CS251798B2 - Method of bis-indole compound's pharmaceutically suitable metallic complexes production - Google Patents

Method of bis-indole compound's pharmaceutically suitable metallic complexes production Download PDF

Info

Publication number
CS251798B2
CS251798B2 CS857387A CS738785A CS251798B2 CS 251798 B2 CS251798 B2 CS 251798B2 CS 857387 A CS857387 A CS 857387A CS 738785 A CS738785 A CS 738785A CS 251798 B2 CS251798 B2 CS 251798B2
Authority
CS
Czechoslovakia
Prior art keywords
bis
indole compound
zinc
calcium
formula
Prior art date
Application number
CS857387A
Other languages
Czech (cs)
English (en)
Inventor
Nagy G Takacsi
Gabor Szepesi
Maria Gazdag
Zsofia Pap
Kalman Burger
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of CS251798B2 publication Critical patent/CS251798B2/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
CS857387A 1984-10-16 1985-10-16 Method of bis-indole compound's pharmaceutically suitable metallic complexes production CS251798B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU843861A HU195513B (en) 1984-10-16 1984-10-16 Process for producing stable solutions of alkaloides with bis-indole skeleton

Publications (1)

Publication Number Publication Date
CS251798B2 true CS251798B2 (en) 1987-08-13

Family

ID=10965811

Family Applications (1)

Application Number Title Priority Date Filing Date
CS857387A CS251798B2 (en) 1984-10-16 1985-10-16 Method of bis-indole compound's pharmaceutically suitable metallic complexes production

Country Status (29)

Country Link
US (1) US4684638A (it)
JP (1) JPS61106584A (it)
CN (1) CN1007958B (it)
AT (1) AT389996B (it)
AU (1) AU580342B2 (it)
BE (1) BE903447A (it)
CA (1) CA1272192A (it)
CH (1) CH667459A5 (it)
CS (1) CS251798B2 (it)
DD (1) DD239207A5 (it)
DE (1) DE3536745A1 (it)
DK (1) DK169972B1 (it)
ES (1) ES8701185A1 (it)
FI (1) FI84134C (it)
FR (1) FR2571724B1 (it)
GB (1) GB2165540B (it)
GR (1) GR852510B (it)
HU (1) HU195513B (it)
IE (1) IE58467B1 (it)
IL (1) IL76719A (it)
IN (1) IN162910B (it)
IT (1) IT1186776B (it)
LT (1) LT2203B (it)
LU (1) LU86115A1 (it)
LV (1) LV5175A3 (it)
NL (1) NL192779C (it)
SE (1) SE466017B (it)
SU (1) SU1706372A3 (it)
ZA (1) ZA857905B (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341262C (en) * 1987-08-06 2001-06-26 Camille A. Boulet A new process of the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine
US5170515A (en) * 1987-09-16 1992-12-15 Toto Ltd. Water closet
FR2623089B1 (fr) * 1987-11-13 1990-04-27 Pf Medicament Composition pharmaceutique pour l'administration parenterale de navelbine
HU204995B (en) * 1989-11-07 1992-03-30 Richter Gedeon Vegyeszet Process for producing pharmaceutical composition comprising alkaloid with bis-indole skeleton, with antitumour activity and suitable fr parenteral purposes
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US8017368B2 (en) * 2005-10-20 2011-09-13 University Of South Florida Molecular delivery to cells using aspirin-related compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE595570C (de) * 1932-10-07 1934-04-16 I G Farbenindustrie Akt Ges Verfahren zur Darstellung waesseriger Loesungen von Schwermetallverbindungen der aromatischen Halogenylsulfamide
US3426024A (en) * 1967-11-17 1969-02-04 Vanderbilt Co R T Amine complexes of zinc salts of chlorinated thiobisphenols
DE2502932C2 (de) * 1975-01-24 1985-04-18 Bayer Ag, 5090 Leverkusen Metallkomplexe von N-Trityl-azolen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
FR2349335A1 (fr) * 1976-04-28 1977-11-25 Inst Int Pathologie Cellulaire Complexes d'alcaloides bis-indoliques du type vinblastine avec la tubuline, leur procede d'obtention et leur utilisation
EP0004770B1 (en) * 1978-04-11 1984-06-13 Efamol Limited Pharmaceutical and dietary composition comprising gamma-linolenic acids
ATE11014T1 (de) * 1981-07-14 1985-01-15 Efamol Limited Pharmazeutische und diaetetische zusammensetzung zur erhoehung der serie-l-pg-produktion.
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi

