CS235306B2 - Method of new aminocompounds production - Google Patents

Method of new aminocompounds production Download PDF

Info

Publication number
CS235306B2
CS235306B2 CS83754A CS75483A CS235306B2 CS 235306 B2 CS235306 B2 CS 235306B2 CS 83754 A CS83754 A CS 83754A CS 75483 A CS75483 A CS 75483A CS 235306 B2 CS235306 B2 CS 235306B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
compound
group
compounds
ester
Prior art date
Application number
CS83754A
Other languages
Czech (cs)
English (en)
Inventor
Geoffrey G Coker
John W A Findlay
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Priority to CS842019A priority Critical patent/CS235348B2/cs
Priority to CS842018A priority patent/CS235347B2/cs
Priority to CS842021A priority patent/CS235350B2/cs
Priority to CS842020A priority patent/CS235349B2/cs
Publication of CS235306B2 publication Critical patent/CS235306B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CS83754A 1982-02-04 1983-02-03 Method of new aminocompounds production CS235306B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CS842019A CS235348B2 (cs) 1982-02-04 1984-03-21 Způsob výroby nových aminosloučenin
CS842018A CS235347B2 (cs) 1982-02-04 1984-03-21 Způsob výroby nových aminosloučenin
CS842021A CS235350B2 (cs) 1982-02-04 1984-03-21 Způsob výroby nových aminosloučenin
CS842020A CS235349B2 (cs) 1982-02-04 1984-03-21 Způsob výroby nových aminosloučenin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8203261 1982-02-04
GB8229705 1982-10-18

Publications (1)

Publication Number Publication Date
CS235306B2 true CS235306B2 (en) 1985-05-15

Family

ID=26281898

Family Applications (1)

Application Number Title Priority Date Filing Date
CS83754A CS235306B2 (en) 1982-02-04 1983-02-03 Method of new aminocompounds production

Country Status (32)

Country Link
EP (2) EP0085959B1 (pl)
JP (2) JPS6479153A (pl)
KR (6) KR880001466B1 (pl)
AT (2) ATE42282T1 (pl)
AU (1) AU555083B2 (pl)
BG (6) BG42185A3 (pl)
CA (2) CA1249830A (pl)
CS (1) CS235306B2 (pl)
CY (1) CY1627A (pl)
DD (1) DD209446A5 (pl)
DE (2) DE3382321D1 (pl)
DK (1) DK164662C (pl)
ES (6) ES8403872A1 (pl)
FI (1) FI82450C (pl)
GB (1) GB2114565B (pl)
GR (1) GR77407B (pl)
HK (1) HK25892A (pl)
HU (1) HU189223B (pl)
IE (1) IE54600B1 (pl)
IL (3) IL67829A (pl)
MC (1) MC1498A1 (pl)
NL (1) NL930057I2 (pl)
NO (2) NO162556C (pl)
NZ (1) NZ203171A (pl)
PH (1) PH21348A (pl)
PL (6) PL141639B1 (pl)
PT (1) PT76192B (pl)
SG (1) SG106091G (pl)
SI (1) SI8310221A8 (pl)
SU (1) SU1301312A3 (pl)
UY (1) UY23404A1 (pl)
YU (1) YU44821B (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562258A (en) * 1982-02-04 1985-12-31 Findlay John W A 6-[3-Amino-1-(4-tolyl)prop-1E-enyl]pyridine-2-carboxylic acid derivatives having antihistaminic activity
US4610995A (en) * 1984-07-27 1986-09-09 Coker Geoffrey G Certain 1,1-diaryl-propenyl-3-(1-pyrrolidino-2-carboxylic acids, derivatives thereof and their anti-histaminic properties
LU86387A1 (fr) * 1986-04-04 1987-12-07 Oreal Composes aromatiques,leur procede de preparation et leur utilisation en medicine humaine et veterinaire et en cosmetique
GB8707416D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
DE3711866A1 (de) * 1987-04-08 1988-10-27 Hoechst Ag Synthese von peptidamiden mittels festphasenmethode unter verwendung von saeurelabilen ankergruppen
GB8914040D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
PT94402A (pt) * 1989-06-19 1991-03-20 Wellcome Found Processo para a preparacao de compostos azotados que contem sistemas de aneis ciclicos aromaticos e de composicoes farmaceuticas que os contem
GB8914060D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
FR2711651B1 (fr) * 1993-10-28 1995-12-22 Adir Nouveaux analogues cyclisés de métabolites d'acides gras, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
US5420866A (en) * 1994-03-29 1995-05-30 Scientific-Atlanta, Inc. Methods for providing conditional access information to decoders in a packet-based multiplexed communications system
GB9508748D0 (en) * 1995-04-28 1995-06-14 British Biotech Pharm Benzimidazole derivatives
BR9609892A (pt) * 1995-08-05 1999-05-25 British Biotech Pharm Derivados de imidazopiridina
IT1277597B1 (it) * 1995-09-15 1997-11-11 Smithkline Beecham Spa Derivati di diarilalchenilammina
CN101838235B (zh) * 2009-06-12 2013-08-07 重庆华邦制药有限公司 3-苯基-3＇-吡啶基丙烯胺类化合物及其合成方法
US20140309244A1 (en) * 2010-09-23 2014-10-16 Syngenta Participations Ag Novel microbiocides
WO2013159884A2 (en) 2012-04-23 2013-10-31 Saudi Basic Industries Corporation Solar energy based countinuous process and reactor system for the production of an alkene by dehydrogenation of the corresponding alkane

