CL2016002840A1 - Composiciones que comprenden aav que expresa constructos de anticuerpos duales y sus usos - Google Patents

Composiciones que comprenden aav que expresa constructos de anticuerpos duales y sus usos

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Publication number
CL2016002840A1
CL2016002840A1 CL2016002840A CL2016002840A CL2016002840A1 CL 2016002840 A1 CL2016002840 A1 CL 2016002840A1 CL 2016002840 A CL2016002840 A CL 2016002840A CL 2016002840 A CL2016002840 A CL 2016002840A CL 2016002840 A1 CL2016002840 A1 CL 2016002840A1
Authority
CL
Chile
Prior art keywords
compositions
antibody constructs
dual antibody
aav expressing
orf
Prior art date
Application number
CL2016002840A
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English (en)
Inventor
James M Wilson
Anna Tretiakova
Original Assignee
Univ Pennsylvania
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Publication of CL2016002840A1 publication Critical patent/CL2016002840A1/es

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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Abstract

La presente solicitud hace referencia a virus adenoasociados AAV recombinante, que expresa un ácido nucleico que es capaz de expresar al menos dos anticuerpos monoespecificos funcionales en una célula, y un segundo anticuerpo bi especifico, donde el AAV comprende una ITR, un primer ORF, un segundo ORF, un enlazador y un tercer ORF.
CL2016002840A 2014-05-13 2016-11-09 Composiciones que comprenden aav que expresa constructos de anticuerpos duales y sus usos CL2016002840A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461992649P 2014-05-13 2014-05-13

Publications (1)

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CL2016002840A1 true CL2016002840A1 (es) 2017-05-05

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CL2016002840A CL2016002840A1 (es) 2014-05-13 2016-11-09 Composiciones que comprenden aav que expresa constructos de anticuerpos duales y sus usos

Country Status (27)

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US (4) US10138295B2 (es)
EP (1) EP3142750B1 (es)
JP (3) JP6974943B2 (es)
KR (1) KR102550926B1 (es)
CN (1) CN106470736B (es)
AU (2) AU2015259188B2 (es)
CA (1) CA2947614C (es)
CL (1) CL2016002840A1 (es)
CR (1) CR20160519A (es)
DK (1) DK3142750T3 (es)
EA (1) EA037980B1 (es)
ES (1) ES2833230T3 (es)
HR (1) HRP20201530T1 (es)
HU (1) HUE050609T2 (es)
IL (1) IL248508B2 (es)
MA (2) MA44179B1 (es)
MX (1) MX365658B (es)
MY (1) MY186389A (es)
PE (1) PE20170261A1 (es)
PH (1) PH12016502239B1 (es)
PL (1) PL3142750T3 (es)
PT (1) PT3142750T (es)
SA (1) SA516380285B1 (es)
SG (1) SG11201609207SA (es)
SI (1) SI3142750T1 (es)
UA (1) UA123986C2 (es)
WO (1) WO2015175639A1 (es)

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