
MX2022005152A (es) | 2019-11-05 | 2022-06-29 | Celgene Corp | Uso de receptores de antigenos quimericos anti-bcma. |
BR112022010206A2 (pt) | 2019-11-26 | 2022-11-29 | Novartis Ag | Receptores de antígeno quiméricos e usos dos mesmos |
CN112980886B (zh) * | 2019-12-02 | 2022-02-22 | 河北森朗生物科技有限公司 | 一种能高效制备且应用安全的嵌合抗原受体t细胞及其制备方法与应用 |
CA3161789A1 (en) * | 2019-12-04 | 2021-06-10 | Celularity Inc. | Placenta-derived allogeneic car-t cells and uses thereof |
EP4077398A4 (en) * | 2019-12-16 | 2024-04-10 | Legend Biotech Ireland Ltd | SINGLE DOMAIN ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS TARGETTING BCMA AND METHODS OF USE THEREOF |
MX2022009830A (es) * | 2020-02-12 | 2022-10-28 | Juno Therapeutics Inc | Composiciones de celulas t que expresan receptores de antigenos quimericos dirigidos a bcma y metodos y usos de las mismas. |
CN115087666B (zh) | 2020-02-13 | 2023-10-03 | 北京艺妙神州医药科技有限公司 | 嵌合抗原受体的优化 |
KR20220146530A (ko) | 2020-02-27 | 2022-11-01 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포의 제조 방법 |
BR112022016633A2 (pt) | 2020-02-27 | 2022-12-13 | Novartis Ag | Métodos para produzir células que expressam receptor de antígeno quimérico |
WO2021207689A2 (en) | 2020-04-10 | 2021-10-14 | Juno Therapeutics, Inc. | Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting b-cell maturation antigen |
MX2022013530A (es) | 2020-04-28 | 2023-02-01 | Juno Therapeutics Inc | Combinación de terapia de células t dirigida a bcma y un compuesto inmunomodulador. |
CN115968300A (zh) * | 2020-05-11 | 2023-04-14 | 艾宾妥斯生物公司 | 用于体内转导的载体和方法 |
CN116096862A (zh) | 2020-06-11 | 2023-05-09 | 诺华股份有限公司 | Zbtb32抑制剂及其用途 |
CN116348477A (zh) | 2020-07-20 | 2023-06-27 | 英安塔制药有限公司 | 作为抗病毒剂的功能化肽 |
CN111909271B (zh) * | 2020-08-12 | 2021-03-23 | 深圳市茵冠生物科技有限公司 | 一种基于单域抗体的bcma嵌合抗原受体及其应用 |
JP2023538118A (ja) | 2020-08-21 | 2023-09-06 | ノバルティス アーゲー | Car発現細胞のインビボ生成のための組成物及び方法 |
CN111944850B (zh) * | 2020-08-28 | 2023-03-31 | 澳门大学 | 表达抗cd22嵌合抗原受体和pd-l1阻断蛋白的细胞的制备方法、表达载体及应用 |
US11352363B1 (en) | 2020-11-23 | 2022-06-07 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
WO2022109360A1 (en) | 2020-11-23 | 2022-05-27 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
US11384090B2 (en) | 2020-11-23 | 2022-07-12 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
CN116888474A (zh) | 2020-12-04 | 2023-10-13 | 细胞基因公司 | 嵌合抗原受体(car)t细胞疗法与炎症相关可溶性因子抑制剂的组合用途 |
AU2021401052A1 (en) | 2020-12-18 | 2023-06-22 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
EP4301755A1 (en) | 2021-03-03 | 2024-01-10 | Juno Therapeutics, Inc. | Combination of a t cell therapy and a dgk inhibitor |
WO2022192863A1 (en) * | 2021-03-08 | 2022-09-15 | Flagship Pioneering Innovations Vi, Llc | Lentivirus with altered integrase activity |
IL307598A (en) | 2021-04-16 | 2023-12-01 | Juno Therapeutics Inc | T-cell therapy in patients who have had a previous stem cell transplant |
CA3214683A1 (en) | 2021-04-16 | 2022-10-20 | Julie Ann RYTLEWSKI | Combination therapies with bcma-directed t cell therapy |
CN118056008A (zh) | 2021-04-27 | 2024-05-17 | 诺华股份有限公司 | 病毒载体生产系统 |
CN117916256A (zh) | 2021-05-06 | 2024-04-19 | 朱诺治疗学有限公司 | 用于刺激和转导t细胞的方法 |
US11319325B1 (en) | 2021-05-11 | 2022-05-03 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
CA3221566A1 (en) * | 2021-05-26 | 2022-12-01 | Flagship Pioneering Innovations Vi, Llc | Integrase compositions and methods |
