CR20110079A - Anticuerpos neutralizantes del virus anti-influenza y usos de los mismos - Google Patents

Anticuerpos neutralizantes del virus anti-influenza y usos de los mismos

Info

Publication number
CR20110079A
CR20110079A CR20110079A CR20110079A CR20110079A CR 20110079 A CR20110079 A CR 20110079A CR 20110079 A CR20110079 A CR 20110079A CR 20110079 A CR20110079 A CR 20110079A CR 20110079 A CR20110079 A CR 20110079A
Authority
CR
Costa Rica
Prior art keywords
same
influenza virus
neutralizing antibodies
subtype
group
Prior art date
Application number
CR20110079A
Other languages
English (en)
Spanish (es)
Inventor
Antonio Lanzavecchia
Original Assignee
Inst Research In Biomedicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Research In Biomedicine filed Critical Inst Research In Biomedicine
Publication of CR20110079A publication Critical patent/CR20110079A/es

Links

Classifications

    • C07K16/108—
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CR20110079A 2008-07-25 2011-02-11 Anticuerpos neutralizantes del virus anti-influenza y usos de los mismos CR20110079A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8383808P 2008-07-25 2008-07-25
US18158209P 2009-05-27 2009-05-27

Publications (1)

Publication Number Publication Date
CR20110079A true CR20110079A (es) 2011-07-18

Family

ID=41570664

Family Applications (2)

Application Number Title Priority Date Filing Date
CR20110079A CR20110079A (es) 2008-07-25 2011-02-11 Anticuerpos neutralizantes del virus anti-influenza y usos de los mismos
CR20110084A CR20110084A (es) 2008-07-25 2011-02-14 Anticuerpos neutralizantes del virus anti-influenza a y usos de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20110084A CR20110084A (es) 2008-07-25 2011-02-14 Anticuerpos neutralizantes del virus anti-influenza a y usos de los mismos

Country Status (20)

