ES2064149T3 - Nuevos derivados del indol, procedimiento de preparacion y medicamentos que los contienen. - Google Patents
Nuevos derivados del indol, procedimiento de preparacion y medicamentos que los contienen.Info
- Publication number
- ES2064149T3 ES2064149T3 ES92400764T ES92400764T ES2064149T3 ES 2064149 T3 ES2064149 T3 ES 2064149T3 ES 92400764 T ES92400764 T ES 92400764T ES 92400764 T ES92400764 T ES 92400764T ES 2064149 T3 ES2064149 T3 ES 2064149T3
- Authority
- ES
- Spain
- Prior art keywords
- indol
- alkyl
- represent
- new derivatives
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
NUEVOS DERIVADOS DEL INDOL, PROCESO DE PREPARACION Y MEDICAMENTOS QUE LOS CONTIENEN. LA INVENCION SE REFIERE A DERIVADOS DEL INDOL DE FORMULA, EN LA QUE R1 Y R2 REPRESENTAN H, ALQUILO, ALCENILO, CICLOALQUILO, N-ALQUILAMINO LMETILO O FENILO EVENTUALMENTE SUSTITUIDOS, R3 Y R4 REPRESENTAN H, HALOGENO, ALQUILO, ALCOXI, ALQUILTIO, CF3, NO2, N-ALQUILAMINO O N,N-DIALQUILAMINO, BENCILO O FENILO EVENTUALMENTE SUSTITUIDOS, R5 REPRESENTA H, ALQUILO, CICLOALQUILO O BENCILO EVENTUALMENTE SUSTITUIDO. R6 DESIGNA UN RADICAL ALQUILO, FENILO O HETEROCICLICO EVENTUALMENTE SUSTITUIDOS, Z DESIGNA LOS BIRRADICALES: -(CH2)N N=0-2, P=0-2 Y N + P MENOR O IGUAL A 2, R7 Y R8 REPRESENTAN H, ALQUILO, ALCENILO, CICLOALQUILO, N-ALQUILAMINO, N,N-DIALQUILAMINO, N-ALIKILAMINO PUEDEN ESTAR SUSTITUIDOS, O FORMAN JUNTOS CADENAS POLIMETILENA U OXA-, TIA SUS PROCESOS DE PREPARACION Y APLICACION COMO MEDICAMENTOS HIPOLIPIDEMIANTES, ANTIATEROMATOSOS Y ANTIDIABETICOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9103618A FR2674522B1 (fr) | 1991-03-26 | 1991-03-26 | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064149T3 true ES2064149T3 (es) | 1995-01-16 |
Family
ID=9411107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92400764T Expired - Lifetime ES2064149T3 (es) | 1991-03-26 | 1992-03-20 | Nuevos derivados del indol, procedimiento de preparacion y medicamentos que los contienen. |
Country Status (25)
Country | Link |
---|---|
US (1) | US5219859A (es) |
EP (1) | EP0506532B1 (es) |
JP (1) | JPH0597802A (es) |
KR (1) | KR950007753B1 (es) |
AT (1) | ATE111078T1 (es) |
AU (1) | AU658609B2 (es) |
CA (1) | CA2063170A1 (es) |
CS (1) | CS89592A3 (es) |
DE (1) | DE69200378T2 (es) |
DK (1) | DK0506532T3 (es) |
ES (1) | ES2064149T3 (es) |
FR (1) | FR2674522B1 (es) |
HU (1) | HUT65489A (es) |
IE (1) | IE65366B1 (es) |
IL (1) | IL101248A (es) |
MA (1) | MA22474A1 (es) |
MX (1) | MX9201365A (es) |
NO (1) | NO178260C (es) |
NZ (1) | NZ242078A (es) |
OA (1) | OA09573A (es) |
RU (1) | RU2074179C1 (es) |
SI (1) | SI9210305A (es) |
TN (1) | TNSN92022A1 (es) |
YU (1) | YU30592A (es) |
ZA (1) | ZA922163B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2687402B1 (fr) * | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
JPH07503737A (ja) * | 1992-05-28 | 1995-04-20 | フアイザー・インコーポレイテツド | アシル補酵素a:コレステロールアシルトランスフェラーゼ(acat)の阻害剤としての新規なn−アリールおよびn−ヘテロアリール尿素誘導体 |
NZ250916A (en) * | 1993-02-27 | 1995-08-28 | Nihon Nohyaku Co Ltd | N-heteroaryl-n'-phenylureas, their use as acat inhibitors |
IL109568A0 (en) * | 1993-05-19 | 1994-08-26 | Fujisawa Pharmaceutical Co | Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
JP3720395B2 (ja) | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
KR100241643B1 (ko) * | 1995-06-06 | 2000-03-02 | 디. 제이. 우드 | 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체 |
DK0832065T3 (da) * | 1995-06-06 | 2001-11-19 | Pfizer | Substituerede N-(indol-2-carbonyl)glycinamider og derivater som glycogenphosphorylaseinhibitorer |
MX9709874A (es) | 1995-06-06 | 1998-03-31 | Pfizer | N-(INDOL-2-CARBONIL) beta-ALANILAMIDAS SUSTITUIDAS Y DERIVADOS COMO INHIBIDORES DE GLUCOGENO FOSFORILASA, USO DE LOS MISMOS Y COMPOSICIONES QUE LOS CONTIENEN. |
AU679887B2 (en) * | 1995-09-11 | 1997-07-10 | Nihon Nohyaku Co., Ltd. | Azole derivatives, their use, production and usage |
ES2164920T3 (es) * | 1995-10-05 | 2002-03-01 | Kyoto Pharma Ind | Nuevos derivados heterociclicos y uso medicinal de los mismos. |
EP0773218A1 (en) * | 1995-11-13 | 1997-05-14 | Mitsubishi Chemical Corporation | N-(Piperazinylalkoxyphenyl)-N'phenylalkylurea derivatives as ACAT inhibitors for the treatment of atheroschlerosis |
FR2763334A1 (fr) * | 1997-05-13 | 1998-11-20 | Lipha | Derives anthraniliques |
US6545022B1 (en) * | 1997-12-16 | 2003-04-08 | Pfizer Inc. | 4(3)substituted-4(3)-aminomethyl-(thio)pyran or piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
BR9813656A (pt) * | 1997-12-16 | 2000-10-10 | Warner Lambert Co | Aminas como agentes farmacêuticos |
CN1495160A (zh) * | 1997-12-16 | 2004-05-12 | ��ʲ | 1-取代-1-氨基甲基-环烷衍生物(=加巴喷丁类似物)、其制备及其在治疗神经病方面的用途 |
SK282727B6 (sk) | 1997-12-19 | 2002-11-06 | Slovakofarma, A. S. | 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy |
US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
US7153882B2 (en) | 2000-11-02 | 2006-12-26 | The United States Of America As Represented By The Department Of Health And Human Services | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof |
AU2003236247A1 (en) * | 2002-05-03 | 2003-11-17 | Warner-Lambert Company Llc | Bombesin antagonists |
US7429612B2 (en) * | 2002-07-17 | 2008-09-30 | Kyoto Pharmaceutical Industries, Ltd. | Indoline compound and medicinal use thereof |
EP1615900A1 (en) * | 2003-04-01 | 2006-01-18 | Eli Lilly And Company | Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors |
JP2009517430A (ja) | 2005-11-30 | 2009-04-30 | エフ.ホフマン−ラ ロシュ アーゲー | 3−アミノ−1−アリールプロピルインドール類及びアザ置換インドール類 |
RU2008120141A (ru) | 2005-11-30 | 2010-01-10 | Ф. Хоффманн-Ля Рош Аг (Ch) | 3-амино-2-арилпропилазаиндолы и их применения |
RU2361581C2 (ru) * | 2007-09-14 | 2009-07-20 | Закрытое Акционерное Общество "Мастерклон" | Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний |
SK287385B6 (sk) | 2007-11-27 | 2010-08-09 | Hameln-Rds, A. S. | 1,3-Disubstituované močoviny, spôsob ich prípravy a použitia |
CN104628621A (zh) * | 2015-01-22 | 2015-05-20 | 湖南华腾制药有限公司 | 一种氟取代吲哚衍生物的制备方法 |
CN110913854B (zh) | 2017-06-26 | 2023-04-28 | 卢内拉生物技术有限公司 | mitoketoscin:靶向癌细胞中酮代谢的基于线粒体的治疗剂 |
MX2021010193A (es) | 2019-02-27 | 2021-09-21 | Univ California | Azepino-indoles y otros heterociclos para el tratamiento de trastornos cerebrales. |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55151505A (en) * | 1979-05-14 | 1980-11-26 | Kuraray Co Ltd | Indole agricultural and horticultural fungicide |
CA1299174C (en) * | 1987-02-02 | 1992-04-21 | Michael Edward Flaugh | Alkylmelatonins |
EP0375133A1 (en) * | 1988-11-14 | 1990-06-27 | The Upjohn Company | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
IL95584A (en) * | 1989-09-07 | 1995-03-15 | Abbott Lab | Indole-, benzoporene- and benzothiophene compounds including lipoxygenase-inhibiting compounds and pharmaceutical compounds containing them |
MX22406A (es) * | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
ATE130002T1 (de) * | 1990-08-13 | 1995-11-15 | Hoechst Roussel Pharma | 1-(pyridinylalkyl)-1h-indole, -indoline und analoge. |
FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
WO1993005020A1 (en) * | 1991-09-06 | 1993-03-18 | Merck & Co., Inc. | Indoles as inhibitors of hiv reverse transcriptase |
-
1991
- 1991-03-26 FR FR9103618A patent/FR2674522B1/fr not_active Expired - Fee Related
-
1992
- 1992-03-16 IL IL10124892A patent/IL101248A/en not_active IP Right Cessation
- 1992-03-17 CA CA002063170A patent/CA2063170A1/en not_active Abandoned
- 1992-03-20 ES ES92400764T patent/ES2064149T3/es not_active Expired - Lifetime
- 1992-03-20 EP EP92400764A patent/EP0506532B1/fr not_active Expired - Lifetime
- 1992-03-20 DE DE69200378T patent/DE69200378T2/de not_active Expired - Fee Related
- 1992-03-20 NZ NZ242078A patent/NZ242078A/en unknown
- 1992-03-20 AU AU13094/92A patent/AU658609B2/en not_active Ceased
- 1992-03-20 DK DK92400764.4T patent/DK0506532T3/da active
- 1992-03-20 US US07/855,544 patent/US5219859A/en not_active Expired - Fee Related
- 1992-03-20 AT AT92400764T patent/ATE111078T1/de active
- 1992-03-23 MA MA22763A patent/MA22474A1/fr unknown
- 1992-03-24 IE IE920937A patent/IE65366B1/en not_active IP Right Cessation
- 1992-03-24 NO NO921141A patent/NO178260C/no unknown
- 1992-03-25 CS CS92895A patent/CS89592A3/cs unknown
- 1992-03-25 RU SU925011235A patent/RU2074179C1/ru active
- 1992-03-25 JP JP4067252A patent/JPH0597802A/ja active Pending
- 1992-03-25 ZA ZA922163A patent/ZA922163B/xx unknown
- 1992-03-25 HU HU9200997A patent/HUT65489A/hu unknown
- 1992-03-26 MX MX9201365A patent/MX9201365A/es not_active IP Right Cessation
- 1992-03-26 OA OA60177A patent/OA09573A/fr unknown
- 1992-03-26 TN TNTNSN92022A patent/TNSN92022A1/fr unknown
- 1992-03-26 SI SI9210305A patent/SI9210305A/sl unknown
- 1992-03-26 YU YU30592A patent/YU30592A/sh unknown
- 1992-03-26 KR KR1019920005020A patent/KR950007753B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IE920937A1 (en) | 1992-10-07 |
IL101248A0 (en) | 1992-11-15 |
DE69200378T2 (de) | 1995-03-09 |
MX9201365A (es) | 1992-10-01 |
KR920018022A (ko) | 1992-10-21 |
ZA922163B (en) | 1993-09-27 |
SI9210305A (en) | 1996-02-29 |
HUT65489A (en) | 1994-06-28 |
EP0506532B1 (fr) | 1994-09-07 |
FR2674522B1 (fr) | 1993-07-16 |
AU1309492A (en) | 1992-10-01 |
NO178260C (no) | 1996-02-21 |
JPH0597802A (ja) | 1993-04-20 |
NO921141L (no) | 1992-09-28 |
IE65366B1 (en) | 1995-10-18 |
CS89592A3 (en) | 1992-10-14 |
DK0506532T3 (da) | 1995-02-20 |
EP0506532A1 (fr) | 1992-09-30 |
NZ242078A (en) | 1994-10-26 |
US5219859A (en) | 1993-06-15 |
YU30592A (sh) | 1994-12-28 |
IL101248A (en) | 1996-12-05 |
KR950007753B1 (ko) | 1995-07-14 |
HU9200997D0 (en) | 1992-05-28 |
DE69200378D1 (de) | 1994-10-13 |
RU2074179C1 (ru) | 1997-02-27 |
TNSN92022A1 (fr) | 1993-06-08 |
NO921141D0 (no) | 1992-03-24 |
ATE111078T1 (de) | 1994-09-15 |
MA22474A1 (fr) | 1992-10-01 |
OA09573A (fr) | 1993-01-31 |
NO178260B (no) | 1995-11-13 |
FR2674522A1 (fr) | 1992-10-02 |
CA2063170A1 (en) | 1992-09-27 |
AU658609B2 (en) | 1995-04-27 |
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