CO4520184A1 - Nuevos taxoides, su preparacion y composiciones farmaceuticas que les contienen - Google Patents

Nuevos taxoides, su preparacion y composiciones farmaceuticas que les contienen

Info

Publication number
CO4520184A1
CO4520184A1 CO96067023A CO96067023A CO4520184A1 CO 4520184 A1 CO4520184 A1 CO 4520184A1 CO 96067023 A CO96067023 A CO 96067023A CO 96067023 A CO96067023 A CO 96067023A CO 4520184 A1 CO4520184 A1 CO 4520184A1
Authority
CO
Colombia
Prior art keywords
carbon
atoms
radical
take
alkyl
Prior art date
Application number
CO96067023A
Other languages
English (en)
Spanish (es)
Inventor
Herve Bouchard
Alain Commercon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of CO4520184A1 publication Critical patent/CO4520184A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CO96067023A 1995-12-22 1996-12-20 Nuevos taxoides, su preparacion y composiciones farmaceuticas que les contienen CO4520184A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
CO4520184A1 true CO4520184A1 (es) 1997-10-15

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96067023A CO4520184A1 (es) 1995-12-22 1996-12-20 Nuevos taxoides, su preparacion y composiciones farmaceuticas que les contienen

Country Status (40)

Country Link
US (1) US5728849A (OSRAM)
EP (1) EP0876362B1 (OSRAM)
JP (1) JP3953106B2 (OSRAM)
KR (1) KR100500351B1 (OSRAM)
CN (1) CN1103766C (OSRAM)
AR (1) AR005197A1 (OSRAM)
AT (1) ATE250593T1 (OSRAM)
AU (1) AU712597B2 (OSRAM)
BG (1) BG63204B1 (OSRAM)
BR (1) BR9612135A (OSRAM)
CA (1) CA2238884C (OSRAM)
CO (1) CO4520184A1 (OSRAM)
CZ (1) CZ294972B6 (OSRAM)
DE (1) DE69630145T2 (OSRAM)
DK (1) DK0876362T3 (OSRAM)
DZ (1) DZ2149A1 (OSRAM)
EA (1) EA001533B1 (OSRAM)
ES (1) ES2202490T3 (OSRAM)
FR (1) FR2742751B1 (OSRAM)
HU (1) HU225032B1 (OSRAM)
IL (1) IL124994A (OSRAM)
IN (4) IN186768B (OSRAM)
MA (1) MA26412A1 (OSRAM)
MX (1) MX9804688A (OSRAM)
MY (1) MY113934A (OSRAM)
NO (1) NO317358B1 (OSRAM)
NZ (1) NZ324337A (OSRAM)
OA (1) OA10700A (OSRAM)
PE (1) PE25198A1 (OSRAM)
PL (1) PL189311B1 (OSRAM)
PT (1) PT876362E (OSRAM)
RO (1) RO116194B1 (OSRAM)
SK (1) SK282835B6 (OSRAM)
TN (1) TNSN96169A1 (OSRAM)
TR (1) TR199801179T2 (OSRAM)
TW (1) TW371659B (OSRAM)
UA (1) UA48205C2 (OSRAM)
UY (1) UY24386A1 (OSRAM)
WO (1) WO1997023473A1 (OSRAM)
ZA (1) ZA9610737B (OSRAM)

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GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
EP1165550A1 (en) 2000-02-02 2002-01-02 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes as antitumor agents
HU230382B1 (hu) * 2001-02-24 2016-03-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xantinszármazékok, előállításuk és alkalmazásuk gyógyszerként
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
WO2004103344A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (en) * 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP2016079A1 (de) 2006-05-04 2009-01-21 Boehringer Ingelheim International GmbH Polymorphe
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
WO2009024542A2 (en) * 2007-08-17 2009-02-26 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
EA031225B1 (ru) * 2008-08-15 2018-12-28 Бёрингер Ингельхайм Интернациональ Гмбх Ингибиторы дпп-4 для заживления ран
WO2010029089A2 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
EA022310B1 (ru) 2008-12-23 2015-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Солевые формы органического соединения
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
NZ599298A (en) 2009-11-27 2014-11-28 Boehringer Ingelheim Int Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
MX366325B (es) 2010-05-05 2019-07-05 Boehringer Ingelheim Int Terapia de combinacion.
KR20190050871A (ko) 2010-06-24 2019-05-13 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
EP3517539B1 (en) 2011-07-15 2022-12-14 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
ES2929025T3 (es) 2012-05-14 2022-11-24 Boehringer Ingelheim Int Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
EP3685839A1 (en) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin for use in the treatment of albuminuria and kidney related diseases
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
WO2015127685A1 (en) 2014-02-28 2015-09-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
NZ739830A (en) 2015-07-12 2021-12-24 Hangzhou Dac Biotech Co Ltd Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CA3022202A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin
AU2016429272A1 (en) 2016-11-14 2019-05-02 Hangzhou Dac Biotech Co., Ltd. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
CA3236930A1 (en) 2021-11-03 2022-04-21 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
ES2134847T3 (es) * 1992-04-17 1999-10-16 Abbott Lab Derivados de taxol.
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
MX9307777A (es) * 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.

Also Published As

Publication number Publication date
DE69630145D1 (de) 2003-10-30
CN1205697A (zh) 1999-01-20
CA2238884C (fr) 2007-02-06
BG102569A (en) 1999-04-30
MX9804688A (es) 1998-10-31
BR9612135A (pt) 1999-07-13
PL327405A1 (en) 1998-12-07
IN188680B (OSRAM) 2002-10-26
HU225032B1 (en) 2006-05-29
NO982580L (no) 1998-06-05
AU1180997A (en) 1997-07-17
IL124994A (en) 2000-12-06
JP2000502671A (ja) 2000-03-07
HUP9904046A3 (en) 2001-08-28
CZ294972B6 (cs) 2005-04-13
MY113934A (en) 2002-06-29
EP0876362A1 (fr) 1998-11-11
EA199800588A1 (ru) 1998-12-24
DE69630145T2 (de) 2004-07-15
AR005197A1 (es) 1999-04-14
BG63204B1 (bg) 2001-06-29
WO1997023473A1 (fr) 1997-07-03
UY24386A1 (es) 2001-08-27
NO982580D0 (no) 1998-06-05
AU712597B2 (en) 1999-11-11
SK282835B6 (sk) 2002-12-03
FR2742751B1 (fr) 1998-01-30
MA26412A1 (fr) 2004-12-20
HUP9904046A1 (hu) 2001-04-28
TNSN96169A1 (fr) 2005-03-15
FR2742751A1 (fr) 1997-06-27
IL124994A0 (en) 1999-01-26
PL189311B1 (pl) 2005-07-29
KR19990076680A (ko) 1999-10-15
PT876362E (pt) 2004-02-27
CN1103766C (zh) 2003-03-26
JP3953106B2 (ja) 2007-08-08
ATE250593T1 (de) 2003-10-15
TR199801179T2 (xx) 1998-10-21
CA2238884A1 (fr) 1997-07-03
NO317358B1 (no) 2004-10-18
DZ2149A1 (fr) 2002-10-23
IN186768B (OSRAM) 2001-11-03
KR100500351B1 (ko) 2005-12-21
PE25198A1 (es) 1998-05-10
NZ324337A (en) 2000-03-27
US5728849A (en) 1998-03-17
IN188469B (OSRAM) 2002-09-28
OA10700A (fr) 2002-11-27
IN188470B (OSRAM) 2002-09-28
CZ196198A3 (cs) 1998-09-16
TW371659B (en) 1999-10-11
UA48205C2 (uk) 2002-08-15
ES2202490T3 (es) 2004-04-01
SK85398A3 (en) 1998-11-04
HK1017895A1 (en) 1999-12-03
EP0876362B1 (fr) 2003-09-24
EA001533B1 (ru) 2001-04-23
RO116194B1 (ro) 2000-11-30
ZA9610737B (en) 1997-06-27
DK0876362T3 (da) 2004-02-02

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