SG11202107825WA - Mesoporous silica particles compositions for viral delivery - Google Patents
Mesoporous silica particles compositions for viral deliveryInfo
- Publication number
- SG11202107825WA SG11202107825WA SG11202107825WA SG11202107825WA SG11202107825WA SG 11202107825W A SG11202107825W A SG 11202107825WA SG 11202107825W A SG11202107825W A SG 11202107825WA SG 11202107825W A SG11202107825W A SG 11202107825WA SG 11202107825W A SG11202107825W A SG 11202107825WA
- Authority
- SG
- Singapore
- Prior art keywords
- silica particles
- mesoporous silica
- viral delivery
- particles compositions
- compositions
- Prior art date
Links
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
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- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/4643—Vertebrate antigens
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- A61K39/464403—Receptors for growth factors
- A61K39/464404—Epidermal growth factor receptors [EGFR]
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
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- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- A61K9/51—Nanocapsules; Nanoparticles
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- C12N15/86—Viral vectors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C—CHEMISTRY; METALLURGY
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- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- C12N2510/00—Genetically modified cells
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962810260P | 2019-02-25 | 2019-02-25 | |
PCT/US2020/019461 WO2020176397A1 (en) | 2019-02-25 | 2020-02-24 | Mesoporous silica particles compositions for viral delivery |
Publications (1)
Publication Number | Publication Date |
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SG11202107825WA true SG11202107825WA (en) | 2021-09-29 |
Family
ID=69941486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202107825WA SG11202107825WA (en) | 2019-02-25 | 2020-02-24 | Mesoporous silica particles compositions for viral delivery |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220152150A1 (en) |
EP (1) | EP3930763A1 (en) |
JP (1) | JP2022523204A (en) |
KR (1) | KR20210134339A (en) |
CN (1) | CN113412127A (en) |
AR (2) | AR118185A1 (en) |
AU (1) | AU2020229806A1 (en) |
CA (1) | CA3126087A1 (en) |
CL (2) | CL2021002249A1 (en) |
IL (1) | IL284631A (en) |
MX (1) | MX2021010150A (en) |
SG (1) | SG11202107825WA (en) |
TW (1) | TW202045207A (en) |
WO (1) | WO2020176397A1 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2901960C (en) | 2013-02-20 | 2022-10-04 | Novartis Ag | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
ES2769574T3 (en) | 2013-03-15 | 2020-06-26 | Michael C Milone | Recognition of cytotoxic cells with chimeric receptors for adoptive immunotherapy |
TW202140557A (en) | 2014-08-19 | 2021-11-01 | 瑞士商諾華公司 | Treatment of cancer using a cd123 chimeric antigen receptor |
JP7114457B2 (en) | 2015-04-17 | 2022-08-08 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Methods for Improving Efficacy and Growth of Chimeric Antigen Receptor-Expressing Cells |
WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
CN108780084B (en) | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | Biomarkers predictive of cytokine release syndrome |
EP3432924A1 (en) | 2016-03-23 | 2019-01-30 | Novartis AG | Cell secreted minibodies and uses thereof |
WO2018067992A1 (en) | 2016-10-07 | 2018-04-12 | Novartis Ag | Chimeric antigen receptors for the treatment of cancer |
US11535662B2 (en) | 2017-01-26 | 2022-12-27 | Novartis Ag | CD28 compositions and methods for chimeric antigen receptor therapy |
CA3100724A1 (en) | 2018-06-13 | 2019-12-19 | Novartis Ag | B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof |
EP3976196A4 (en) * | 2019-05-29 | 2023-06-14 | Orbis Health Solutions, LLC | Delivery vectors and particles for expressing chimeric receptors and methods of using the same |
EP4199960A2 (en) * | 2020-08-21 | 2023-06-28 | Novartis AG | Compositions and methods for in vivo generation of car expressing cells |
WO2022121966A1 (en) * | 2020-12-10 | 2022-06-16 | Wuxi Biologics (Shanghai) Co., Ltd. | An antibody against p-cadherin and uses thereof |
WO2022194742A1 (en) * | 2021-03-17 | 2022-09-22 | Miltenyi Biotec B.V. & Co. KG | Artificial target for the antigen-specific activation and expansion of car t cells |
CA3218362A1 (en) | 2021-04-27 | 2022-11-03 | Novartis Ag | Viral vector production system |
WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR901228A (en) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Ring gap magnet system |
US5869620A (en) | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
GB9012995D0 (en) | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
WO1994009817A1 (en) | 1992-11-04 | 1994-05-11 | City Of Hope | Novel antibody construct |
US5395619A (en) | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
CA2293632C (en) | 1997-06-12 | 2011-11-29 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
PL207501B1 (en) | 1999-08-17 | 2010-12-31 | Apotech R & D Sa | Baff receptor (bcma), an immunoregulatory agent |
US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
EP1362061A2 (en) | 2001-02-20 | 2003-11-19 | ZymoGenetics, Inc. | Antibodies that bind both bcma and taci |
CN1294148C (en) | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | Single-stranded cyctic trispecific antibody |
US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
WO2005004809A2 (en) | 2003-07-01 | 2005-01-20 | Immunomedics, Inc. | Multivalent carriers of bi-specific antibodies |
US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
WO2006020258A2 (en) | 2004-07-17 | 2006-02-23 | Imclone Systems Incorporated | Novel tetravalent bispecific antibody |
SG2014010029A (en) | 2005-08-19 | 2014-08-28 | Abbott Lab | Dual variable domain immunoglobin and uses thereof |
DK2406284T5 (en) | 2009-03-10 | 2017-06-12 | Biogen Ma Inc | ANTI-BCMA ANTIBODIES |
EP2514718A4 (en) | 2009-12-18 | 2013-09-04 | Kao Corp | Method for producing mesoporous silica particles |
JP5603063B2 (en) | 2009-12-21 | 2014-10-08 | 花王株式会社 | Method for producing composite silica particles |
RU2012141952A (en) | 2010-03-02 | 2014-04-10 | Кинг Абдулла Юнивесити Ов Сайенс Энд Текнолэджи | SILICON OXIDE FIBER NANOPARTICLES WITH DEVELOPED SURFACE |
WO2011108649A1 (en) | 2010-03-04 | 2011-09-09 | 地方独立行政法人東京都立産業技術研究センター | Process for producing porous silica, and porous silica |
WO2012066058A1 (en) | 2010-11-16 | 2012-05-24 | Boehringer Ingelheim International Gmbh | Agents and methods for treating diseases that correlate with bcma expression |
CN108103085A (en) | 2010-12-09 | 2018-06-01 | 宾夕法尼亚大学董事会 | The purposes of the T cell treating cancer of Chimeric antigen receptor-modification |
US20130101599A1 (en) | 2011-04-21 | 2013-04-25 | Boehringer Ingelheim International Gmbh | Bcma-based stratification and therapy for multiple myeloma patients |
UA112434C2 (en) | 2011-05-27 | 2016-09-12 | Ґлаксо Ґруп Лімітед | ANTIGENCY BINDING SPECIFICALLY Binds to ALL |
CN106279418A (en) | 2011-05-27 | 2017-01-04 | 葛兰素集团有限公司 | BCMA(CD269/TNFRSF17) associated proteins |
TWI679212B (en) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | Binding molecules for e3 of bcma and cd3 |
US20130145488A1 (en) | 2011-12-06 | 2013-06-06 | Iowa State University Research Foundation, Inc. | Mesoporous silica nanoparticles suitable for co-delivery |
JP2015513399A (en) | 2012-02-22 | 2015-05-14 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Compositions and methods for generating surviving populations of T cells useful for the treatment of cancer |
EP2836239A1 (en) | 2012-04-11 | 2015-02-18 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Chimeric antigen receptors targeting b-cell maturation antigen |
PT2838515T (en) | 2012-04-16 | 2020-02-25 | Harvard College | Mesoporous silica compositions for modulating immune responses |
UA119227C2 (en) | 2012-04-20 | 2019-05-27 | Аптево Рісьорч Енд Девелопмент Ллс | Cd3 binding polypeptides |
EP2904106A4 (en) | 2012-10-01 | 2016-05-11 | Univ Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
US10117896B2 (en) | 2012-10-05 | 2018-11-06 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
AU2013340799B2 (en) | 2012-11-01 | 2018-08-09 | Max-Delbruck-Centrum Fur Molekulare Medizin (Mdc) | An antibody that binds CD269 (BCMA) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
US9243058B2 (en) | 2012-12-07 | 2016-01-26 | Amgen, Inc. | BCMA antigen binding proteins |
CN111848796A (en) | 2013-02-05 | 2020-10-30 | 英格玛布有限责任公司 | Method for selecting antibodies against BCMA |
CA2901960C (en) | 2013-02-20 | 2022-10-04 | Novartis Ag | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
ES2814962T3 (en) | 2013-02-20 | 2021-03-29 | Novartis Ag | Efficient targeting of primary human leukemia using anti-CD123 chimeric antigen receptor modified T cells |
AR095374A1 (en) | 2013-03-15 | 2015-10-14 | Amgen Res (Munich) Gmbh | UNION MOLECULES FOR BCMA AND CD3 |
TWI654206B (en) | 2013-03-16 | 2019-03-21 | 諾華公司 | Treatment of cancer with a humanized anti-CD19 chimeric antigen receptor |
SG11201604815RA (en) | 2013-12-19 | 2016-07-28 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