Country Link
US (2) US8685402B2 (show.php)
EP (2) EP2313433A2 (show.php)
JP (3) JP5607620B2 (show.php)
KR (2) KR20110049802A (show.php)
CN (2) CN102164613B (show.php)
AU (2) AU2009275226B2 (show.php)
BR (1) BRPI0911699B8 (show.php)
CA (2) CA2733218A1 (show.php)
CO (1) CO6341572A2 (show.php)
CR (2) CR20110079A (show.php)
EC (1) ECSP11010823A (show.php)
ES (1) ES2662519T3 (show.php)
GT (1) GT201100023A (show.php)
IL (2) IL210771A0 (show.php)
MA (1) MA32577B1 (show.php)
MX (2) MX2011000767A (show.php)
NZ (2) NZ590890A (show.php)
RU (1) RU2553325C2 (show.php)
WO (2) WO2010010467A2 (show.php)
ZA (2) ZA201101113B (show.php)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101970483A (zh) 2007-12-06 2011-02-09 达纳-法伯癌症研究公司 抗流感病毒抗体及其使用方法
EP2313433A2 (en) * 2008-07-25 2011-04-27 Institute for Research in Biomedicine Neutralizing anti-influenza a virus antibodies and uses thereof
US8871207B2 (en) 2008-07-25 2014-10-28 Humabs, LLC Neutralizing anti-influenza A virus antibodies and uses thereof
CA2849668A1 (en) * 2010-03-08 2011-09-15 Celltrion, Inc. Human monoclonal antibodies derived from human b cells and having neutralizing activity against influenza a viruses
US10676520B2 (en) 2010-06-17 2020-06-09 Trellis Bioscience, Llc Antibodies useful in passive influenza immunization
US9534042B2 (en) * 2010-09-03 2017-01-03 Fujita Health University Influenza virus-neutralizing antibody and screening method therefor
WO2012045001A2 (en) * 2010-09-30 2012-04-05 Vanderbilt University Influenza virus antibodies and immunogens and uses therefor
WO2012145572A1 (en) 2011-04-20 2012-10-26 The Trustees Of The University Of Pennsylvania Regimens and compositions for aav-mediated passive immunization of airborne pathogens
CA2838999C (en) 2011-07-14 2021-02-16 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza a viruses of phylogenetic group 1 and phylogenetic group 2 and influenza b viruses
CA2841551C (en) * 2011-07-18 2020-07-28 Institute For Research In Biomedicine Neutralizing anti-influenza a virus antibodies and uses thereof
CN107417789A (zh) * 2011-07-18 2017-12-01 生物医学学会 中和抗甲型流感病毒抗体及其用途
WO2013020074A2 (en) * 2011-08-03 2013-02-07 Children's Medical Center Corporation A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin
WO2013030165A1 (en) * 2011-08-27 2013-03-07 Universität Zürich Multi-strain-reactive antibodies for therapy and diagnosis of influenza
WO2013048153A2 (ko) 2011-09-30 2013-04-04 (주)셀트리온 인간 ｂ 세포에서 생산된 인플루엔자 ａ 바이러스 중화 활성을 가지는 결합 분자
EP2768858B1 (en) * 2011-10-18 2018-08-01 Emory University Antibodies directed against influenza
KR20130059721A (ko) * 2011-11-29 2013-06-07 (주)셀트리온 인간 ｂ 세포에서 생산된 인플루엔자 ａ 바이러스 중화 활성을 가지는 결합 분자
CA2892992A1 (en) 2011-12-02 2013-06-06 Aimm Therapeutics B.V. Influenza a virus specific antibodies
JP6371222B2 (ja) * 2011-12-05 2018-08-08 トレリス バイオサイエンス リミテッド ライアビリティー カンパニー インフルエンザの受動免疫用抗体
ES2564138T3 (es) * 2011-12-12 2016-03-18 Novartis Ag Ensayo para Hemaglutinina del virus de la influenza
WO2013089496A1 (ko) * 2011-12-15 2013-06-20 (주)에이프로젠 H1n1-감염된 환자들로부터 유도된 매우 잠재력 있는 넓은-스펙트럼 중화 단일클론 항체 및 이를 포함하는 바이러스의 치료용 조성물
RU2502745C2 (ru) * 2011-12-30 2013-12-27 Общество с ограниченной ответственностью "Технофарма" Наноантитело "anti-flu", рекомбинантные вирусные векторы и фармацевтические композиции для профилактики и терапии гриппа типа а
JP6328061B2 (ja) * 2012-03-08 2018-05-23 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． Ｂ型インフルエンザウイルスに結合して中和することができるヒト結合分子およびその使用
US9969794B2 (en) * 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
JP6431477B2 (ja) 2012-05-10 2018-12-05 マサチューセッツ インスティテュート オブ テクノロジー インフルエンザの中和のための薬剤
CN103665157B (zh) * 2012-09-14 2016-06-29 中国科学院上海生命科学研究院 一种抗流感病毒广谱中和性的中和分子1c4
CN103665154B (zh) * 2012-09-14 2016-08-03 中国科学院上海生命科学研究院 一种抗流感病毒广谱中和性的中和分子3c4
CN103665155B (zh) * 2012-09-14 2016-07-06 中国科学院上海生命科学研究院 一种抗流感病毒广谱中和性的中和分子1f2
CN103665156B (zh) * 2012-09-14 2016-08-03 中国科学院上海生命科学研究院 一种抗流感病毒广谱中和性的结合分子3e1
MX2015005860A (es) 2012-11-13 2015-08-10 Genentech Inc Anticuerpos de antihemaglutinina y metodo de uso.
MX387277B (es) * 2013-03-14 2025-03-12 Contrafect Corp Composiciones basadas en anticuerpos neutralizantes suministrados intranasalmente para eficacia terapéutica aumentada.
KR20140118682A (ko) 2013-03-29 2014-10-08 (주)셀트리온 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물
CN104098692B (zh) * 2013-04-02 2018-11-30 厦门大学 识别流感病毒血凝素蛋白ha1结构域的广谱单克隆抗体
CN118005782A (zh) * 2013-10-02 2024-05-10 免疫医疗有限责任公司 中和抗甲型流感抗体及其用途
WO2015068781A1 (ja) * 2013-11-06 2015-05-14 国立大学法人大阪大学 インフルエンザウイルスａ型のグループ１に対して広域な中和活性を有する抗体
US10639370B2 (en) 2014-02-04 2020-05-05 Contrafect Corporation Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof
WO2015120097A2 (en) 2014-02-04 2015-08-13 Contrafect Corporation Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof
CN104892753B (zh) * 2014-03-07 2019-11-29 神州细胞工程有限公司 一种中和人感染h7n9甲型流感病毒的抗体及其用途
HRP20201530T1 (hr) 2014-05-13 2020-12-11 The Trustees Of The University Of Pennsylvania Kompozicije koje sadrže aav koji eksprimira konstrukte dvojnih antitijela i njihove primjene
JP6495434B2 (ja) * 2014-07-14 2019-04-03 ザ ペン ステイト リサーチ ファンデーション サーファクタントタンパク質ａ受容体を標的とする組成物及び方法
EP3169407A4 (en) 2014-07-15 2018-04-25 Medimmune, LLC Neutralizing anti-influenza b antibodies and uses thereof
WO2016010160A1 (ja) * 2014-07-18 2016-01-21 国立感染症研究所長が代表する日本国 抗インフルエンザウイルス抗体及びその利用
US20180008702A1 (en) * 2014-12-05 2018-01-11 Celltrion Inc. Adjuvant composition containing at least one influenza virus neutralizing and binding molecule and vaccine composition containing same
WO2016089181A1 (ko) * 2014-12-05 2016-06-09 (주)셀트리온 1 이상의 인플루엔자 바이러스 중화 결합 분자를 포함하는 애주번트 조성물 및 이를 포함하는 백신 조성물
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
CN108135994B (zh) 2015-05-13 2022-01-25 宾夕法尼亚州大学信托人 Aav-介导的抗-流感抗体的表达及其使用方法
EP3303384B1 (en) 2015-06-01 2021-08-25 Medimmune, LLC Neutralizing anti-influenza binding molecules and uses thereof
EP3374390A1 (en) 2015-11-13 2018-09-19 Visterra, Inc. Compositions and methods for treating and preventing influenza
AU2017207330C1 (en) * 2016-01-13 2022-06-09 Medimmune, Llc Method of treating influenza A
AU2017222564A1 (en) 2016-02-24 2018-09-06 Visterra, Inc. Formulations of antibody molecules to influenza virus
CN109803640B (zh) * 2016-08-10 2022-01-04 赛特瑞恩股份有限公司 稳定的液体抗流感病毒抗体医药调配物
JP2017086068A (ja) * 2016-10-31 2017-05-25 インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ Ａ型インフルエンザウイルス中和抗体及びその使用法
RU2656142C1 (ru) * 2016-12-30 2018-05-31 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA1FI6-ht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IGA1
RU2664184C2 (ru) * 2016-12-30 2018-08-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA1FI6-Intht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IgA1
RU2671477C2 (ru) * 2016-12-30 2018-10-31 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA2m1F16-ht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IGA2m1
JOP20190200A1 (ar) 2017-02-28 2019-08-27 Univ Pennsylvania تركيبات نافعة في معالجة ضمور العضل النخاعي
EP4272765A3 (en) 2017-02-28 2024-02-21 The Trustees of The University of Pennsylvania Adeno-associated virus (aav) clade f vector and uses therefor
SG11201907611WA (en) 2017-02-28 2019-09-27 Univ Pennsylvania Influenza vaccines based on aav vectors
JP7403733B2 (ja) 2017-09-04 2023-12-25 国立感染症研究所長 インフルエンザｈａスプリットワクチンの製造方法
CN111433369A (zh) * 2017-09-18 2020-07-17 阿迈瑞斯公司 用于毕赤酵母和其他宿主细胞基因组整合的方法
US11685934B2 (en) 2017-09-18 2023-06-27 Amyris, Inc. Methods for genomic integration for Kluyveromyces host cells
CN109988236B (zh) * 2017-12-30 2022-04-01 中国科学院天津工业生物技术研究所 一种流感病毒抗体的应用
BR112020014343A2 (pt) * 2018-01-23 2020-12-08 Janssen Vaccines & Prevention B.V. Vacinas contra o vírus da influenza e seus usos
JP6622825B2 (ja) * 2018-01-25 2019-12-18 インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ Ａ型インフルエンザウイルス中和抗体及びその使用法
CA3088194A1 (en) 2018-01-26 2019-08-01 Regeneron Pharmaceuticals, Inc. Human antibodies to influenza hemagglutinin
WO2020022272A1 (ja) 2018-07-23 2020-01-30 公益財団法人ヒューマンサイエンス振興財団 インフルエンザワクチンを含む組成物
US11407828B2 (en) 2019-02-01 2022-08-09 Novarock Biotherapeutics, Ltd. Anti-CLauDiN 18 antibodies and methods of use thereof
WO2020179797A1 (ja) 2019-03-04 2020-09-10 公益財団法人ヒューマンサイエンス振興財団 インフルエンザｈａスプリットワクチンの製造方法
EP3946613A1 (en) 2019-03-25 2022-02-09 Visterra, Inc. Compositions and methods for treating and preventing influenza
JP2020048568A (ja) * 2019-11-22 2020-04-02 インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ Ａ型インフルエンザウイルス中和抗体及びその使用法
JP2023506156A (ja) 2019-12-11 2023-02-15 ビステラ， インコーポレイテッド インフルエンザを処置または予防するための組成物および方法
WO2021201677A1 (en) 2020-04-01 2021-10-07 Kiadis Pharma Intellectual Property B.V. Compositions and methods targeting influenza
CN111825763B (zh) * 2020-07-15 2022-04-19 扬州大学 流感病毒ha蛋白茎部特异性单克隆抗体及其制备方法和应用
CN114181303B (zh) * 2020-09-14 2022-12-23 东莞市朋志生物科技有限公司 抗甲型流感病毒的抗体和试剂盒
MX2023006444A (es) 2020-12-01 2023-08-10 Univ Pennsylvania Composiciones novedosas con motivos dirigidos a tejido específico y composiciones que los contienen.
EP4329885A1 (en) 2021-04-27 2024-03-06 Generation Bio Co. Non-viral dna vectors expressing therapeutic antibodies and uses thereof
AU2023235112A1 (en) 2022-03-14 2024-10-17 Generation Bio Co. Heterologous prime boost vaccine compositions and methods of use
KR20240088574A (ko) 2022-11-21 2024-06-20 (주)샤페론 인플루엔자 바이러스에 대한 단일 도메인 항체 및 이의 용도
CN119930806B (zh) * 2025-01-21 2025-12-02 中国医学科学院病原生物学研究所 一种甲型流感病毒中和抗体及其应用

