CZ294972B6 - Taxoidy, meziprodukty pro jejich přípravu, způsoby přípravy taxoidů a farmaceutická kompozice tyto taxoidy obsahující - Google Patents

Taxoidy, meziprodukty pro jejich přípravu, způsoby přípravy taxoidů a farmaceutická kompozice tyto taxoidy obsahující Download PDF

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Publication number
CZ294972B6
CZ294972B6 CZ19981961A CZ196198A CZ294972B6 CZ 294972 B6 CZ294972 B6 CZ 294972B6 CZ 19981961 A CZ19981961 A CZ 19981961A CZ 196198 A CZ196198 A CZ 196198A CZ 294972 B6 CZ294972 B6 CZ 294972B6
Authority
CZ
Czechia
Prior art keywords
group
hydrogen
carbon atoms
formula
compound
Prior art date
Application number
CZ19981961A
Other languages
Czech (cs)
English (en)
Other versions
CZ196198A3 (cs
Inventor
Hervé Bouchard
Alain Commerçon
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of CZ196198A3 publication Critical patent/CZ196198A3/cs
Publication of CZ294972B6 publication Critical patent/CZ294972B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CZ19981961A 1995-12-22 1996-12-19 Taxoidy, meziprodukty pro jejich přípravu, způsoby přípravy taxoidů a farmaceutická kompozice tyto taxoidy obsahující CZ294972B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
CZ196198A3 CZ196198A3 (cs) 1998-09-16
CZ294972B6 true CZ294972B6 (cs) 2005-04-13

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ19981961A CZ294972B6 (cs) 1995-12-22 1996-12-19 Taxoidy, meziprodukty pro jejich přípravu, způsoby přípravy taxoidů a farmaceutická kompozice tyto taxoidy obsahující

Country Status (40)

Country Link
US (1) US5728849A (OSRAM)
EP (1) EP0876362B1 (OSRAM)
JP (1) JP3953106B2 (OSRAM)
KR (1) KR100500351B1 (OSRAM)
CN (1) CN1103766C (OSRAM)
AR (1) AR005197A1 (OSRAM)
AT (1) ATE250593T1 (OSRAM)
AU (1) AU712597B2 (OSRAM)
BG (1) BG63204B1 (OSRAM)
BR (1) BR9612135A (OSRAM)
CA (1) CA2238884C (OSRAM)
CO (1) CO4520184A1 (OSRAM)
CZ (1) CZ294972B6 (OSRAM)
DE (1) DE69630145T2 (OSRAM)
DK (1) DK0876362T3 (OSRAM)
DZ (1) DZ2149A1 (OSRAM)
EA (1) EA001533B1 (OSRAM)
ES (1) ES2202490T3 (OSRAM)
FR (1) FR2742751B1 (OSRAM)
HU (1) HU225032B1 (OSRAM)
IL (1) IL124994A (OSRAM)
IN (4) IN186768B (OSRAM)
MA (1) MA26412A1 (OSRAM)
MX (1) MX9804688A (OSRAM)
MY (1) MY113934A (OSRAM)
NO (1) NO317358B1 (OSRAM)
NZ (1) NZ324337A (OSRAM)
OA (1) OA10700A (OSRAM)
PE (1) PE25198A1 (OSRAM)
PL (1) PL189311B1 (OSRAM)
PT (1) PT876362E (OSRAM)
RO (1) RO116194B1 (OSRAM)
SK (1) SK282835B6 (OSRAM)
TN (1) TNSN96169A1 (OSRAM)
TR (1) TR199801179T2 (OSRAM)
TW (1) TW371659B (OSRAM)
UA (1) UA48205C2 (OSRAM)
UY (1) UY24386A1 (OSRAM)
WO (1) WO1997023473A1 (OSRAM)
ZA (1) ZA9610737B (OSRAM)

