YU30592A - Novi derivati indola i postupci dobijanja - Google Patents

Novi derivati indola i postupci dobijanja

Info

Publication number
YU30592A
YU30592A YU30592A YU30592A YU30592A YU 30592 A YU30592 A YU 30592A YU 30592 A YU30592 A YU 30592A YU 30592 A YU30592 A YU 30592A YU 30592 A YU30592 A YU 30592A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
alkylamino
benzyl
indole derivatives
optionally substituted
Prior art date
Application number
YU30592A
Other languages
English (en)
Inventor
D. Descours
R. Bellemin
J. Decerprit
Original Assignee
Lipha Lyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha Lyonnaise Industrielle Pharmaceutique filed Critical Lipha Lyonnaise Industrielle Pharmaceutique
Priority to SI9210305A priority Critical patent/SI9210305A/sl
Publication of YU30592A publication Critical patent/YU30592A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NOVI DERIVATI INDOLA I POSTUPCI DOBIJANJA, pronalazak se odnosi na derivate formule u kojoj, R1 i R2 predstavljaju H, alkil, alkenil, cikloalkil, N-alkilamino- ili N,N-dialkilaminoalkil, benzil, piridilmetil ili fenil eventualno supstituisane, R3 i R4 predstavljaju H, halogen, alkil, alkoksi, alkiltio, CF3, NO2, N-alkilamino ili N,N-dialkilamino, benzil ili fenil eventualno supstituisane, R5 predstavlja H, alkil, cikloalkil ili benzil eventualno supstituisane, R6 označava radikal alkila, fenila ili heterocilila eventualno supstituisane, Z označava biradikale:-(CH2)n-C(R7R8)-(CH2)p-, -CH=CH-C(R7R8)-u kojima n=0-2, p=0-2 i n+p-2, R7 i R8 predstavljaju H, alkil, alkenil, cikloalkil, N-alkilamino, N,N-dialkilamino, N-alkilamino- ili N,N-dialkilaminoalkil, benzil ili fenil koji mogu da budu supstituisani, ili formiraju zajedno lance polimetilena ili oksi-, tia- ili aminopolimetilena, kao na njihove tautomerne oblike, postupke za njihovo dobijanje i primenu kao lekova hipolipidemianta, anti-arteroskleroznih i antidijabetičnih.
YU30592A 1991-03-26 1992-03-26 Novi derivati indola i postupci dobijanja YU30592A (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI9210305A SI9210305A (en) 1991-03-26 1992-03-26 Indole derivatives, processes for their preparation and medicaments containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9103618A FR2674522B1 (fr) 1991-03-26 1991-03-26 Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.

Publications (1)

Publication Number Publication Date
YU30592A true YU30592A (sh) 1994-12-28

Family

ID=9411107

Family Applications (1)

Application Number Title Priority Date Filing Date
YU30592A YU30592A (sh) 1991-03-26 1992-03-26 Novi derivati indola i postupci dobijanja

Country Status (25)

