HRP20201530T1 - Kompozicije koje sadrže aav koji eksprimira konstrukte dvojnih antitijela i njihove primjene - Google Patents
Kompozicije koje sadrže aav koji eksprimira konstrukte dvojnih antitijela i njihove primjene Download PDFInfo
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- HRP20201530T1 HRP20201530T1 HRP20201530TT HRP20201530T HRP20201530T1 HR P20201530 T1 HRP20201530 T1 HR P20201530T1 HR P20201530T T HRP20201530T T HR P20201530TT HR P20201530 T HRP20201530 T HR P20201530T HR P20201530 T1 HRP20201530 T1 HR P20201530T1
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- recombinant aav
- expression cassette
- orf
- expression
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- 239000000203 mixture Substances 0.000 title claims 3
- 230000009977 dual effect Effects 0.000 title 1
- 108700026244 Open Reading Frames Proteins 0.000 claims 19
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 6
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 6
- 230000001105 regulatory effect Effects 0.000 claims 6
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 4
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 241000702421 Dependoparvovirus Species 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 230000002457 bidirectional effect Effects 0.000 claims 2
- 210000000234 capsid Anatomy 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
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- C12N2750/14011—Parvoviridae
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
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- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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Claims (20)
1. Rekombinantni adeno-asocirani virus (AAV - recombinant adeno-associated virus) koji ima AAV kapsidu i u njemu upakiranu heterolognu nukleinsku kiselinu koja eksprimira dva funkcionalna monospecifična antitijela u stanici, gdje rekombinantni AAV sadrži:
5' AAV invertirano terminalno ponavljanje (ITR);
prvu ekspresijsku kasetu koja kodira barem prvi otvoreni okvir čitanja (ORF – open reading frame) za prvi imunoglobulin pod kontrolom regulatornih kontrolnih sekvenci koje upravljaju njegovim eksprimiranjem;
drugu ekspresijsku kasetu koja sadrži drugi ORF, veznik, i treći ORF pod kontrolom regulatornih kontrolnih sekvenci koje upravljaju njegovim eksprimiranjem, gdje su drugi i treći ORF za drugi i treći imunoglobulinski konstrukt; i
3'AAV ITR,
pri čemu su laki lanac imunoglobulina, prvi teški lanac imunoglobulina i drugi teški lanac imunoglobulina kodirani.
2. Rekombinantni AAV prema patentnom zahtjevu 1, pri čemu rekombinantni AAV dalje eksprimira bispecifično antitijelo.
3. Rekombinantni AAV prema patentnom zahtjevu 1, pri čemu rekombinantni AAV sadrži bidirekcijski pojačivač koji je smješten između prve ekspresijske kasete i druge ekspresijske kasete.
4. Rekombinantni AAV prema patentnom zahtjevu 1, pri čemu prvi ORF kodira laki lanac imunoglobulina, drugi ORF kodira prvi teški lanac imunoglobulina i treći ORF kodira drugi teški lanac, pri čemu ekspresioni funkcionalni konstrukti antitijela imaju dva različita teška lanca sa različitim specifičnostima koji dijele laki lanac.
5. Rekombinantni AAV prema patentnom zahtjevu 1, gdje barem jedan od drugog ili trećeg ORF sadrži modificirane Fc kodirajuće sekvence.
6. Rekombinantni AAV prema patentnom zahtjevu 1, gdje veznik u drugoj kaseti sadrži veznik odabran od IRES ili F2A.
7. Rekombinantni AAV prema patentnom zahtjevu 1, gdje regulatorne kontrolne sekvence za prvu ekspresijsku kasetu i/ili drugu kasetu sadrže minimalni promoter.
8. Rekombinantni AAV prema patentnom zahtjevu 1, gdje regulatorne kontrolne sekvence za prvu ekspresijsku kasetu i/ili drugu ekspresijsku kasetu sadrže minimalni ili sintetički poliA.
9. Rekombinantni AAV prema patentnom zahtjevu 1, gdje je prva ekspresijska kaseta bicistronska i sadrži dalje ORF.
10. Rekombinantni AAV prema patentnom zahtjevu 9, gdje svaki od ORF sadrži scFv.
11. Rekombinantni AAV prema patentnom zahtjevu 1, gdje vektor sadrži bidirekcijski poliA između prve ekspresijske kasete i druge ekspresijske kasete.
