DE69113911T2 - N-sulphonylindolinderivate, deren Herstellung und diese enthaltende Arzneimittel. - Google Patents

N-sulphonylindolinderivate, deren Herstellung und diese enthaltende Arzneimittel.

Info

Publication number
DE69113911T2
DE69113911T2 DE69113911T DE69113911T DE69113911T2 DE 69113911 T2 DE69113911 T2 DE 69113911T2 DE 69113911 T DE69113911 T DE 69113911T DE 69113911 T DE69113911 T DE 69113911T DE 69113911 T2 DE69113911 T2 DE 69113911T2
Authority
DE
Germany
Prior art keywords
denotes
alkyl
group
trifluoromethyl
naphthyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69113911T
Other languages
English (en)
Other versions
DE69113911D1 (de
Inventor
Jean Wagnon
Cointet Paul De
Dino Nisato
Claude Plouzane
Claudine Serradeil-Legal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of DE69113911D1 publication Critical patent/DE69113911D1/de
Application granted granted Critical
Publication of DE69113911T2 publication Critical patent/DE69113911T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69113911T 1990-07-31 1991-07-30 N-sulphonylindolinderivate, deren Herstellung und diese enthaltende Arzneimittel. Expired - Fee Related DE69113911T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9009778A FR2665441B1 (fr) 1990-07-31 1990-07-31 Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.

Publications (2)

Publication Number Publication Date
DE69113911D1 DE69113911D1 (de) 1995-11-23
DE69113911T2 true DE69113911T2 (de) 1996-03-28

Family

ID=9399281

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69113911T Expired - Fee Related DE69113911T2 (de) 1990-07-31 1991-07-30 N-sulphonylindolinderivate, deren Herstellung und diese enthaltende Arzneimittel.

Country Status (17)

Country Link
EP (1) EP0469984B1 (de)
JP (1) JP3195381B2 (de)
KR (1) KR100211434B1 (de)
AT (1) ATE129236T1 (de)
AU (2) AU645585B2 (de)
CA (1) CA2048139C (de)
DE (1) DE69113911T2 (de)
ES (1) ES2080922T3 (de)
FI (1) FI97224C (de)
FR (1) FR2665441B1 (de)
HU (1) HU220765B1 (de)
IE (1) IE73452B1 (de)
IL (2) IL99012A (de)
NO (1) NO175254C (de)
NZ (1) NZ239182A (de)
PT (1) PT98476B (de)
ZA (1) ZA916031B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5481005A (en) * 1990-07-31 1996-01-02 Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
US5338755A (en) * 1990-07-31 1994-08-16 Elf Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2679903B1 (fr) * 1991-08-02 1993-12-03 Elf Sanofi Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.
EP0708765A4 (de) * 1993-07-16 1996-06-26 Merck & Co Inc Substituierte piperazinylkampher-derivate als oxytoxin-antagonisten
ATE216580T1 (de) * 1993-07-16 2002-05-15 Merck & Co Inc Benzoxazinon- und benzopyrimidinon- piperidinyl- verbindungen als tokolytische oxytocin-rezeptor- antagonisten
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
FR2714378B1 (fr) * 1993-12-24 1996-03-15 Sanofi Sa Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
GB9918684D0 (en) * 1999-08-09 1999-10-13 Novartis Ag Organic compounds
JP4080868B2 (ja) 2000-10-17 2008-04-23 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 医薬として活性なスルファニリド誘導体
GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
GB0116594D0 (en) 2001-07-06 2001-08-29 Cancer Res Ventures Ltd Therapeutic compounds
ES2249636T3 (es) 2001-12-20 2006-04-01 Applied Research Systems Ars Holding N.V. Triazoles como antagonistas de la oxitocina.
EP2402310A1 (de) * 2002-05-24 2012-01-04 Millennium Pharmaceuticals, Inc. CCR9-Hemmer und Verwendungsverfahren dafür
JP4465281B2 (ja) * 2002-12-20 2010-05-19 キャンサー・リサーチ・テクノロジー・リミテッド 治療薬としての４−（１−（スルホニル）−１ｈ−インドール−２−イル）−４−（ヒドロキシ）−シクロヘキサ−２，５−ジエノン化合物およびその類似体
FR2853650B1 (fr) * 2003-04-10 2006-07-07 Merck Sante Sas Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance
FR2880023B1 (fr) 2004-12-23 2007-02-23 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique
FR2927625B1 (fr) 2008-02-19 2010-03-12 Sanofi Aventis Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
FR2930249B1 (fr) 2008-04-21 2010-05-14 Sanofi Aventis Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3838167A (en) * 1972-08-01 1974-09-24 Lilly Co Eli Process for preparing indoles
US4479963A (en) * 1981-02-17 1984-10-30 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
DE3705934A1 (de) * 1987-02-25 1988-09-08 Nattermann A & Cie Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB8820129D0 (en) * 1988-08-24 1988-09-28 Schering Agrochemicals Ltd Fungicides
FR2679903B1 (fr) * 1991-08-02 1993-12-03 Elf Sanofi Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.

