CS89592A3 - Novel indole derivative, process of its preparation and a pharmaceuticalcomprising thereof - Google Patents
Novel indole derivative, process of its preparation and a pharmaceuticalcomprising thereof Download PDFInfo
- Publication number
- CS89592A3 CS89592A3 CS92895A CS89592A CS89592A3 CS 89592 A3 CS89592 A3 CS 89592A3 CS 92895 A CS92895 A CS 92895A CS 89592 A CS89592 A CS 89592A CS 89592 A3 CS89592 A3 CS 89592A3
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- phenyl
- indolyl
- methyl
- urea
- diisopropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9103618A FR2674522B1 (fr) | 1991-03-26 | 1991-03-26 | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
Publications (1)
Publication Number | Publication Date |
---|---|
CS89592A3 true CS89592A3 (en) | 1992-10-14 |
Family
ID=9411107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS92895A CS89592A3 (en) | 1991-03-26 | 1992-03-25 | Novel indole derivative, process of its preparation and a pharmaceuticalcomprising thereof |
Country Status (25)
Country | Link |
---|---|
US (1) | US5219859A (sh) |
EP (1) | EP0506532B1 (sh) |
JP (1) | JPH0597802A (sh) |
KR (1) | KR950007753B1 (sh) |
AT (1) | ATE111078T1 (sh) |
AU (1) | AU658609B2 (sh) |
CA (1) | CA2063170A1 (sh) |
CS (1) | CS89592A3 (sh) |
DE (1) | DE69200378T2 (sh) |
DK (1) | DK0506532T3 (sh) |
ES (1) | ES2064149T3 (sh) |
FR (1) | FR2674522B1 (sh) |
HU (1) | HUT65489A (sh) |
IE (1) | IE65366B1 (sh) |
IL (1) | IL101248A (sh) |
MA (1) | MA22474A1 (sh) |
MX (1) | MX9201365A (sh) |
NO (1) | NO178260C (sh) |
NZ (1) | NZ242078A (sh) |
OA (1) | OA09573A (sh) |
RU (1) | RU2074179C1 (sh) |
SI (1) | SI9210305A (sh) |
TN (1) | TNSN92022A1 (sh) |
YU (1) | YU30592A (sh) |
ZA (1) | ZA922163B (sh) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2687402B1 (fr) * | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
WO1993024458A1 (en) * | 1992-05-28 | 1993-12-09 | Pfizer Inc. | New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (acat) |
NZ250916A (en) * | 1993-02-27 | 1995-08-28 | Nihon Nohyaku Co Ltd | N-heteroaryl-n'-phenylureas, their use as acat inhibitors |
IL109568A0 (en) * | 1993-05-19 | 1994-08-26 | Fujisawa Pharmaceutical Co | Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
JP3720395B2 (ja) | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
JP3314938B2 (ja) * | 1995-06-06 | 2002-08-19 | ファイザー・インコーポレーテッド | グリコーゲンホスホリラーゼ抑制剤としての置換されたn−(インドール−2−カルボニル)−グリシンアミド類および誘導体 |
MY114711A (en) * | 1995-06-06 | 2002-12-31 | Pfizer | Substituted n-(indole-2-carbonyl)-b-alanmamides and derivatives as antidiabetic agents |
AP9600817A0 (en) | 1995-06-06 | 1996-07-31 | Pfizer | Novel cryatal form of anhydrous 7-( [1A,5A,6A]-6-amino3-3-azabicyclo [3.1.0.] hex-3-yl) -6-fluro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt. |
NZ299242A (en) * | 1995-09-11 | 1997-12-19 | Nihon Nohyaku Co Ltd | N-phenyl-n'-(phenyl substituted imidazol-5-yl, -oxazol-4-yl, and -thiazol-4-yl)urea derivatives |
IL123939A (en) * | 1995-10-05 | 2001-11-25 | Kyoto Pharma Ind | The history of the heterocycles and the pharmaceutical preparations containing them |
