MX9304190A - Derivados novedosos de 4-[3-benzofuranil]piperidinilo y 4-[3-benzotientil]piperidinilo. - Google Patents

Derivados novedosos de 4-[3-benzofuranil]piperidinilo y 4-[3-benzotientil]piperidinilo.

Info

Publication number
MX9304190A
MX9304190A MX9304190A MX9304190A MX9304190A MX 9304190 A MX9304190 A MX 9304190A MX 9304190 A MX9304190 A MX 9304190A MX 9304190 A MX9304190 A MX 9304190A MX 9304190 A MX9304190 A MX 9304190A
Authority
MX
Mexico
Prior art keywords
piperidinyl
hydrogen
chr4
benzotientil
benzofuranil
Prior art date
Application number
MX9304190A
Other languages
English (en)
Inventor
Theresia Van Heertum
Jan Vandenberk
Ludo Edmond Josephine Kennis
Albertus Henricus Maria
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX9304190A publication Critical patent/MX9304190A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La invención se refiere a compuestos novedosos de la fórmula (Ver fórmula I); las sales ácidas de adición farmacéuticamente aceptables de los mismos y las formas estereoquimicamente isoméricas de los mismos, en donde X es oxígeno o azufre; R1 es hidrógeno o halógeno R2 es hidrógeno, alquilo de C1-C4, fenilmetilo o halogenofenilmetil; Alq es alcanodiilo de C1-4; -Z-A es un radical divalente seleccionado del grupo que consiste de -S-CH2-CH2-, -S-CH2-CH2-CH2-, -S-CHCH-, -CHCH-CHCH-, C(CHR3)-CH2-CH2-CH2-, -CHCH-O-, -CHR4-CH2-CH2-, -CHR4-CH2-CH2-CH2-, -CHR4-CH2-CH2-CH2-CH2-; en dichos radicales bivalentes un hidrógeno puede ser reemplazado por alquilo de C1-4; R3 es fenilo o halógenofenilo; cada R4 representa independientemente hidrógeno, hidroxi, fenilmetilo o halógenofenilmetilo. Las composiciones farmacéuticas de dichos compuestos y uso como una medicina.
MX9304190A 1992-07-13 1993-07-12 Derivados novedosos de 4-[3-benzofuranil]piperidinilo y 4-[3-benzotientil]piperidinilo. MX9304190A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91239692A 1992-07-13 1992-07-13

Publications (1)

Publication Number Publication Date
MX9304190A true MX9304190A (es) 1994-02-28

Family

ID=25431850

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304190A MX9304190A (es) 1992-07-13 1993-07-12 Derivados novedosos de 4-[3-benzofuranil]piperidinilo y 4-[3-benzotientil]piperidinilo.

Country Status (18)

Country Link
US (1) US6348457B1 (es)
EP (1) EP0672043B1 (es)
JP (1) JPH07508741A (es)
KR (1) KR100251892B1 (es)
AT (1) ATE201684T1 (es)
AU (1) AU669196B2 (es)
CA (1) CA2137673C (es)
DE (1) DE69330283T2 (es)
DK (1) DK0672043T3 (es)
ES (1) ES2159526T3 (es)
FI (1) FI109536B (es)
GR (1) GR3036445T3 (es)
IL (1) IL106311A0 (es)
MX (1) MX9304190A (es)
NZ (1) NZ254113A (es)
PT (1) PT672043E (es)
WO (1) WO1994001437A1 (es)
ZA (1) ZA935017B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016968A1 (fr) * 1994-11-25 1996-06-06 Meiji Seika Kabushiki Kaisha Compose thiazole bicyclique
ES2097093B1 (es) * 1995-05-26 1998-01-16 Ferrer Int Nuevos compuestos derivados de 5h-tiazolo (3,2-a) pirimidin-5-ona.
GB9513467D0 (en) * 1995-07-01 1995-09-06 Knoll Ag Therapeutic agents
WO1999047515A1 (fr) * 1998-03-19 1999-09-23 Nihon Nohyaku Co., Ltd. Derives d'arylpiperidine et utilisation de ceux-ci
US6258819B1 (en) 1999-08-05 2001-07-10 Syntex (U.S.A.) Llc Substituted 2(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)-4(3H)-azaquinazolinones
US6806275B2 (en) 2000-09-13 2004-10-19 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
US6924653B2 (en) 2002-08-26 2005-08-02 Micron Technology, Inc. Selectively configurable microelectronic probes
US6919334B2 (en) * 2002-09-12 2005-07-19 Wyeth Antidepressant azaheterocyclymethyl derivatives of 4,5-dihydroimidazo[1,4,5-de][1,4]benzoxazine
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342870A (en) 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4443451A (en) 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
DE3900541A1 (de) * 1989-01-06 1990-07-19 Schering Ag Substituierte alkene, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US5140029A (en) 1989-01-09 1992-08-18 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones

Also Published As

Publication number Publication date
ATE201684T1 (de) 2001-06-15
DE69330283D1 (de) 2001-07-05
AU669196B2 (en) 1996-05-30
KR100251892B1 (ko) 2000-09-01
US6348457B1 (en) 2002-02-19
GR3036445T3 (en) 2001-11-30
EP0672043B1 (en) 2001-05-30
DK0672043T3 (da) 2001-08-27
NZ254113A (en) 1995-08-28
EP0672043A1 (en) 1995-09-20
PT672043E (pt) 2001-11-30
AU4565993A (en) 1994-01-31
CA2137673C (en) 2005-09-06
FI950138A0 (fi) 1995-01-12
CA2137673A1 (en) 1994-01-20
JPH07508741A (ja) 1995-09-28
ES2159526T3 (es) 2001-10-16
IL106311A0 (en) 1993-11-15
DE69330283T2 (de) 2002-01-10
ZA935017B (en) 1995-01-12
FI109536B (fi) 2002-08-30
FI950138A (fi) 1995-01-12
WO1994001437A1 (en) 1994-01-20

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees