SE466017B - Metallkomplex av vinkristin eller vinblastin och vattenhaltiga farmaceutiska kompositioner innehaallande dessa - Google Patents

Metallkomplex av vinkristin eller vinblastin och vattenhaltiga farmaceutiska kompositioner innehaallande dessa

Info

Publication number
SE466017B
SE466017B SE8504786A SE8504786A SE466017B SE 466017 B SE466017 B SE 466017B SE 8504786 A SE8504786 A SE 8504786A SE 8504786 A SE8504786 A SE 8504786A SE 466017 B SE466017 B SE 466017B
Authority
SE
Sweden
Prior art keywords
zinc
calcium
vincristine
magnesium
complex
Prior art date
Application number
SE8504786A
Other languages
English (en)
Swedish (sv)
Other versions
SE8504786D0 (sv
SE8504786L (sv
Inventor
Nagy G Takacsi
G Szepesi
M Gazdag
Z Pap
K Burger
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8504786D0 publication Critical patent/SE8504786D0/xx
Publication of SE8504786L publication Critical patent/SE8504786L/xx
Publication of SE466017B publication Critical patent/SE466017B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
SE8504786A 1984-10-16 1985-10-15 Metallkomplex av vinkristin eller vinblastin och vattenhaltiga farmaceutiska kompositioner innehaallande dessa SE466017B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU843861A HU195513B (en) 1984-10-16 1984-10-16 Process for producing stable solutions of alkaloides with bis-indole skeleton

Publications (3)

Publication Number Publication Date
SE8504786D0 SE8504786D0 (sv) 1985-10-15
SE8504786L SE8504786L (sv) 1986-04-17
SE466017B true SE466017B (sv) 1991-12-02

Family

ID=10965811

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8504786A SE466017B (sv) 1984-10-16 1985-10-15 Metallkomplex av vinkristin eller vinblastin och vattenhaltiga farmaceutiska kompositioner innehaallande dessa

Country Status (29)

Country Link
US (1) US4684638A (it)
JP (1) JPS61106584A (it)
CN (1) CN1007958B (it)
AT (1) AT389996B (it)
AU (1) AU580342B2 (it)
BE (1) BE903447A (it)
CA (1) CA1272192A (it)
CH (1) CH667459A5 (it)
CS (1) CS251798B2 (it)
DD (1) DD239207A5 (it)
DE (1) DE3536745A1 (it)
DK (1) DK169972B1 (it)
ES (1) ES8701185A1 (it)
FI (1) FI84134C (it)
FR (1) FR2571724B1 (it)
GB (1) GB2165540B (it)
GR (1) GR852510B (it)
HU (1) HU195513B (it)
IE (1) IE58467B1 (it)
IL (1) IL76719A (it)
IN (1) IN162910B (it)
IT (1) IT1186776B (it)
LT (1) LT2203B (it)
LU (1) LU86115A1 (it)
LV (1) LV5175A3 (it)
NL (1) NL192779C (it)
SE (1) SE466017B (it)
SU (1) SU1706372A3 (it)
ZA (1) ZA857905B (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341262C (en) * 1987-08-06 2001-06-26 Camille A. Boulet A new process of the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine
US5170515A (en) * 1987-09-16 1992-12-15 Toto Ltd. Water closet
FR2623089B1 (fr) * 1987-11-13 1990-04-27 Pf Medicament Composition pharmaceutique pour l'administration parenterale de navelbine
HU204995B (en) * 1989-11-07 1992-03-30 Richter Gedeon Vegyeszet Process for producing pharmaceutical composition comprising alkaloid with bis-indole skeleton, with antitumour activity and suitable fr parenteral purposes
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US8017368B2 (en) * 2005-10-20 2011-09-13 University Of South Florida Molecular delivery to cells using aspirin-related compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE595570C (de) * 1932-10-07 1934-04-16 I G Farbenindustrie Akt Ges Verfahren zur Darstellung waesseriger Loesungen von Schwermetallverbindungen der aromatischen Halogenylsulfamide
US3426024A (en) * 1967-11-17 1969-02-04 Vanderbilt Co R T Amine complexes of zinc salts of chlorinated thiobisphenols
DE2502932C2 (de) * 1975-01-24 1985-04-18 Bayer Ag, 5090 Leverkusen Metallkomplexe von N-Trityl-azolen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
FR2349335A1 (fr) * 1976-04-28 1977-11-25 Inst Int Pathologie Cellulaire Complexes d'alcaloides bis-indoliques du type vinblastine avec la tubuline, leur procede d'obtention et leur utilisation
DE2967049D1 (en) * 1978-04-11 1984-07-19 Efamol Ltd Pharmaceutical and dietary composition comprising gamma-linolenic acids
EP0071357B1 (en) * 1981-07-14 1985-01-02 Efamol Limited Pharmaceutical and dietary composition when used for enhancement of 1-series pg production
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi

Also Published As

Publication number Publication date
AT389996B (de) 1990-02-26
IL76719A (en) 1989-10-31
DD239207A5 (de) 1986-09-17
AU4871485A (en) 1986-04-24
GB2165540A (en) 1986-04-16
DK472085A (da) 1986-04-17
CA1272192A (en) 1990-07-31
IT8522482A0 (it) 1985-10-15
CN1007958B (zh) 1990-05-16
DE3536745A1 (de) 1986-04-17
IL76719A0 (en) 1986-02-28
NL192779B (nl) 1997-10-01
CS251798B2 (en) 1987-08-13
IE58467B1 (en) 1993-09-22
US4684638A (en) 1987-08-04
NL192779C (nl) 1998-02-03
JPH0339489B2 (it) 1991-06-14
DK472085D0 (da) 1985-10-15
IN162910B (it) 1988-07-23
BE903447A (fr) 1986-04-15
GB2165540B (en) 1988-04-27
IE852531L (en) 1986-04-16
LV5175A3 (lv) 1993-10-10
DE3536745C2 (it) 1992-01-23
CN85107053A (zh) 1986-06-10
FR2571724A1 (fr) 1986-04-18
SE8504786D0 (sv) 1985-10-15
ES547862A0 (es) 1986-11-16
SE8504786L (sv) 1986-04-17
LT2203B (lt) 1993-10-15
ATA297985A (de) 1989-08-15
HU195513B (en) 1988-05-30
LU86115A1 (de) 1986-03-24
FI84134B (fi) 1991-07-15
FI853123A0 (fi) 1985-08-15
FR2571724B1 (fr) 1988-08-26
NL8502821A (nl) 1986-05-16
DK169972B1 (da) 1995-04-18
GB8525360D0 (en) 1985-11-20
IT1186776B (it) 1987-12-16
GR852510B (it) 1986-02-18
JPS61106584A (ja) 1986-05-24
CH667459A5 (de) 1988-10-14
SU1706372A3 (ru) 1992-01-15
ES8701185A1 (es) 1986-11-16
FI853123L (fi) 1986-04-17
AU580342B2 (en) 1989-01-12
FI84134C (fi) 1991-10-25
ZA857905B (en) 1986-06-25

Similar Documents

Publication Publication Date Title
AP957A (en) Novel stable liquid paracetamol compositions, and method for preparing same.
JP3547755B2 (ja) オキサリプラティヌムの医薬的に安定な製剤
US2980584A (en) Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
KR100351713B1 (ko) 백금(ii) 항종양제의 안정용액
US6559154B2 (en) Composition of sodium channel blocking compound
JP2537531B2 (ja) 化学療法剤としてのビス白金複合体
SE466017B (sv) Metallkomplex av vinkristin eller vinblastin och vattenhaltiga farmaceutiska kompositioner innehaallande dessa
JPS60172923A (ja) シスジクロロジアンミン白金を含有する安定な注射液に適した水溶液
HU177557B (en) Process for preparing stable aequous sterile solution of cys-platinic/ii/-diamine-dichloride
Kolthoff et al. Intramolecular hydrogen bonding involving hydroxyl groups in mono-and dianions of diprotic acids in acetonitrile and dimethyl sulfoxide
JPS6360008B2 (it)
JPS61180771A (ja) 安定な抗バクテリア剤水溶液
Florey Aztreonam
US20100093849A1 (en) Oxaliplatin pharmaceutical composition with alcoholic sugar-based buffer
HU181940B (en) Process for producing solutions of vincane derivatives for parentheral application
RU2742565C1 (ru) Фармацевтическая композиция, содержащая биологически активные комплексы аллоферона с цинком, и способ ее получения
Casy et al. Ionisation constants and partition coefficients of some analgesically active 2‐benzylbenzimidazole derivatives and related compounds
JPH02124822A (ja) セファロスポリン含有注射用組成物
US6979676B2 (en) Pharmaceutical composition containing and indolopyrrolocarbazole derivative
CZ300664B6 (cs) Sterilní kapalná farmaceutická kompozice a zpusob její výroby
EP0328862B1 (en) A stabilizing agent and an injectable composition containing the same
Stuckey The applications of ultra-violet absorption spectrophotometry in pharmaceutical analysis
SE453497B (sv) Antitumormedel och kompositioner pa basis derav samt forfarande for framstellning av dessa kompositioner
Burton Synthesis and evaluation of spermidine siderophores for iron chelation therapy and the role of cyclohexaamylose in catalytic hydrolysis

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8504786-8

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8504786-8

Format of ref document f/p: F