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US630064A (en) * 1899-02-10 1899-08-01 William Martindale Safety-hook.
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3766162A (en) 1971-08-24 1973-10-16 Hoffmann La Roche Barbituric acid antigens and antibodies specific therefor
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
JPS5896026A (ja) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
DE3380726D1 (en) 1982-06-24 1989-11-23 Japan Chem Res Long-acting composition
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4831175A (en) 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
RU2031941C1 (ru) * 1991-03-14 1995-03-27 Научно-исследовательский институт гриппа РАМН Штамм вируса гриппа а(нini) для получения живой гриппозной интраназальной вакцины для взрослых и детей
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
ES2176484T3 (es) 1995-08-18 2002-12-01 Morphosys Ag Bancos de proteinas/(poli)peptidos.
US6300104B1 (en) 1997-06-19 2001-10-09 The Regents Of The University Of California Secretory immunoglobulin produced by single cells and methods for making and using same
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
WO2001062907A1 (fr) * 2000-02-22 2001-08-30 Medical & Biological Laboratories Co., Ltd. Bibliotheque d'anticorps
WO2004007667A2 (en) 2002-07-11 2004-01-22 The General Hospital Corporation Polynucleotide and polypeptide fat metabolism regulators and uses thereof
CN1756562A (zh) * 2003-03-07 2006-04-05 麦克公司 流感病毒疫苗
CN1867355A (zh) 2003-08-11 2006-11-22 财团法人阪大微生物病研究会 包含诱导粘膜免疫的佐剂的新型疫苗
WO2006124269A2 (en) 2005-05-16 2006-11-23 Amgen Fremont Inc. Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
CA2625664C (en) * 2005-10-21 2016-01-05 Novartis Ag Human antibodies against il13 and therapeutic uses
TWI477602B (zh) 2006-02-09 2015-03-21 Educational Foundation Jichi Medical Univ Novel viral vector
JP2009537147A (ja) * 2006-05-15 2009-10-29 シー レーン バイオテクノロジーズ， エルエルシー インフルエンザウイルスに対する中和抗体
AU2007293662B2 (en) * 2006-09-07 2012-10-04 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof
ES2859825T3 (es) * 2006-10-02 2021-10-04 Regeneron Pharma Anticuerpos humanos con alta afinidad para el receptor IL-4 humano
AU2007325872B2 (en) * 2006-11-08 2012-12-13 Macrogenics West, Inc. TES7 and antibodies that bind thereto
EP1925318A1 (en) * 2006-11-20 2008-05-28 Paul-Ehrlich-Institut Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu
NO347649B1 (no) 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
GB0700133D0 (en) * 2007-01-04 2007-02-14 Humabs Llc Human cytomegalovirus neutralising antibodies and use thereof
JP5346820B2 (ja) * 2007-03-13 2013-11-20 エイチユーエムエイビーエス・リミテッド・ライアビリティ・カンパニー Ｈ５ｎ１亜型ａ型インフルエンザウィルスに対する抗体
ITTO20080204A1 (it) 2008-03-17 2009-09-18 Pomona Biotechnologies Llc Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a
US8871207B2 (en) * 2008-07-25 2014-10-28 Humabs, LLC Neutralizing anti-influenza A virus antibodies and uses thereof
EP2313433A2 (en) 2008-07-25 2011-04-27 Institute for Research in Biomedicine Neutralizing anti-influenza a virus antibodies and uses thereof

