MA54079A - Récepteurs antigéniques chimériques spécifiques du gprc5d (élément d du groupe 5 de classe c des récepteurs couplés à la protéine g) - Google Patents
Récepteurs antigéniques chimériques spécifiques du gprc5d (élément d du groupe 5 de classe c des récepteurs couplés à la protéine g)Info
- Publication number
- MA54079A MA54079A MA054079A MA54079A MA54079A MA 54079 A MA54079 A MA 54079A MA 054079 A MA054079 A MA 054079A MA 54079 A MA54079 A MA 54079A MA 54079 A MA54079 A MA 54079A
- Authority
- MA
- Morocco
- Prior art keywords
- gprc5d
- group
- chimeric antigen
- coupled receptor
- protein coupled
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title 1
- 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 title 1
- 102000027583 GPCRs class C Human genes 0.000 title 1
- 108091008882 GPCRs class C Proteins 0.000 title 1
- 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
- A61K2239/28—Expressing multiple CARs, TCRs or antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
- A61K2239/29—Multispecific CARs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
- A61K2239/30—Mixture of cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862754576P | 2018-11-01 | 2018-11-01 | |
US201862774159P | 2018-11-30 | 2018-11-30 | |
US201962819422P | 2019-03-15 | 2019-03-15 | |
US201962904197P | 2019-09-23 | 2019-09-23 | |
US201962904187P | 2019-09-23 | 2019-09-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA54079A true MA54079A (fr) | 2021-09-08 |
Family
ID=68655690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA054079A MA54079A (fr) | 2018-11-01 | 2019-10-31 | Récepteurs antigéniques chimériques spécifiques du gprc5d (élément d du groupe 5 de classe c des récepteurs couplés à la protéine g) |
Country Status (16)
Country | Link |
---|---|
US (1) | US20210393689A1 (fr) |
EP (1) | EP3873937A2 (fr) |
JP (1) | JP2022506598A (fr) |
KR (1) | KR20210102888A (fr) |
CN (1) | CN113614108A (fr) |
AU (1) | AU2019374103A1 (fr) |
CA (1) | CA3116413A1 (fr) |
CL (1) | CL2021001153A1 (fr) |
CO (1) | CO2021007254A2 (fr) |
IL (1) | IL282666A (fr) |
MA (1) | MA54079A (fr) |
MX (1) | MX2021005022A (fr) |
PE (1) | PE20211058A1 (fr) |
SG (1) | SG11202103873VA (fr) |
TW (1) | TW202021981A (fr) |
WO (1) | WO2020092854A2 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3227324A4 (fr) * | 2014-12-05 | 2018-08-29 | Memorial Sloan Kettering Cancer Center | Anticorps ciblant le récepteur couplé aux protéines g et procédés d'utilisation |
SG10202007326QA (en) | 2014-12-05 | 2020-08-28 | Memorial Sloan Kettering Cancer Center | Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof |
EP3703750A1 (fr) | 2017-11-01 | 2020-09-09 | Juno Therapeutics, Inc. | Récepterus chimériques d'antigène contre l'antigène de maturation des cellules b et polynucleotides codants |
KR20200074997A (ko) | 2017-11-01 | 2020-06-25 | 주노 쎄러퓨티크스 인코퍼레이티드 | B-세포 성숙 항원에 특이적인 항체 및 키메릭 항원 수용체 |
US11423000B2 (en) * | 2020-04-02 | 2022-08-23 | Sap Se | Data transfer and management system for in-memory database |
US20230398148A1 (en) | 2020-11-04 | 2023-12-14 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods |
WO2022133094A1 (fr) * | 2020-12-18 | 2022-06-23 | Bioardis, Llc | Molécules de liaison à fap et leurs utilisations |
WO2022148370A1 (fr) * | 2021-01-05 | 2022-07-14 | Lanova Medicines Development Co., Ltd. | Anticorps monoclonaux anti-gprc5d et leurs utilisations |