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GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
KR20010111582A (ko) 2000-02-02 2001-12-19 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 항종양제로서 ｃ１０ 카르보네이트 치환된 탁산
SK288003B6 (sk) * 2001-02-24 2012-10-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthin derivatives, method for the preparation thereof, pharmaceutical composition containing thereof and their use
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
WO2004103344A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (en) * 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
NZ573360A (en) 2006-05-04 2012-08-31 Boehringer Ingelheim Int Polymorphic forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
MX2010001821A (es) * 2007-08-17 2010-03-10 Boehringer Ingelheim Int Derivados de purina para uso en el tratamiento de enfermedades relacionadas con fap.
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
ES2764251T3 (es) * 2008-08-15 2020-06-02 Boehringer Ingelheim Int Inhibidores de DPP-4 para uso en el tratamiento de curación de heridas en pacientes diabéticos
KR20110067096A (ko) 2008-09-10 2011-06-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 및 관련 상태를 치료하기 위한 병용 요법
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
EA022310B1 (ru) 2008-12-23 2015-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Солевые формы органического соединения
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
BR112012012641A2 (pt) 2009-11-27 2020-08-11 Boehringer Ingelheim International Gmbh TRATAMENTO DE PACIENTES DIABÉTICOS GENOTIPADOS COM INIBIDORES DE DPP-lVTAL COMO LINAGLIPTINA
NZ602921A (en) 2010-05-05 2016-01-29 Boehringer Ingelheim Int Combination therapy comprising the administration of a glp-1 receptor agonist and a ddp-4 inhibitor
KR20190050871A (ko) 2010-06-24 2019-05-13 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
CA2841552C (en) 2011-07-15 2020-06-23 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
ES2929025T3 (es) 2012-05-14 2022-11-24 Boehringer Ingelheim Int Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
EP3685839A1 (en) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin for use in the treatment of albuminuria and kidney related diseases
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
DK3122757T3 (da) 2014-02-28 2023-10-09 Hangzhou Dac Biotech Co Ltd Ladede linkere og anvendelse deraf til konjugering
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
NZ739830A (en) 2015-07-12 2021-12-24 Hangzhou Dac Biotech Co Ltd Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
JP2019517542A (ja) 2016-06-10 2019-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング リナグリプチンおよびメトホルミンの組合せ
KR20220147720A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
CA3236930A1 (en) 2021-11-03 2022-04-21 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
AU672006B2 (en) * 1992-04-17 1996-09-19 Abbott Laboratories Taxol derivatives
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
MX9307777A (es) * 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.

Also Published As

Publication number Publication date
FR2742751A1 (fr) 1997-06-27
BR9612135A (pt) 1999-07-13
CO4520184A1 (es) 1997-10-15
HUP9904046A1 (hu) 2001-04-28
NZ324337A (en) 2000-03-27
UA48205C2 (uk) 2002-08-15
RO116194B1 (ro) 2000-11-30
DE69630145T2 (de) 2004-07-15
IN188470B (OSRAM) 2002-09-28
NO982580D0 (no) 1998-06-05
NO982580L (no) 1998-06-05
DE69630145D1 (de) 2003-10-30
EP0876362A1 (fr) 1998-11-11
JP2000502671A (ja) 2000-03-07
OA10700A (fr) 2002-11-27
NO317358B1 (no) 2004-10-18
KR100500351B1 (ko) 2005-12-21
CN1205697A (zh) 1999-01-20
IN186768B (OSRAM) 2001-11-03
MY113934A (en) 2002-06-29
EP0876362B1 (fr) 2003-09-24
CA2238884A1 (fr) 1997-07-03
CA2238884C (fr) 2007-02-06
IN188680B (OSRAM) 2002-10-26
PT876362E (pt) 2004-02-27
IN188469B (OSRAM) 2002-09-28
SK85398A3 (en) 1998-11-04
BG102569A (en) 1999-04-30
JP3953106B2 (ja) 2007-08-08
UY24386A1 (es) 2001-08-27
DK0876362T3 (da) 2004-02-02
PL189311B1 (pl) 2005-07-29
CN1103766C (zh) 2003-03-26
AU712597B2 (en) 1999-11-11
ES2202490T3 (es) 2004-04-01
DZ2149A1 (fr) 2002-10-23
MA26412A1 (fr) 2004-12-20
MX9804688A (es) 1998-10-31
WO1997023473A1 (fr) 1997-07-03
EA199800588A1 (ru) 1998-12-24
US5728849A (en) 1998-03-17
IL124994A (en) 2000-12-06
KR19990076680A (ko) 1999-10-15
HU225032B1 (en) 2006-05-29
HK1017895A1 (en) 1999-12-03
ATE250593T1 (de) 2003-10-15
TW371659B (en) 1999-10-11
AU1180997A (en) 1997-07-17
CZ196198A3 (cs) 1998-09-16
PL327405A1 (en) 1998-12-07
IL124994A0 (en) 1999-01-26
HUP9904046A3 (en) 2001-08-28
AR005197A1 (es) 1999-04-14
EA001533B1 (ru) 2001-04-23
FR2742751B1 (fr) 1998-01-30
SK282835B6 (sk) 2002-12-03
TNSN96169A1 (fr) 2005-03-15
PE25198A1 (es) 1998-05-10
BG63204B1 (bg) 2001-06-29
ZA9610737B (en) 1997-06-27
TR199801179T2 (xx) 1998-10-21

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20121219