Also Published As

Publication number Publication date
AT389996B (de) 1990-02-26
JPH0339489B2 (it) 1991-06-14
LV5175A3 (lv) 1993-10-10
IT8522482A0 (it) 1985-10-15
FI84134B (fi) 1991-07-15
IT1186776B (it) 1987-12-16
LU86115A1 (de) 1986-03-24
GB2165540A (en) 1986-04-16
IL76719A (en) 1989-10-31
FR2571724A1 (fr) 1986-04-18
ATA297985A (de) 1989-08-15
IL76719A0 (en) 1986-02-28
SU1706372A3 (ru) 1992-01-15
SE8504786L (sv) 1986-04-17
ZA857905B (en) 1986-06-25
JPS61106584A (ja) 1986-05-24
FI853123A0 (fi) 1985-08-15
DK472085A (da) 1986-04-17
DE3536745A1 (de) 1986-04-17
CN85107053A (zh) 1986-06-10
ES547862A0 (es) 1986-11-16
DD239207A5 (de) 1986-09-17
BE903447A (fr) 1986-04-15
LT2203B (lt) 1993-10-15
FR2571724B1 (fr) 1988-08-26
FI84134C (fi) 1991-10-25
NL192779B (nl) 1997-10-01
CN1007958B (zh) 1990-05-16
GB8525360D0 (en) 1985-11-20
SE8504786D0 (sv) 1985-10-15
US4684638A (en) 1987-08-04
ES8701185A1 (es) 1986-11-16
CH667459A5 (de) 1988-10-14
IE58467B1 (en) 1993-09-22
HU195513B (en) 1988-05-30
DK472085D0 (da) 1985-10-15
NL8502821A (nl) 1986-05-16
DE3536745C2 (it) 1992-01-23
CA1272192A (en) 1990-07-31
FI853123L (fi) 1986-04-17
SE466017B (sv) 1991-12-02
AU580342B2 (en) 1989-01-12
GB2165540B (en) 1988-04-27
AU4871485A (en) 1986-04-24
DK169972B1 (da) 1995-04-18
GR852510B (it) 1986-02-18
IE852531L (en) 1986-04-16
NL192779C (nl) 1998-02-03
IN162910B (it) 1988-07-23

Similar Documents

Publication Publication Date Title
CA2468916C (en) A stable oxaliplatin solution formulation
RU2571566C2 (ru) Способ и композиция
CN114126596A (zh) 用于皮下注射的氯胺酮制剂
CS251798B2 (en) Method of bis-indole compound's pharmaceutically suitable metallic complexes production
JPWO2018221487A1 (ja) エリブリンまたはその薬剤学的に許容される塩を含む注射剤
JPWO2008152764A1 (ja) 医薬組成物
JP3042702B2 (ja) 注射用溶液及びその調製方法
JP2023551145A (ja) 医薬化合物の錯化剤塩製剤
US7812052B2 (en) Stable aqueous formulation of a platin derivative
JP2001163776A (ja) 安定化された液剤
CN114569545B (zh) 一种稳定的米托蒽醌制剂
CN113766952B (zh) 放射性药品的制造方法及放射性药品
CZ300664B6 (cs) Sterilní kapalná farmaceutická kompozice a zpusob její výroby
WO2019131998A1 (ja) アスタチン溶液及びその製造方法
US3865940A (en) Pharmaceutical preparation
CN114569544A (zh) 一种米托蒽醌注射剂的制备方法
JP2023539699A (ja) 糖尿病を治療するためのイオン性液体製剤
KR20240024961A (ko) 디메틸-치환된 티아졸로락탐 화합물 및 이의 용도
JPH01221382A (ja) 新規クロリン誘導体及び腫瘍診断薬
JPH05262650A (ja) 安定な注射用組成物
JPH0433767B2 (it)
JPS6064931A (ja) テクネチウム−９９ｍ標識つきがん診断剤