DK0876362T3 - Nye taxoider, deres fremstilling og farmaceutiske præparater deraf - Google Patents

Nye taxoider, deres fremstilling og farmaceutiske præparater deraf

Info

Publication number
DK0876362T3
DK0876362T3 DK96942433T DK96942433T DK0876362T3 DK 0876362 T3 DK0876362 T3 DK 0876362T3 DK 96942433 T DK96942433 T DK 96942433T DK 96942433 T DK96942433 T DK 96942433T DK 0876362 T3 DK0876362 T3 DK 0876362T3
Authority
DK
Denmark
Prior art keywords
preparation
pharmaceutical compositions
new taxoids
taxoids
new
Prior art date
Application number
DK96942433T
Other languages
Danish (da)
English (en)
Inventor
Alain Commercon
Herve Bouchard
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of DK0876362T3 publication Critical patent/DK0876362T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK96942433T 1995-12-22 1996-12-19 Nye taxoider, deres fremstilling og farmaceutiske præparater deraf DK0876362T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/002031 WO1997023473A1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK0876362T3 true DK0876362T3 (da) 2004-02-02

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96942433T DK0876362T3 (da) 1995-12-22 1996-12-19 Nye taxoider, deres fremstilling og farmaceutiske præparater deraf

Country Status (40)

Country Link
US (1) US5728849A (OSRAM)
EP (1) EP0876362B1 (OSRAM)
JP (1) JP3953106B2 (OSRAM)
KR (1) KR100500351B1 (OSRAM)
CN (1) CN1103766C (OSRAM)
AR (1) AR005197A1 (OSRAM)
AT (1) ATE250593T1 (OSRAM)
AU (1) AU712597B2 (OSRAM)
BG (1) BG63204B1 (OSRAM)
BR (1) BR9612135A (OSRAM)
CA (1) CA2238884C (OSRAM)
CO (1) CO4520184A1 (OSRAM)
CZ (1) CZ294972B6 (OSRAM)
DE (1) DE69630145T2 (OSRAM)
DK (1) DK0876362T3 (OSRAM)
DZ (1) DZ2149A1 (OSRAM)
EA (1) EA001533B1 (OSRAM)
ES (1) ES2202490T3 (OSRAM)
FR (1) FR2742751B1 (OSRAM)
HU (1) HU225032B1 (OSRAM)
IL (1) IL124994A (OSRAM)
IN (4) IN186768B (OSRAM)
MA (1) MA26412A1 (OSRAM)
MX (1) MX9804688A (OSRAM)
MY (1) MY113934A (OSRAM)
NO (1) NO317358B1 (OSRAM)
NZ (1) NZ324337A (OSRAM)
OA (1) OA10700A (OSRAM)
PE (1) PE25198A1 (OSRAM)
PL (1) PL189311B1 (OSRAM)
PT (1) PT876362E (OSRAM)
RO (1) RO116194B1 (OSRAM)
SK (1) SK282835B6 (OSRAM)
TN (1) TNSN96169A1 (OSRAM)
TR (1) TR199801179T2 (OSRAM)
TW (1) TW371659B (OSRAM)
UA (1) UA48205C2 (OSRAM)
UY (1) UY24386A1 (OSRAM)
WO (1) WO1997023473A1 (OSRAM)
ZA (1) ZA9610737B (OSRAM)