WO2023288267A1 (en) | 2021-07-14 | 2023-01-19 | 2Seventy Bio, Inc. | Engineered t cell receptors fused to binding domains from antibodies |
US11339170B1 (en) | 2021-07-23 | 2022-05-24 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
US11325916B1 (en) | 2021-07-29 | 2022-05-10 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
WO2023021477A1 (en) | 2021-08-20 | 2023-02-23 | Novartis Ag | Methods of making chimeric antigen receptor–expressing cells |
WO2023081735A1 (en) | 2021-11-03 | 2023-05-11 | Celgene Corporation | Chimeric antigen receptors specific for b-cell maturation antigen for use in treating myeloma |
WO2023079494A1 (en) | 2021-11-03 | 2023-05-11 | Janssen Biotech, Inc. | Corticosteriod reduction in treatment with anti-cd38 antibodies |
WO2023081750A1 (en) * | 2021-11-04 | 2023-05-11 | The Children's Hospital Of Philadelphia | Compositions and methods for treating metachromatic leukodystrophy disease and related disorders |
WO2023147515A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Methods of manufacturing cellular compositions |
WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
WO2023230512A1 (en) | 2022-05-26 | 2023-11-30 | 2Seventy Bio, Inc. | Compositions for maintaining lentiviral vector and uses thereof |
WO2024031091A2 (en) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
WO2024077256A1 (en) | 2022-10-07 | 2024-04-11 | The General Hospital Corporation | Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins |
WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
WO2024097905A1 (en) | 2022-11-02 | 2024-05-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
WO2024124044A1 (en) | 2022-12-07 | 2024-06-13 | The Brigham And Women’S Hospital, Inc. | Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression |
WO2024124132A1 (en) | 2022-12-09 | 2024-06-13 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
Family Cites Families (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
ATE86967T1 (de) | 1988-01-09 | 1993-04-15 | Asta Medica Ag | 1,2-bis(aminomethyl)cyclobutan-platin-komplexe. |
US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
US7479269B2 (en) | 1988-11-23 | 2009-01-20 | Genetics Institute, Llc | Methods for selectively enriching TH1 and TH2 cells |
US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
DE69334258D1 (de) | 1992-08-21 | 2009-02-26 | Univ Bruxelles | Immunoglobuline ohne Leichtkette |
ES2162863T3 (es) | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
DE4415263C1 (de) | 1994-04-15 | 1995-11-30 | Asta Medica Ag | Cis-[trans-1,2-Cyclobutanbis(methylamin)-N,N']-[(2S)-lactato-O·1·, O·2·]-platin(II)-trihydrat (Lobaplatin-Trihydrat), seine Herstellung und arzneiliche Verwendung |
US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
AU726198B2 (en) | 1996-03-04 | 2000-11-02 | Targeted Genetics Corporation | Modified rapid expansion methods ("modified-REM") for in vitro propagation of T lymphocytes |
US20020177125A1 (en) | 1997-03-04 | 2002-11-28 | Kamb Carl Alexander | Human rhinovirus assays, and compositions therefrom |
US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
FR2777909B1 (fr) | 1998-04-24 | 2002-08-02 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
JP2004500095A (ja) | 2000-02-24 | 2004-01-08 | エクサイト セラピーズ, インコーポレイテッド | 細胞の同時の刺激および濃縮 |
