CN107207598B - Bcma嵌合抗原受体 - Google Patents
Bcma嵌合抗原受体 Download PDFInfo
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- CN107207598B CN107207598B CN201580073309.6A CN201580073309A CN107207598B CN 107207598 B CN107207598 B CN 107207598B CN 201580073309 A CN201580073309 A CN 201580073309A CN 107207598 B CN107207598 B CN 107207598B
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/70521—CD28, CD152
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011266755.8A CN112358551B (zh) | 2014-12-12 | 2015-12-07 | Bcma嵌合抗原受体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462091419P | 2014-12-12 | 2014-12-12 | |
| US62/091,419 | 2014-12-12 | ||
| US201562200505P | 2015-08-03 | 2015-08-03 | |
| US62/200,505 | 2015-08-03 | ||
| PCT/US2015/064269 WO2016094304A2 (en) | 2014-12-12 | 2015-12-07 | Bcma chimeric antigen receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011266755.8A Division CN112358551B (zh) | 2014-12-12 | 2015-12-07 | Bcma嵌合抗原受体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107207598A CN107207598A (zh) | 2017-09-26 |
| CN107207598B true CN107207598B (zh) | 2020-12-08 |
Family
ID=56108356
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011266755.8A Active CN112358551B (zh) | 2014-12-12 | 2015-12-07 | Bcma嵌合抗原受体 |
| CN201580073309.6A Active CN107207598B (zh) | 2014-12-12 | 2015-12-07 | Bcma嵌合抗原受体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011266755.8A Active CN112358551B (zh) | 2014-12-12 | 2015-12-07 | Bcma嵌合抗原受体 |
Country Status (30)
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|---|---|
| US (11) | US10383929B2 (enExample) |
| EP (4) | EP3640262A1 (enExample) |
| JP (4) | JP6671370B2 (enExample) |
| KR (3) | KR102731379B1 (enExample) |
| CN (2) | CN112358551B (enExample) |
| AU (2) | AU2015360845B2 (enExample) |
| BR (1) | BR112017012502B1 (enExample) |
| CA (1) | CA2970466A1 (enExample) |
| CL (2) | CL2017001515A1 (enExample) |
| CO (1) | CO2017006808A2 (enExample) |
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| DK (2) | DK3230321T3 (enExample) |
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| EC (1) | ECSP17044494A (enExample) |
| ES (2) | ES2750725T3 (enExample) |
| HK (1) | HK1245801B (enExample) |
| HR (2) | HRP20191873T1 (enExample) |
| HU (2) | HUE056074T2 (enExample) |
| IL (2) | IL252783B (enExample) |
| LT (2) | LT3628687T (enExample) |
| MX (2) | MX383542B (enExample) |
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| PL (2) | PL3628687T3 (enExample) |
| PT (2) | PT3230321T (enExample) |
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| WO (1) | WO2016094304A2 (enExample) |
| ZA (1) | ZA201704059B (enExample) |
Families Citing this family (210)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2925864B1 (en) | 2012-11-27 | 2018-10-31 | The Children's Medical Center Corporation | Targeting bcl11a distal regulatory elements for fetal hemoglobin reinduction |
| KR101605421B1 (ko) | 2014-03-05 | 2016-03-23 | 국립암센터 | B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도 |
| AU2015249554B2 (en) | 2014-04-23 | 2021-08-19 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| SG11201608744VA (en) | 2014-04-25 | 2016-11-29 | Bluebird Bio Inc | Improved methods for manufacturing adoptive cell therapies |
| SMT202100700T1 (it) | 2014-04-25 | 2022-01-10 | 2Seventy Bio Inc | Recettori antigenici chimerici con promotore mnd |
| RU2707540C2 (ru) | 2014-04-25 | 2019-11-27 | Чилдрен'С Медикал Сентр Корпорэйшн | Композиции и способы для лечения гемоглобинопатий |
| EP3151672B1 (en) | 2014-06-06 | 2020-11-04 | Bluebird Bio, Inc. | Improved t cell compositions |
| JP7054622B2 (ja) | 2014-07-21 | 2022-04-14 | ノバルティス アーゲー | ヒト化抗bcmaキメラ抗原受容体を使用した癌の処置 |
| KR102523934B1 (ko) | 2014-07-24 | 2023-04-20 | 2세븐티 바이오, 인코포레이티드 | Bcma 키메릭 항원 수용체 |
| ES2966099T3 (es) | 2014-12-05 | 2024-04-18 | Memorial Sloan Kettering Cancer Center | Receptores de antígeno quiméricos dirigidos al antígeno de maduración de células B y usos de los mismos |
| HUE053995T2 (hu) | 2014-12-05 | 2021-08-30 | Memorial Sloan Kettering Cancer Center | B-sejt-érési antigént célzó antitestek és alkalmazási eljárások |
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