Country Link
US (1) US5219859A (sh)
EP (1) EP0506532B1 (sh)
JP (1) JPH0597802A (sh)
KR (1) KR950007753B1 (sh)
AT (1) ATE111078T1 (sh)
AU (1) AU658609B2 (sh)
CA (1) CA2063170A1 (sh)
CS (1) CS89592A3 (sh)
DE (1) DE69200378T2 (sh)
DK (1) DK0506532T3 (sh)
ES (1) ES2064149T3 (sh)
FR (1) FR2674522B1 (sh)
HU (1) HUT65489A (sh)
IE (1) IE65366B1 (sh)
IL (1) IL101248A (sh)
MA (1) MA22474A1 (sh)
MX (1) MX9201365A (sh)
NO (1) NO178260C (sh)
NZ (1) NZ242078A (sh)
OA (1) OA09573A (sh)
RU (1) RU2074179C1 (sh)
SI (1) SI9210305A (sh)
TN (1) TNSN92022A1 (sh)
YU (1) YU30592A (sh)
ZA (1) ZA922163B (sh)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687402B1 (fr) * 1992-02-14 1995-06-30 Lipha Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
US6001860A (en) * 1992-05-28 1999-12-14 Pfizer Inc. N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT)
NZ250916A (en) * 1993-02-27 1995-08-28 Nihon Nohyaku Co Ltd N-heteroaryl-n'-phenylureas, their use as acat inhibitors
IL109568A0 (en) * 1993-05-19 1994-08-26 Fujisawa Pharmaceutical Co Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4401893A1 (de) * 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
JP3720395B2 (ja) * 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
JP3314938B2 (ja) * 1995-06-06 2002-08-19 ファイザー・インコーポレーテッド グリコーゲンホスホリラーゼ抑制剤としての置換されたｎ−（インドール−２−カルボニル）−グリシンアミド類および誘導体
MX9709874A (es) 1995-06-06 1998-03-31 Pfizer N-(INDOL-2-CARBONIL) beta-ALANILAMIDAS SUSTITUIDAS Y DERIVADOS COMO INHIBIDORES DE GLUCOGENO FOSFORILASA, USO DE LOS MISMOS Y COMPOSICIONES QUE LOS CONTIENEN.
KR100241643B1 (ko) * 1995-06-06 2000-03-02 디. 제이. 우드 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체
AU679887B2 (en) * 1995-09-11 1997-07-10 Nihon Nohyaku Co., Ltd. Azole derivatives, their use, production and usage
DK0866059T3 (da) * 1995-10-05 2002-03-25 Kyoto Pharma Ind Nye heterocykliske derivater og medicinsk anvendelse deraf
EP0773218A1 (en) * 1995-11-13 1997-05-14 Mitsubishi Chemical Corporation N-(Piperazinylalkoxyphenyl)-N'phenylalkylurea derivatives as ACAT inhibitors for the treatment of atheroschlerosis
FR2763334A1 (fr) * 1997-05-13 1998-11-20 Lipha Derives anthraniliques
US6521650B1 (en) * 1997-12-16 2003-02-18 Pfizer, Inc. Amines as pharmaceutical agents
TR200001795T2 (tr) * 1997-12-16 2000-11-21 Warner-Lambert Company 1-İkameli-1-Aminometil-sikloalkan türevleri (=Gabapentin analogları), bunların hazırlanması ve nörolojik bozuklukların tedavisinde kullanımı.
IL135315A0 (en) * 1997-12-16 2001-05-20 Warner Lambert Co 4(3)-substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (gabapentin analogues), their preparation and their use in the treatment of neurological disorders
SK282727B6 (sk) 1997-12-19 2002-11-06 Slovakofarma, A. S. 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
US7153882B2 (en) 2000-11-02 2006-12-26 The United States Of America As Represented By The Department Of Health And Human Services Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof
MXPA04010780A (es) * 2002-05-03 2005-03-07 Warner Lambert Co Antagonistas de bombesina.
RU2318808C2 (ru) * 2002-07-17 2008-03-10 Киото Фармасьютикал Индастриз, Лтд. Новое соединение индолина и его применение в медицине
EP1615900A1 (en) * 2003-04-01 2006-01-18 Eli Lilly And Company Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors
RU2008120141A (ru) 2005-11-30 2010-01-10 Ф. Хоффманн-Ля Рош Аг (Ch) 3-амино-2-арилпропилазаиндолы и их применения
CA2629962A1 (en) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
RU2361581C2 (ru) * 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
SK287385B6 (sk) 2007-11-27 2010-08-09 Hameln-Rds, A. S. 1,3-Disubstituované močoviny, spôsob ich prípravy a použitia
CN104628621A (zh) * 2015-01-22 2015-05-20 湖南华腾制药有限公司 一种氟取代吲哚衍生物的制备方法
JP7397672B2 (ja) 2017-06-26 2023-12-13 ルネラ・バイオテック・インコーポレーテッド ミトケトシン：癌細胞におけるケトン代謝を標的とするミトコンドリアに基づく治療薬
CN113784962A (zh) 2019-02-27 2021-12-10 加利福尼亚大学董事会 用于治疗脑部疾病的氮杂环庚三烯并-吲哚类和其他杂环

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151505A (en) * 1979-05-14 1980-11-26 Kuraray Co Ltd Indole agricultural and horticultural fungicide
CA1299174C (en) * 1987-02-02 1992-04-21 Michael Edward Flaugh Alkylmelatonins
EP0375133A1 (en) * 1988-11-14 1990-06-27 The Upjohn Company Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
PH30133A (en) * 1989-09-07 1997-01-21 Abbott Lab Indole-, benzofuran-, and benzothiophene-containing lipoxygenase inhibiting compounds
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
ATE130002T1 (de) * 1990-08-13 1995-11-15 Hoechst Roussel Pharma 1-(pyridinylalkyl)-1h-indole, -indoline und analoge.
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
WO1993005020A1 (en) * 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase

Also Published As

Publication number Publication date
HU9200997D0 (en) 1992-05-28
DE69200378D1 (de) 1994-10-13
NO178260C (no) 1996-02-21
NZ242078A (en) 1994-10-26
SI9210305A (en) 1996-02-29
RU2074179C1 (ru) 1997-02-27
OA09573A (fr) 1993-01-31
NO921141D0 (no) 1992-03-24
HUT65489A (en) 1994-06-28
CA2063170A1 (en) 1992-09-27
US5219859A (en) 1993-06-15
EP0506532B1 (fr) 1994-09-07
AU658609B2 (en) 1995-04-27
IE65366B1 (en) 1995-10-18
MX9201365A (es) 1992-10-01
FR2674522A1 (fr) 1992-10-02
MA22474A1 (fr) 1992-10-01
FR2674522B1 (fr) 1993-07-16
DK0506532T3 (da) 1995-02-20
NO921141L (no) 1992-09-28
ZA922163B (en) 1993-09-27
IL101248A0 (en) 1992-11-15
NO178260B (no) 1995-11-13
KR950007753B1 (ko) 1995-07-14
IL101248A (en) 1996-12-05
AU1309492A (en) 1992-10-01
IE920937A1 (en) 1992-10-07
ES2064149T3 (es) 1995-01-16
EP0506532A1 (fr) 1992-09-30
JPH0597802A (ja) 1993-04-20
TNSN92022A1 (fr) 1993-06-08
ATE111078T1 (de) 1994-09-15
CS89592A3 (en) 1992-10-14
KR920018022A (ko) 1992-10-21
DE69200378T2 (de) 1995-03-09

Similar Documents

Publication Publication Date Title
YU30592A (sh) Novi derivati indola i postupci dobijanja
CO5031253A1 (es) Antagonistas receptores y5 de neuropeptidos composiciones farmaceuticas que las contienen
YU128091A (sh) Derivati hinuklidina
ATE149999T1 (de) Monofluorierte derivate von n-propargyl-1- aminoindan und deren verwendung als monoamino- oxidaseinhibitoren
HN1998000035A (es) Nuevos derivados del acido hexanoico
CY1110399T1 (el) Ρυθμιστες της τετραϋδροπυρανυλο κυκλοπεντυλο τετραϋδροπυριδοπυριδινης για την ενεργοτητα των υποδοχεων των χημειοκινων
YU29892A (sh) Postupak za stereoselektivno dobijanje supstituisanih piperidina
YU30491A (sh) Derivati 1-piridilimidazola i njegova proizvodnja i upotreba
AR003955A1 (es) Derivados de n-(indol-2-carbonil)-glicinamidas, procedimiento para su obtencion y composiciones que los contienen.
ES2180530T3 (es) Sulfonamidas de tiofeno utiles como inhibidores de anhidrasa carbonica.
ES2053451T3 (es) Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.
AR007828A1 (es) Compuestos derivados de piridilpirrol, procedimiento de preparacion y composiciones farmaceuticas conteniendo los mismos
NO960630L (no) Heterocykler anvendelige som neurokinin antagonister
ES531121A0 (es) Procedimiento de preparar derivados benzofuran- o benzopirancar-boxamidicos
AR017542A1 (es) Compuestos [indol]naftopiranos, procedimiento para prepararlos, un (co)polimero, un compuesto fotocromatico, una composicion fotocromatica, una matriz(co)polimerica, un articulo solar y un vidriado, todos basados en los compuestos
DK0489877T3 (da) Antiatherosklerotiske og antithrombotiske 2-amino-6-phenyl-4H-pyran-4-oner
DE69727305D1 (de) Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen
CY1106396T1 (el) Γραμμικες ή κυκλικες ουριες, μεθοδος παρασκευης αυτων και φαρμακευτικες συνθεσεις οι οποιες τις πepιεχουν
AR027134A1 (es) Derivados de indol.
ES2117678T3 (es) Derivados de eteres milbemicina, su preparacion y su aplicacion terapeutica y agroquimica.
DK1017681T3 (da) Hydrazon-benzazulenderivater, farmaceutiske præparater og mellemprodukter
AR006084A1 (es) Aminofeniluracilos substituidos y empleo de los mismos para la lucha contra las plantas indeseables
ES2123122T3 (es) Derivados de tetrahidrocarbazol como agonistas similares a 5-ht1.
ATE199252T1 (de) 1-amino-3-benzyluracile
ES542074A0 (es) Procedimiento para preparar derivados de benzotiazol