MD4649C1 - Pirol[2,3-d]pirimidinil, pirol[2,3-b]pirazinil şi pirol[2,3-d]piridinil acrilamide - Google Patents

Pirol[2,3-d]pirimidinil, pirol[2,3-b]pirazinil şi pirol[2,3-d]piridinil acrilamide

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Publication number
MD4649C1
MD4649C1 MDA20160058A MD20160058A MD4649C1 MD 4649 C1 MD4649 C1 MD 4649C1 MD A20160058 A MDA20160058 A MD A20160058A MD 20160058 A MD20160058 A MD 20160058A MD 4649 C1 MD4649 C1 MD 4649C1
Authority
MD
Moldova
Prior art keywords
pyrrolo
pyrazinyl
pyrimidinyl
acrylamides
pyridinyl
Prior art date
Application number
MDA20160058A
Other languages
English (en)
Russian (ru)
Other versions
MD4649B1 (ro
MD20160058A2 (ro
Inventor
Мэттью Фрэнк Браун
Августин КАЗИМИРО-ГАРСИЯ
Е Чэ
Джотам Уодсворт Коу
Марк Эдвард ФЛАНАГАН
Адам Мэтью Гилберт
Мэттью Меррилл Хэйворд
Джонатан Дэвид ЛАНЖИЛЬ
Джастин Ян МОНТГОМЕРИ
Жан-Батист ТЕЛЬЕЗ
Атли Тораренсен
Райоманд Джал Унвалла
Джон И. ТРУЖИЛЬО
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52144776&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD4649(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of MD20160058A2 publication Critical patent/MD20160058A2/ro
Publication of MD4649B1 publication Critical patent/MD4649B1/ro
Publication of MD4649C1 publication Critical patent/MD4649C1/ro

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Prezenta invenţie se referă la pirol[2,3-d]pirimidinil, pirol[2,3-b]pirazinil şi pirol[2,3-d]piridinil acrilamide farmaceutic active şi analogii acestora. Astfel de compuşi sunt utili pentru inhibiţia Kinazei Janus (JAK). De asemenea, invenţia se referă la compoziţii, ce cuprind asemenea compuşi, şi la metode de tratament şi prevenire a stărilor mediate de JAK.
MDA20160058A 2013-12-05 2014-11-20 Pirol[2,3-d]pirimidinil, pirol[2,3-b]pirazinil şi pirol[2,3-d]piridinil acrilamide MD4649C1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361912074P 2013-12-05 2013-12-05
PCT/IB2014/066202 WO2015083028A1 (en) 2013-12-05 2014-11-20 Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides

Publications (3)

Publication Number Publication Date
MD20160058A2 MD20160058A2 (ro) 2016-11-30
MD4649B1 MD4649B1 (ro) 2019-09-30
MD4649C1 true MD4649C1 (ro) 2020-04-30

Family

ID=52144776

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20160058A MD4649C1 (ro) 2013-12-05 2014-11-20 Pirol[2,3-d]pirimidinil, pirol[2,3-b]pirazinil şi pirol[2,3-d]piridinil acrilamide

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US (3) US9617258B2 (ro)
EP (2) EP3318565B1 (ro)
JP (2) JP6192839B2 (ro)
KR (1) KR101930603B1 (ro)
CN (2) CN107417684A (ro)
AP (1) AP2016009269A0 (ro)
AR (1) AR099363A1 (ro)
AU (1) AU2014358792C1 (ro)
BR (1) BR112016012262B1 (ro)
CA (1) CA2932425C (ro)
CL (1) CL2016001216A1 (ro)
CR (1) CR20160250A (ro)
CU (1) CU24396B1 (ro)
CY (2) CY1119778T1 (ro)
DK (2) DK3077395T3 (ro)
DO (1) DOP2016000124A (ro)
EA (1) EA030472B1 (ro)
ES (2) ES2871524T3 (ro)
FI (1) FIC20230035I1 (ro)
GE (1) GEP20186840B (ro)
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HR (2) HRP20171846T1 (ro)
HU (3) HUE054560T2 (ro)
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HUS2300040I1 (hu) 2023-12-28
LT3318565T (lt) 2021-06-25
EA030472B1 (ru) 2018-08-31
MA39092B1 (fr) 2018-09-28
RS56728B1 (sr) 2018-03-30
ME02883B (me) 2018-04-20
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NL301245I2 (nl) 2023-11-20
JP2018008996A (ja) 2018-01-18
EP3077395B1 (en) 2017-11-15
HRP20210770T1 (hr) 2021-06-25
PT3077395T (pt) 2018-01-03
MD20160058A2 (ro) 2016-11-30
CR20160250A (es) 2016-09-19
CA2932425A1 (en) 2015-06-11
CA2932425C (en) 2018-07-17
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PL3077395T3 (pl) 2018-04-30

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