SG11201701040XA - Chimeric antigen receptors - Google Patents
Chimeric antigen receptorsInfo
- Publication number
- SG11201701040XA SG11201701040XA SG11201701040XA SG11201701040XA SG11201701040XA SG 11201701040X A SG11201701040X A SG 11201701040XA SG 11201701040X A SG11201701040X A SG 11201701040XA SG 11201701040X A SG11201701040X A SG 11201701040XA SG 11201701040X A SG11201701040X A SG 11201701040XA
- Authority
- SG
- Singapore
- Prior art keywords
- chimeric antigen
- antigen receptors
- receptors
- chimeric
- antigen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462052947P | 2014-09-19 | 2014-09-19 | |
US201462052901P | 2014-09-19 | 2014-09-19 | |
US201462076836P | 2014-11-07 | 2014-11-07 | |
US201462094603P | 2014-12-19 | 2014-12-19 | |
US201562167650P | 2015-05-28 | 2015-05-28 | |
PCT/US2015/050975 WO2016044745A1 (en) | 2014-09-19 | 2015-09-18 | Chimeric antigen receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201701040XA true SG11201701040XA (en) | 2017-03-30 |
Family
ID=54261082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201701040XA SG11201701040XA (en) | 2014-09-19 | 2015-09-18 | Chimeric antigen receptors |
Country Status (13)
Country | Link |
---|---|
US (1) | US20160081314A1 (en) |
EP (1) | EP3193592A1 (en) |
JP (1) | JP2017529841A (en) |
KR (1) | KR20170083534A (en) |
CN (1) | CN107072184A (en) |
AU (1) | AU2015317370A1 (en) |
BR (1) | BR112017005245A2 (en) |
CA (1) | CA2959428A1 (en) |
IL (1) | IL250536A0 (en) |
MX (1) | MX2017003640A (en) |
RU (1) | RU2017113134A (en) |
SG (1) | SG11201701040XA (en) |
WO (1) | WO2016044745A1 (en) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
CN105264127B (en) | 2013-03-15 | 2019-04-09 | Gpb科学有限责任公司 | The on piece microfluidic process of particle |
CN113512522A (en) | 2013-03-15 | 2021-10-19 | 普林斯顿大学理事会 | Method and apparatus for high throughput purification |
US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
SG11201606583VA (en) * | 2014-03-05 | 2016-09-29 | Ucl Business Plc | Chimeric antigen receptor (car) with antigen binding domains to the t cell receptor beta constant region |
US20230021548A1 (en) | 2014-03-05 | 2023-01-26 | Autolus Limited | Methods |
FR3029449B1 (en) * | 2014-12-03 | 2017-10-13 | Pole De Plasturgie De Lest | MOLDING DEVICE FOR MANUFACTURING COMPOSITE MATERIAL PARTS FROM LIQUID POLYMER RESIN. |
MX2017008190A (en) * | 2014-12-19 | 2018-03-23 | Regeneron Pharma | Methods and compositions for targeted genetic modification through single-step multiple targeting. |
SG11201708706YA (en) | 2015-05-06 | 2017-11-29 | Snipr Tech Ltd | Altering microbial populations & modifying microbiota |
US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
CA3001008A1 (en) | 2015-10-05 | 2017-04-13 | Precision Biosciences, Inc. | Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene |
EP4108255A1 (en) | 2015-10-05 | 2022-12-28 | Precision Biosciences, Inc. | Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene |
UA123276C2 (en) | 2016-04-01 | 2021-03-10 | Кайт Фарма, Інк. | Chimeric receptors and methods of use thereof |
KR102591930B1 (en) | 2016-04-01 | 2023-10-24 | 카이트 파마 인코포레이티드 | Bcma binding molecules and methods of use thereof |
WO2017173256A1 (en) | 2016-04-01 | 2017-10-05 | Kite Pharma, Inc. | Chimeric antigen and t cell receptors and methods of use |
EP4180519A1 (en) | 2016-04-15 | 2023-05-17 | Memorial Sloan Kettering Cancer Center | Transgenic t cell and chimeric antigen receptor t cell compositions and related methods |