12. Rekombinantni AAV prema patentnom zahtjevu 10, gdje prva ekspresijska kaseta sadrži pojačivač i minimalni promoter.
13. Rekombinantni AAV prema patentnom zahtjevu 12, gdje druga ekspresijska kaseta sadrži pojačivač i minimalni promoter.
14. Rekombinantni AAV prema patentnom zahtjevu 8, gdje prva i druga ekspresijska kaseta zajedno eksprimiraju dva Fab-a.
15. Rekombinantni AAV prema patentnom zahtjevu 1, gdje dva monospecifična antitijela imaju različite specifičnosti.
16. Rekombinantni AAV prema patentnom zahtjevu 1, gdje su dva monospecifična antitijela nezavisno odabrana od monoklonskog antitijela, imunoadhezina, Fab-a, bifunkcionalnog antitijela, i njihovih kombinacija.
17. Rekombinantni adeno-asocirani virus (AAV) koji ima AAV kapsidu i u njemu upakiranu heterolognu nukleinsku kiselinu koja eksprimira dva funkcionalna monospecifična antitijela, gdje rekombinantni AAV eksprimira prvo monoklonsko antitijelo koje ima prvu specifičnost, drugo monoklonsko antitijelo koje ima specifičnost različitu od prvog monoklonskog antitijela, i bispecifično antitijelo, i gdje rekombinantni AAV sadrži:
5' AAV invertirano terminalno ponavljanje (ITR);
prvu ekspresijsku kasetu koja kodira barem prvi otvoreni okvir čitanja (ORF) za prvi imunoglobulin pod kontrolom regulatornih kontrolnih sekvenci koje upravljaju njegovim eksprimiranjem;
drugu ekspresijsku kasetu koja sadrži drugi ORF, veznik, i treći ORF pod kontrolom regulatornih kontrolnih sekvenci koje upravljaju njegovim eksprimiranjem, gdje su drugi i treći ORF za drugi i treći konstrukt imunoglobulina; i
3'AAV ITR,
pri čemu su laki lanac imunoglobulina, prvi teški lanac imunoglobulina i drugi teški lanac imunoglobulina kodirani.
18. Farmaceutska kompozicija koja sadrži rekombinantni AAV prema bilo kojem od patentnih zahtjeva 1 do 17 i farmaceutski prihvatljiv nosač.
19. Kompozicija za primjenu u postupku dostavljanja dva funkcionalna monospecifična antitijela subjektu, pri čemu navedena kompozicija sadrži rekombinantni AAV prema bilo kojem od patentnih zahtjeva 1 do 17.
20. Rekombinantni AAV prema patentnom zahtjevu 17, gdje prvi ORF kodira laki lanac imunoglobulina, drugi ORF kodira prvi teški lanac imunoglobulina i treći ORF kodira drugi teški lanac, pri čemu ekspresioni funkcionalni konstrukti antitijela imaju dva različita teška lanca sa različitim specifičnostima koji dijele laki lanac.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461992649P | 2014-05-13 | 2014-05-13 | |
| PCT/US2015/030533 WO2015175639A1 (en) | 2014-05-13 | 2015-05-13 | Compositions comprising aav expressing dual antibody constructs and uses thereof |
| EP15792528.0A EP3142750B1 (en) | 2014-05-13 | 2015-05-13 | Compositions comprising aav expressing dual antibody constructs and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201530T1 true HRP20201530T1 (hr) | 2020-12-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201530TT HRP20201530T1 (hr) | 2014-05-13 | 2020-09-24 | Kompozicije koje sadrže aav koji eksprimira konstrukte dvojnih antitijela i njihove primjene |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US10138295B2 (hr) |
| EP (1) | EP3142750B1 (hr) |
| JP (3) | JP6974943B2 (hr) |
| KR (1) | KR102550926B1 (hr) |
| CN (1) | CN106470736B (hr) |
| AU (2) | AU2015259188B2 (hr) |
| CA (1) | CA2947614C (hr) |
| CL (1) | CL2016002840A1 (hr) |
| CR (1) | CR20160519A (hr) |
| DK (1) | DK3142750T3 (hr) |
| EA (1) | EA037980B1 (hr) |
| ES (1) | ES2833230T3 (hr) |
| HR (1) | HRP20201530T1 (hr) |
| HU (1) | HUE050609T2 (hr) |
| IL (1) | IL248508B2 (hr) |
| MA (2) | MA44179B1 (hr) |
| MX (1) | MX365658B (hr) |
| MY (1) | MY186389A (hr) |
| PE (1) | PE20170261A1 (hr) |
| PH (1) | PH12016502239B1 (hr) |
| PL (1) | PL3142750T3 (hr) |
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Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015012924A2 (en) | 2013-04-29 | 2015-01-29 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof |
| DK3142750T3 (da) | 2014-05-13 | 2020-09-14 | Univ Pennsylvania | Sammensætninger omfattende aav, som udtrykker dobbelt-antistofkonstrukter og anvendelser deraf |
| EP3307310A2 (en) | 2015-05-13 | 2018-04-18 | The Trustees Of The University Of Pennsylvania | Aav-mediated expression of anti-influenza antibodies and methods of use thereof |
| US11174495B2 (en) | 2015-12-04 | 2021-11-16 | Board Of Regents, The University Of Texas System | Reporter system for detecting and targeting activated cells |
| JP2019515027A (ja) * | 2016-04-15 | 2019-06-06 | レジェンクスバイオ インコーポレーテッド | 翻訳後修飾された完全ヒト抗ＶＥＧＦ Ｆａｂを用いる眼疾患の治療 |
| MA44873A (fr) * | 2016-04-15 | 2019-03-13 | Univ Pennsylvania | Composition pour le traitement de la dégénérescence maculaire liée a l'âge exsudative |
| US11401527B2 (en) | 2016-04-17 | 2022-08-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods useful for prophylaxis of organophosphates |
| EP3448875A4 (en) * | 2016-04-29 | 2020-04-08 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| BR112018072865A2 (pt) * | 2016-05-12 | 2019-04-30 | Janssen Vaccines & Prevention B.V. | promotor bidirecional potente e equilibrado |
| MX2018015540A (es) | 2016-06-20 | 2019-04-11 | Janssen Vaccines & Prevention Bv | Promotor bidireccional potente y equilibrado. |
| SG10201912976WA (en) | 2017-02-28 | 2020-02-27 | Univ Pennsylvania | Adeno-associated virus (aav) clade f vector and uses therefor |
| SG10201913833PA (en) | 2017-02-28 | 2020-03-30 | Univ Pennsylvania | Influenza vaccines based on aav vectors |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| EP3668520A4 (en) * | 2017-08-17 | 2021-05-12 | The Trustees Of The University Of Pennsylvania | MODIFIED RNA VACCINES CODING FOR HERPES SIMPLEX VIRUS GLYCOPROTEINS AND THEIR USES |
| EP3727468A4 (en) | 2017-12-19 | 2021-09-22 | Akouos, Inc. | AAV-MEDIATED DELIVERY OF THERAPEUTIC ANTIBODIES TO THE INNER EAR |
| CN108424934A (zh) * | 2018-04-16 | 2018-08-21 | 和元生物技术（上海）股份有限公司 | 一种慢病毒cag-cmv双启动子改造载体构建及应用 |
| JP2021533753A (ja) * | 2018-08-09 | 2021-12-09 | バイオベラティブ セラピューティクス インコーポレイテッド | 核酸分子及び非ウイルス遺伝子治療のためのそれらの使用 |
| US20200148762A1 (en) * | 2018-11-09 | 2020-05-14 | Avamab Pharma Inc. | Methods for regulating endogenous production of antibodies against infectious diseases |
| EP3898965A4 (en) * | 2018-12-21 | 2022-10-12 | Merck Sharp & Dohme Corp. | EXPRESSION VECTORS FOR EUKARYOT EXPRESSION SYSTEMS |
| EP3917566A4 (en) | 2019-01-31 | 2022-10-26 | Oregon Health & Science University | METHODS OF USING DIRECTED, TRANSCRIPTION-DEPENDENT EVOLUTION OF AAV CAPSIDS |
| CN116615462A (zh) * | 2020-11-23 | 2023-08-18 | 诺华股份有限公司 | 抗体构建体的表达技术 |
| WO2022165313A1 (en) | 2021-02-01 | 2022-08-04 | Regenxbio Inc. | Gene therapy for neuronal ceroid lipofuscinoses |
| JP2024505027A (ja) * | 2021-02-02 | 2024-02-02 | アレン インスティテュート | Ｇａｂａ作動性ニューロン及び星状膠細胞における遺伝子発現の調節のための人工発現構築物 |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
| US6268213B1 (en) | 1992-06-03 | 2001-07-31 | Richard Jude Samulski | Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy |
| US5869305A (en) | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| US6204059B1 (en) | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| US5811524A (en) | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
| US5741683A (en) | 1995-06-07 | 1998-04-21 | The Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
| CA2287478C (en) | 1997-04-14 | 2007-06-19 | Richard J. Samulski | Methods for increasing the efficiency of recombinant aav product |
| ES2246069T3 (es) | 1997-05-02 | 2006-02-01 | Genentech, Inc. | Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos. |
| US5891994A (en) | 1997-07-11 | 1999-04-06 | Thymon L.L.C. | Methods and compositions for impairing multiplication of HIV-1 |