Also Published As

Publication number Publication date
ES2080922T3 (es) 1996-02-16
FR2665441B1 (fr) 1992-12-04
NO912970L (no) 1992-02-03
PT98476B (pt) 1997-10-31
IE73452B1 (en) 1997-06-04
IL99012A (en) 1996-07-23
HU220765B1 (hu) 2002-05-28
ATE129236T1 (de) 1995-11-15
JP3195381B2 (ja) 2001-08-06
PT98476A (pt) 1992-05-29
FR2665441A1 (fr) 1992-02-07
NO912970D0 (no) 1991-07-30
JPH04234361A (ja) 1992-08-24
EP0469984A3 (de) 1992-03-11
CA2048139C (en) 2002-02-12
AU5047393A (en) 1994-01-13
IE912696A1 (en) 1992-02-12
HU912552D0 (en) 1992-01-28
ZA916031B (en) 1992-04-29
EP0469984B1 (de) 1995-10-18
HUT59669A (en) 1992-06-29
FI97224B (fi) 1996-07-31
FI97224C (fi) 1996-11-11
NO175254C (no) 1994-09-21
EP0469984A2 (de) 1992-02-05
KR920002537A (ko) 1992-02-28
IL114934A0 (en) 1995-12-08
NZ239182A (en) 1995-07-26
NO175254B (no) 1994-06-13
AU664491B2 (en) 1995-11-16
IL99012A0 (en) 1992-07-15
KR100211434B1 (ko) 1999-08-02
FI913614A (fi) 1992-02-01
CA2048139A1 (en) 1992-02-01
FI913614A0 (fi) 1991-07-29
AU645585B2 (en) 1994-01-20
DE69113911D1 (de) 1995-11-23
AU8147891A (en) 1992-02-06

Similar Documents

Publication Publication Date Title
DE69113911D1 (de) N-sulphonylindolinderivate, deren Herstellung und diese enthaltende Arzneimittel.
AU677852B2 (en) Acetamide derivatives and their use for modifying feeding behavior modifiers
AU6788296A (en) Use of adamantane derivatives for treating diseases of the inner ear
DE3768689D1 (de) N-substituierte 3,4,5,6-tetrahydrophthalimide und deren vorprodukte.
ATE135687T1 (de) Perhydroisoindolderivate, ihre herstellung und diese enthaltende arzneimittel
GR3033505T3 (en) Indole, indazole and benzisoxazole derivatives as 5-HT1-like agonists.
DE69433984D1 (de) Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
DE69319925D1 (de) Indol-piperazin-derivate als selektive liganden der 5ht1d und 5ht1b receptoren verwendbar als arzneimittel
DK0646110T3 (da) N-substituerede 3-azabicyclo(3.2.0) heptanderivater som neuroleptika
DK0689534T3 (da) Amidderivater som 5-HT1A-ligander
BR9506763A (pt) Derivados de carbamoil metil uréia
ZA941334B (en) Amide derivative .
PA8491601A1 (es) Compuestos de 1, 2, 3, 4 - tetrahidro-1-naftalenamina utiles en terapia
ATE109485T1 (de) Derivate von n-(vincristinyl-23) und n- (noranhydro-5-vinblastinyl-23) von amino-1- methylphosphonsäure, ihre verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
GR3006582T3 (de)
FI882421A (fi) 5-fenyl-1,2,3a,4,5,9b-hexahydro-3h -benz(e)indol, deras framstaellning och anvaendning som laekemedel.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8339 Ceased/non-payment of the annual fee