ZA201704059B - Bcma chimeric antigen receptors - Google Patents

Bcma chimeric antigen receptors

Info

Publication number
ZA201704059B
ZA201704059B ZA2017/04059A ZA201704059A ZA201704059B ZA 201704059 B ZA201704059 B ZA 201704059B ZA 2017/04059 A ZA2017/04059 A ZA 2017/04059A ZA 201704059 A ZA201704059 A ZA 201704059A ZA 201704059 B ZA201704059 B ZA 201704059B
Authority
ZA
South Africa
Prior art keywords
chimeric antigen
antigen receptors
bcma chimeric
bcma
receptors
Prior art date
Application number
ZA2017/04059A
Other languages
English (en)
Inventor
Richard Morgan
Kevin Friedman
Original Assignee
Bluebird Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bluebird Bio Inc filed Critical Bluebird Bio Inc
Publication of ZA201704059B publication Critical patent/ZA201704059B/en

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70517—CD8
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    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/09—Recombinant DNA-technology
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
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ZA2017/04059A 2014-12-12 2017-06-13 Bcma chimeric antigen receptors ZA201704059B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462091419P 2014-12-12 2014-12-12
US201562200505P 2015-08-03 2015-08-03
PCT/US2015/064269 WO2016094304A2 (en) 2014-12-12 2015-12-07 Bcma chimeric antigen receptors

Publications (1)

Publication Number Publication Date
ZA201704059B true ZA201704059B (en) 2021-08-25

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ZA2017/04059A ZA201704059B (en) 2014-12-12 2017-06-13 Bcma chimeric antigen receptors

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US (11) US10383929B2 (enExample)
EP (4) EP3640262A1 (enExample)
JP (4) JP6671370B2 (enExample)
KR (3) KR20240166596A (enExample)
CN (2) CN112358551B (enExample)
AU (2) AU2015360845B2 (enExample)
BR (1) BR112017012502B1 (enExample)
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ES2759260T3 (es) 2014-04-23 2020-05-08 Juno Therapeutics Inc Métodos para aislar, cultivar y modificar genéticametne poblaciones de células inmunes para la terapia adoptiva
RU2708311C2 (ru) 2014-04-25 2019-12-05 Блубёрд Био, Инк. Химерные антигенные рецепторы с mnd-промотором
BR112016024565A2 (pt) 2014-04-25 2018-01-23 Children's Medical Center Corporation composições e métodos de tratar hemoglobinopatias
DK3134095T3 (da) 2014-04-25 2020-06-29 Bluebird Bio Inc Forbedrede fremgangsmåder til fremstilling af adoptive celleterapier
SI3151672T1 (sl) 2014-06-06 2021-03-31 Bluebird Bio, Inc. Izboljšani T-celični sestavki
KR102612313B1 (ko) 2014-07-21 2023-12-12 노파르티스 아게 인간화 항-bcma 키메라 항원 수용체를 사용한 암의 치료
US20170226216A1 (en) * 2014-07-24 2017-08-10 Bluebird Bio, Inc. Bcma chimeric antigen receptors
CN113603795A (zh) 2014-12-05 2021-11-05 纪念斯隆-凯特琳癌症中心 靶向b-细胞成熟抗原的嵌合抗原受体及其用途
SMT202100221T1 (it) 2014-12-05 2021-07-12 Memorial Sloan Kettering Cancer Center Anticorpi bersaglianti l'antigene di maturazione delle cellule e metodi d'uso
EP3640262A1 (en) 2014-12-12 2020-04-22 Bluebird Bio, Inc. Bcma chimeric antigen receptors for use in the treatment of a hematological malignancy
US11253546B2 (en) 2014-12-15 2022-02-22 The Regents Of The University Of California Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20
US11384350B2 (en) 2014-12-15 2022-07-12 The Regents Of The University Of California Cytotoxic molecules responsive to intracellular ligands for selective T cell mediated killing
KR102528825B1 (ko) 2015-04-13 2023-05-08 화이자 인코포레이티드 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체
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