CS241021B2 - Method of 2,6-dimethyl-4-(i8o-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxyl acid's 3-methyl-5-ethylester production - Google Patents

Method of 2,6-dimethyl-4-(i8o-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxyl acid's 3-methyl-5-ethylester production Download PDF

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Publication number
CS241021B2
CS241021B2 CS794585A CS458579A CS241021B2 CS 241021 B2 CS241021 B2 CS 241021B2 CS 794585 A CS794585 A CS 794585A CS 458579 A CS458579 A CS 458579A CS 241021 B2 CS241021 B2 CS 241021B2
Authority
CS
Czechoslovakia
Prior art keywords
sub
methyl
compound
dimethyl
dihydropyridine
Prior art date
Application number
CS794585A
Other languages
Czech (cs)
English (en)
Inventor
Peder B Berntsson
Stig A I Carlsson
Jan Oe Gaarder
Bengt R Ljung
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20335348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS241021(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Haessle Ab filed Critical Haessle Ab
Priority to CS829181A priority Critical patent/CS241038B2/cs
Publication of CS241021B2 publication Critical patent/CS241021B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS794585A 1978-06-30 1979-06-29 Method of 2,6-dimethyl-4-(i8o-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxyl acid's 3-methyl-5-ethylester production CS241021B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS829181A CS241038B2 (cs) 1978-06-30 1979-06-29 Způsob výroby 3-methyl-5-ethylesteru kyseliny 2,6-dimethyl-4-(2,3-dichlorfenyl)-l,4-dihydropyridin-3,S- -dikarboxylové

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7807404A SE429652B (sv) 1978-06-30 1978-06-30 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester

Publications (1)

Publication Number Publication Date
CS241021B2 true CS241021B2 (en) 1986-03-13

Family

ID=20335348

Family Applications (1)

Application Number Title Priority Date Filing Date
CS794585A CS241021B2 (en) 1978-06-30 1979-06-29 Method of 2,6-dimethyl-4-(i8o-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxyl acid's 3-methyl-5-ethylester production

Country Status (24)

Country Link
US (1) US4264611A (bg)
EP (1) EP0007293B1 (bg)
JP (1) JPS559083A (bg)
AT (1) ATE1237T1 (bg)
AU (1) AU529116B2 (bg)
BG (1) BG61420B2 (bg)
CA (1) CA1117530A (bg)
CS (1) CS241021B2 (bg)
CY (1) CY1299A (bg)
DD (1) DD144667A5 (bg)
DE (1) DE2963150D1 (bg)
DK (1) DK148978C (bg)
FI (1) FI70573C (bg)
HK (1) HK60585A (bg)
HU (1) HU178568B (bg)
IE (1) IE48650B1 (bg)
LU (2) LU88666I2 (bg)
NL (2) NL930054I2 (bg)
NO (3) NO151965C (bg)
NZ (1) NZ190809A (bg)
SE (1) SE429652B (bg)
SG (1) SG26085G (bg)
SU (2) SU856380A3 (bg)
ZA (1) ZA792804B (bg)

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DE3447170A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
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JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
WO2009032286A2 (en) 2007-09-06 2009-03-12 Nektar Therapeutics Al, Corporation Oligomer-calcium channel blocker conjugates
AU2008324858A1 (en) * 2007-11-07 2009-05-14 Janssen Pharmaceutica N.V. Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists
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CN102827068A (zh) * 2011-06-17 2012-12-19 张锐豪 一种4-(2, 3-二氯苯基)-2, 6-二甲基-1, 4-二氢-5-甲氧基羰基-3-吡啶羧酸的制备方法
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CN104177286A (zh) * 2014-08-11 2014-12-03 广东东阳光药业有限公司 一种地平类药物的制备方法
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CN107952483B (zh) * 2017-12-18 2020-07-28 万华化学集团股份有限公司 一种催化剂，使用该催化剂的反应器，以及一种制备β-苯乙醇的方法
CN108840819B (zh) * 2018-04-02 2021-07-30 常州瑞明药业有限公司 一种非洛地平的制备方法
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Also Published As

Publication number Publication date
NL930054I1 (nl) 1993-09-01
SG26085G (en) 1986-01-24
LU88306I2 (fr) 1994-05-04
CA1117530A (en) 1982-02-02
NL930054I2 (nl) 1994-02-16
NO1996006I1 (no) 1996-06-24
DE2963150D1 (en) 1982-08-12
HU178568B (en) 1982-05-28
EP0007293B1 (en) 1982-06-23
IE48650B1 (en) 1985-04-03
FI70573C (fi) 1986-09-24
ZA792804B (en) 1980-06-25
SE7807404L (sv) 1979-12-31
LU88666I2 (fr) 1996-02-01
NL940012I1 (nl) 1994-08-01
SE429652B (sv) 1983-09-19
BG61420B2 (bg) 1997-07-31
IE791217L (en) 1979-12-30
EP0007293A1 (en) 1980-01-23
AU529116B2 (en) 1983-05-26
DK148978B (da) 1985-12-09
DD144667A5 (de) 1980-10-29
NZ190809A (en) 1982-03-09
NO151965C (no) 1985-07-10
SU915799A3 (en) 1982-03-23
HK60585A (en) 1985-08-23
NO1994026I1 (no) 1994-12-21
ATE1237T1 (de) 1982-07-15
DK275079A (da) 1979-12-31
FI792058A (fi) 1979-12-31
FI70573B (fi) 1986-06-06
US4264611B1 (bg) 1984-07-17
AU4831679A (en) 1980-02-07
JPS559083A (en) 1980-01-22
CY1299A (en) 1985-10-18
DK148978C (da) 1986-08-18
NO151965B (no) 1985-04-01
NO792112L (no) 1980-01-03
US4264611A (en) 1981-04-28
SU856380A3 (ru) 1981-08-15
JPS6121550B2 (bg) 1986-05-27

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