KR20230130038A (ko) | 2021-01-05 | 2023-09-11 | 라노바 메디신즈 디벨롭먼트 컴퍼니 리미티드 | 항-gprc5d 단클론성 항체 및 이의 용도 |
JP2024509853A (ja) | 2021-03-03 | 2024-03-05 | ジュノー セラピューティクス インコーポレイテッド | T細胞療法およびdgk阻害剤の組合せ |
WO2022234009A2 (fr) | 2021-05-06 | 2022-11-10 | Juno Therapeutics Gmbh | Méthodes de stimulation et de transduction de lymphocytes t |
CN115386010A (zh) * | 2021-05-23 | 2022-11-25 | 上海邦耀生物科技有限公司 | 靶向gprc5d的嵌合抗原受体及其用途 |
WO2023030272A1 (fr) * | 2021-08-30 | 2023-03-09 | 原启生物科技(上海)有限责任公司 | Protéine de liaison à l'antigène anti-gprc5d et son utilisation |
WO2023125888A1 (fr) * | 2021-12-31 | 2023-07-06 | 山东先声生物制药有限公司 | Anticorps gprc5d et son utilisation |
WO2023213969A1 (fr) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Protéine de liaison virale et réactifs, articles et méthodes d'utilisation associés |
WO2023225569A1 (fr) | 2022-05-17 | 2023-11-23 | Umoja Biopharma, Inc. | Fabrication de particules virales |
WO2023240282A1 (fr) | 2022-06-10 | 2023-12-14 | Umoja Biopharma, Inc. | Cellules souches modifiées et leurs utilisations |
WO2024007020A1 (fr) | 2022-06-30 | 2024-01-04 | Indapta Therapeutics, Inc. | Combinaison de cellules tueuses naturelles (nk) modifiées et d'une thérapie par anticorps et méthodes associées |
WO2024002308A1 (fr) * | 2022-06-30 | 2024-01-04 | 康诺亚生物医药科技(成都)有限公司 | Développement et utilisation d'un nouvel inhibiteur de tumeur multispécifique |
WO2024017326A1 (fr) * | 2022-07-21 | 2024-01-25 | 山东先声生物制药有限公司 | Nanocorps anti-gprc5d et son utilisation |
WO2024017362A1 (fr) * | 2022-07-22 | 2024-01-25 | 上海先博生物科技有限公司 | Récepteur antigénique chimérique ciblant gprc5d et/ou bcma, et son utilisation |
WO2024054944A1 (fr) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combinaison de thérapie cellulaire t et de dosage continu ou intermittent d'inhibiteurs de dgk |
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2019
- 2019-10-31 EP EP19809277.7A patent/EP3873937A2/fr active Pending
- 2019-10-31 US US17/290,060 patent/US20210393689A1/en active Pending
- 2019-10-31 CN CN201980087584.1A patent/CN113614108A/zh active Pending
- 2019-10-31 MX MX2021005022A patent/MX2021005022A/es unknown
- 2019-10-31 JP JP2021524035A patent/JP2022506598A/ja active Pending
- 2019-10-31 WO PCT/US2019/059285 patent/WO2020092854A2/fr active Application Filing
- 2019-10-31 SG SG11202103873VA patent/SG11202103873VA/en unknown
- 2019-10-31 KR KR1020217016651A patent/KR20210102888A/ko active Search and Examination
- 2019-10-31 TW TW108139583A patent/TW202021981A/zh unknown
- 2019-10-31 PE PE2021000647A patent/PE20211058A1/es unknown
- 2019-10-31 AU AU2019374103A patent/AU2019374103A1/en active Pending
- 2019-10-31 MA MA054079A patent/MA54079A/fr unknown
- 2019-10-31 CA CA3116413A patent/CA3116413A1/fr active Pending
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US20210393689A1 (en) | 2021-12-23 |
CN113614108A (zh) | 2021-11-05 |
TW202021981A (zh) | 2020-06-16 |
CL2021001153A1 (es) | 2022-01-07 |
SG11202103873VA (en) | 2021-05-28 |
WO2020092854A2 (fr) | 2020-05-07 |
WO2020092854A3 (fr) | 2020-07-02 |
CO2021007254A2 (es) | 2021-08-30 |
IL282666A (en) | 2021-06-30 |
KR20210102888A (ko) | 2021-08-20 |
MX2021005022A (es) | 2021-09-08 |
PE20211058A1 (es) | 2021-06-07 |
EP3873937A2 (fr) | 2021-09-08 |
JP2022506598A (ja) | 2022-01-17 |
CA3116413A1 (fr) | 2020-05-07 |
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