Also Published As

Publication number Publication date
ECSP11010823A (es) 2011-08-31
IL210771A0 (en) 2011-03-31
CN102164613B (zh) 2014-11-26
CA2731686C (en) 2020-04-07
JP2011528902A (ja) 2011-12-01
NZ590891A (en) 2013-03-28
WO2010010466A3 (en) 2010-07-29
JP5607620B2 (ja) 2014-10-15
US20100080813A1 (en) 2010-04-01
BRPI0911699B8 (pt) 2023-02-28
EP2313433A2 (en) 2011-04-27
KR20110049802A (ko) 2011-05-12
US20100086555A1 (en) 2010-04-08
RU2011105062A (ru) 2012-08-27
NZ590890A (en) 2013-05-31
WO2010010467A3 (en) 2010-12-16
JP2014237714A (ja) 2014-12-18
MX2011000767A (es) 2011-09-21
JP6022515B2 (ja) 2016-11-09
EP2313112A2 (en) 2011-04-27
IL210772A0 (en) 2011-03-31
WO2010010466A2 (en) 2010-01-28
BRPI0911699B1 (pt) 2020-11-17
KR20110047193A (ko) 2011-05-06
ZA201101113B (en) 2012-08-29
GT201100023A (es) 2013-12-10
US9340603B2 (en) 2016-05-17
JP2011528901A (ja) 2011-12-01
HK1161110A1 (zh) 2012-08-24
US8685402B2 (en) 2014-04-01
CA2733218A1 (en) 2010-01-28
MA32577B1 (fr) 2011-08-01
WO2010010467A2 (en) 2010-01-28
CO6341572A2 (es) 2011-11-21
AU2009275226A1 (en) 2010-01-28
ZA201101150B (en) 2012-08-29
EP2313112B1 (en) 2017-12-27
CR20110084A (es) 2011-07-18
CN102164613A (zh) 2011-08-24
CN102216327A (zh) 2011-10-12
RU2553325C2 (ru) 2015-06-10
AU2009275226B2 (en) 2015-05-14
KR101732056B1 (ko) 2017-05-02
AU2009275227A1 (en) 2010-01-28
MX2011000768A (es) 2011-10-05
BRPI0911699A2 (pt) 2014-09-23
CA2731686A1 (en) 2010-01-28
ES2662519T3 (es) 2018-04-06

