CS268672B2 - Method of substituted imidazo-(1,5-a)pyridine derivatives production - Google Patents

Method of substituted imidazo-(1,5-a)pyridine derivatives production Download PDF

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Publication number
CS268672B2
CS268672B2 CS854449A CS444985A CS268672B2 CS 268672 B2 CS268672 B2 CS 268672B2 CS 854449 A CS854449 A CS 854449A CS 444985 A CS444985 A CS 444985A CS 268672 B2 CS268672 B2 CS 268672B2
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Czechoslovakia
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oder
freies
die
verethertes
acid
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CS854449A
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Czech (cs)
English (en)
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CS444985A2 (en
Inventor
Leslie J Dr Browne
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Ciba Geigy Ag
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Priority to CS868019A priority Critical patent/CS268685B2/cs
Priority to CS868022A priority patent/CS268688B2/cs
Priority to CS868020A priority patent/CS268686B2/cs
Priority to CS868021A priority patent/CS268687B2/cs
Priority to CS868018A priority patent/CS268684B2/cs
Publication of CS444985A2 publication Critical patent/CS444985A2/cs
Publication of CS268672B2 publication Critical patent/CS268672B2/cs

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/10Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS854449A 1984-06-20 1985-06-18 Method of substituted imidazo-(1,5-a)pyridine derivatives production CS268672B2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CS868019A CS268685B2 (en) 1984-06-20 1986-11-05 Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production
CS868022A CS268688B2 (en) 1985-06-18 1986-11-05 Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production
CS868020A CS268686B2 (en) 1985-06-18 1986-11-05 Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production
CS868021A CS268687B2 (en) 1984-06-20 1986-11-05 Method of substituted imidazopyridine derivatives production
CS868018A CS268684B2 (en) 1984-06-20 1986-11-05 Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/622,421 US4617307A (en) 1984-06-20 1984-06-20 Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors

Publications (2)

Publication Number Publication Date
CS444985A2 CS444985A2 (en) 1989-07-12
CS268672B2 true CS268672B2 (en) 1990-04-11

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CS854449A CS268672B2 (en) 1984-06-20 1985-06-18 Method of substituted imidazo-(1,5-a)pyridine derivatives production

Country Status (31)

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US (1) US4617307A (es)
EP (1) EP0165904B1 (es)
JP (1) JPS6112688A (es)
KR (1) KR900008566B1 (es)
AT (1) ATE62415T1 (es)
AU (1) AU589565B2 (es)
BG (7) BG60262B2 (es)
CA (1) CA1276633C (es)
CS (1) CS268672B2 (es)
CY (1) CY1750A (es)
DD (1) DD237510A5 (es)
DE (1) DE3582452D1 (es)
DK (1) DK170302B1 (es)
DZ (1) DZ799A1 (es)
ES (6) ES8702406A1 (es)
FI (1) FI80694C (es)
GR (1) GR851487B (es)
HK (1) HK23494A (es)
HU (1) HU202529B (es)
IE (1) IE58070B1 (es)
IL (1) IL75546A (es)
MA (1) MA20459A1 (es)
MX (1) MX9203369A (es)
NO (1) NO162467C (es)
NZ (1) NZ212483A (es)
PH (1) PH23390A (es)
PL (6) PL145104B1 (es)
PT (1) PT80661B (es)
RO (1) RO92583A (es)
SU (6) SU1433413A3 (es)
ZA (1) ZA854615B (es)

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Also Published As

Publication number Publication date
ES555538A0 (es) 1988-03-16
IL75546A0 (en) 1985-10-31
MX9203369A (es) 1992-09-01
CS444985A2 (en) 1989-07-12
IL75546A (en) 1990-01-18
NO162467C (no) 1990-01-10
EP0165904A2 (de) 1985-12-27
BG60262B1 (bg) 1994-03-31
DK170302B1 (da) 1995-07-31
PT80661B (en) 1987-05-04
NO852474L (no) 1985-12-23
SU1433413A3 (ru) 1988-10-23
ES8802048A1 (es) 1988-03-16
PT80661A (en) 1985-07-01
IE851520L (en) 1985-12-20
HU202529B (en) 1991-03-28
ES555540A0 (es) 1987-12-16
ES555539A0 (es) 1988-04-01
CA1276633C (en) 1990-11-20
DK277685D0 (da) 1985-06-19
DK277685A (da) 1985-12-21
DZ799A1 (fr) 2004-09-13
RO92583A (ro) 1987-11-30
SU1482530A3 (ru) 1989-05-23
JPS6112688A (ja) 1986-01-21
ES8802155A1 (es) 1988-04-01
PL145814B1 (en) 1988-11-30
CY1750A (en) 1994-06-03
DE3582452D1 (de) 1991-05-16
AU4385785A (en) 1986-01-02
HUT37936A (en) 1986-03-28
SU1436880A3 (ru) 1988-11-07
ES8801262A1 (es) 1987-12-16
BG60352B2 (bg) 1994-11-30
MA20459A1 (fr) 1985-12-31
HK23494A (en) 1994-03-25
SU1436878A3 (ru) 1988-11-07
FI852399L (fi) 1985-12-21
NZ212483A (en) 1988-10-28
FI80694B (fi) 1990-03-30
ES8800681A1 (es) 1987-11-16
FI852399A0 (fi) 1985-06-17
PH23390A (en) 1989-07-26
GR851487B (es) 1985-11-25
ES8802049A1 (es) 1988-03-16
BG60402B2 (bg) 1995-02-28
SU1436879A3 (ru) 1988-11-07
PL145105B1 (en) 1988-08-31
PL254099A1 (en) 1986-09-09
ES555541A0 (es) 1987-11-16
ES8702406A1 (es) 1987-01-01
IE58070B1 (en) 1993-06-30
ZA854615B (en) 1986-02-26
KR860000299A (ko) 1986-01-27
KR900008566B1 (ko) 1990-11-24
PL145087B1 (en) 1988-08-31
DD237510A5 (de) 1986-07-16
ATE62415T1 (de) 1991-04-15
JPH047746B2 (es) 1992-02-12
SU1443802A3 (ru) 1988-12-07
BG60305B2 (bg) 1994-07-25
AU589565B2 (en) 1989-10-19
BG60262B2 (en) 1994-03-31
PL145103B1 (en) 1988-08-31
US4617307A (en) 1986-10-14
FI80694C (fi) 1990-07-10
ES544344A0 (es) 1987-01-01
PL145348B1 (en) 1988-09-30
ES555542A0 (es) 1988-03-16
BG60306B2 (bg) 1994-07-25
EP0165904A3 (en) 1987-09-09
EP0165904B1 (de) 1991-04-10
BG60353B2 (bg) 1994-11-30
NO162467B (no) 1989-09-25
BG60307B2 (en) 1994-07-25
PL145104B1 (en) 1988-08-31

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