US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
AU2002238052A1 (en) | 2001-02-20 | 2002-09-04 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
AU2002257420A1 (en) | 2001-05-01 | 2002-11-11 | National Research Council Of Canada | A system for inducible expression in eukaryotic cells |
DE10132502A1 (de) | 2001-07-05 | 2003-01-23 | Gsf Forschungszentrum Umwelt | Angriff auf Tumorzellen mit fehlender, niedriger oder anormaler MHC-Expression durch kombinieren von nicht MHC-Restringierten T-Zellen/NK-Zellen und MHC-Restringierten Zellen |
WO2003057171A2 (en) | 2002-01-03 | 2003-07-17 | The Trustees Of The University Of Pennsylvania | Activation and expansion of t-cells using an engineered multivalent signaling platform |
GB0224442D0 (en) | 2002-10-21 | 2002-11-27 | Molmed Spa | A delivery system |
AU2003300359A1 (en) | 2003-05-08 | 2004-12-13 | Xcyte Therapies, Inc. | Generation and isolation of antigen-specific t cells |
WO2005118788A2 (en) | 2004-05-27 | 2005-12-15 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
FR2872170B1 (fr) | 2004-06-25 | 2006-11-10 | Centre Nat Rech Scient Cnrse | Lentivirus non interactif et non replicatif, preparation et utilisations |
GB0503936D0 (en) | 2005-02-25 | 2005-04-06 | San Raffaele Centro Fond | Method |
JP2008539796A (ja) | 2005-05-20 | 2008-11-20 | バイレクシス コーポレイション | 初代細胞の形質導入 |
WO2007018318A1 (ja) | 2005-08-10 | 2007-02-15 | National University Corporation Kanazawa University | 小脳星状細胞及び/又は籠細胞特異的な遺伝子発現方法 |
GB2444853B (en) | 2006-12-14 | 2010-02-24 | Medical Res Council | Methods & uses |
JP5666903B2 (ja) | 2007-05-23 | 2015-02-12 | サンガモ バイオサイエンシーズ, インコーポレイテッド | 導入遺伝子の発現を増強するための方法および組成物 |
WO2009091826A2 (en) | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
HUE058891T2 (hu) | 2008-08-26 | 2022-09-28 | Hope City | Módszer és készítmények a T-sejtek fokozott tumorellenes effektor mûködésének fokozására |
RS53782B1 (en) | 2008-10-01 | 2015-06-30 | Immatics Biotechnologies Gmbh | TUMOR-ASSOCIATED PEPTIDES PREPARED AND ANTI-CHANGE RESPONSE FOR GLIOBLASTOMA (GBM) AND OTHER CANCER TREATMENTS |
AU2010224160A1 (en) | 2009-03-10 | 2011-09-22 | Biogen Idec Ma Inc. | Anti-BCMA antibodies |
EP2483301A1 (en) | 2009-10-01 | 2012-08-08 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
DK2496698T3 (en) | 2009-11-03 | 2019-04-15 | Hope City | TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRUNCATED T-CELL SELECTION |
US8999398B2 (en) | 2009-11-06 | 2015-04-07 | Transtarget Inc. | Polyclonal bispecific antibody compositions and method of use |
GB201004200D0 (en) | 2010-03-15 | 2010-04-28 | Univ Basel | Spirocyclic compounds and their use as therapeutic agents and diagnostic probes |
US9493740B2 (en) | 2010-09-08 | 2016-11-15 | Baylor College Of Medicine | Immunotherapy of cancer using genetically engineered GD2-specific T cells |
DK3214091T3 (en) | 2010-12-09 | 2019-01-07 | Univ Pennsylvania | USE OF CHEMICAL ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF CANCER |
MX2013008376A (es) | 2011-01-18 | 2013-08-12 | Univ Pennsylvania | Composiciones y metodos para el tratamiento de cancer. |
US20160002601A1 (en) | 2011-03-03 | 2016-01-07 | Stempeutics Research Pvt. Ltd. | Methods of upscaling mesenchymal stromal cell production, compositions and kit thereof |
MX359513B (es) | 2011-03-23 | 2018-10-01 | Hutchinson Fred Cancer Res | Metodo y composiciones para inmunoterapia celular. |