RU2753585C2 (en) * | 2016-06-03 | 2021-08-18 | Регенерон Фармасьютикалз, Инк. | Non-human animals expressing exogenous terminal deoxynucleotidyl transferase |
GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
WO2018011573A1 (en) * | 2016-07-12 | 2018-01-18 | Kymab Limited | Animals, cells, ligands, polypeptides & methods |
EP3504245A4 (en) * | 2016-08-23 | 2020-04-22 | The Regents of The University of California | Proteolytically cleavable chimeric polypeptides and methods of use thereof |
WO2018075586A1 (en) * | 2016-10-18 | 2018-04-26 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins targeting melanoma differentiation antigens and uses thereof |
EP3558368A4 (en) | 2016-12-23 | 2020-12-30 | MacroGenics, Inc. | Adam9-binding molecules, and methods of use thereof |
EP3579877A4 (en) * | 2017-02-09 | 2020-12-09 | The Regents of The University of California | Chimeric t cell antigen receptors and methods of use thereof |
TW201837175A (en) | 2017-03-13 | 2018-10-16 | 美商凱特製藥公司 | Chimeric antigen receptors for melanoma and uses thereof |
WO2018184558A1 (en) * | 2017-04-05 | 2018-10-11 | 凯惠科技发展(上海)有限公司 | Humanized anti-tpbg antibody, preparation method therefor, conjugate thereof, and applications |
JOP20180042A1 (en) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | Humanized Antigen-Binding Domains and Methods of Use |
US11053484B2 (en) | 2017-06-30 | 2021-07-06 | Precision Biosciences, Inc. | Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene |
KR20200033259A (en) | 2017-07-31 | 2020-03-27 | 리제너론 파마슈티칼스 인코포레이티드 | Methods and compositions for evaluating CRISPR / Cas-mediated destruction or deletion in vivo and CRISPR / Cas-induced recombination with exogenous donor nucleic acids |
KR20200032693A (en) | 2017-07-31 | 2020-03-26 | 리제너론 파마슈티칼스 인코포레이티드 | Cas-transformed mouse embryonic stem cells and mice and uses thereof |
AU2018323875A1 (en) | 2017-09-01 | 2020-04-23 | Gpb Scientific, Inc. | Methods for preparing therapeutically active cells using microfluidics |
IL310960A (en) | 2017-09-22 | 2024-04-01 | Wuxi Biologics Ireland Ltd | Novel bispecific polypeptide complexes |
CN109535257B (en) | 2017-09-22 | 2021-05-28 | 同润生物医药(上海)有限公司 | Novel bispecific CD3/CD19 polypeptide complex |
KR20230034416A (en) | 2017-10-27 | 2023-03-09 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | Targeted replacement of endogenous t cell receptors |
WO2019099707A1 (en) | 2017-11-16 | 2019-05-23 | Kite Pharma, Inc | Modified chimeric antigen receptors and methods of use |
AU2018375796A1 (en) * | 2017-11-30 | 2020-04-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized TRKB locus |
JP2021513839A (en) | 2018-02-16 | 2021-06-03 | カイト ファーマ インコーポレイテッドKite Pharma, Inc | Modified pluripotent stem cells and manufacturing method and usage method |
CN116349651A (en) | 2018-03-19 | 2023-06-30 | 瑞泽恩制药公司 | Transcription modulation of animals using CRISPR/CAS systems |
BR112020019026A2 (en) * | 2018-03-24 | 2020-12-29 | Regeneron Pharmaceuticals, Inc. | GENETICALLY MODIFIED NON-HUMAN ANIMAL, METHODS FOR PRODUCING GENETICALLY MODIFIED NON-HUMAN ANIMAL, FOR GENERATION OF AN ANTIGEN-BINDING PROTEIN, FOR OBTAINING A NUCLEIC ACID, AND FOR OBTAINING A CELL THAT EXPRESSES AN IMMUNOGLOBULIN HEAVY CHAIN VARIABLE DOMAIN HUMAN IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN AND/OR HUMAN IMMUNOGLOBULIN, IN VITRO METHOD OF PRODUCTION OF HUMAN IMMUNOGLOBULIN VARIABLE DOMAIN, NUCLEIC ACID, HOST CELL, ISOLATED CELL, AND HUMINOGLOBULIN HEAVY CHAIN VARIABLE DOMAIN |
US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
