CY1111141T1 - Ανθρωπινα αντισωματα ειδικα για kdr και χρησεις αυτων - Google Patents
Ανθρωπινα αντισωματα ειδικα για kdr και χρησεις αυτωνInfo
- Publication number
- CY1111141T1 CY1111141T1 CY20101100793T CY101100793T CY1111141T1 CY 1111141 T1 CY1111141 T1 CY 1111141T1 CY 20101100793 T CY20101100793 T CY 20101100793T CY 101100793 T CY101100793 T CY 101100793T CY 1111141 T1 CY1111141 T1 CY 1111141T1
- Authority
- CY
- Cyprus
- Prior art keywords
- kdr
- antibodies
- human
- particulars
- special
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 241000206761 Bacillariophyta Species 0.000 abstract 1
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 102000058223 human VEGFA Human genes 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Η εφεύρεση παρέχει αντισώματα τα οποία δεσμεύονται σε KDR με μια συγγένεια συγκρίσιμη με ή υψηλότερη από ανθρώπινο VEGF, και τα οποία εξουδετερώνουν ενεργοποίηση του KDR. Τα αντισώματα περιλαμβάνουν ακέραιες ανοσοσφαιρίνες, μονοσθενή Fabs και απλής αλυσίδας αντισώματα, πολυσθενή απλής αλυσίδας αντισώματα, διασωμάτια, τρισωμάτια, και απλού τομέα αντισώματα. Η εφεύρεση περαιτέρω παρέχει νουκλεϊνικά οξέα και κύτταρα ξενιστές που κωδικοποιούν και εκφράζουν αυτά τα αντισώματα. Η εφεύρεση περαιτέρω παρέχει μία μέθοδο εξουδετέρωσης της ενεργοποίησης του KDR, μία μέθοδο αναστολής της αγγειογένεσης σε ένα θηλαστικό και μία μέθοδο αναστολής της ανάπτυξης όγκου σε ένα θηλαστικό.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36178302P | 2002-03-04 | 2002-03-04 | |
EP03711375A EP1487856B1 (en) | 2002-03-04 | 2003-03-04 | Human antibodies specific to kdr and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111141T1 true CY1111141T1 (el) | 2015-06-11 |
Family
ID=27805075
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100793T CY1111141T1 (el) | 2002-03-04 | 2010-08-30 | Ανθρωπινα αντισωματα ειδικα για kdr και χρησεις αυτων |
CY20111100630T CY1111629T1 (el) | 2002-03-04 | 2011-06-29 | Ανθρωπινα αντισωματα ειδικα για kdr και χρησεις αυτων |
CY2015018C CY2015018I1 (el) | 2002-03-04 | 2015-04-30 | Ανθρωπινα αντισωματα ειδικα για kdr και χρησεις αυτων |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100630T CY1111629T1 (el) | 2002-03-04 | 2011-06-29 | Ανθρωπινα αντισωματα ειδικα για kdr και χρησεις αυτων |
CY2015018C CY2015018I1 (el) | 2002-03-04 | 2015-04-30 | Ανθρωπινα αντισωματα ειδικα για kdr και χρησεις αυτων |
Country Status (18)
Country | Link |
---|---|
US (2) | US7498414B2 (el) |
EP (3) | EP1487856B1 (el) |
JP (3) | JP2005526506A (el) |
AT (2) | ATE475431T1 (el) |
AU (1) | AU2003213687A1 (el) |
BE (1) | BE2015C027I2 (el) |
CA (1) | CA2478169C (el) |
CY (3) | CY1111141T1 (el) |
DE (1) | DE60333554D1 (el) |
DK (2) | DK1916001T3 (el) |
ES (2) | ES2362931T3 (el) |
FR (1) | FR15C0034I2 (el) |
HK (1) | HK1118229A1 (el) |
HU (1) | HUS1500025I1 (el) |
LU (1) | LU92710I2 (el) |
PT (2) | PT1916001E (el) |
SI (2) | SI1487856T1 (el) |
WO (1) | WO2003075840A2 (el) |
Families Citing this family (98)
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CA2553946C (en) * | 2004-02-06 | 2019-02-26 | University Of Massachusetts | Antibodies against clostridium difficile toxins and uses thereof |
ES2387809T3 (es) | 2004-03-19 | 2012-10-02 | Imclone Llc | Anticuerpo frente al receptor del factor de crecimiento epidérmico humano |
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PT2028193E (pt) | 2005-01-05 | 2012-06-15 | Star Biotech Forschung Entw Gmbh | Domínios de imunoglobulina sintéticos com propriedades de ligação modificadas em regiões da molécula diferentes das regiões de determinação de complementaridade |
US20060234941A1 (en) | 2005-04-15 | 2006-10-19 | The Gov. Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Peptide epitopes of VEGFR-2/KDR that inhibit angiogenesis |
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- 2003-03-04 JP JP2003574116A patent/JP2005526506A/ja active Pending
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- 2003-03-04 EP EP07023361A patent/EP1916001B1/en not_active Expired - Lifetime
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- 2003-03-04 AT AT03711375T patent/ATE475431T1/de active
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