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US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
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US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
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DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
CN109503584A (zh) 2006-05-04 2019-03-22 勃林格殷格翰国际有限公司 多晶型
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
EP3542801A1 (en) * 2007-08-17 2019-09-25 Boehringer Ingelheim International GmbH Purin derivatives for use in the treatment of fap-related diseases
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
PE20110297A1 (es) * 2008-08-15 2011-05-26 Boehringer Ingelheim Int Inhibidores de dpp-4 para la cicatrizacion de heridas
KR20110067096A (ko) 2008-09-10 2011-06-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 및 관련 상태를 치료하기 위한 병용 요법
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
EP2382216A1 (en) 2008-12-23 2011-11-02 Boehringer Ingelheim International GmbH Salt forms of organic compound
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
KR20120107080A (ko) 2009-11-27 2012-09-28 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
EA033415B1 (ru) 2010-05-05 2019-10-31 Boehringer Ingelheim Int Способы лечения ожирения, применение ингибитора dpp-4 в этих способах и способ лечения пациентов, страдающих диабетом типа 2
KR20130093012A (ko) 2010-06-24 2013-08-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
PL3517539T3 (pl) 2011-07-15 2023-04-24 Boehringer Ingelheim International Gmbh Podstawiona dimeryczna pochodna chinazoliny, sposób jej wytwarzania i jej zastosowanie w kompozycjach farmaceutycznych do leczenia cukrzycy typu I i II
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
EP2849754B1 (en) 2012-05-14 2022-09-14 Boehringer Ingelheim International GmbH Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2014080251A1 (en) 2012-11-24 2014-05-30 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
WO2015127685A1 (en) 2014-02-28 2015-09-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
WO2015151081A2 (en) 2015-07-12 2015-10-08 Suzhou M-Conj Biotech Co., Ltd Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2017276758A1 (en) 2016-06-10 2018-11-08 Boehringer Ingelheim International Gmbh Combinations of Linagliptin and metformin
US12364767B2 (en) 2016-11-14 2025-07-22 Hangzhou Dac Biotech Co., Ltd. Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers
JP2024541058A (ja) 2021-11-03 2024-11-06 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． 抗体の特異的共役

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RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
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US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
MX9307777A (es) * 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.

Also Published As

Publication number Publication date
CN1205697A (zh) 1999-01-20
DE69630145D1 (de) 2003-10-30
AU1180997A (en) 1997-07-17
CO4520184A1 (es) 1997-10-15
FR2742751A1 (fr) 1997-06-27
OA10700A (fr) 2002-11-27
WO1997023473A1 (fr) 1997-07-03
PL327405A1 (en) 1998-12-07
PE25198A1 (es) 1998-05-10
RO116194B1 (ro) 2000-11-30
ATE250593T1 (de) 2003-10-15
HU225032B1 (en) 2006-05-29
EP0876362A1 (fr) 1998-11-11
HK1017895A1 (en) 1999-12-03
DE69630145T2 (de) 2004-07-15
TR199801179T2 (xx) 1998-10-21
BR9612135A (pt) 1999-07-13
TNSN96169A1 (fr) 2005-03-15
ES2202490T3 (es) 2004-04-01
KR19990076680A (ko) 1999-10-15
IL124994A (en) 2000-12-06
DZ2149A1 (fr) 2002-10-23
EA199800588A1 (ru) 1998-12-24
BG102569A (en) 1999-04-30
MA26412A1 (fr) 2004-12-20
ZA9610737B (en) 1997-06-27
AR005197A1 (es) 1999-04-14
UY24386A1 (es) 2001-08-27
US5728849A (en) 1998-03-17
CZ196198A3 (cs) 1998-09-16
NO982580L (no) 1998-06-05
IL124994A0 (en) 1999-01-26
EA001533B1 (ru) 2001-04-23
JP2000502671A (ja) 2000-03-07
JP3953106B2 (ja) 2007-08-08
MY113934A (en) 2002-06-29
MX9804688A (es) 1998-10-31
TW371659B (en) 1999-10-11
CZ294972B6 (cs) 2005-04-13
KR100500351B1 (ko) 2005-12-21
UA48205C2 (uk) 2002-08-15
SK85398A3 (en) 1998-11-04
PT876362E (pt) 2004-02-27
NO982580D0 (no) 1998-06-05
FR2742751B1 (fr) 1998-01-30
IN188680B (OSRAM) 2002-10-26
CA2238884A1 (fr) 1997-07-03
HUP9904046A3 (en) 2001-08-28
HUP9904046A1 (hu) 2001-04-28
PL189311B1 (pl) 2005-07-29
BG63204B1 (bg) 2001-06-29
IN186768B (OSRAM) 2001-11-03
CN1103766C (zh) 2003-03-26
NZ324337A (en) 2000-03-27
EP0876362B1 (fr) 2003-09-24
CA2238884C (fr) 2007-02-06
IN188469B (OSRAM) 2002-09-28
SK282835B6 (sk) 2002-12-03
AU712597B2 (en) 1999-11-11
IN188470B (OSRAM) 2002-09-28
NO317358B1 (no) 2004-10-18

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