CN108424931A (en) * | 2018-03-29 | 2018-08-21 | 内蒙古大学 | The method that CRISPR/Cas9 technologies mediate goat VEGF Gene targetings |
ES2955408T3 (en) | 2018-04-12 | 2023-11-30 | Prec Biosciences Inc | Optimized genetically modified nucleases that have specificity for the human t cell receptor alpha constant region gene |
US11851663B2 (en) | 2018-10-14 | 2023-12-26 | Snipr Biome Aps | Single-vector type I vectors |
BR112021012172A2 (en) | 2018-12-12 | 2021-08-31 | Kite Pharma, Inc. | CHIMERIC AND T-CELL ANTIGEN RECEPTORS AND METHODS OF USE |
KR20210109000A (en) * | 2018-12-27 | 2021-09-03 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | T-cell receptor variant |
IL286905B1 (en) | 2019-04-04 | 2024-02-01 | Regeneron Pharma | Non-human animals comprising a humanized coagulation factor 12 locus |
JP2022534867A (en) | 2019-06-04 | 2022-08-04 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Non-human animals containing humanized TTR loci with beta slip mutations and methods of use |
AU2020289581A1 (en) | 2019-06-07 | 2021-11-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized albumin locus |
CN114302733A (en) * | 2019-07-03 | 2022-04-08 | 里珍纳龙药品有限公司 | anti-New York esophageal squamous cell carcinoma 1(NY-ESO-1) antigen binding proteins and methods of use thereof |
EP3999081A1 (en) | 2019-07-18 | 2022-05-25 | GPB Scientific, Inc. | Ordered processing of blood products to produce therapeutically active cells |
CA3166192A1 (en) | 2019-12-28 | 2021-07-01 | Gpb Scientific, Inc. | Microfluidic cartridges for processing particles and cells |
CN111320703A (en) * | 2020-03-11 | 2020-06-23 | 北京双赢科创生物科技有限公司 | Chimeric antigen receptor targeting CD22 and application thereof |
WO2021190580A1 (en) * | 2020-03-26 | 2021-09-30 | Wuxi Biologics (Shanghai) Co., Ltd. | Bispecific polypeptide complexes, compositions, and methods of preparation and use |
CN114746152A (en) * | 2020-08-23 | 2022-07-12 | 应用干细胞有限公司 | HLA-F modified cells and methods |
EP4333892A1 (en) * | 2021-05-07 | 2024-03-13 | Senti Biosciences, Inc. | Chimeric antigen receptors and methods of use |
EP4215042A1 (en) * | 2022-01-21 | 2023-07-26 | Max-Delbrück-Centrum für Molekulare Medizin | A non-human mammal comprising in its genome at least two human leukocyte antigen (hla) class i alleles, methods of making such mammal and uses thereof |
CN116138212B (en) * | 2023-01-11 | 2024-03-05 | 江苏省中医院 | Method for preparing cytokine release syndrome mouse model and application |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
JPS6463394A (en) * | 1987-09-04 | 1989-03-09 | Kyowa Hakko Kogyo Kk | Novel chimera polypeptide |
IL86278A (en) * | 1988-05-04 | 2003-06-24 | Yeda Res & Dev | Endowing cells with antibody specificity using chimeric t cell receptor |
DE69133566T2 (en) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Formation of xenogenic antibodies |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US6045796A (en) | 1992-12-17 | 2000-04-04 | Anergen, Inc. | Vaccination with peptide of MHC class II molecules for treatment of autoimmune disease |
US5512295A (en) | 1994-11-10 | 1996-04-30 | The Board Of Trustees Of The Leland Stanford Junior University | Synthetic liposomes for enhanced uptake and delivery |
US6001349A (en) | 1995-02-22 | 1999-12-14 | Therion Biologics Corporation | Generation of human cytotoxic T-cells specific for carcinoma self-associated antigens and uses thereof |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5869270A (en) | 1996-01-31 | 1999-02-09 | Sunol Molecular Corporation | Single chain MHC complexes and uses thereof |