CA2190041A1 (en) * | 1995-11-13 | 1997-05-14 | Shinya Inoue | Urea derivatives |
FR2763334A1 (fr) * | 1997-05-13 | 1998-11-20 | Lipha | Derives anthraniliques |
WO1999031074A2 (en) * | 1997-12-16 | 1999-06-24 | Warner-Lambert Company | ((cyclo)alkyl substituted)-.gamma.-aminobutyric acid derivatives (=gaba analogues), their preparation and their use in the treatment of neurological disorders |
JP2002508352A (ja) * | 1997-12-16 | 2002-03-19 | ワーナー−ランバート・カンパニー | 4(3)置換−4(3)−アミノメチル−(チオ)ピラン又はピペリジン誘導体(=ガバペンチン類似体)、それらの製法および神経病理学的疾患の治療における使用 |
NZ503963A (en) * | 1997-12-16 | 2002-09-27 | Warner Lambert Co | 1-substituted-1-aminomethyl-cycloalkane derivatives, or gabapentin analogues, preparation and use in the treatment of neurological disorders |
SK282727B6 (sk) | 1997-12-19 | 2002-11-06 | Slovakofarma, A. S. | 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy |
US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
EP1349858B1 (en) | 2000-11-02 | 2008-08-27 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof |
JP2005538047A (ja) * | 2002-05-03 | 2005-12-15 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | ボンベシンアンタゴニスト |
IL166313A0 (en) * | 2002-07-17 | 2006-01-15 | Kyoto Pharma Ind | Indoline derivatives and pharmaceutical compositions containing the same |
EP1615900A1 (en) * | 2003-04-01 | 2006-01-18 | Eli Lilly And Company | Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors |
WO2007062996A1 (en) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles and aza-substituted indoles |
ATE442368T1 (de) | 2005-11-30 | 2009-09-15 | Hoffmann La Roche | 3-amino-2-arylpropylazaindole und anwendungen davon |
RU2361581C2 (ru) * | 2007-09-14 | 2009-07-20 | Закрытое Акционерное Общество "Мастерклон" | Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний |
SK287385B6 (sk) | 2007-11-27 | 2010-08-09 | Hameln-Rds, A. S. | 1,3-Disubstituované močoviny, spôsob ich prípravy a použitia |
CN104628621A (zh) * | 2015-01-22 | 2015-05-20 | 湖南华腾制药有限公司 | 一种氟取代吲哚衍生物的制备方法 |
MX2019014806A (es) | 2017-06-26 | 2020-02-10 | Lunella Biotech Inc | Mitocetoscinas: agentes terapeuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en celulas cancerosas. |
BR112021016620A2 (pt) | 2019-02-27 | 2021-11-03 | Univ California | Azepino-indóis e outros heterociclos para o tratamento de distúrbios cerebrais |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55151505A (en) * | 1979-05-14 | 1980-11-26 | Kuraray Co Ltd | Indole agricultural and horticultural fungicide |
CA1299174C (en) * | 1987-02-02 | 1992-04-21 | Michael Edward Flaugh | Alkylmelatonins |
EP0375133A1 (en) * | 1988-11-14 | 1990-06-27 | The Upjohn Company | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
PH30133A (en) * | 1989-09-07 | 1997-01-21 | Abbott Lab | Indole-, benzofuran-, and benzothiophene-containing lipoxygenase inhibiting compounds |
WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
DK0471296T3 (da) * | 1990-08-13 | 1996-03-11 | Hoechst Roussel Pharma | 1-(Pyridinylalkyl)-1H-indoler, -indoliner og beslægtede analoge |
FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
WO1993005020A1 (en) * | 1991-09-06 | 1993-03-18 | Merck & Co., Inc. | Indoles as inhibitors of hiv reverse transcriptase |
-
1991
- 1991-03-26 FR FR9103618A patent/FR2674522B1/fr not_active Expired - Fee Related
-
1992
- 1992-03-16 IL IL10124892A patent/IL101248A/en not_active IP Right Cessation
- 1992-03-17 CA CA002063170A patent/CA2063170A1/en not_active Abandoned
- 1992-03-20 ES ES92400764T patent/ES2064149T3/es not_active Expired - Lifetime
- 1992-03-20 DK DK92400764.4T patent/DK0506532T3/da active
- 1992-03-20 AT AT92400764T patent/ATE111078T1/de active
- 1992-03-20 AU AU13094/92A patent/AU658609B2/en not_active Ceased
- 1992-03-20 EP EP92400764A patent/EP0506532B1/fr not_active Expired - Lifetime
- 1992-03-20 NZ NZ242078A patent/NZ242078A/en unknown
- 1992-03-20 DE DE69200378T patent/DE69200378T2/de not_active Expired - Fee Related
- 1992-03-20 US US07/855,544 patent/US5219859A/en not_active Expired - Fee Related
- 1992-03-23 MA MA22763A patent/MA22474A1/fr unknown
- 1992-03-24 NO NO921141A patent/NO178260C/no unknown
- 1992-03-24 IE IE920937A patent/IE65366B1/en not_active IP Right Cessation
- 1992-03-25 HU HU9200997A patent/HUT65489A/hu unknown
- 1992-03-25 CS CS92895A patent/CS89592A3/cs unknown
- 1992-03-25 JP JP4067252A patent/JPH0597802A/ja active Pending
- 1992-03-25 ZA ZA922163A patent/ZA922163B/xx unknown
- 1992-03-25 RU SU925011235A patent/RU2074179C1/ru active
- 1992-03-26 OA OA60177A patent/OA09573A/fr unknown
- 1992-03-26 KR KR1019920005020A patent/KR950007753B1/ko not_active IP Right Cessation
- 1992-03-26 TN TNTNSN92022A patent/TNSN92022A1/fr unknown
- 1992-03-26 MX MX9201365A patent/MX9201365A/es not_active IP Right Cessation
- 1992-03-26 SI SI9210305A patent/SI9210305A/sl unknown
- 1992-03-26 YU YU30592A patent/YU30592A/sh unknown
Also Published As
Publication number | Publication date |
---|---|
RU2074179C1 (ru) | 1997-02-27 |
EP0506532A1 (fr) | 1992-09-30 |
AU658609B2 (en) | 1995-04-27 |
FR2674522B1 (fr) | 1993-07-16 |
SI9210305A (en) | 1996-02-29 |
AU1309492A (en) | 1992-10-01 |
IE920937A1 (en) | 1992-10-07 |
HU9200997D0 (en) | 1992-05-28 |
IL101248A (en) | 1996-12-05 |
KR950007753B1 (ko) | 1995-07-14 |
ZA922163B (en) | 1993-09-27 |
IL101248A0 (en) | 1992-11-15 |
CA2063170A1 (en) | 1992-09-27 |
DE69200378T2 (de) | 1995-03-09 |
ES2064149T3 (es) | 1995-01-16 |
NZ242078A (en) | 1994-10-26 |
MA22474A1 (fr) | 1992-10-01 |
IE65366B1 (en) | 1995-10-18 |
MX9201365A (es) | 1992-10-01 |
DE69200378D1 (de) | 1994-10-13 |
KR920018022A (ko) | 1992-10-21 |
NO921141D0 (no) | 1992-03-24 |
NO921141L (no) | 1992-09-28 |
ATE111078T1 (de) | 1994-09-15 |
EP0506532B1 (fr) | 1994-09-07 |
YU30592A (sh) | 1994-12-28 |
NO178260B (no) | 1995-11-13 |
US5219859A (en) | 1993-06-15 |
TNSN92022A1 (fr) | 1993-06-08 |
NO178260C (no) | 1996-02-21 |
HUT65489A (en) | 1994-06-28 |
JPH0597802A (ja) | 1993-04-20 |
FR2674522A1 (fr) | 1992-10-02 |
DK0506532T3 (da) | 1995-02-20 |
OA09573A (fr) | 1993-01-31 |
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