KR20200032763A (en) | 2014-02-04 | 2020-03-26 | 카이트 파마 인코포레이티드 | Methods for producing autologous t cells useful to treat b cell malignancies and other cancers and compositions thereof |
ES2939760T3 (en) | 2014-03-15 | 2023-04-26 | Novartis Ag | Cancer treatment using a chimeric receptor for antigens |
CA2940671A1 (en) | 2014-04-07 | 2015-10-15 | Novartis Ag | Treatment of cancer using anti-cd19 chimeric antigen receptor |
EP3131927B8 (en) | 2014-04-14 | 2020-12-23 | Cellectis | Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy |
NZ725169A (en) | 2014-04-25 | 2018-02-23 | Bluebird Bio Inc | Mnd promoter chimeric antigen receptors |
PL3134095T3 (en) | 2014-04-25 | 2020-10-19 | Bluebird Bio, Inc. | Improved methods for manufacturing adoptive cell therapies |
US10144782B2 (en) | 2014-04-30 | 2018-12-04 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft | Humanized antibodies against CD269 (BCMA) |
JP2017521998A (en) | 2014-05-12 | 2017-08-10 | ヌマブ アクチェンゲゼルシャフト | Novel multispecific molecules and novel therapeutic methods based on such multispecific molecules |
PL3151672T3 (en) | 2014-06-06 | 2021-05-31 | Bluebird Bio, Inc. | Improved t cell compositions |
TWI718992B (en) | 2014-07-21 | 2021-02-21 | 瑞士商諾華公司 | Treatment of cancer using a cll-1 chimeric antigen receptor |
RU2747384C2 (en) | 2014-07-21 | 2021-05-04 | Новартис Аг | Cancer treatment with chimeric cd33 antigen receptor |
SG11201700476VA (en) | 2014-07-21 | 2017-02-27 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
AU2015292590B2 (en) | 2014-07-24 | 2020-01-16 | 2Seventy Bio, Inc. | BCMA chimeric antigen receptors |
EP2982692A1 (en) | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
WO2016025880A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using gfr alpha-4 chimeric antigen receptor |
TW202140557A (en) | 2014-08-19 | 2021-11-01 | 瑞士商諾華公司 | Treatment of cancer using a cd123 chimeric antigen receptor |
EP3023437A1 (en) | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
EP3029068A1 (en) | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
LT3226897T (en) | 2014-12-05 | 2021-05-25 | Memorial Sloan Kettering Cancer Center | Antibodies targeting b-cell maturation antigen and methods of use |
FI3227432T3 (en) | 2014-12-05 | 2024-01-09 | Memorial Sloan Kettering Cancer Center | Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof |
KR20230146100A (en) | 2014-12-12 | 2023-10-18 | 2세븐티 바이오, 인코포레이티드 | Bcma chimeric antigen receptors |
WO2016130598A1 (en) | 2015-02-09 | 2016-08-18 | University Of Florida Research Foundation, Inc. | Bi-specific chimeric antigen receptor and uses thereof |
WO2016154055A1 (en) | 2015-03-20 | 2016-09-29 | Bluebird Bio, Inc. | Vector formulations |
MX2017012939A (en) | 2015-04-08 | 2018-05-22 | Novartis Ag | Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell. |
DK3283106T3 (en) | 2015-04-13 | 2022-01-10 | Pfizer | Therapeutic antibodies and uses thereof |
MX2017013298A (en) | 2015-04-13 | 2018-06-19 | Pfizer | Chimeric antigen receptors targeting b-cell maturation antigen. |
AU2016283102B2 (en) | 2015-06-25 | 2021-03-11 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (CARs), compositions and methods of use thereof |
CN108026174B (en) | 2015-07-10 | 2023-02-17 | 美勒斯公司 | Human CD3 binding antibodies |
MA42895A (en) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | MODIFIED CELLS FOR ADOPTIVE CELL THERAPY |
CN108137706A (en) | 2015-07-15 | 2018-06-08 | 酵活有限公司 | The bispecific antigen-binding constructs of drug conjugate |
DK3331910T3 (en) | 2015-08-03 | 2020-03-16 | Engmab Sarl | MONOCLONAL ANTIBODIES AGAINST HUMANT B CELL REFRIGERATION ANTIGEN (BCMA) |
CN105384825B (en) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | A kind of bispecific chimeric antigen receptor and its application based on single domain antibody |
WO2017031104A1 (en) | 2015-08-17 | 2017-02-23 | Janssen Pharmaceutica Nv | Anti-bcma antibodies, bispecific antigen binding molecules that bind bcma and cd3, and uses thereof |
JP7082055B2 (en) | 2015-12-22 | 2022-06-07 | ノバルティス アーゲー | Antibodies to Mesothelin Chimeric Antigen Receptor (CAR) and PD-L1 Inhibitors for Combined Use in Anticancer Treatment |
CN115305229A (en) | 2016-07-13 | 2022-11-08 | 哈佛学院院长等 | Antigen presenting cell mimetic scaffolds and methods of making and using same |
WO2018067992A1 (en) | 2016-10-07 | 2018-04-12 | Novartis Ag | Chimeric antigen receptors for the treatment of cancer |
CA3100724A1 (en) | 2018-06-13 | 2019-12-19 | Novartis Ag | B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof |
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CL2021002249A1 (en) | 2022-04-22 |
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