Similar Documents

Publication Publication Date Title
CR20110079A (es) Anticuerpos neutralizantes del virus anti-influenza y usos de los mismos
MX382043B (es) Anticuerpo anti-influenza a neutralizantes y usos de los mismos.
EA201500854A1 (ru) Композиция, содержащая по меньшей мере две связывающие молекулы, нейтрализующие вирус гриппа а
MX366180B (es) Nuevos agentes de union a ha.
MX2017010009A (es) Moléculas de unión dirigidas contra hemaglutinina de virus influenza y usos de las mismas.
NZ588238A (en) Monoclonal antibodies capable of reacting with a plurality of influenza virus a subtypes
CL2017001610A1 (es) Anticuerpos humanos para hemagglutinina de influenza
EA201490288A1 (ru) Связывающие молекулы человека, способные нейтрализовать вирусы гриппа a филогенетической группы 1 и филогенетической группы 2 и вирусы гриппа b
EA201391713A1 (ru) Нейтрализующие вирус иммунодефицита человека антитела и способы их применения
EA201171383A1 (ru) Человеческие связывающие молекулы, обладающие способностью нейтрализовывать вирус гриппа h3n2, и их применение
MX360056B (es) Moléculas de unión humanas que pueden unirse a los virus de la influenza b y neutralizarlos, y sus usos.
MX389274B (es) Anticuerpo que neutraliza el virus respiratorio sincitial humano.
MX2020012132A (es) Compuestos de azapiridona y usos de los mismos.
CR20120184A (es) Anticuerpos monoclonales frente a progastrina y su usos
MX2014000749A (es) Anticuerpos neutralizantes del virus de la influenza a y usos de estos.
EA200970255A1 (ru) Связывающие молекулы человека, способные нейтрализовать вирус гриппа h5n1, и их применение
GT201300293A (es) 4-aril-n-fenil-1,3,5-triazin-2-aminas que contienen un grupo sulfoximina.
BR112016014731A2 (pt) Anticorpos anti-baff
EA201290955A1 (ru) Полноразмерные иммуноглобулины изотипа igg, способные к распознаванию нейтрализующего эпитопа в области стебля гемагглютинина различных подтипов, и их использование в качестве лекарственного средства против гриппа
MX392761B (es) Anticuerpos anti-influenza b neutralizantes y usos de los mismos.
MX2017015189A (es) Neutralizacion de moleculas de union anti-influenza y usos de las mismas.
MX2019007252A (es) Metodos y composiciones para vacunas del virus del dengue.
CY1121237T1 (el) Ενωσεις για αγωγη του αποκλεισμου επαναμυελινωσης σε παθησεις που συσχετιζονται με την εκφραση της πρωτεϊνης φακελου herv-w
EA201590877A1 (ru) Антитела к прокинетициновым рецепторам (prokr) их применение
HK1169126A (en) Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof