ES2080922T3 - Derivados de la n-sulfonil-indolina, su preparacion, y las composiciones farmaceuticas que los contienen. - Google Patents

Derivados de la n-sulfonil-indolina, su preparacion, y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2080922T3
ES2080922T3 ES91402123T ES91402123T ES2080922T3 ES 2080922 T3 ES2080922 T3 ES 2080922T3 ES 91402123 T ES91402123 T ES 91402123T ES 91402123 T ES91402123 T ES 91402123T ES 2080922 T3 ES2080922 T3 ES 2080922T3
Authority
ES
Spain
Prior art keywords
denotes
alkyl
group
trifluoromethyl
naphthyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91402123T
Other languages
English (en)
Inventor
Jean Wagnon
Cointet Paul De
Dino Nisato
Claude Plouzane
Claudine Serradeil-Legal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2080922T3 publication Critical patent/ES2080922T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA: EN LA QUE COXI EN C SUB 1-C SUB 4, UN HIDROXILO, UN GRUPO BENALOXI, CIANO, TRIFLUOROMETILO, NITRO O AMINO; UILO EN C SUB 1-C SUB 6, UN CICLOALQUILO EN C SUB 3-C SUB 7, UN CICLOALCENO EN C SUB 5-C SUB 7, UN FENILO NO SUSTITUIDO , MONO UB 4, UN HALOGENO, UN GRUPO TRIFLUOROMETILO, NITRO O AMINO; R SUB 3 REPRESENTA UN ATOMO DE HIDROGENO O UN ALQUILO EN C SUB 1-C SUB 4; LCOXICARBONILO EN C SUB 1-C SUB 6, UN GRUPO BENCILOXICARBONILO O UN GRUPO CARBOXAMIDA DE FORMULA CONR SUB 6 R SUB 7; 5 REPRESENTA UN ALQUILO EN C SUB 1-C SUB 4; UN NOFTIL-1; UN NOFTIL-2; UN DIMETILAMINO-5 NOFTIL-1; UN FENILO NO SUSTITUIDO O SUSTITUIDO POR UNO O VARIOS SUSTITUTOS ELEGIDOS ENTRE UN HALOGENO, UN ALQUILO EN C SUB 1-C SUB 4, UN GRUPO TRIFLUOROMETILO, NITRO, AMINO LIBRE O SUSTITUIDO POR UNO O 2 ALQUILOS EN C SUB 1-C SUB 4, UN HIDROXILO, UN ALCOXI EN C SUB 1-C SUB 4, UN ALCENOXI EN C SUB 1-C SUB 4, UN ALQUILTIO EN C SUB 1-C SUB 4, UN GRUPO TRIFLUOROMETOXI, BENCILOXI, CIANO, CARBOXI, ALCOXICARBONILO EN C SUB 1-C SUB 4, CARBAMOILO O ALQUILAMIDO EN C SUB 1-C SUB 4, O, CUANDO M = 0, R SUB 5 PUEDE REPRESENTAR UN GRUPO: SUB 6 Y R SUB 7 REPRESENTAN CADA UNO INDEPENDIENTEMENTE HIDROGENO; UN ALQUILO EN C SUB 1-C SUB 6, UN FENILALQUILO EN EL QUE EL ALQUILO ESTA EN C SUB 1-C SUB 4 O R SUB 6 Y R SUB 7, JUNTOS CONSTITUYEN UNA AGRUPACION -(CH SUB 2) SUB P-; 0,1 O 2 SUS SALES EVENTUALES. ESTOS COMPUESTOS TIENEN UNA AFINIDAD PARA LOS RECEPTORES DE LA VASOPRESINA Y DE LA OCITOCINA.
ES91402123T 1990-07-31 1991-07-30 Derivados de la n-sulfonil-indolina, su preparacion, y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2080922T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9009778A FR2665441B1 (fr) 1990-07-31 1990-07-31 Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.

Publications (1)

Publication Number Publication Date
ES2080922T3 true ES2080922T3 (es) 1996-02-16

Family

ID=9399281

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91402123T Expired - Lifetime ES2080922T3 (es) 1990-07-31 1991-07-30 Derivados de la n-sulfonil-indolina, su preparacion, y las composiciones farmaceuticas que los contienen.