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2567245A (en) * 1948-05-10 1951-09-11 Schering Corp Aryl-(2-pyridyl)-amino alkanes and their production
DE1227464B (de) * 1951-09-10 1966-10-27 Wellcome Found Verfahren zur Herstellung der trans-Form des neuen 1-(4'-Methylphenyl)-1-(2''-pyridyl)-3-pyrrolidinopropens-(1)
FR1228802A (fr) * 1954-05-03 1960-09-02 Farbwerke Hoechst Ag Vomals Me Procédé de préparation de composés tertio-amino-cétoniques
FR2197583B1 (pl) * 1972-09-07 1975-10-17 Rhone Poulenc Ind

Also Published As

Publication number Publication date
GR77407B (pl) 1984-09-13
PL140708B1 (en) 1987-05-30
AU555083B2 (en) 1986-09-11
YU22183A (en) 1986-02-28
IE54600B1 (en) 1989-12-06
PL240412A1 (en) 1985-01-30
EP0249950B1 (en) 1991-06-19
KR870001918B1 (ko) 1987-10-22
SG106091G (en) 1992-03-20
HK25892A (en) 1992-04-16
NL930057I2 (nl) 1994-02-16
IL78419A (en) 1989-01-31
FI82450C (fi) 1991-03-11
ES8500233A1 (es) 1984-10-01
KR840003628A (ko) 1984-09-15
ES523416A0 (es) 1984-10-01
HU189223B (en) 1986-06-30
DK43683A (da) 1983-08-05
NZ203171A (en) 1986-12-05
NO172341B (no) 1993-03-29
PL140811B1 (en) 1987-05-30
ES519491A0 (es) 1984-04-01
JPH0468B2 (pl) 1992-01-06
NO162556B (no) 1989-10-09
KR880001466B1 (ko) 1988-08-11
PT76192A (en) 1983-03-01
CA1249830A (en) 1989-02-07
ES8403872A1 (es) 1984-04-01
IL78419A0 (en) 1986-08-31
DK164662B (da) 1992-07-27
EP0085959B1 (en) 1989-04-19
JPS6479153A (en) 1989-03-24
JPH01301661A (ja) 1989-12-05
CA1275102A (en) 1990-10-09
SI8310221A8 (en) 1995-10-31
IL67829A0 (en) 1983-06-15
EP0249950A1 (en) 1987-12-23
DK43683D0 (da) 1983-02-03
BG41822A3 (en) 1987-08-14
SU1301312A3 (ru) 1987-03-30
IL67829A (en) 1988-06-30
ES8500231A1 (es) 1984-10-01
FI830380L (fi) 1983-08-05
FI82450B (fi) 1990-11-30
PL245845A1 (en) 1985-01-30
DE3379654D1 (en) 1989-05-24
CA1275102C (pl) 1990-10-09
KR870001915B1 (ko) 1987-10-22
PL245841A1 (en) 1985-01-30
BG42004A3 (en) 1987-09-15
YU44821B (en) 1991-02-28
PL141639B1 (en) 1987-08-31
ES8500235A1 (es) 1984-10-01
NO172341C (no) 1993-07-07
JPH0251897B2 (pl) 1990-11-08
PL140812B1 (en) 1987-05-30
EP0085959A2 (en) 1983-08-17
NO874330L (no) 1983-08-05
PL245844A1 (en) 1985-01-30
DK164662C (da) 1992-12-14
ES8500234A1 (es) 1984-10-01
GB8302971D0 (en) 1983-03-09
GB2114565A (en) 1983-08-24
ES523417A0 (es) 1984-10-01
PL245842A1 (en) 1985-01-30
CY1627A (en) 1992-07-10
ES523418A0 (es) 1984-10-01
ES8500232A1 (es) 1984-10-01
PL140809B1 (en) 1987-05-30
KR870001927B1 (ko) 1987-10-22
PL140810B1 (en) 1987-05-30
FI830380A0 (fi) 1983-02-03
BG41821A3 (en) 1987-08-14
MC1498A1 (fr) 1983-11-17
GB2114565B (en) 1985-06-26
PT76192B (en) 1986-01-24
ES523414A0 (es) 1984-10-01
ATE64596T1 (de) 1991-07-15
DD209446A5 (de) 1984-05-09
UY23404A1 (es) 1992-10-19
NL930057I1 (nl) 1993-09-01
BG42005A3 (en) 1987-09-15
DE3382321D1 (de) 1991-07-25
NO874330D0 (no) 1987-10-16
BG42003A3 (en) 1987-09-15
IE830213L (en) 1983-08-04
KR870001917B1 (ko) 1987-10-22
PL245843A1 (en) 1985-01-30
NO830368L (no) 1983-08-05
EP0085959A3 (en) 1984-07-18
AU1098283A (en) 1983-08-11
ES523415A0 (es) 1984-10-01
BG42185A3 (en) 1987-10-15
NO162556C (no) 1990-01-17
KR870001916B1 (ko) 1987-10-22
ATE42282T1 (de) 1989-05-15
PH21348A (en) 1987-10-13

Similar Documents

Publication Publication Date Title
US5374648A (en) Indole derivatives and pharmaceutical use thereof
US7932275B2 (en) 2-aminopyridine compounds useful as β-secretase inhibitors for the treatment of alzheimer's disease
CS235306B2 (en) Method of new aminocompounds production
DE60127595T2 (de) Inhibitoren der TNF-Alpha Bildung zur Behandlung von Autoimmunerkrankungen
JP2021511374A (ja) ピリドン誘導体と、その組成物、並びにそれらが抗ウイルス薬物としての応用
JPH06107649A (ja) ベンズアニリド誘導体
MX2014014961A (es) Compuestos y composiciones que modulan la actividad del receptor del factor de crecimiento epidermico (egfr).
KR20190086442A (ko) 피리딘 화합물
UA100867C2 (uk) Похідна (аза)індолу, заміщена в положенні 5, фармацевтична композиція, що містить її, проміжні сполуки та спосіб їх одержання
KR20110067029A (ko) 안드로겐 수용체 조절제로서 신규의 이미다졸리딘 화합물
CN102666526A (zh) 作为ccr1受体拮抗剂的吲唑和吡唑并吡啶化合物
EP1535922A1 (en) Pyrrolopyridine derivative and use thereof
JP7299382B2 (ja) Ｔｎｆ活性のモジュレーターとしての縮合五環式イミダゾール誘導体
TW202115077A (zh) Ｍａｌｔ１抑制劑及其用途
CA3066328A1 (en) Chemical compounds as atf4 pathway inhibitors
PT94070A (pt) Processo para a preparacao de derivados de piperazina
AU617988B2 (en) Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds
WO2008025526A1 (en) Indole derivatives, their manufacture and use as pharmaceutical agents
JPH02289548A (ja) ピリジン化合物
WO1998058930A1 (fr) Composes de triazolo-1,4-diazepine et composition medicinale les contenant
WO2020211836A1 (zh) 苯甲烯哌啶衍生物及其制备方法、中间体和用途
WO1995019345A1 (fr) Derive du diazacycloalcanealkylsufonamide
US4690933A (en) Pyridylvinyl-1H tetrazole having antihistamine activity
KR20000029564A (ko) 5ＨＴ2ｃ길항제및Ｄ2길항제를함유하는약제학적조성물
EP0133534B1 (en) Pyridyl compounds