US9476028B2 (en) | 2011-04-13 | 2016-10-25 | Immunicum Ab | Method for proliferation of antigen-specific T cells |
EA201790330A1 (ru) | 2011-05-27 | 2018-02-28 | Глаксо Груп Лимитед | Белки, связывающиеся с bcma (cd269/tnfrsf17) |
US9789139B2 (en) | 2011-06-10 | 2017-10-17 | Bluebird Bio, Inc. | Gene therapy vectors for adrenoleukodystrophy and adrenomyeloneuropathy |
US20140322216A1 (en) | 2011-11-08 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
CA3084919A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
EA033110B1 (ru) | 2012-04-11 | 2019-08-30 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерный рецептор антигена, направленный на антиген созревания b-клеток, кодирующая его нуклеиновая кислота, соответствующие экспрессионный вектор, клетка-хозяин, применения и способы |
US20130280220A1 (en) | 2012-04-20 | 2013-10-24 | Nabil Ahmed | Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes |
AU2013204923A1 (en) | 2012-06-21 | 2014-01-16 | Anthrogenesis Corporation | Modified t lymphocytes having improved specificity |
US9572836B2 (en) | 2012-07-13 | 2017-02-21 | The Trustees Of The University Of Pennsylvania | Methods for assessing the suitability of transduced T cells for administration |
LT2884999T (lt) | 2012-08-20 | 2021-04-12 | Fred Hutchinson Cancer Research Center | Ląstelinės imunoterapijos būdas ir kompozicijos |
CN104769103B (zh) | 2012-09-04 | 2018-06-08 | 塞勒克提斯公司 | 多链嵌合抗原受体和其用途 |
EP2711418B1 (en) | 2012-09-25 | 2017-08-23 | Miltenyi Biotec GmbH | Method for polyclonal stimulation of T cells by flexible nanomatrices |
TW201414837A (zh) | 2012-10-01 | 2014-04-16 | Univ Pennsylvania | 標定基質細胞以治療癌症之組合物和方法 |
JP6441802B2 (ja) | 2012-10-02 | 2018-12-19 | メモリアル スローン ケタリング キャンサー センター | 免疫療法のための組成物および方法 |
WO2014055771A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
JP6401704B2 (ja) | 2012-10-10 | 2018-10-10 | サンガモ セラピューティクス, インコーポレイテッド | T細胞を修飾する化合物およびその使用 |
TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Bcma抗原結合蛋白質 |
AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
CN104781789B (zh) | 2012-12-20 | 2018-06-05 | 三菱电机株式会社 | 车载装置 |
US20150329640A1 (en) | 2012-12-20 | 2015-11-19 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
WO2014130635A1 (en) * | 2013-02-20 | 2014-08-28 | Novartis Ag | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗-cd19嵌合抗原受體治療癌症 |
US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
KR20220119176A (ko) | 2014-02-04 | 2022-08-26 | 카이트 파마 인코포레이티드 | B 세포 악성종양 및 다른 암을 치료하는데 유용한 자가 t 세포 및 그의 조성물의 생산 방법 |
CN106132423B (zh) | 2014-02-14 | 2020-07-31 | 贝里坤制药股份有限公司 | 用诱导型嵌合多肽活化t细胞的方法 |
EP3131927B8 (en) | 2014-04-14 | 2020-12-23 | Cellectis | Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy |
NZ725169A (en) | 2014-04-25 | 2018-02-23 | Bluebird Bio Inc | Mnd promoter chimeric antigen receptors |
RU2741899C2 (ru) | 2014-04-25 | 2021-01-29 | Блубёрд Био, Инк. | Улучшенные способы производства средств адоптивной клеточной терапии |
WO2015164739A1 (en) | 2014-04-25 | 2015-10-29 | Bluebird Bio, Inc. | Kappa/lambda chimeric antigen receptors |
CA2951044C (en) | 2014-06-06 | 2023-10-03 | Bluebird Bio, Inc. | Improved t cell compositions |
RU2751660C2 (ru) | 2014-07-21 | 2021-07-15 | Новартис Аг | Лечение злокачественного новообразования с использованием гуманизированного химерного антигенного рецептора против всма |
