CR20160250A - Acrilamidas de pirrolo[2,3-d]piriminilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinilo - Google Patents
Acrilamidas de pirrolo[2,3-d]piriminilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridiniloInfo
- Publication number
- CR20160250A CR20160250A CR20160250A CR20160250A CR20160250A CR 20160250 A CR20160250 A CR 20160250A CR 20160250 A CR20160250 A CR 20160250A CR 20160250 A CR20160250 A CR 20160250A CR 20160250 A CR20160250 A CR 20160250A
- Authority
- CR
- Costa Rica
- Prior art keywords
- pirrolo
- pyriminyl
- piridinyl
- pyrazinyl
- acrylic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
La presente invención provee acrilamidas farmacéuticamente activas de pirrolo [ 2 ,3- d ] pirimidinilo y pirrolo [ 2 ,3- d ] piridinilo y análogos de las mismas. Dichos compuestos son útiles para inhibir quinasa de Janus. Esta invención también estádirigida a composiciones que comprenden métodos para hacer dichos compuestos, y métodos para tratar y prevenir condiciones mediadas por JAK.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361912074P | 2013-12-05 | 2013-12-05 | |
PCT/IB2014/066202 WO2015083028A1 (en) | 2013-12-05 | 2014-11-20 | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides |
Publications (1)
Publication Number | Publication Date |
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CR20160250A true CR20160250A (es) | 2016-09-19 |
Family
ID=52144776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20160250A CR20160250A (es) | 2013-12-05 | 2014-11-20 | Acrilamidas de pirrolo[2,3-d]piriminilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinilo |
Country Status (46)
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101879422B1 (ko) * | 2013-09-18 | 2018-07-17 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | Btk 및/또는 jak3 키나제의 활성을 억제하는 화합물 |
KR101930603B1 (ko) * | 2013-12-05 | 2018-12-18 | 화이자 인코포레이티드 | 피롤로[2,3-d]피리미디닐, 피롤로[2,3-b]피라지닐 및 피롤로[2,3-d]피리디닐 아크릴아미드 |
WO2016000615A1 (en) * | 2014-07-02 | 2016-01-07 | Sunshine Lake Pharma Co., Ltd. | Heteroaryl compounds and pharmaceutical applications thereof |
CA2958966C (en) | 2014-08-28 | 2020-01-14 | Asceneuron Sa | Substituted cyclic amines as glucosidase inhibitors |
CN105712998B (zh) * | 2014-12-05 | 2019-12-13 | 上海润诺生物科技有限公司 | 氮杂吲哚类衍生物、其制备方法及其在医药上的应用 |
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