| GB9720585D0 (en) | 1997-09-26 | 1997-11-26 | Smithkline Beecham Biolog | Vaccine |
| CZ121599A3 (cs) * | 1998-04-09 | 1999-10-13 | Aventis Pharma Deutschland Gmbh | Jednořetězcová molekula vázající několik antigenů, způsob její přípravy a léčivo obsahující tuto molekulu |
| US6146874A (en) | 1998-05-27 | 2000-11-14 | University Of Florida | Method of preparing recombinant adeno-associated virus compositions |
| US6491907B1 (en) | 1998-11-10 | 2002-12-10 | The University Of North Carolina At Chapel Hill | Recombinant parvovirus vectors and method of making |
| EP2369002A1 (en) | 1999-08-09 | 2011-09-28 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms intrastrand base pairs |
| US6780639B1 (en) * | 1999-08-24 | 2004-08-24 | Universite Libre De Bruxelles | Antibiotic inducible/repressible genetic construct for gene therapy or gene immunization |
| CZ20022643A3 (cs) | 2000-01-31 | 2003-02-12 | Smithkline Beecham Biologicals S. A. | Farmaceutický prostředek |
| AU2001269723B9 (en) | 2000-06-01 | 2006-11-16 | University Of North Carolina At Chapel Hill | Duplexed parvovirus vectors |
| ES2327609T3 (es) | 2000-06-01 | 2009-11-02 | University Of North Carolina At Chapel Hill | Procedimientos y compuestos para controlar la liberacion de vectores de parvovirus reconbinantes. |
| CA2406745C (en) | 2001-11-13 | 2006-01-10 | The Trustees Of The University Of Pennsylvania | A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby |
| DK1453547T3 (en) | 2001-12-17 | 2016-12-05 | Univ Pennsylvania | ADENOASSOCATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING THESE AND APPLICATIONS THEREOF |
| US20070015238A1 (en) | 2002-06-05 | 2007-01-18 | Snyder Richard O | Production of pseudotyped recombinant AAV virions |
| DK2314629T4 (da) * | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| WO2004065611A1 (ja) * | 2003-01-21 | 2004-08-05 | Chugai Seiyaku Kabushiki Kaisha | 抗体の軽鎖スクリーニング方法 |
| US8005620B2 (en) | 2003-08-01 | 2011-08-23 | Dna Twopointo Inc. | Systems and methods for biopolymer engineering |
| WO2005013090A2 (en) | 2003-08-01 | 2005-02-10 | Dna Twopointo Inc. | Systems and methods for biopolymer engineering |
| AU2004278684B2 (en) | 2003-09-30 | 2011-05-12 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor |
| US20060246079A1 (en) | 2003-11-14 | 2006-11-02 | Morrow Phillip R | Neutralizing human antibodies to anthrax toxin |
| EP1629096A1 (en) * | 2004-05-10 | 2006-03-01 | BASF Plant Science GmbH | Methods for assembling multiple expression constructs |
| JP2008506389A (ja) * | 2004-07-13 | 2008-03-06 | セル ジェネシス インコーポレイテッド | Ａａｖベクター組成物および免疫グロブリンの発現の増強のための方法ならびにその使用方法 |
| CN112029737A (zh) | 2005-04-07 | 2020-12-04 | 宾夕法尼亚大学托管会 | 增强腺相关病毒载体功能的方法 |
| WO2007120542A2 (en) | 2006-03-30 | 2007-10-25 | The Board Of Trustees Of The Leland Stanford Junior University | Aav capsid library and aav capsid proteins |
| US20070292922A1 (en) | 2006-03-31 | 2007-12-20 | Cell Genesys, Inc. | Regulated expression of recombinant proteins from adeno-associated viral vectors |
| WO2007127264A2 (en) | 2006-04-28 | 2007-11-08 | The Trustees Of The University Of Pennsylvania | Scalable production method for aav |
| WO2008103475A1 (en) | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Somatic hypermutation systems |
| US9217020B2 (en) | 2007-04-17 | 2015-12-22 | National Research Council Of Canada | Constructs for enhancement of gene expression in muscle |
| US7879326B2 (en) | 2007-06-15 | 2011-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Human neutralizing monoclonal antibodies to H5N1 influenza A virus |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| EP2313435A4 (en) | 2008-07-01 | 2012-08-08 | Aveo Pharmaceuticals Inc | FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) BINDING PROTEINS |
| WO2010010467A2 (en) | 2008-07-25 | 2010-01-28 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| SG172977A1 (en) * | 2009-01-26 | 2011-08-29 | Genmab As | Methods for producing mixtures of antibodies |