US20170226216A1 (en) | 2014-07-24 | 2017-08-10 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
EP3971210A1 (en) | 2014-12-12 | 2022-03-23 | 2seventy bio, Inc. | Composition for use in the treatment of b cell related conditions in a subject in need thereof comprisine an effector cell comrising a bcma chimeric antigen receptors |
WO2016164429A1 (en) | 2015-04-06 | 2016-10-13 | The General Hospital Corporation | Anti-cspg4 chimeric antigen receptors |
WO2017099712A1 (en) | 2015-12-07 | 2017-06-15 | Bluebird Bio, Inc. | Improved t cell compositions |
US9916433B2 (en) | 2016-02-10 | 2018-03-13 | ContinUse Biometrics Ltd. | Condition authentication based upon temporal-spatial analysis of vibrational responsivity |
WO2018085690A1 (en) | 2016-11-04 | 2018-05-11 | Bluebird Bio, Inc. | Anti-bcma car t cell compositions |
-
2015
- 2015-12-07 EP EP21187802.0A patent/EP3971210A1/en active Pending
- 2015-12-07 KR KR1020177019116A patent/KR102584938B1/ko active IP Right Grant
- 2015-12-07 US US15/535,365 patent/US10383929B2/en active Active
- 2015-12-07 EA EA201791310A patent/EA036379B1/ru unknown
- 2015-12-07 RS RS20211267A patent/RS62527B1/sr unknown
- 2015-12-07 HU HUE15868392A patent/HUE046815T2/hu unknown
- 2015-12-07 RS RS20191327A patent/RS59537B1/sr unknown
- 2015-12-07 KR KR1020237033164A patent/KR20230146100A/ko not_active Application Discontinuation
- 2015-12-07 JP JP2017531301A patent/JP6671370B2/ja active Active
- 2015-12-07 HR HRP20211648TT patent/HRP20211648T1/hr unknown
- 2015-12-07 EP EP19210785.2A patent/EP3640262A1/en active Pending
- 2015-12-07 EP EP19193858.8A patent/EP3628687B1/en active Active
- 2015-12-07 WO PCT/US2015/064269 patent/WO2016094304A2/en active Application Filing
- 2015-12-07 LT LTEP19193858.8T patent/LT3628687T/lt unknown
- 2015-12-07 MX MX2017007575A patent/MX2017007575A/es unknown
- 2015-12-07 ES ES19193858T patent/ES2895640T3/es active Active
- 2015-12-07 EP EP15868392.0A patent/EP3230321B1/en active Active
- 2015-12-07 HU HUE19193858A patent/HUE056074T2/hu unknown
- 2015-12-07 AU AU2015360845A patent/AU2015360845B2/en active Active
- 2015-12-07 SI SI201531734T patent/SI3628687T1/sl unknown
- 2015-12-07 DK DK19193858.8T patent/DK3628687T3/da active
- 2015-12-07 SI SI201530905T patent/SI3230321T1/sl unknown
- 2015-12-07 PL PL15868392T patent/PL3230321T3/pl unknown
- 2015-12-07 PT PT158683920T patent/PT3230321T/pt unknown
- 2015-12-07 NZ NZ733025A patent/NZ733025A/en unknown
- 2015-12-07 DK DK15868392T patent/DK3230321T3/da active
- 2015-12-07 SG SG10202013144UA patent/SG10202013144UA/en unknown
- 2015-12-07 PL PL19193858T patent/PL3628687T3/pl unknown
- 2015-12-07 ES ES15868392T patent/ES2750725T3/es active Active
- 2015-12-07 CN CN201580073309.6A patent/CN107207598B/zh active Active
- 2015-12-07 CN CN202011266755.8A patent/CN112358551B/zh active Active
- 2015-12-07 CA CA2970466A patent/CA2970466A1/en active Pending
- 2015-12-07 BR BR112017012502-1A patent/BR112017012502B1/pt active IP Right Grant
- 2015-12-07 PT PT191938588T patent/PT3628687T/pt unknown
- 2015-12-07 LT LT15868392T patent/LT3230321T/lt unknown
- 2015-12-07 SG SG11201704727WA patent/SG11201704727WA/en unknown
-
2017
- 2017-06-08 IL IL252783A patent/IL252783B/en active IP Right Grant
- 2017-06-09 MX MX2021007011A patent/MX2021007011A/es unknown
