AU8147891A - N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present - Google Patents
N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are presentInfo
- Publication number
- AU8147891A AU8147891A AU81478/91A AU8147891A AU8147891A AU 8147891 A AU8147891 A AU 8147891A AU 81478/91 A AU81478/91 A AU 81478/91A AU 8147891 A AU8147891 A AU 8147891A AU 8147891 A AU8147891 A AU 8147891A
- Authority
- AU
- Australia
- Prior art keywords
- denotes
- alkyl
- group
- trifluoromethyl
- naphthyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compounds of formula: <IMAGE> in which - R1 denotes a halogen atom, a C1-C4 alkyl or alkoxy, a hydroxyl or a benzyloxy, cyano, trifluoromethyl, nitro or amino group; - R2 denotes a C1-C6 alkyl, a C3-C7 cycloalkyl, a C5-C7 cycloalkene, a phenyl, unsubstituted or mono- or polysubstituted by a C1-C4 alkyl or alkoxy, a halogen or a trifluoromethyl, nitro or amino group; - R3 denotes a hydrogen atom or a C1-C4 alkyl; - R4 denotes a carboxyl group, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group or a carboxamide group of formula CONR6R7; - R5 denotes a C1-C4 alkyl, 1-naphthyl, 2-naphthyl, 5-dimethylamino-1-naphthyl, phenyl, unsubstituted or substituted by one or more substituents chosen from a halogen, a C1-C4 alkyl, a trifluoromethyl, nitro, amino group free or substituted by one or 2 C1-C4 alkyls, a hydroxyl, a C1-C4 alkoxy, a C1-C4 alkenoxy, a C1-C4 alkylthio or a trifluoromethoxy, benzyloxy, cyano, carboxyl, C1-C4 alkoxycarbonyl, carbamoyl or C1-C4 alkylamido group or, when m = 0, R5 may denote a group: <IMAGE> - each of R6 and R7 independently denotes hydrogen, a C1-C6 alkyl, a phenylalkyl in which the alkyl is C1-C4 or R6 and R7 together form a -(CH2)p- group; - n denotes 0, 1 or 2; - m denotes 0, 1 or 2; - p denotes 4, 5 or 6; and their optional salts. These compounds have an affinity for the vasopressin and ocytocin receptors.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9009778A FR2665441B1 (en) | 1990-07-31 | 1990-07-31 | N-SULFONYL INDOLINE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
FR9009778 | 1990-07-31 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU50473/93A Division AU664491B2 (en) | 1990-07-31 | 1993-11-05 | Intermediates useful in the preparation of N-sulfonyl-indoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
AU8147891A true AU8147891A (en) | 1992-02-06 |
AU645585B2 AU645585B2 (en) | 1994-01-20 |
Family
ID=9399281
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU81478/91A Ceased AU645585B2 (en) | 1990-07-31 | 1991-07-31 | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
AU50473/93A Ceased AU664491B2 (en) | 1990-07-31 | 1993-11-05 | Intermediates useful in the preparation of N-sulfonyl-indoline derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU50473/93A Ceased AU664491B2 (en) | 1990-07-31 | 1993-11-05 | Intermediates useful in the preparation of N-sulfonyl-indoline derivatives |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0469984B1 (en) |
JP (1) | JP3195381B2 (en) |
KR (1) | KR100211434B1 (en) |
AT (1) | ATE129236T1 (en) |
AU (2) | AU645585B2 (en) |
CA (1) | CA2048139C (en) |
DE (1) | DE69113911T2 (en) |
ES (1) | ES2080922T3 (en) |
FI (1) | FI97224C (en) |
FR (1) | FR2665441B1 (en) |
HU (1) | HU220765B1 (en) |
IE (1) | IE73452B1 (en) |
IL (2) | IL99012A (en) |
NO (1) | NO175254C (en) |
NZ (1) | NZ239182A (en) |
PT (1) | PT98476B (en) |
ZA (1) | ZA916031B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU658664B2 (en) * | 1991-08-02 | 1995-04-27 | Sanofi-Synthelabo | Indoline derivatives having an amide function, their preparation, and pharmaceutical compositions containing them |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5481005A (en) * | 1990-07-31 | 1996-01-02 | Sanofi | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
US5338755A (en) * | 1990-07-31 | 1994-08-16 | Elf Sanofi | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
EP0708765A4 (en) * | 1993-07-16 | 1996-06-26 | Merck & Co Inc | Substituted piperazinylcamphor derivatives as oxytocin antagonists |
ATE216580T1 (en) * | 1993-07-16 | 2002-05-15 | Merck & Co Inc | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL COMPOUNDS AS TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS |
FR2708606B1 (en) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | N-phenylalkylindol-2-one derivatives, their preparation, pharmaceutical compositions containing them. |
FR2714378B1 (en) * | 1993-12-24 | 1996-03-15 | Sanofi Sa | Indol-2-one derivatives substituted in 3 with a nitrogen group, their preparation, pharmaceutical compositions containing them. |
GB9918684D0 (en) * | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
JP4080868B2 (en) | 2000-10-17 | 2008-04-23 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | Pharmaceutically active sulfanilide derivatives |
GB0115515D0 (en) * | 2001-06-25 | 2001-08-15 | Ferring Bv | Oxytocin agonisys |
GB0116594D0 (en) | 2001-07-06 | 2001-08-29 | Cancer Res Ventures Ltd | Therapeutic compounds |
ES2249636T3 (en) | 2001-12-20 | 2006-04-01 | Applied Research Systems Ars Holding N.V. | TRIAZOLS AS ANTAGONISTS OF OXITOCINE. |
EP2402310A1 (en) * | 2002-05-24 | 2012-01-04 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
JP4465281B2 (en) * | 2002-12-20 | 2010-05-19 | キャンサー・リサーチ・テクノロジー・リミテッド | 4- (1- (sulfonyl) -1H-indol-2-yl) -4- (hydroxy) -cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents |
FR2853650B1 (en) * | 2003-04-10 | 2006-07-07 | Merck Sante Sas | AMINE DEDOUBLING PROCESS USEFUL FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INSULINO-RESISTANCE SYNDROME |
FR2880023B1 (en) | 2004-12-23 | 2007-02-23 | Sanofi Aventis Sa | N - [(4,5-DIPHENYL-3-ALKYL-2-THIENYL) METHYL] AMINE DERIVATIVES AND THEIR PREPARATION AND THERAPEUTIC USE |
FR2927625B1 (en) | 2008-02-19 | 2010-03-12 | Sanofi Aventis | NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
FR2930249B1 (en) | 2008-04-21 | 2010-05-14 | Sanofi Aventis | NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3838167A (en) * | 1972-08-01 | 1974-09-24 | Lilly Co Eli | Process for preparing indoles |
US4479963A (en) * | 1981-02-17 | 1984-10-30 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
DE3705934A1 (en) * | 1987-02-25 | 1988-09-08 | Nattermann A & Cie | Indolyl derivatives, processes for their preparation, and their use as medicaments |
GB8820129D0 (en) * | 1988-08-24 | 1988-09-28 | Schering Agrochemicals Ltd | Fungicides |
FR2679903B1 (en) * | 1991-08-02 | 1993-12-03 | Elf Sanofi | DERIVATIVES OF N-SULFONYL INDOLINE CARRYING AN AMIDIC FUNCTION, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
-
1990
- 1990-07-31 FR FR9009778A patent/FR2665441B1/en not_active Expired - Fee Related
-
1991
- 1991-07-29 PT PT98476A patent/PT98476B/en not_active IP Right Cessation
- 1991-07-29 FI FI913614A patent/FI97224C/en not_active IP Right Cessation
- 1991-07-30 NO NO912970A patent/NO175254C/en not_active IP Right Cessation
- 1991-07-30 AT AT91402123T patent/ATE129236T1/en not_active IP Right Cessation
- 1991-07-30 NZ NZ239182A patent/NZ239182A/en unknown
- 1991-07-30 CA CA002048139A patent/CA2048139C/en not_active Expired - Fee Related
- 1991-07-30 ES ES91402123T patent/ES2080922T3/en not_active Expired - Lifetime
- 1991-07-30 DE DE69113911T patent/DE69113911T2/en not_active Expired - Fee Related
- 1991-07-30 IL IL9901291A patent/IL99012A/en not_active IP Right Cessation
- 1991-07-30 EP EP91402123A patent/EP0469984B1/en not_active Expired - Lifetime
- 1991-07-31 JP JP19207891A patent/JP3195381B2/en not_active Expired - Fee Related
- 1991-07-31 ZA ZA916031A patent/ZA916031B/en unknown
- 1991-07-31 KR KR1019910013249A patent/KR100211434B1/en not_active IP Right Cessation
- 1991-07-31 IE IE269691A patent/IE73452B1/en not_active IP Right Cessation
- 1991-07-31 AU AU81478/91A patent/AU645585B2/en not_active Ceased
- 1991-07-31 HU HU9102552A patent/HU220765B1/en not_active IP Right Cessation
-
1993
- 1993-11-05 AU AU50473/93A patent/AU664491B2/en not_active Ceased
-
1995
- 1995-08-15 IL IL11493495A patent/IL114934A0/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU658664B2 (en) * | 1991-08-02 | 1995-04-27 | Sanofi-Synthelabo | Indoline derivatives having an amide function, their preparation, and pharmaceutical compositions containing them |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HB | Alteration of name in register |
Free format text: SANOFI-SYNTHELABO |