US6770291B2 (en) | 1996-08-30 | 2004-08-03 | The United States Of America As Represented By The Department Of Health And Human Services | Liposome complexes for increased systemic delivery |
US7001614B2 (en) | 1996-08-19 | 2006-02-21 | The United States Of America As Represented By The Department Of Health And Human Services | Liposome complexes for increased systemic delivery |
CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
US7112338B2 (en) | 1997-03-12 | 2006-09-26 | The Regents Of The University Of California | Cationic liposome delivery of taxanes to angiogenic blood vessels |
US6749863B1 (en) | 1997-11-19 | 2004-06-15 | Georgetown University | Targeted liposome gene delivery |
US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
EP1485075A4 (en) | 2002-02-20 | 2006-04-26 | Dyax Corp | Mhc-peptide complex binding ligands |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US20090042291A1 (en) | 2002-03-01 | 2009-02-12 | Xencor, Inc. | Optimized Fc variants |
US7662925B2 (en) | 2002-03-01 | 2010-02-16 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
US20040072262A1 (en) | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
JP2006514549A (en) | 2002-12-16 | 2006-05-11 | アメリカ合衆国 | Recombinant vaccine virus expressing IL-15 and method of use thereof |
US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
US8218805B2 (en) | 2003-10-11 | 2012-07-10 | Charles Hornback | Wireless speaker system for use with ceiling fans |
WO2005063815A2 (en) | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Fcϝ receptor-binding polypeptide variants and methods related thereto |
DE602005027309D1 (en) | 2004-01-16 | 2011-05-19 | Regeneron Pharma | FOR ACTIVATING RECEPTORS CAPABLE FUSION POLYPEPTIDES |
EP1773383B1 (en) | 2004-05-27 | 2012-09-12 | Jon A. Weidanz | Antibodies as t cell receptor mimics, methods of production and uses thereof |
CA2827654C (en) | 2004-10-19 | 2019-04-02 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
AU2005335714B2 (en) | 2004-11-10 | 2012-07-26 | Macrogenics, Inc. | Engineering Fc antibody regions to confer effector function |
WO2007001457A2 (en) | 2004-11-12 | 2007-01-04 | Xencor, Inc. | Antibodies operably linked to selected chemoattractants |
US20060275282A1 (en) | 2005-01-12 | 2006-12-07 | Xencor, Inc. | Antibodies and Fc fusion proteins with altered immunogenicity |
US20070190063A1 (en) | 2005-08-19 | 2007-08-16 | Bahjat Keith S | Antibody-mediated enhancement of immune response |
EP4174179A3 (en) | 2005-08-23 | 2023-09-27 | The Trustees of the University of Pennsylvania | Rna containing modified nucleosides and methods of use thereof |
EP2003960B1 (en) | 2006-03-31 | 2015-06-10 | E. R. Squibb & Sons, L.L.C. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
RU2499606C2 (en) | 2007-10-18 | 2013-11-27 | Бавэариан Нордик Инк. | Using mva (modified vaccinia ankara) for treating prostate cancer |
US8225343B2 (en) | 2008-01-11 | 2012-07-17 | Sony Computer Entertainment America Llc | Gesture cataloging and recognition |
US8691502B2 (en) | 2008-10-31 | 2014-04-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
ES2603559T5 (en) | 2010-02-08 | 2021-02-22 | Regeneron Pharma | Mouse common light chain |
CA2794708C (en) | 2010-03-29 | 2021-11-16 | Zymeworks Inc. | Antibodies with enhanced or suppressed effector function |
RU2601297C2 (en) | 2010-06-22 | 2016-10-27 | Ридженерон Фармасьютикалз, Инк. | Mice expressing an immunoglobulin hybrid light chain |
US8539547B2 (en) | 2010-08-18 | 2013-09-17 | Certes Networks, Inc. | Policy selector representation for fast retrieval |