- 2017-06-12 CL CL2017001515A patent/CL2017001515A1/es unknown
- 2017-06-13 ZA ZA2017/04059A patent/ZA201704059B/en unknown
- 2017-07-06 CO CONC2017/0006808A patent/CO2017006808A2/es unknown
- 2017-07-12 EC ECIEPI201744494A patent/ECSP17044494A/es unknown
-
2018
- 2018-03-26 HK HK18104137.6A patent/HK1245801B/zh unknown
- 2018-06-12 CL CL2018001556A patent/CL2018001556A1/es unknown
-
2019
- 2019-07-03 US US16/502,972 patent/US10624960B2/en active Active
- 2019-07-03 US US16/502,966 patent/US10639358B2/en active Active
- 2019-07-08 US US16/504,859 patent/US10646558B2/en active Active
- 2019-07-08 US US16/504,853 patent/US10639359B2/en active Active
- 2019-10-10 CY CY20191101066T patent/CY1122528T1/el unknown
- 2019-10-15 HR HRP20191873TT patent/HRP20191873T1/hr unknown
-
2020
- 2020-03-03 JP JP2020035520A patent/JP7065136B2/ja active Active
- 2020-04-01 US US16/837,610 patent/US11633463B2/en active Active
- 2020-10-23 US US17/079,037 patent/US11382965B2/en active Active
- 2020-10-23 US US17/078,950 patent/US11351236B2/en active Active
- 2020-10-23 US US17/079,006 patent/US20210077603A1/en active Pending
- 2020-10-23 US US17/079,072 patent/US11020466B2/en active Active
-
2021
- 2021-02-22 AU AU2021201147A patent/AU2021201147A1/en active Pending
- 2021-03-14 IL IL281484A patent/IL281484B/en unknown
- 2021-10-20 CY CY20211100919T patent/CY1124886T1/el unknown
-
2022
- 2022-04-25 JP JP2022071485A patent/JP7375098B2/ja active Active
-
2023
- 2023-10-25 JP JP2023183217A patent/JP2023178438A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20211648T1 (hr) | Kimerni receptori antigena bcma | |
HRP20211910T1 (hr) | Mnd promotor himerni antigen receptori | |
HRP20211566T1 (hr) | Antigeni, vektori, pripravci virusa humane imunodeficijencije i postupci njihove uporabe | |
RU2014100160A (ru) | Векторы генной терапии адренолейкодистрофии и адреномиелонейропатии | |
Haynes et al. | Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates | |
US20170166623A1 (en) | Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule | |
RU2017130985A (ru) | Фармацевтическая композиция и способ снижения ингибирующего эффекта pd-l1 на т-клетки человека | |
JP2018526028A5 (hr) | ||
EP2926830A3 (en) | Human immunodeficiency virus (HIV)-neutralizing antibodies | |
JP2019515672A (ja) | 免疫調整性il2r融合タンパク質およびその使用 | |
JP2018514209A5 (hr) | ||
US9752160B2 (en) | Use of non-subtype B gag proteins for lentiviral packaging | |
US20200331975A1 (en) | Dap10/12 based cars adapted for rush | |
JP2019536484A5 (hr) | ||
US7378515B2 (en) | Synthetic gagpol genes and their uses | |
WO2002087341A1 (en) | Novel self-inactivating (sin) lentiviral vectors | |
Maetzig et al. | Retroviral protein transfer: falling apart to make an impact | |
Yen et al. | Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques | |
Richardson et al. | Intrabody-mediated knockout of the high-affinity IL-2 receptor in primary human T cells using a bicistronic lentivirus vector | |
Wolfrum et al. | Impact of viral accessory proteins of SIVsmmPBj on early steps of infection of quiescent cells | |
WO2015111024A1 (en) | Lentiviral vectors for generating immune responses against human t lymphotrophic virus type 1 | |
Spirin et al. | Lentiviral vectors | |
JP2014528699A5 (hr) | ||
JP2020500562A5 (hr) | ||
Gholami et al. | Production of Recombinant Proteins through Viral Vector Engineering |