Country Status (17)

Country Link
EP (1) EP0469984B1 (es)
JP (1) JP3195381B2 (es)
KR (1) KR100211434B1 (es)
AT (1) ATE129236T1 (es)
AU (2) AU645585B2 (es)
CA (1) CA2048139C (es)
DE (1) DE69113911T2 (es)
ES (1) ES2080922T3 (es)
FI (1) FI97224C (es)
FR (1) FR2665441B1 (es)
HU (1) HU220765B1 (es)
IE (1) IE73452B1 (es)
IL (2) IL99012A (es)
NO (1) NO175254C (es)
NZ (1) NZ239182A (es)
PT (1) PT98476B (es)
ZA (1) ZA916031B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5481005A (en) * 1990-07-31 1996-01-02 Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
US5338755A (en) * 1990-07-31 1994-08-16 Elf Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2679903B1 (fr) * 1991-08-02 1993-12-03 Elf Sanofi Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.
JPH09500133A (ja) * 1993-07-16 1997-01-07 メルク エンド カンパニー インコーポレーテッド オキシトシンのアンタゴニストである置換ピペラジニル樟脳誘導体
WO1995002405A1 (en) * 1993-07-16 1995-01-26 Merck & Co., Inc. Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
FR2714378B1 (fr) * 1993-12-24 1996-03-15 Sanofi Sa Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
GB9918684D0 (en) 1999-08-09 1999-10-13 Novartis Ag Organic compounds
CA2423933A1 (en) 2000-10-17 2002-04-25 Applied Research Systems Ars Holding N.V. Pharmaceutically active sulfanilide derivatives
GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
GB0116594D0 (en) 2001-07-06 2001-08-29 Cancer Res Ventures Ltd Therapeutic compounds
ES2249636T3 (es) 2001-12-20 2006-04-01 Applied Research Systems Ars Holding N.V. Triazoles como antagonistas de la oxitocina.
WO2003099773A1 (en) * 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
CA2508275A1 (en) 2002-12-20 2004-07-08 Cancer Research Technology Limited 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents
FR2853650B1 (fr) * 2003-04-10 2006-07-07 Merck Sante Sas Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance
FR2880023B1 (fr) 2004-12-23 2007-02-23 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique
FR2927625B1 (fr) 2008-02-19 2010-03-12 Sanofi Aventis Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
FR2930249B1 (fr) 2008-04-21 2010-05-14 Sanofi Aventis Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3838167A (en) * 1972-08-01 1974-09-24 Lilly Co Eli Process for preparing indoles
US4479963A (en) * 1981-02-17 1984-10-30 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
DE3705934A1 (de) * 1987-02-25 1988-09-08 Nattermann A & Cie Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB8820129D0 (en) * 1988-08-24 1988-09-28 Schering Agrochemicals Ltd Fungicides
FR2679903B1 (fr) * 1991-08-02 1993-12-03 Elf Sanofi Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.

Also Published As

Publication number Publication date
ATE129236T1 (de) 1995-11-15
NZ239182A (en) 1995-07-26
FR2665441B1 (fr) 1992-12-04
HU220765B1 (hu) 2002-05-28
EP0469984A3 (fr) 1992-03-11
FI913614A0 (fi) 1991-07-29
IL114934A0 (en) 1995-12-08
FR2665441A1 (fr) 1992-02-07
DE69113911T2 (de) 1996-03-28
NO912970D0 (no) 1991-07-30
EP0469984B1 (fr) 1995-10-18
HU912552D0 (en) 1992-01-28
AU5047393A (en) 1994-01-13
CA2048139A1 (en) 1992-02-01
KR100211434B1 (ko) 1999-08-02
JP3195381B2 (ja) 2001-08-06
FI97224B (fi) 1996-07-31
ZA916031B (en) 1992-04-29
DE69113911D1 (de) 1995-11-23
FI97224C (fi) 1996-11-11
EP0469984A2 (fr) 1992-02-05
IE73452B1 (en) 1997-06-04
IL99012A (en) 1996-07-23
IL99012A0 (en) 1992-07-15
AU8147891A (en) 1992-02-06
CA2048139C (en) 2002-02-12
NO175254C (no) 1994-09-21
FI913614A (fi) 1992-02-01
IE912696A1 (en) 1992-02-12
PT98476A (pt) 1992-05-29
HUT59669A (en) 1992-06-29
PT98476B (pt) 1997-10-31
KR920002537A (ko) 1992-02-28
AU664491B2 (en) 1995-11-16
JPH04234361A (ja) 1992-08-24
AU645585B2 (en) 1994-01-20
NO912970L (no) 1992-02-03
NO175254B (no) 1994-06-13

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