ES2770424T3 (en) | 2011-02-25 | 2020-07-01 | Regeneron Pharma | ADAM6 mice |
JP5893258B2 (en) | 2011-03-31 | 2016-03-23 | フェリカネットワークス株式会社 | Information processing apparatus and method, and program |
US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
CA3074400A1 (en) | 2011-10-28 | 2013-05-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
RS56330B1 (en) | 2011-10-28 | 2017-12-29 | Regeneron Pharma | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
KR102542272B1 (en) * | 2011-10-28 | 2023-06-13 | 리제너론 파아마슈티컬스, 인크. | Genetically modified t cell receptor mice |
US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
DK2773671T3 (en) | 2011-11-04 | 2021-11-15 | Zymeworks Inc | DESIGN OF STABLE HETERODIMED ANTIBODY WITH MUTATIONS IN THE FC DOMAIN |
US9547499B2 (en) | 2011-12-09 | 2017-01-17 | Microsoft Technology Licensing, Llc | Device configuration with cached pre-assembled driver state |
WO2013126726A1 (en) * | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
JP5920830B2 (en) | 2012-09-28 | 2016-05-18 | シスメックス株式会社 | Sample preparation device and cell analysis device |
EP3351095A1 (en) | 2013-02-20 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Non-human animals with modified immunoglobulin heavy chain sequences |
DK2958938T3 (en) | 2013-02-20 | 2019-07-15 | Regeneron Pharma | Mice expressing humanized T cell co-receptors |
US10154658B2 (en) | 2013-02-22 | 2018-12-18 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
-
2015
- 2015-09-18 RU RU2017113134A patent/RU2017113134A/en not_active Application Discontinuation
- 2015-09-18 KR KR1020177010023A patent/KR20170083534A/en unknown
- 2015-09-18 US US14/858,597 patent/US20160081314A1/en not_active Abandoned
- 2015-09-18 JP JP2017515087A patent/JP2017529841A/en active Pending
- 2015-09-18 BR BR112017005245A patent/BR112017005245A2/en not_active Application Discontinuation
- 2015-09-18 AU AU2015317370A patent/AU2015317370A1/en not_active Abandoned
- 2015-09-18 WO PCT/US2015/050975 patent/WO2016044745A1/en active Application Filing
- 2015-09-18 SG SG11201701040XA patent/SG11201701040XA/en unknown
- 2015-09-18 CN CN201580050602.0A patent/CN107072184A/en active Pending
- 2015-09-18 MX MX2017003640A patent/MX2017003640A/en unknown
- 2015-09-18 EP EP15775854.1A patent/EP3193592A1/en not_active Withdrawn
- 2015-09-18 CA CA2959428A patent/CA2959428A1/en not_active Abandoned
-
2017
- 2017-02-09 IL IL250536A patent/IL250536A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2015317370A1 (en) | 2017-03-23 |
CA2959428A1 (en) | 2016-03-24 |
RU2017113134A (en) | 2018-10-19 |
JP2017529841A (en) | 2017-10-12 |
US20160081314A1 (en) | 2016-03-24 |
MX2017003640A (en) | 2017-10-31 |
IL250536A0 (en) | 2017-03-30 |
CN107072184A (en) | 2017-08-18 |
BR112017005245A2 (en) | 2017-12-12 |
WO2016044745A1 (en) | 2016-03-24 |
EP3193592A1 (en) | 2017-07-26 |
KR20170083534A (en) | 2017-07-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL250536A0 (en) | Chimeric antigen receptors | |
HK1245801B (en) | Bcma chimeric antigen receptors | |
IL251030A0 (en) | Chimeric antigen receptors | |
IL254254B (en) | Chimeric antigen receptor | |
ZA201700730B (en) | Bcma chimeric antigen receptors | |
SG11201606790XA (en) | Chimeric antigen receptor | |
GB201503742D0 (en) | Chimeric antigen receptor | |
GB201617290D0 (en) | Novel chimeric antigen receptors | |
PT3230310T (en) | Anti-cd70 chimeric antigen receptors | |
GB201519900D0 (en) | Chimeric antigen receptor | |
GB201409761D0 (en) | Chimeric antigen receptor | |
GB201403481D0 (en) | Chimeric antigen receptor |