| BRPI1006448B1 (pt) | 2009-03-25 | 2021-08-17 | Genentech, Inc | Anticorpo antagonista anti-fgfr3, anticorpo monoclonal, polinucleotídeo, vetor, microorganismo transgênico, método para produção de um anticorpo anti-fgfr3, formulação farmacêutica e usos do anticorpo antagonista anti-fgfr3 |
| WO2010119991A2 (en) | 2009-04-17 | 2010-10-21 | Takeda Pharmaceutical Company Limited | Novel method of treating cancer |
| NZ596032A (en) | 2009-05-11 | 2013-09-27 | Crucell Holland Bv | Human binding molecules capable of neutralizing influenza virus h3n2 and uses thereof |
| IT1395961B1 (it) | 2009-06-01 | 2012-11-02 | Pomona Biotechnologies Llc | Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv) |
| NZ617191A (en) | 2009-06-25 | 2015-06-26 | Medimmune Llc | Swine influenza hemagglutinin variants |
| CN101649328A (zh) * | 2009-09-09 | 2010-02-17 | 陕西师范大学 | 表达多个外源基因的Ad5 D24条件复制型腺病毒载体及其构建方法和应用 |
| US8598331B2 (en) | 2009-09-28 | 2013-12-03 | The University Of British Columbia | CLDN5 mini-promoters |
| US10143186B2 (en) | 2010-02-08 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| JP2013524218A (ja) | 2010-03-30 | 2013-06-17 | バテル メモリアル インスティチュート | 軟膜セパレータフロートシステムおよび方法 |
| JP2013529076A (ja) | 2010-05-11 | 2013-07-18 | アベオ ファーマシューティカルズ， インコーポレイテッド | 抗ｆｇｆｒ２抗体 |
| ES2961381T3 (es) | 2010-06-19 | 2024-03-11 | Memorial Sloan Kettering Cancer Center | Anticuerpos anti-GD2 |
| NO2603530T3 (hr) | 2010-08-13 | 2018-04-07 | ||
| CA2808482C (en) * | 2010-08-16 | 2021-10-26 | Novimmune S.A. | Methods for the generation of multispecific and multivalent antibodies |
| CN103492574B (zh) * | 2011-02-22 | 2015-12-09 | 加州理工学院 | 使用腺相关病毒（aav）载体递送蛋白 |
| EP2500434A1 (en) | 2011-03-12 | 2012-09-19 | Association Institut de Myologie | Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery |
| SG185832A1 (en) | 2011-05-10 | 2012-12-28 | Agency Science Tech & Res | Fgfr1 antibodies and treatment of cancer |
| CN103596983B (zh) | 2011-04-07 | 2016-10-26 | 霍夫曼-拉罗奇有限公司 | 抗fgfr4抗体及使用方法 |
| EP2699688A1 (en) | 2011-04-20 | 2014-02-26 | The Trustees Of The University Of Pennsylvania | Regimens and compositions for aav-mediated passive immunization of airborne pathogens |
| US20140127749A1 (en) | 2011-04-21 | 2014-05-08 | Arizona Borad Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizo | Methods of protein production and compositions thereof |
| EP2748394B1 (en) | 2011-09-29 | 2019-01-09 | Avery Dennison Corporation | Anti-theft security device to increase marketing opportunities |
| TW201817745A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| US9127056B2 (en) * | 2011-10-17 | 2015-09-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monospecific and bispecific human monoclonal antibodies targeting insulin-like growth factor II (IGF-II) |
| AR088941A1 (es) | 2011-11-23 | 2014-07-16 | Bayer Ip Gmbh | Anticuerpos anti-fgfr2 y sus usos |
| WO2013155222A2 (en) | 2012-04-10 | 2013-10-17 | The Regents Of The University Of California | Brain-specific enhancers for cell-based therapy |
| WO2013163427A1 (en) * | 2012-04-25 | 2013-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Antibodies to treat hiv-1 infection |
| TWI609882B (zh) | 2012-05-22 | 2018-01-01 | 必治妥美雅史谷比公司 | 雙特異性抗體及其使用方法 |
| CA2880649C (en) * | 2012-08-01 | 2023-03-14 | Elizabeth MCNALLY | Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (ltbp4) |
| WO2015012924A2 (en) | 2013-04-29 | 2015-01-29 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof |
| WO2015142661A1 (en) | 2014-03-15 | 2015-09-24 | Novartis Ag | Regulatable chimeric antigen receptor |
| DK3142750T3 (da) | 2014-05-13 | 2020-09-14 | Univ Pennsylvania | Sammensætninger omfattende aav, som udtrykker dobbelt-antistofkonstrukter og anvendelser deraf |
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